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2024-04-26 11:19:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005587 5569 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens myocyte enhancer factor 2A (MEF2A), transcript variant
1, mRNA.
ACCESSION NM_005587
VERSION NM_005587.2 GI:195972798
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5569)
AUTHORS Nitert,M.D., Dayeh,T., Volkov,P., Elgzyri,T., Hall,E., Nilsson,E.,
Yang,B.T., Lang,S., Parikh,H., Wessman,Y., Weishaupt,H., Attema,J.,
Abels,M., Wierup,N., Almgren,P., Jansson,P.A., Ronn,T., Hansson,O.,
Eriksson,K.F., Groop,L. and Ling,C.
TITLE Impact of an exercise intervention on DNA methylation in skeletal
muscle from first-degree relatives of patients with type 2 diabetes
JOURNAL Diabetes 61 (12), 3322-3332 (2012)
PUBMED 23028138
REMARK GeneRIF: DNA methylation of genes in retinol metabolism and calcium
signaling pathways (P < 3 x 10-6) and with known functions in
muscle and T2D including MEF2A, RUNX1, NDUFC2, and THADA decreased
after exercise
REFERENCE 2 (bases 1 to 5569)
AUTHORS Zhao,W., Zhao,S.P. and Peng,D.Q.
TITLE The effects of myocyte enhancer factor 2A gene on the
proliferation, migration and phenotype of vascular smooth muscle
cells
JOURNAL Cell Biochem. Funct. 30 (2), 108-113 (2012)
PUBMED 22028303
REMARK GeneRIF: MEF2A dominant negative mutation enhanced cell
proliferation and cell migration.
REFERENCE 3 (bases 1 to 5569)
AUTHORS Liu,Y., Niu,W., Wu,Z., Su,X., Chen,Q., Lu,L. and Jin,W.
TITLE Variants in exon 11 of MEF2A gene and coronary artery disease:
evidence from a case-control study, systematic review, and
meta-analysis
JOURNAL PLoS ONE 7 (2), E31406 (2012)
PUBMED 22363637
REMARK GeneRIF: The rare 21-bp deletion might have a more compelling
effect on coronary artery disease (CAD) than the common (CAG)(n)
polymorphism, and MEF2A genetic variant might be a rare but
specific cause of CAD/myocardial infarction.
Review article
REFERENCE 4 (bases 1 to 5569)
AUTHORS Katsarou,K., Tsitoura,P. and Georgopoulou,U.
TITLE MEK5/ERK5/mef2: a novel signaling pathway affected by hepatitis C
virus non-enveloped capsid-like particles
JOURNAL Biochim. Biophys. Acta 1813 (10), 1854-1862 (2011)
PUBMED 21767578
REMARK GeneRIF: HCVne particles are capable of inducing the recently
discovered ERK5 pathway, in a dose dependent way.
REFERENCE 5 (bases 1 to 5569)
AUTHORS She,H. and Mao,Z.
TITLE Regulation of myocyte enhancer factor-2 transcription factors by
neurotoxins
JOURNAL Neurotoxicology 32 (5), 563-566 (2011)
PUBMED 21741404
REMARK GeneRIF: [review] In this work, the mechanisms of regulation of
MEF2 function by several well-known neurotoxins and their
implications in various neurodegenerative diseases are reviewed.
Review article
REFERENCE 6 (bases 1 to 5569)
AUTHORS Molkentin,J.D., Black,B.L., Martin,J.F. and Olson,E.N.
TITLE Cooperative activation of muscle gene expression by MEF2 and
myogenic bHLH proteins
JOURNAL Cell 83 (7), 1125-1136 (1995)
PUBMED 8548800
REFERENCE 7 (bases 1 to 5569)
AUTHORS Hobson,G.M., Krahe,R., Garcia,E., Siciliano,M.J. and Funanage,V.L.
TITLE Regional chromosomal assignments for four members of the MADS
domain transcription enhancer factor 2 (MEF2) gene family to human
chromosomes 15q26, 19p12, 5q14, and 1q12-q23
JOURNAL Genomics 29 (3), 704-711 (1995)
PUBMED 8575763
REFERENCE 8 (bases 1 to 5569)
AUTHORS Funk,W.D. and Wright,W.E.
