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2024-03-29 01:11:07, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005577               6489 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens lipoprotein, Lp(a) (LPA), mRNA.
ACCESSION   NM_005577 XM_926329 XM_941794
VERSION     NM_005577.2  GI:116292749
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6489)
  AUTHORS   Kamstrup,P.R., Tybjaerg-Hansen,A. and Nordestgaard,B.G.
  TITLE     Extreme lipoprotein(a) levels and improved cardiovascular risk
            prediction
  JOURNAL   J. Am. Coll. Cardiol. 61 (11), 1146-1156 (2013)
   PUBMED   23375930
  REMARK    GeneRIF: Extreme lipoprotein(a) levels or corresponding LPA
            KIV-2/rs10455872 risk genotypes substantially improved MI and CHD
            risk prediction
REFERENCE   2  (bases 1 to 6489)
  AUTHORS   Thanassoulis,G., Campbell,C.Y., Owens,D.S., Smith,J.G., Smith,A.V.,
            Peloso,G.M., Kerr,K.F., Pechlivanis,S., Budoff,M.J., Harris,T.B.,
            Malhotra,R., O'Brien,K.D., Kamstrup,P.R., Nordestgaard,B.G.,
            Tybjaerg-Hansen,A., Allison,M.A., Aspelund,T., Criqui,M.H.,
            Heckbert,S.R., Hwang,S.J., Liu,Y., Sjogren,M., van der Pals,J.,
            Kalsch,H., Muhleisen,T.W., Nothen,M.M., Cupples,L.A., Caslake,M.,
            Di Angelantonio,E., Danesh,J., Rotter,J.I., Sigurdsson,S., Wong,Q.,
            Erbel,R., Kathiresan,S., Melander,O., Gudnason,V., O'Donnell,C.J.
            and Post,W.S.
  CONSRTM   CHARGE Extracoronary Calcium Working Group
  TITLE     Genetic associations with valvular calcification and aortic
            stenosis
  JOURNAL   N. Engl. J. Med. 368 (6), 503-512 (2013)
   PUBMED   23388002
  REMARK    GeneRIF: Genetic variation in the LPA locus, mediated by Lp(a)
            levels, is associated with aortic-valve calcification across
            multiple ethnic groups and with incident clinical aortic stenosis.
REFERENCE   3  (bases 1 to 6489)
  AUTHORS   Enkhmaa,B., Anuurad,E., Zhang,W., Abbuthalha,A., Li,X.D.,
            Dotterweich,W., Pollard,R.B., Asmuth,D.M. and Berglund,L.
  TITLE     HIV disease activity as a modulator of lipoprotein(a) and
            allele-specific apolipoprotein(a) levels
  JOURNAL   Arterioscler. Thromb. Vasc. Biol. 33 (2), 387-392 (2013)
   PUBMED   23202367
  REMARK    GeneRIF: Report HIV disease activity modulates lipoprotein(a) and
            allele-specific apolipoprotein(a) levels and cardiovascular risk.
REFERENCE   4  (bases 1 to 6489)
  AUTHORS   Chu,A.Y., Guilianini,F., Grallert,H., Dupuis,J., Ballantyne,C.M.,
            Barratt,B.J., Nyberg,F., Chasman,D.I. and Ridker,P.M.
  TITLE     Genome-wide association study evaluating lipoprotein-associated
            phospholipase A2 mass and activity at baseline and after
            rosuvastatin therapy
  JOURNAL   Circ Cardiovasc Genet 5 (6), 676-685 (2012)
   PUBMED   23118302
REFERENCE   5  (bases 1 to 6489)
  AUTHORS   Malek,F., Dvorak,J., Svitil,J., Skalnikova,V., Mates,M.,
            Kmonicek,P., Formanek,P., Aschermann,O., Kopriva,K. and Neuzil,P.
  TITLE     Correlation of lipoprotein (a) concentration with the extent of
            coronary artery disease in patients on lipid lowering therapy
  JOURNAL   Neuro Endocrinol. Lett. 33 (SUPPL 2), 55-59 (2012)
   PUBMED   23183511
  REMARK    GeneRIF: Only Lp(a) levels correlated with the extent of coronary
            artery disease as assessed with coronary angiography in patients
            treated with lipid lowering therapy.
