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2024-04-19 13:35:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005623 1351 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens chemokine (C-C motif) ligand 8 (CCL8), mRNA.
ACCESSION NM_005623
VERSION NM_005623.2 GI:22538815
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1351)
AUTHORS Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
Peter,I.
TITLE A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
novel susceptibility loci
JOURNAL PLoS Genet. 8 (3), E1002559 (2012)
PUBMED 22412388
REFERENCE 2 (bases 1 to 1351)
AUTHORS Dajani,R., Al-Haj Ali,E. and Dajani,B.
TITLE Macrophage colony stimulating factor and monocyte chemoattractant
protein 2 are elevated in intrinsic asthmatics
JOURNAL Cytokine 56 (3), 641-647 (2011)
PUBMED 21945122
REMARK GeneRIF: Macrophage Colony Stimulating Factor and Monocyte
Chemoattractant Protein are elevated in sera of intrinsic
asthmatics compared to normal controls.
REFERENCE 3 (bases 1 to 1351)
AUTHORS Ma,H., Shu,Y., Pan,S., Chen,J., Dai,J., Jin,G., Hu,Z. and Shen,H.
TITLE Polymorphisms of key chemokine genes and survival of non-small cell
lung cancer in Chinese
JOURNAL Lung Cancer 74 (2), 164-169 (2011)
PUBMED 21514686
REMARK GeneRIF: genetic polymorphhism is associated with a risk of death
for non-small cell lung cancer in Chinese
REFERENCE 4 (bases 1 to 1351)
AUTHORS Fan,J., Ishmael,F.T., Fang,X., Myers,A., Cheadle,C., Huang,S.K.,
Atasoy,U., Gorospe,M. and Stellato,C.
TITLE Chemokine transcripts as targets of the RNA-binding protein HuR in
human airway epithelium
JOURNAL J. Immunol. 186 (4), 2482-2494 (2011)
PUBMED 21220697
REMARK GeneRIF: Cytokine treatment increases mRNA stability only for
chemokines CCL2 and CCL8 in airway epithelium, and transient
silencing and overexpression of human antigen R affects only
chemokine CCL2 and CCL8 expression in primary and transformed
epithelial cells.
REFERENCE 5 (bases 1 to 1351)
AUTHORS Schuurhof,A., Bont,L., Siezen,C.L., Hodemaekers,H., van
Houwelingen,H.C., Kimman,T.G., Hoebee,B., Kimpen,J.L. and
Janssen,R.
TITLE Interleukin-9 polymorphism in infants with respiratory syncytial
virus infection: an opposite effect in boys and girls
JOURNAL Pediatr. Pulmonol. 45 (6), 608-613 (2010)
PUBMED 20503287
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 1351)
AUTHORS Kim,K.S., Rajarathnam,K., Clark-Lewis,I. and Sykes,B.D.
TITLE Structural characterization of a monomeric chemokine: monocyte
chemoattractant protein-3
JOURNAL FEBS Lett. 395 (2-3), 277-282 (1996)
PUBMED 8898111
REFERENCE 7 (bases 1 to 1351)
AUTHORS Naruse,K., Ueno,M., Satoh,T., Nomiyama,H., Tei,H., Takeda,M.,
Ledbetter,D.H., Coillie,E.V., Opdenakker,G., Gunge,N., Sakaki,Y.,
Iio,M. and Miura,R.
TITLE A YAC contig of the human CC chemokine genes clustered on
chromosome 17q11.2
JOURNAL Genomics 34 (2), 236-240 (1996)
PUBMED 8661057
REFERENCE 8 (bases 1 to 1351)
AUTHORS Van Damme,J., Proost,P., Put,W., Arens,S., Lenaerts,J.P.,
Conings,R., Opdenakker,G., Heremans,H. and Billiau,A.
TITLE Induction of monocyte chemotactic proteins MCP-1 and MCP-2 in human
fibroblasts and leukocytes by cytokines and cytokine inducers.
Chemical synthesis of MCP-2 and development of a specific RIA
JOURNAL J. Immunol. 152 (11), 5495-5502 (1994)
PUBMED 8189067
REFERENCE 9 (bases 1 to 1351)
AUTHORS Van Damme,J., Proost,P., Lenaerts,J.P. and Opdenakker,G.
