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2024-04-26 01:26:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005564 840 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens lipocalin 2 (LCN2), mRNA.
ACCESSION NM_005564
VERSION NM_005564.3 GI:108936956
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 840)
AUTHORS Jang,E., Lee,S., Kim,J.H., Kim,J.H., Seo,J.W., Lee,W.H., Mori,K.,
Nakao,K. and Suk,K.
TITLE Secreted protein lipocalin-2 promotes microglial M1 polarization
JOURNAL FASEB J. 27 (3), 1176-1190 (2013)
PUBMED 23207546
REMARK GeneRIF: LCN2 is an M1-amplifier in brain microglial cells.
REFERENCE 2 (bases 1 to 840)
AUTHORS Liu,S., Che,M., Xue,S., Xie,B., Zhu,M., Lu,R., Zhang,W., Qian,J.
and Yan,Y.
TITLE Urinary L-FABP and its combination with urinary NGAL in early
diagnosis of acute kidney injury after cardiac surgery in adult
patients
JOURNAL Biomarkers 18 (1), 95-101 (2013)
PUBMED 23167703
REMARK GeneRIF: Urinary L-FABP and NGAL increased at an early stage after
cardiac surgery. The combination of the two biomarkers enhanced the
accuracy of the early detection of postoperative acute kidney
injury after cardiac surgery before a rise in serum creatinine.
REFERENCE 3 (bases 1 to 840)
AUTHORS Volpe,V., Raia,Z., Sanguigno,L., Somma,D., Mastrovito,P.,
Moscato,F., Mellone,S., Leonardi,A. and Pacifico,F.
TITLE NGAL controls the metastatic potential of anaplastic thyroid
carcinoma cells
JOURNAL J. Clin. Endocrinol. Metab. 98 (1), 228-235 (2013)
PUBMED 23150684
REMARK GeneRIF: NGAL is a novel target of nuclear factor-kappaB
prometastatic activity in thyroid cancer through enhancement of
MMP-9 enzymatic activity.
REFERENCE 4 (bases 1 to 840)
AUTHORS Virzi,G.M., Clementi,A., de Cal,M., Cruz,D.N. and Ronco,C.
TITLE Genomics and biological activity of neutrophil
gelatinase-associated lipocalin in several clinical settings
JOURNAL Blood Purif. 35 (1-3), 139-143 (2013)
PUBMED 23343559
REMARK GeneRIF: The NGAL gene is a rapid response gene whose expression is
driven in a dose-dependent manner by different stimuli which
generally induce tissue damage. (Review)
Review article
REFERENCE 5 (bases 1 to 840)
AUTHORS Sirota,J.C., Walcher,A., Faubel,S., Jani,A., McFann,K.,
Devarajan,P., Davis,C.L. and Edelstein,C.L.
TITLE Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute
kidney injury following liver transplantation
JOURNAL BMC Nephrol 14, 17 (2013)
PUBMED 23327592
REMARK GeneRIF: Serum IL-8 and urine IL-18, NGAL, IL-6, and IL-8 are
elevated in AKI within the first 24 hours following liver
transplantation.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 840)
AUTHORS Blaser,J., Triebel,S. and Tschesche,H.
TITLE A sandwich enzyme immunoassay for the determination of neutrophil
lipocalin in body fluids
JOURNAL Clin. Chim. Acta 235 (2), 137-145 (1995)
PUBMED 7554268
REFERENCE 7 (bases 1 to 840)
AUTHORS Bartsch,S. and Tschesche,H.
TITLE Cloning and expression of human neutrophil lipocalin cDNA derived
from bone marrow and ovarian cancer cells
JOURNAL FEBS Lett. 357 (3), 255-259 (1995)
PUBMED 7835423
REFERENCE 8 (bases 1 to 840)
AUTHORS Chan,P., Simon-Chazottes,D., Mattei,M.G., Guenet,J.L. and
Salier,J.P.
TITLE Comparative mapping of lipocalin genes in human and mouse: the four
genes for complement C8 gamma chain, prostaglandin-D-synthase,
oncogene-24p3, and progestagen-associated endometrial protein map
to HSA9 and MMU2
JOURNAL Genomics 23 (1), 145-150 (1994)
PUBMED 7829063
REFERENCE 9 (bases 1 to 840)
AUTHORS Kjeldsen,L., Johnsen,A.H., Sengelov,H. and Borregaard,N.