REFERENCE   6  (bases 1 to 6489)
  AUTHORS   Scanu,A.M., Pfaffinger,D., Lee,J.C. and Hinman,J.
  TITLE     A single point mutation (Trp72-->Arg) in human apo(a) kringle 4-37
            associated with a lysine binding defect in Lp(a)
  JOURNAL   Biochim. Biophys. Acta 1227 (1-2), 41-45 (1994)
   PUBMED   7918682
REFERENCE   7  (bases 1 to 6489)
  AUTHORS   Salonen,E.M., Jauhiainen,M., Zardi,L., Vaheri,A. and Ehnholm,C.
  TITLE     Lipoprotein(a) binds to fibronectin and has serine proteinase
            activity capable of cleaving it
  JOURNAL   EMBO J. 8 (13), 4035-4040 (1989)
   PUBMED   2531657
REFERENCE   8  (bases 1 to 6489)
  AUTHORS   Utermann,G.
  TITLE     The mysteries of lipoprotein(a)
  JOURNAL   Science 246 (4932), 904-910 (1989)
   PUBMED   2530631
  REMARK    Review article
REFERENCE   9  (bases 1 to 6489)
  AUTHORS   Frank,S.L., Klisak,I., Sparkes,R.S., Mohandas,T., Tomlinson,J.E.,
            McLean,J.W., Lawn,R.M. and Lusis,A.J.
  TITLE     The apolipoprotein(a) gene resides on human chromosome 6q26-27, in
            close proximity to the homologous gene for plasminogen
  JOURNAL   Hum. Genet. 79 (4), 352-356 (1988)
   PUBMED   3410459
REFERENCE   10 (bases 1 to 6489)
  AUTHORS   McLean,J.W., Tomlinson,J.E., Kuang,W.J., Eaton,D.L., Chen,E.Y.,
            Fless,G.M., Scanu,A.M. and Lawn,R.M.
  TITLE     cDNA sequence of human apolipoprotein(a) is homologous to
            plasminogen
  JOURNAL   Nature 330 (6144), 132-137 (1987)
   PUBMED   3670400
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109933.25 and AL596089.19.
            This sequence is a reference standard in the RefSeqGene project.
            On Oct 20, 2006 this sequence version replaced gi:5031884.
            
            Summary: The protein encoded by this gene is a serine proteinase
            that inhibits the activity of tissue-type plasminogen activator I.
            The encoded protein constitutes a substantial portion of
            lipoprotein(a) and is proteolytically cleaved, resulting in
            fragments that attach to atherosclerotic lesions and promote
            thrombogenesis. Elevated plasma levels of this protein are linked
            to atherosclerosis. Depending on the individual, the encoded
            protein contains 2-43 copies of kringle-type domains. The allele
            represented here contains 15 copies of the kringle-type repeats and
            corresponds to that found in the reference genome sequence.
            [provided by RefSeq, Dec 2009].