TITLE Structural and functional identification of two human,
tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3)
belonging to the chemokine family
JOURNAL J. Exp. Med. 176 (1), 59-65 (1992)
PUBMED 1613466
REFERENCE 10 (bases 1 to 1351)
AUTHORS Chang,H.C., Hsu,F., Freeman,G.J., Griffin,J.D. and Reinherz,E.L.
TITLE Cloning and expression of a gamma-interferon-inducible gene in
monocytes: a new member of a cytokine gene family
JOURNAL Int. Immunol. 1 (4), 388-397 (1989)
PUBMED 2518726
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from Y16645.1.
On Aug 29, 2002 this sequence version replaced gi:5032080.
Summary: This gene is one of several cytokine genes clustered on
the q-arm of chromosome 17. Cytokines are a family of secreted
proteins involved in immunoregulatory and inflammatory processes.
The protein encoded by this gene is structurally related to the CXC
subfamily of cytokines. Members of this subfamily are characterized
by two cysteines separated by a single amino acid. This cytokine
displays chemotactic activity for monocytes, lymphocytes, basophils
and eosinophils. By recruiting leukocytes to sites of inflammation
this cytokine may contribute to tumor-associated leukocyte
infiltration and to the antiviral state against HIV infection.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: Y16645.1, AV733664.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025086 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
FEATURES Location/Qualifiers
source 1..1351
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q11.2"
gene 1..1351
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="chemokine (C-C motif) ligand 8"
/db_xref="GeneID:6355"
/db_xref="HGNC:10635"
/db_xref="HPRD:03791"
/db_xref="MIM:602283"
exon 1..531
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/inference="alignment:Splign:1.39.8"
variation 6
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201250013"
variation 11
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:202099684"
variation 30
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200291096"
variation 31
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201300758"
variation 38
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:202179423"
variation 53
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:200341571"
variation 66
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:41410552"
variation 75
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:199521640"
variation 91
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:144109368"
variation 92
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200838025"
variation 109
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201758090"
variation 121
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:144003271"
variation 123
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200579783"
variation 166
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201375146"
variation 181
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200121981"
variation 185
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200585139"
STS 193..1085
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/db_xref="UniSTS:489795"
STS 194..821
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/db_xref="UniSTS:495217"
variation 200
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:201677716"
variation 204
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:73987796"
variation 206
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200973085"
variation 207
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:183097812"
variation 229
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:202247332"
variation 237
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:200079914"
variation 268
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200957138"
variation 286
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:41468844"
variation 292
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:200428662"
variation 304
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201596060"
misc_feature 333..335
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="upstream in-frame stop codon"
variation 338
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:112770170"
variation 346
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:148699932"
STS 378..960
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/db_xref="UniSTS:481767"
variation 381
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:115582326"
variation 382
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:199868476"
variation 397
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:200602745"
variation 404
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:113350491"
variation 406
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:199536140"
variation 408..409
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace=""
/replace="c"
/db_xref="dbSNP:35694639"
variation 413
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200651459"
variation 415
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:202065406"
STS 426..788
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/db_xref="UniSTS:482420"
variation 435
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:199714946"
variation 437
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="g"
/db_xref="dbSNP:200834045"
variation 441
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="g"
/db_xref="dbSNP:375015363"
variation 444
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201631782"
variation 454
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:200100731"
CDS 456..755
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="small inducible cytokine subfamily A (Cys-Cys),
member 8 (monocyte chemotactic protein 2); monocyte
chemoattractant protein 2; C-C motif chemokine 8;
small-inducible cytokine A8"
/codon_start=1
/product="C-C motif chemokine 8 precursor"
/protein_id="NP_005614.2"
/db_xref="GI:22538816"
/db_xref="CCDS:CCDS11280.1"
/db_xref="GeneID:6355"
/db_xref="HGNC:10635"
/db_xref="HPRD:03791"
/db_xref="MIM:602283"