TITLE Cyclic amplification and selection of targets for multicomponent
complexes: myogenin interacts with factors recognizing binding
sites for basic helix-loop-helix, nuclear factor 1,
myocyte-specific enhancer-binding factor 2, and COMP1 factor
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (20), 9484-9488 (1992)
PUBMED 1329097
REFERENCE 9 (bases 1 to 5569)
AUTHORS Yu,Y.T., Breitbart,R.E., Smoot,L.B., Lee,Y., Mahdavi,V. and
Nadal-Ginard,B.
TITLE Human myocyte-specific enhancer factor 2 comprises a group of
tissue-restricted MADS box transcription factors
JOURNAL Genes Dev. 6 (9), 1783-1798 (1992)
PUBMED 1516833
REFERENCE 10 (bases 1 to 5569)
AUTHORS Pollock,R. and Treisman,R.
TITLE Human SRF-related proteins: DNA-binding properties and potential
regulatory targets
JOURNAL Genes Dev. 5 (12A), 2327-2341 (1991)
PUBMED 1748287
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA778137.1, BC013437.2,
AB208985.1, AC022692.11 and N93079.1.
This sequence is a reference standard in the RefSeqGene project.
On Aug 9, 2008 this sequence version replaced gi:5031906.
Summary: The protein encoded by this gene is a DNA-binding
transcription factor that activates many muscle-specific, growth
factor-induced, and stress-induced genes. The encoded protein can
act as a homodimer or as a heterodimer and is involved in several
cellular processes, including muscle development, neuronal
differentiation, cell growth control, and apoptosis. Defects in
this gene could be a cause of autosomal dominant coronary artery
disease 1 with myocardial infarction (ADCAD1). Several transcript
variants encoding different isoforms have been found for this
gene.[provided by RefSeq, Jan 2010].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC013437.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025086 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-455 DA778137.1 1-455
456-2052 BC013437.2 374-1970
2053-2890 AB208985.1 2232-3069
2891-5356 AC022692.11 153286-155751
5357-5569 N93079.1 1-213 c
FEATURES Location/Qualifiers
source 1..5569
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q26"
gene 1..5569
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="myocyte enhancer factor 2A"
/db_xref="GeneID:4205"
/db_xref="HGNC:6993"
/db_xref="MIM:600660"
exon 1..177
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
exon 178..259
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 225
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:115186154"
exon 260..455
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
misc_feature 393..395
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="upstream in-frame stop codon"
CDS 402..1901
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="isoform 1 is encoded by transcript variant 1; MADS
box transcription enhancer factor 2, polypeptide A
(myocyte enhancer factor 2A); myocyte-specific enhancer
factor 2A; serum response factor-like protein 1"
/codon_start=1
/product="myocyte-specific enhancer factor 2A isoform 1"
/protein_id="NP_005578.2"
/db_xref="GI:195972799"
/db_xref="CCDS:CCDS45362.1"
/db_xref="GeneID:4205"
/db_xref="HGNC:6993"
/db_xref="MIM:600660"
/translation="
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVEALNKKEHRGCDSPDPDTSYVLTPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVPVTSPNALSYTNPGSSLVSPSLAASSTLTDSSMLSPPQTTLHRNVSPGAPQRPPSTGNAGGMLSTTDLTVPNGAGSSPVGNGFVNSRASPNLIGATGANSLGKVMPTKSPPPPGGGNLGMNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAYNTDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISIKSEPISPPRDRMTPSGFQQQQQQQQQQQPPPPPQPQPQPPQPQPRQEMGRSPVDSLSSSSSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRMDAWVT
"
misc_feature 405..635
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="MEF2 (myocyte enhancer factor 2)-like/Type II
subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF
(serum response factor) box family of eukaryotic
transcriptional regulators. Binds DNA and exists as hetero
and homo-dimers. Differs from SRF-like/Type I...; Region:
MADS_MEF2_like; cd00265"
/db_xref="CDD:29020"
misc_feature order(405..413,417..419,423..425,438..440,444..446,
456..461,468..473,477..482,489..494,498..503,513..515)
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:29020"
misc_feature order(462..464,483..488,495..500,504..509,516..518,
531..533,537..539,543..545,561..563,567..569,585..587,
594..599,606..608,615..620)
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:29020"
misc_feature 576..578
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="putative phosphorylation site [posttranslational
modification]; other site"
/db_xref="CDD:29020"
misc_feature 669..866
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/note="Holliday junction regulator protein family
C-terminal repeat; Region: HJURP_C; pfam12347"
/db_xref="CDD:152782"
misc_feature 693..695