            
            Sequence Note: This gene is highly polymorphic in length and number
            of exons due to variation in the number of kringle IV-2 repeats
            which vary from 2-43 copies among individuals. This RefSeq record
            was created from the reference genome assembly based on the exon
            representation found in DQ452068.1 whose sequence is consistent
            with the reference genome sequence, and includes 15 copies of the
            kringle IV-2 repeats.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support ERS025082, ERS025084
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AL109933.25        16267-16341         c
            76-169              AL109933.25        14132-14225         c
            170-329             AL109933.25        304-463             c
            330-511             AL596089.19        129931-130112       c
            512-671             AL596089.19        128564-128723       c
            672-853             AL596089.19        124384-124565       c
            854-1013            AL596089.19        123017-123176       c
            1014-1195           AL596089.19        118840-119021       c
            1196-1355           AL596089.19        117470-117629       c
            1356-1537           AL596089.19        113291-113472       c
            1538-1697           AL596089.19        111924-112083       c
            1698-1879           AL596089.19        107747-107928       c
            1880-2039           AL596089.19        106380-106539       c
            2040-2221           AL596089.19        102201-102382       c
            2222-2381           AL596089.19        100834-100993       c
            2382-2563           AL596089.19        96649-96830         c
            2564-2723           AL596089.19        95279-95438         c
            2724-2905           AL596089.19        90194-90375         c
            2906-3065           AL596089.19        88763-88922         c
            3066-3247           AL596089.19        84634-84815         c
            3248-3407           AL596089.19        83217-83376         c
            3408-3589           AL596089.19        79071-79252         c
            3590-3749           AL596089.19        77675-77834         c
            3750-3907           AL596089.19        74661-74818         c
            3908-4067           AL596089.19        73270-73429         c
            4068-4249           AL596089.19        70166-70347         c
            4250-4409           AL596089.19        68763-68922         c
            4410-4591           AL596089.19        62240-62421         c
            4592-4751           AL596089.19        60853-61012         c
            4752-4933           AL596089.19        41107-41288         c
            4934-5093           AL596089.19        39742-39901         c
            5094-5275           AL596089.19        32195-32376         c
            5276-5424           AL596089.19        31506-31654         c
            5425-5518           AL596089.19        29157-29250         c
            5519-5639           AL596089.19        26405-26525         c
            5640-5714           AL596089.19        24824-24898         c
            5715-5855           AL596089.19        23760-23900         c
            5856-5962           AL596089.19        21572-21678         c
            5963-6081           AL596089.19        16248-16366         c
            6082-6489           AL596089.19        15200-15607         c
FEATURES             Location/Qualifiers
     source          1..6489
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q26"
     gene            1..6489
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="lipoprotein, Lp(a)"
                     /db_xref="GeneID:4018"
                     /db_xref="HGNC:6667"
                     /db_xref="MIM:152200"
     exon            1..75
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    73..75
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="upstream in-frame stop codon"
     exon            76..169
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       89
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1623955"
     variation       100
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1800769"
     CDS             121..6243
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /EC_number="3.4.21.-"
                     /note="antiangiogenic AK38 protein; apolipoprotein(a);
                     lp(a); apo(a)"
                     /codon_start=1
                     /product="apolipoprotein(a) precursor"
                     /protein_id="NP_005568.2"
                     /db_xref="GI:116292750"
                     /db_xref="CCDS:CCDS43523.1"
                     /db_xref="GeneID:4018"
                     /db_xref="HGNC:6667"
                     /db_xref="MIM:152200"
                     /translation="
MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSSFDCGKPQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQEVNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEAQLLVIENEVCNHYKYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN
"
     sig_peptide     121..177
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     178..6240
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /product="apolipoprotein(a)"
     misc_feature    196..438
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    229..231
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(274..276,304..306,379..381,385..387,409..411)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    538..780
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    571..573
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(616..618,646..648,721..723,727..729,751..753)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    880..1122
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    913..915