/translation="
MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP
"
sig_peptide 456..524
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 525..752
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/product="C-C motif chemokine 8"
misc_feature 525..527
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P80075.2);
other site"
misc_feature 534..536
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:01703"
misc_feature 537..539
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
mat_peptide 540..752
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/product="MCP-2(6-76)"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P80075.2)"
misc_feature 555..728
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="Chemokine_CC: 1 of 4 subgroup designations based
on the arrangement of the two N-terminal cysteine
residues; includes a number of secreted growth factors and
interferons involved in mitogenic, chemotactic, and
inflammatory activity; some members (e.g; Region:
Chemokine_CC; cd00272"
/db_xref="CDD:29111"
misc_feature order(555..569,573..596,627..632,696..728)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="putative receptor binding site; other site"
/db_xref="CDD:29111"
misc_feature order(561..563,567..569,606..608,612..614,630..632,
645..653,675..683,699..704,711..716,723..728)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="tetramer interface [polypeptide binding]; other
site"
/db_xref="CDD:29111"
misc_feature order(561..563,567..569,621..623,627..632,648..650,
672..674,678..680)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="dimer interface (P form) [polypeptide binding];
other site"
/db_xref="CDD:29111"
misc_feature order(561..563,648..650,675..677)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="putative receptor binding cleft; other site"
/db_xref="CDD:29111"
misc_feature order(561..569,573..596)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="N-loop; other site"
/db_xref="CDD:29111"
misc_feature order(567..569,606..608,612..614,645..647,651..653,
675..677,681..683,699..704,711..716,723..728)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="dimer interface (I form) [polypeptide binding];
other site"
/db_xref="CDD:29111"
misc_feature order(573..581,588..596,663..665,669..671)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="putative glycosaminoglycan (GAG) binding site
[chemical binding]; other site"
/db_xref="CDD:29111"
misc_feature order(612..614,636..638,690..692,696..698,705..710,
717..719)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="putative glycosaminoglycan (GAG) binding site
[chemical binding]; other site"
/db_xref="CDD:29111"
misc_feature 627..632
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="30s-loop; other site"
/db_xref="CDD:29111"
misc_feature order(657..659,663..665)
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/note="40s-loop; other site"
/db_xref="CDD:29111"
variation 459
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201103777"
variation 473
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:143666282"
variation 477
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:34918489"
variation 482
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:148233199"
variation 496
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:35401229"
variation 499
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200483515"
variation 511
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:150734427"
variation 515
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201624360"
variation 526
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200372834"
exon 532..649
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/inference="alignment:Splign:1.39.8"
variation 542
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:41339751"
variation 549
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:139040907"
variation 566
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:368550510"
variation 567
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201901680"
variation 575
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200084252"
variation 596
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:142323373"
variation 601
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:34202026"
variation 626
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:34027928"
variation 629
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200132107"
variation 630
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:143847741"
variation 635
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:145807959"
variation 645
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201842024"
exon 650..1250
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/inference="alignment:Splign:1.39.8"
variation 653
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200570578"
variation 658
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201535512"
variation 659
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="g"
/db_xref="dbSNP:199719039"
variation 660
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:1133763"
variation 663
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201283546"
variation 664
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:369844009"
variation 675
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:372656531"
variation 685
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:199771538"
variation 687
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:151055256"
variation 702
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:200725168"
variation 707
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:201942423"
variation 720
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:117180331"
variation 725
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:146343582"
variation 753
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201616831"
variation 758
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200077434"
variation 759
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200837160"
variation 763