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q02078.1); phosphorylation site"
misc_feature 927..932
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage (Probable); propagated from
UniProtKB/Swiss-Prot (Q02078.1); cleavage site"
misc_feature 1038..1043
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage (Probable); propagated from
UniProtKB/Swiss-Prot (Q02078.1); cleavage site"
misc_feature 1104..1106
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q02078.1); phosphorylation site"
misc_feature 1146..1148
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q02078.1); acetylation site"
misc_feature 1164..1166
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK14; propagated from
UniProtKB/Swiss-Prot (Q02078.1); phosphorylation site"
misc_feature 1197..1250
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q02078.1);
Region: Required for interaction with MAPKs"
misc_feature 1311..1313
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAPK7 and MAPK14, alternate;
Phosphothreonine, by NLK, alternate; propagated from
UniProtKB/Swiss-Prot (Q02078.1); phosphorylation site"
misc_feature 1332..1334
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by MAPK7 and MAPK14; propagated
from UniProtKB/Swiss-Prot (Q02078.1); phosphorylation
site"
misc_feature 1440..1442
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK7; propagated from
UniProtKB/Swiss-Prot (Q02078.1); phosphorylation site"
misc_feature 1599..1601
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDK5; propagated from
UniProtKB/Swiss-Prot (Q02078.1); phosphorylation site"
misc_feature 1734..1736
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by MAPK; propagated from
UniProtKB/Swiss-Prot (Q02078.1); phosphorylation site"
misc_feature 1773..1778
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage (Probable); propagated from
UniProtKB/Swiss-Prot (Q02078.1); cleavage site"
STS 411..828
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/standard_name="Mef2a"
/db_xref="UniSTS:265600"
variation 425
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:370523988"
exon 456..659
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
STS 473..705
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/standard_name="SHGC-75886"
/db_xref="UniSTS:12336"
variation 515
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:191032083"
variation 543
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:368747387"
variation 566
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:372436031"
variation 569
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:200687749"
STS 658..791
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/standard_name="Mef2a"
/db_xref="UniSTS:265599"
exon 660..797
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 673
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:377723529"
variation 715
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:201205600"
variation 729
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:75248193"
variation 743
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:74751981"
variation 761
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:34195807"
variation 780
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:376743625"
variation 781
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:75705863"
variation 795
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:370659482"
exon 798..1017
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 868
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:374058145"
variation 918
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:189538320"
variation 920
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:3803420"
variation 953
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:146192119"
variation 964
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:370083199"
variation 999
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:373867888"
exon 1018..1077
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 1030
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:199820037"
variation 1046
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:376779827"
variation 1059
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:377207410"
exon 1078..1265
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 1144
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:189526729"
variation 1158
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:199751824"
variation 1163
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:369943942"
variation 1189
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:121918530"
variation 1197
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:79454361"
variation 1208
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:200748600"
variation 1235
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:369552532"
variation 1236
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:373219260"