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(958..960,988..990,1063..1065,1069..1071,1093..1095)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    1222..1464
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    1255..1257
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(1300..1302,1330..1332,1405..1407,1411..1413,
                     1435..1437)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    1564..1806
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    1597..1599
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(1642..1644,1672..1674,1747..1749,1753..1755,
                     1777..1779)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    1906..2148
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    1939..1941
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(1984..1986,2014..2016,2089..2091,2095..2097,
                     2119..2121)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    2248..2490
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    2281..2283
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(2326..2328,2356..2358,2431..2433,2437..2439,
                     2461..2463)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    2590..2832
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    2623..2625
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(2668..2670,2698..2700,2773..2775,2779..2781,
                     2803..2805)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    2932..3174
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    2965..2967
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(3010..3012,3040..3042,3115..3117,3121..3123,
                     3145..3147)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    3205..3207
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:03027"
     misc_feature    3211..3213
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00553"
     misc_feature    3211..3213
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00554"
     misc_feature    3274..3513
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    3307..3309
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(3352..3354,3382..3384,3457..3459,3463..3465,
                     3487..3489)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    3616..3858
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    3649..3651
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(3694..3696,3724..3726,3799..3801,3805..3807,
                     3829..3831)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    3934..4176
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    3967..3969
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(4012..4014,4042..4044,4117..4119,4123..4125,
                     4147..4149)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    4189..4191
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00554"
     misc_feature    4276..4518
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    4309..4311
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(4354..4356,4384..4386,4459..4461,4465..4467,
                     4489..4491)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    4618..4860
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    4651..4653
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(4696..4698,4726..4728,4801..4803,4807..4809,
                     4831..4833)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    4960..5202
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    4993..4995
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(5038..5040,5068..5070,5143..5145,5149..5151,
                     5173..5175)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    5239..5241
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="proteolytic cleavage site; modified site"
                     /db_xref="HPRD:00554"
     misc_feature    5269..5520
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Kringle domain; Kringle domains are believed to
                     play a role in binding mediators, such as peptides, other
                     proteins, membranes, or phospholipids. They are autonomous
                     structural domains, found in a varying number of copies,
                     in blood clotting and...; Region: KR; cd00108"
                     /db_xref="CDD:29008"
     misc_feature    5305..5307
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="putative domain interaction site; other site"
                     /db_xref="CDD:29008"
     misc_feature    order(5350..5352,5383..5385,5461..5463,5467..5469,
                     5491..5493)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:29008"
     misc_feature    5578..6222
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...; Region:
                     Tryp_SPc; cd00190"
                     /db_xref="CDD:29152"
     misc_feature    5578..5580
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="cleavage site"
                     /db_xref="CDD:29152"
     misc_feature    order(5701..5703,5830..5832,6088..6090)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="active site"
                     /db_xref="CDD:29152"
     misc_feature    order(6070..6072,6145..6147,6151..6153)
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="substrate binding sites [chemical binding]; other
                     site"
                     /db_xref="CDD:29152"
     variation       160
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:934266"
     exon            170..329
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    176..510
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            330..511
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    511..852
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            512..671
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            672..853
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    853..1194
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            854..1013