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:192852848"
variation 767
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201646296"
variation 775
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200867051"
variation 776
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200181901"
variation 821..822
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace=""
/replace="c"
/db_xref="dbSNP:35843991"
variation 837
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:141618984"
variation 853
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:202218247"
variation 856
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200364949"
variation 861
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:201294858"
variation 872
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:202176494"
variation 890
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:200335290"
variation 925
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201308836"
variation 945
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:150459473"
variation 952
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200951604"
variation 956..957
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace=""
/replace="c"
/db_xref="dbSNP:35590690"
variation 978
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201580663"
variation 981
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:199751299"
variation 988..989
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace=""
/replace="tgttttt"
/db_xref="dbSNP:370883647"
variation 989
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200578039"
variation 990
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201322935"
variation 995
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200116029"
variation 997..998
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace=""
/replace="t"
/db_xref="dbSNP:71815028"
variation 1030
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:116333519"
variation 1049
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:138262202"
variation 1068
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:199975191"
variation 1131
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="g"
/replace="t"
/db_xref="dbSNP:201092550"
variation 1175
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:202171098"
variation 1185
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200096521"
variation 1187
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:184120436"
variation 1189
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:201937316"
variation 1190
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:200430361"
variation 1195
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:369968443"
variation 1207
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace=""
/replace="a"
/db_xref="dbSNP:377385560"
variation 1208
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201413984"
variation 1229
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:202219411"
variation 1231
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="t"
/db_xref="dbSNP:200421610"
variation 1233
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:201472837"
variation 1237
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="g"
/db_xref="dbSNP:199734704"
variation 1238
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="c"
/replace="t"
/db_xref="dbSNP:200284380"
variation 1239
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/replace="a"
/replace="c"
/db_xref="dbSNP:201121563"
polyA_site 1250
/gene="CCL8"
/gene_synonym="HC14; MCP-2; MCP2; SCYA10; SCYA8"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
gtgatggagagcaccagcaaagccttagggcccatccctggcctcctgttacccacagaggggtaggcccttggctctcttccactatgacgtcagcttccattcttcctttcttatagacaattttccatttcaaggaaatcagagcccttaatagttcagtgaggtcactttgctgagcacaatcccatacccttcagcctctgctccacagagcctaagcaaaagatagaaactcacaacttccttgttttgttatctggaaattatcccaggatctggtgcttactcagcatattcaaggaaggtcttacttcattcttccttgattgtgaccatgcccaggctctctgctccctataaaaggcaggcagagccaccgaggagcagagaggttgagaacaacccagaaaccttcacctctcatgctgaagctcacacccttgccctccaagatgaaggtttctgcagcgcttctgtgcctgctgctcatggcagccactttcagccctcagggacttgctcagccagattcagtttccattccaatcacctgctgctttaacgtgatcaataggaaaattcctatccagaggctggagagctacacaagaatcaccaacatccaatgtcccaaggaagctgtgatcttcaagaccaaacggggcaaggaggtctgtgctgaccccaaggagagatgggtcagggattccatgaagcatctggaccaaatatttcaaaatctgaagccatgagccttcatacatggactgagagtcagagcttgaagaaaagcttatttattttccccaacctcccccaggtgcagtgtgacattattttattataacatccacaaagagattatttttaaataatttaaagcataatatttcttaaaaagtatttaattatatttaagttgttgatgttttaactctatctgtcatacatcctagtgaatgtaaaatgcaaaatcctggtgatgtgttttttgtttttgttttcctgtgagctcaactaagttcacggcaaaatgtcattgttctccctcctacctgtctgtagtgttgtggggtcctcccatggatcatcaaggtgaaacactttggtattctttggcaatcagtgctcctgtaagtcaaatgtgtgctttgtactgctgttgttgaaattgatgttactgtatataactatggaattttgaaaaaaaatttcaaaaagaaaaaaatatatataatttaaaactaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6355 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:6355 -> Molecular function: GO:0008009 [chemokine activity] evidence: IEA
GeneID:6355 -> Molecular function: GO:0008201 [heparin binding] evidence: IEA
GeneID:6355 -> Molecular function: GO:0016004 [phospholipase activator activity] evidence: IDA
GeneID:6355 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:6355 -> Biological process: GO:0006816 [calcium ion transport] evidence: IDA
GeneID:6355 -> Biological process: GO:0006874 [cellular calcium ion homeostasis] evidence: IDA
GeneID:6355 -> Biological process: GO:0006887 [exocytosis] evidence: IDA
GeneID:6355 -> Biological process: GO:0006935 [chemotaxis] evidence: IEA
GeneID:6355 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:6355 -> Biological process: GO:0006955 [immune response] evidence: IEA
GeneID:6355 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6355 -> Biological process: GO:0007267 [cell-cell signaling] evidence: IDA
GeneID:6355 -> Biological process: GO:0009615 [response to virus] evidence: TAS
GeneID:6355 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
by
@meso_cacase at
DBCLS
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