variation 1237
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:121918529"
variation 1249
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:121918531"
variation 1262
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:376183174"
exon 1266..1392
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 1268..1269
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:17854846"
variation 1268
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:325408"
variation 1274
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:325407"
variation 1313
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:3730283"
variation 1349
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:372479689"
variation 1371
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:373204094"
exon 1393..1519
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 1406
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:373943430"
variation 1409
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:368107439"
variation 1410
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:373128826"
exon 1520..5555
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/inference="alignment:Splign:1.39.8"
variation 1520
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:199613639"
variation 1549
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:375108417"
variation 1562
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:369483642"
STS 1579..1736
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/standard_name="G64293"
/db_xref="UniSTS:158672"
variation 1615
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:372533601"
variation 1625
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:144461661"
variation 1627
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:369579124"
variation 1628
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:3730059"
variation 1634..1635
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="cagcag"
/db_xref="dbSNP:374033278"
variation 1635..1640
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="cagcag"
/db_xref="dbSNP:3138597"
variation 1635..1637
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="cag"
/db_xref="dbSNP:373652230"
variation 1639..1644
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="agcagc"
/db_xref="dbSNP:58424802"
variation 1643..1648
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="gcagca"
/db_xref="dbSNP:72276751"
variation 1644..1645
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="cagcag"
/db_xref="dbSNP:72236998"
variation 1645..1646
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="agcagc"
/db_xref="dbSNP:72416294"
variation 1651
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:200861006"
variation 1654..1659
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="agcagc"
/db_xref="dbSNP:72198683"
variation 1663
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:201861701"
variation 1666
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:199811207"
variation 1672
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:369815961"
variation 1682
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:367780642"
variation 1730
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:325400"
variation 1746
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:370921147"
variation 1817
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:34851361"
variation 1818
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:111748677"
variation 1831
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:370778860"
variation 2046..2047
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:145618675"
variation 2046
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:201277440"
variation 2047..2048
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:144020290"
variation 2048..2049
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:10628004"
variation 2053..2054
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="gtgt"
/db_xref="dbSNP:34507751"
variation 2053
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:28444186"
variation 2093
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:374107493"
variation 2140
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:376220587"
variation 2404
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:75665175"
variation 2415
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:140014502"
variation 2427
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:72760574"
variation 2469
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:190007997"
variation 2476
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:201784078"
variation 2476
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="g"
/db_xref="dbSNP:34756453"
variation 2541
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:145205421"
variation 2553