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            1014..1195
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1195..1536
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            1196..1355
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            1356..1537
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1537..1878
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            1538..1697
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            1698..1879
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1879..2220
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            1880..2039
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            2040..2221
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    2221..2562
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            2222..2381
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            2382..2563
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    2563..2904
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            2564..2723
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            2724..2905
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       2794
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41269892"
     misc_feature    2905..3246
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            2906..3065
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            3066..3247
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    3247..3588
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            3248..3407
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            3408..3589
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    3589..3906
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="There is an internal 24 nt deletion, so the size of
                     this repeat is smaller than 342 nts; Region: kringle IV-2
                     repeat"
     exon            3590..3749
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            3750..3907
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    3907..4248
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            3908..4067
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       4013
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41272074"
     exon            4068..4249
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       4167
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41272102"
     misc_feature    4249..4590
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            4250..4409
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       4315
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41272110"
     variation       4382
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41272112"
     exon            4410..4591
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    4591..4932
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            4592..4751
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       4689
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41264288"
     exon            4752..4933
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       4876
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41264306"
     variation       4913
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41264308"
     misc_feature    4933..5274
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /note="Region: kringle IV-2 repeat"
     exon            4934..5093
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            5094..5275
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     STS             5130..5260
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /standard_name="GDB:595276"
                     /db_xref="UniSTS:158018"
     variation       5156
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1801693"
     variation       5246
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:41264338"
     exon            5276..5424
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       5277
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41264848"
     variation       5370
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41264850"
     exon            5425..5518
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       5448
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41264854"
     variation       5449
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41264856"
     exon            5519..5639
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     variation       5585
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41265936"
     exon            5640..5714
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            5715..5855
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            5856..5962
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            5963..6081
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     exon            6082..6489
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /inference="alignment:Splign:1.39.8"
     STS             6245..6375
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /standard_name="STS-X06290"
                     /db_xref="UniSTS:72928"
     STS             6247..6489
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /standard_name="D6S1951"
                     /db_xref="UniSTS:43503"
     variation       6383
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:41266381"
     polyA_signal    6462..6467
                     /gene="LPA"
                     /gene_synonym="AK38; APOA; LP"
ORIGIN      