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:11635271"
STS 2556..2905
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/standard_name="D15S907"
/db_xref="UniSTS:279"
variation 2766
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:182261693"
variation 2917
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:1059750"
variation 2918
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:186608671"
variation 2943
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:1454315"
variation 3093
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:190999757"
variation 3323..3327
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="gttaa"
/db_xref="dbSNP:71982844"
variation 3330
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="aactt"
/db_xref="dbSNP:67611863"
variation 3333
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:1059755"
variation 3334
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:149125295"
variation 3338
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:1059756"
variation 3344
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:1059757"
variation 3368..3369
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:1059758"
variation 3369
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:325399"
variation 3374
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:1136940"
variation 3559
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:142460833"
variation 3560
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:184041593"
variation 3585
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:368872347"
variation 3650
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:897074"
variation 3878
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:188542083"
variation 3897
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:372386338"
variation 3929
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:375267826"
variation 3936
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:59420387"
variation 3938
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:12902459"
variation 3939..3940
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="a"
/db_xref="dbSNP:67644135"
variation 3940
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="c"
/db_xref="dbSNP:58267790"
variation 3942..3943
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="cc"
/db_xref="dbSNP:141367967"
variation 3942
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="c"
/db_xref="dbSNP:144314500"
variation 3944
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:11550216"
variation 3945
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:75869168"
variation 3946
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:148429386"
variation 3951
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="c"
/replace="cc"
/db_xref="dbSNP:58849948"
variation 3959
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:1059759"
variation 3971
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:325383"
variation 4029
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="g"
/db_xref="dbSNP:325382"
variation 4097
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:1059760"
variation 4110
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:11550217"
variation 4115
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:193162969"
variation 4134
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:184981047"
variation 4137
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:187250165"
variation 4220
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:372383636"
variation 4277
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:146891523"
variation 4467
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:191660882"
variation 4576
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:41303617"
variation 4657
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:140716704"
variation 4739
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:325381"
variation 4740
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="g"
/db_xref="dbSNP:200152842"
variation 4758
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:183911417"
variation 4836
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:113970475"
variation 4864
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:188188955"
variation 4869
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="a"
/db_xref="dbSNP:34602555"
variation 4948
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:182321371"
variation 4950
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:113827147"
variation 4990
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:145829205"
variation 4997..4998
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="cat"
/db_xref="dbSNP:374735275"
variation 4997
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:77710130"
variation 4998..4999
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace=""