aggtacctttggggctggctttctcaaggaagcccagctccctgtgattgagaatgaagtgtgcaatcgctatgactgggattgggacacactttctgggcactgctggccagtcccaaaatggaacataaggaagtggttcttctacttcttttatttctgaaatcagcagcacctgagcaaagccatgtggtccaggattgctaccatggtgatggacagagttatcgaggcacgtactccaccactgtcacaggaaggacctgccaagcttggtcatctatgacaccacatcaacataataggaccacagaaaactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcagaggcctggggtgcaggagtgctaccacggtaatggacagagttatcgaggcacatactccaccactgtcactggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcaaaggcctggggtgcaggagtgctaccatggtaatggacagagttatcgaggcacatactccaccactgtcacaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatgctgtggcagctccttattgttatacgagggatcccggtgtcaggtgggagtactgcaacctgacgcaatgctcagacgcagaagggactgccgtcgcgcctccgactgttaccccggttccaagcctagaggctccttccgaacaagcaccgactgagcagaggcctggggtgcaggagtgctaccacggtaatggacagagttatcgaggcacatactccaccactgtcactggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagaatactacccaaatgctggcttgatcatgaactactgcaggaatccagatcctgtggcagccccttattgttatacgagggatcccagtgtcaggtgggagtactgcaacctgacacaatgctcagacgcagaagggactgccgtcgcgcctccaactattaccccgattccaagcctagaggctccttctgaacaagcaccaactgagcaaaggcctggggtgcaggagtgctaccacggaaatggacagagttatcaaggcacatacttcattactgtcacaggaagaacctgccaagcttggtcatctatgacaccacactcgcatagtcggaccccagcatactacccaaatgctggcttgatcaagaactactgccgaaatccagatcctgtggcagccccttggtgttatacaacagatcccagtgtcaggtgggagtactgcaacctgacacgatgctcagatgcagaatggactgccttcgtccctccgaatgttattctggctccaagcctagaggctttttttgaacaagcactgactgaggaaacccccggggtacaggactgctactaccattatggacagagttaccgaggcacatactccaccactgtcacaggaagaacttgccaagcttggtcatctatgacaccacaccagcatagtcggaccccagaaaactacccaaatgctggcctgaccaggaactactgcaggaatccagatgctgagattcgcccttggtgttacaccatggatcccagtgtcaggtgggagtactgcaacctgacacaatgcctggtgacagaatcaagtgtccttgcaactctcacggtggtcccagatccaagcacagaggcttcttctgaagaagcaccaacggagcaaagccccggggtccaggattgctaccatggtgatggacagagttatcgaggctcattctctaccactgtcacaggaaggacatgtcagtcttggtcctctatgacaccacactggcatcagaggacaacagaatattatccaaatggtggcctgaccaggaactactgcaggaatccagatgctgagattagtccttggtgttataccatggatcccaatgtcagatgggagtactgcaacctgacacaatgtccagtgacagaatcaagtgtccttgcgacgtccacggctgtttctgaacaagcaccaacggagcaaagccccacagtccaggactgctaccatggtgatggacagagttatcgaggctcattctccaccactgttacaggaaggacatgtcagtcttggtcctctatgacaccacactggcatcagagaaccacagaatactacccaaatggtggcctgaccaggaactactgcaggaatccagatgctgagattcgcccttggtgttataccatggatcccagtgtcagatgggagtactgcaacctgacgcaatgtccagtgatggaatcaactctcctcacaactcccacggtggtcccagttccaagcacagagcttccttctgaagaagcaccaactgaaaacagcactggggtccaggactgctaccgaggtgatggacagagttatcgaggcacactctccaccactatcacaggaagaacatgtcagtcttggtcgtctatgacaccacattggcatcggaggatcccattatactatccaaatgctggcctgaccaggaactactgcaggaatccagatgctgagattcgcccttggtgttacaccatggatcccagtgtcaggtgggagtactgcaacctgacacgatgtccagtgacagaatcgagtgtcctcacaactcccacagtggccccggttccaagcacagaggctccttctgaacaagcaccacctgagaaaagccctgtggtccaggattgctaccatggtgatggacggagttatcgaggcatatcctccaccactgtcacaggaaggacctgtcaatcttggtcatctatgataccacactggcatcagaggaccccagaaaactacccaaatgctggcctgaccgagaactactgcaggaatccagattctgggaaacaaccctggtgttacacaaccgatccgtgtgtgaggtgggagtactgcaatctgacacaatgctcagaaacagaatcaggtgtcctagagactcccactgttgttccagttccaagcatggaggctcattctgaagcagcaccaactgagcaaacccctgtggtccggcagtgctaccatggtaatggccagagttatcgaggcacattctccaccactgtcacaggaaggacatgtcaatcttggtcatccatgacaccacaccggcatcagaggaccccagaaaactacccaaatgatggcctgacaatgaactactgcaggaatccagatgccgatacaggcccttggtgttttaccatggaccccagcatcaggtgggagtactgcaacctgacgcgatgctcagacacagaagggactgtggtcgctcctccgactgtcatccaggttccaagcctagggcctccttctgaacaagactgtatgtttgggaatgggaaaggataccggggcaagaaggcaaccactgttactgggacgccatgccaggaatgggctgcccaggagccccatagacacagcacgttcattccagggacaaataaatgggcaggtctggaaaaaaattactgccgtaaccctgatggtgacatcaatggtccctggtgctacacaatgaatccaagaaaactttttgactactgtgatatccctctctgtgcatcctcttcatttgattgtgggaagcctcaagtggagccgaagaaatgtcctggaagcattgtaggggggtgtgtggcccacccacattcctggccctggcaagtcagtctcagaacaaggtttggaaagcacttctgtggaggcaccttaatatccccagagtgggtgctgactgctgctcactgcttgaagaagtcctcaaggccttcatcctacaaggtcatcctgggtgcacaccaagaagtgaacctcgaatctcatgttcaggaaatagaagtgtctaggctgttcttggagcccacacaagcagatattgccttgctaaagctaagcaggcctgccgtcatcactgacaaagtaatgccagcttgtctgccatccccagactacatggtcaccgccaggactgaatgttacatcactggctggggagaaacccaaggtacctttgggactggccttctcaaggaagcccagctccttgttattgagaatgaagtgtgcaatcactataagtatatttgtgctgagcatttggccagaggcactgacagttgccagggtgacagtggagggcctctggtttgcttcgagaaggacaaatacattttacaaggagtcacttcttggggtcttggctgtgcacgccccaataagcctggtgtctatgctcgtgtttcaaggtttgttacttggattgagggaatgatgagaaataattaattggacgggagacagagtgaagcatcaacctacttagaagctgaaacgtgggtaaggatttagcatgctggaaataatagacagcaatcaaacgaagacactgttcccagctaccagctatgccaaaccttggcatttttggtatttttgtgtataagcttttaaggtctgactgacaaattctgtattaaggtgtcatagctatgacatttgttaaaaataaactctgcacttattttgatttga
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4018 -> Molecular function: GO:0001968 [fibronectin binding] evidence: IPI
            GeneID:4018 -> Molecular function: GO:0004252 [serine-type endopeptidase activity] evidence: IDA
            GeneID:4018 -> Molecular function: GO:0004866 [endopeptidase inhibitor activity] evidence: TAS
            GeneID:4018 -> Molecular function: GO:0008201 [heparin binding] evidence: NAS
            GeneID:4018 -> Molecular function: GO:0034185 [apolipoprotein binding] evidence: IPI
            GeneID:4018 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
            GeneID:4018 -> Biological process: GO:0006629 [lipid metabolic process] evidence: NAS
            GeneID:4018 -> Biological process: GO:0006869 [lipid transport] evidence: IEA
            GeneID:4018 -> Biological process: GO:0006898 [receptor-mediated endocytosis] evidence: TAS
            GeneID:4018 -> Biological process: GO:0008015 [blood circulation] evidence: TAS
            GeneID:4018 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: TAS
            GeneID:4018 -> Biological process: GO:0042157 [lipoprotein metabolic process] evidence: TAS
            GeneID:4018 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:4018 -> Cellular component: GO:0005576 [extracellular region] evidence: NAS
            GeneID:4018 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
            GeneID:4018 -> Cellular component: GO:0034358 [plasma lipoprotein particle] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005568 -> EC 3.4.21.-

by @meso_cacase at DBCLS
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