/replace="atc"
/db_xref="dbSNP:371572866"
variation 5017
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:28377673"
variation 5031
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="t"
/db_xref="dbSNP:138403437"
variation 5142
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="g"
/db_xref="dbSNP:74033759"
STS 5280..5552
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/standard_name="D15S901"
/db_xref="UniSTS:13157"
variation 5403
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="c"
/replace="t"
/db_xref="dbSNP:150316263"
variation 5465
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="a"
/replace="c"
/db_xref="dbSNP:12442844"
polyA_site 5483
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
polyA_signal 5507..5512
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
polyA_site 5536
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
variation 5543
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
/replace="g"
/replace="t"
/db_xref="dbSNP:325380"
polyA_site 5555
/gene="MEF2A"
/gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
ORIGIN
agaacgagttccggtctggccgaggcttgtctcctaaaaatagccccggtgtggggatccgtgcgcggatgtcccggcgagtcccgggctgaaagaggcggctccgggcggcgcgaagcgctggtggcgggcccgggctgcggcgtgtgcgcgcccgccagctgctccggagatacggaattgcattttgtgaaaaaagaacaagaattttctgcaaggatcatatctaagtgcactttttgctgatacttcatttctaatcttgtagaaaatttcagctgtagcccttggactagaagctgaaataacagaagctgtgtacgatgcattagggtattgaagaaaattaacttttgaattaaatatttggaatataaggaaataaggaaagttgactgaaaatggggcggaagaaaatacaaatcacacgcataatggatgaaaggaaccgacaggtcacttttacaaagagaaagtttggattaatgaagaaagcctatgaacttagtgtgctctgtgactgtgaaatagcactcatcattttcaacagctctaacaaactgtttcaatatgctagcactgatatggacaaagttcttctcaagtatacagaatataatgaacctcatgaaagcagaaccaactcggatattgttgaggctctgaacaagaaggaacacagagggtgcgacagcccagaccctgatacttcatatgtgctaactccacatacagaagaaaaatataaaaaaattaatgaggaatttgataatatgatgcggaatcataaaatcgcacctggtctgccacctcagaacttttcaatgtctgtcacagttccagtgaccagccccaatgctttgtcctacactaacccagggagttcactggtgtccccatctttggcagccagctcaacgttaacagattcaagcatgctctctccacctcaaaccacattacatagaaatgtgtctcctggagctcctcagagaccaccaagtactggcaatgcaggtgggatgttgagcactacagacctcacagtgccaaatggagctggaagcagtccagtggggaatggatttgtaaactcaagagcttctccaaatttgattggagctactggtgcaaatagcttaggcaaagtcatgcctacaaagtctccccctccaccaggtggtggtaatcttggaatgaacagtaggaaaccagatcttcgagttgtcatccccccttcaagcaagggcatgatgcctccactaaatacccaaaggatcagtagttctcaagccactcaacctcttgctaccccagtcgtgtctgtgacaaccccaagcttgcctccgcaaggacttgtgtactcagcaatgccgactgcctacaacactgattattcactgaccagcgctgacctgtcagcccttcaaggcttcaactcgccaggaatgctgtcgctgggacaggtgtcggcctggcagcagcaccacctaggacaagcagccctcagctctcttgttgctggagggcagttatctcagggttccaatttatccattaataccaaccaaaacatcagcatcaagtccgaaccgatttcacctcctcgggatcgtatgaccccatcgggcttccagcagcagcagcagcagcagcagcagcagcagccgccgccaccaccgcagccccagccacaacccccgcagccccagccccgacaggaaatggggcgctcccctgtggacagtctgagcagctctagtagctcctatgatggcagtgatcgggaggatccacggggcgacttccattctccaattgtgcttggccgacccccaaacactgaggacagagaaagcccttctgtaaagcgaatgaggatggacgcgtgggtgacctaaggcttccaagctgatgtttgtacttttgtgttactgcagtgacctgccctacatatctaaatcggtaaataaggacatgagttaaatatatttatatgtacatacatatatatatccctttacatatatatgtatgtgggtgtgagtgtgtatgtgtgggtgtgtgttacatacacagaatcaggcacttacctgcaaactccttgtaggtctgcagatgtgtgtcccatggcagacaaagcaccctgtaggcacagacaagtctggcacttccttggactacttgtttcgtaaagataaccagtttttgcagagaaacgtgtacccatatataattctcccacactagcttgcagaaacctagagggccccctacttgttttatttaactgtgcagtgactgtagttacttaagagaaaatgctttgtagaacagagcagtagaaaagcaggaaccaagaaagcaatactgtacataaaatgtcatttatattttccaacctggcatgggtgtctgttgcaaaggggtgcatgggaaagggctgttgatattaaaaacaaacaaaacaaaaaagccccacacataactgttttgcacgtgcaaaaatgtattgggtcaagaagtgatctttagctaataaagaaagagaatagaaaacacgcatgagatattcagaaaatactagcctagaaatatagagcattaacaaagtaaaattaatatattaagttataattggaatatgtcagaagtttctttttacattcatatcttaaaaattaaagaaactgattttagctcatgtatattttatatgaaagaaaacacccttatgaattgatgactatatataaaattatattcactacttttgaacacattctgctatgaattatttatataagccaaagctatatgttgtaacttttttttagagaatagctttatcttggtttaactctttagttttattttaagaggggaaaacaaaaatatcttgcaagcagaaccttggaaaaaaaaagccatgaacacttattctaaatgtaaattaaaagttgagccaaactctttgtgtatatagcatcttaaatatattatcacctttgatgtaagtacctatgtattgtatggtcaccagattaaaaagtatatttttgtggattgccgccaatctggggggaaaaggcgaggtcctttattaagtattcactgtttaatatttactattttgttaaatatactgtactttggattttaattattagcccagttttttcagaggattgtataaaggggtttctcccctcactggtggtgaatgtgtgatgttacattgtaatctttgtgctgtatgggttgagcatcattatatattttgtatgtgtacataaatagcaaagtggcaaaaaaaattggtgttaagttcatcctgcataagtataaaatgtgttgtaacagattttgtaaggcattatttaaaacttgccttttgtgaggaaaaaatgtagtagaaaaagctgacctaatttaattaatattagagaaaatggcaaaatagtagatgagcacaaaggttttataagtggtaaatgattaggggaaaataatcatggggaaagggatcttttttccttgaccctctgaaaacagaacgatgcagctggttacaaaatcctaccgttatcagctcttctgcacattgcagtgatgctttggtatgcggggagaaacactcttagggtgctggtccttggcatgactcttgccattctaattggaattagtgccaccctcagcttggattttgaacaaggccttattctttcaggaagacaactaatggatgatagcaagttcatccacttactgggcttgtgccatgagcaaaattcaaagtcctgtatatctttcattgtagatttttaaatactccttttcctaaaaaactcaagggtttaaaaattgctattttatattttaaatgatattgagcagctacctacaatttctatgtacattttgttcccccccccccaccccccccccaaattacgttccttttgacattttcctcatctgctgtttgtgacaagtcatcagccagatttcctgactgacacataggtatgatcagtgcaggagagacctgcgcaccacaggctgcaaactggaggttctgttctcatggcagtttgggcagtaacttttgagagaggccaaaaaaaggaggatgacatgctgtctcctctcttcagtatagacattaggctcttattcagaaaggatttttctttaaaaatgtacttactttactgaactacttacaggcacatttcttcataaggccacacctaatccaaacaagacagtctcccaacactgaagttccaaaataatccttaccactttgtaaaccatttatagctttgaaagtgttaagtgattccttcgttattatttatgcatgttcatgaacttctgctgtacattggaataggagttaacacattcacatttactgtctattttcttgtgtgccttatgagatggcttttctgactgtatctcaatagtctttctttctatgcaggtttataatcagtacaactactgttttctaaaatactactactcaaggctcggagtttgtatttaaattacactgaccaagtaacaatgtattccatttcaggaactgaatatttgactgttaacctttttcccatacgtccagtgtggcatggagcatatggacttgacagacatctctcacccagacgcccacgtgtgaacacacccacatccacatctctgggtggaaaccagcctagagaggggacgacgctaatggtgttgctttagaaccgtcttttcttacccttttagactcgtgttttgtatgagacaccattgcaagaaaattttatccctccagaagtattttattactaaagaacaaaagcaaaaaaagcttaaattgcactggttaaagtacagtttccaacagctgtccttcctcagtactctaatggccactccaccgcgagtggaagtcactgttgtgtgtacacaggtggtcccaatcaaaactccatcttttgagcccaattatgtccattttgttatagactaaatcaggggtttgttctacaagaacaatacatgttttaccctttcctttaactagaaggataactagtaatgcatcaacataatttctgtattaaccatcatgcgcacaagaaatacatagtaaataaggaagctgaaaactcctggcattggatcttaagctagatgattagaatgtgaaaaagattttacaaatgtaaaacttctatttctctgtagaaactttcttcactttgctgtgcaagaagacactgctttgctatatttaaaatggcttttttaaaagagatttatgtatttggtaaatgtttgtagtcaacagttcacacaagaagctgtacacggtttgatcatgtaaaaccgtttggcggcacaagctggactttgttgccatccttgagatgaaccttttaagaaaaataagttaatctcaatttttccctgaatgtgttgtttttcttcattatacaataaatataatagtgaactttttatcaaatggtgaagacaatgctaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4205 -> Molecular function: GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] evidence: IDA
GeneID:4205 -> Molecular function: GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] evidence: IDA
GeneID:4205 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
GeneID:4205 -> Molecular function: GO:0001085 [RNA polymerase II transcription factor binding] evidence: IPI
GeneID:4205 -> Molecular function: GO:0001105 [RNA polymerase II transcription coactivator activity] evidence: IDA
GeneID:4205 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
GeneID:4205 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:4205 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:4205 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4205 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IEA
GeneID:4205 -> Molecular function: GO:0033613 [activating transcription factor binding] evidence: IPI
GeneID:4205 -> Molecular function: GO:0035035 [histone acetyltransferase binding] evidence: IPI
GeneID:4205 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IPI
GeneID:4205 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
GeneID:4205 -> Molecular function: GO:0046332 [SMAD binding] evidence: IPI
GeneID:4205 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
GeneID:4205 -> Biological process: GO:0000002 [mitochondrial genome maintenance] evidence: ISS
GeneID:4205 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4205 -> Biological process: GO:0000165 [MAPK cascade] evidence: IDA
GeneID:4205 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IDA
GeneID:4205 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4205 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:4205 -> Biological process: GO:0007507 [heart development] evidence: IEP
GeneID:4205 -> Biological process: GO:0007517 [muscle organ development] evidence: NAS
GeneID:4205 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
GeneID:4205 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:4205 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:4205 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:4205 -> Biological process: GO:0048311 [mitochondrion distribution] evidence: ISS
GeneID:4205 -> Biological process: GO:0048813 [dendrite morphogenesis] evidence: ISS
GeneID:4205 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
GeneID:4205 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:4205 -> Biological process: GO:0055005 [ventricular cardiac myofibril assembly] evidence: ISS
GeneID:4205 -> Biological process: GO:0061337 [cardiac conduction] evidence: ISS
GeneID:4205 -> Biological process: GO:0070375 [ERK5 cascade] evidence: IMP
GeneID:4205 -> Biological process: GO:0071277 [cellular response to calcium ion] evidence: IDA
GeneID:4205 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: ISS
GeneID:4205 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:4205 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
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