TITLE Isolation and primary structure of NGAL, a novel protein associated
with human neutrophil gelatinase
JOURNAL J. Biol. Chem. 268 (14), 10425-10432 (1993)
PUBMED 7683678
REFERENCE 10 (bases 1 to 840)
AUTHORS Triebel,S., Blaser,J., Reinke,H. and Tschesche,H.
TITLE A 25 kDa alpha 2-microglobulin-related protein is a component of
the 125 kDa form of human gelatinase
JOURNAL FEBS Lett. 314 (3), 386-388 (1992)
PUBMED 1281792
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BP272828.1, BC033089.1 and BM977724.1.
On Jun 14, 2006 this sequence version replaced gi:38455401.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CA454137.1, BU168788.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-13 BP272828.1 1-13
14-818 BC033089.1 1-805
819-840 BM977724.1 1-22 c
FEATURES Location/Qualifiers
source 1..840
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
gene 1..840
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/note="lipocalin 2"
/db_xref="GeneID:3934"
/db_xref="HGNC:6526"
/db_xref="MIM:600181"
exon 1..211
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
variation 13
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:12683358"
CDS 74..670
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/note="oncogene 24p3; neutrophil gelatinase-associated
lipocalin; migration-stimulating factor inhibitor; p25;
lipocalin-2; 25 kDa alpha-2-microglobulin-related subunit
of MMP-9; siderocalin LCN2"
/codon_start=1
/product="neutrophil gelatinase-associated lipocalin
precursor"
/protein_id="NP_005555.2"
/db_xref="GI:38455402"
/db_xref="CCDS:CCDS6892.1"
/db_xref="GeneID:3934"
/db_xref="HGNC:6526"
/db_xref="MIM:600181"
/translation="
MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG
"
sig_peptide 74..133
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 134..667
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/product="Neutrophil gelatinase-associated lipocalin"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P80188.2)"
misc_feature 134..136
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P80188.2);
other site"
misc_feature 215..652
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/note="Lipocalin / cytosolic fatty-acid binding protein
family; Region: Lipocalin; pfam00061"
/db_xref="CDD:200967"
misc_feature 326..328
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/experiment="experimental evidence, no additional details
recorded"
/note="glycosylation site"
/citation=[9]
variation 90
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:139418967"
variation 99
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="g"
/replace="t"
/db_xref="dbSNP:147787222"
variation 106
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:147142361"
variation 126
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140285982"
variation 128
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201536301"
variation 166
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:144354643"
variation 179
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147792047"
variation 190
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="g"
/replace="t"
/db_xref="dbSNP:11556770"
variation 203
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:141366243"
exon 212..348
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
variation 228
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200107414"
variation 266
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:370705191"
variation 280
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373535058"
variation 286
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:142623708"
variation 299
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201365744"
variation 302
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:377651206"
variation 338
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200876706"
exon 349..428
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
variation 389
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:367591388"
variation 403
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:371653139"
variation 411
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:150975968"
exon 429..548
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
STS 434..575
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/standard_name="RH93784"
/db_xref="UniSTS:90193"
variation 434
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:2232627"
variation 444
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:79993583"
variation 455
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:141218430"
variation 466
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:373227379"
variation 476
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:368926734"
variation 504
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="c"
/db_xref="dbSNP:145071103"
variation 520
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:11927"
variation 525
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199523944"
variation 530
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201570875"
variation 547
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138858669"
variation 548
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:377601677"
exon 549..650
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
STS 562..646
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/standard_name="PMC152639P4"
/db_xref="UniSTS:271237"
variation 570
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:368254779"
variation 579
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200989488"
variation 608
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:17435161"
variation 632
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:149368200"
variation 649
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="g"
/db_xref="dbSNP:143776517"
exon 651..677
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
exon 678..822
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/inference="alignment:Splign:1.39.8"
variation 693
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373690406"
variation 694
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:112730796"
variation 703
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="a"
/replace="g"
/db_xref="dbSNP:12260"
variation 773
/gene="LCN2"
/gene_synonym="24p3; MSFI; NGAL"
/replace="c"
/replace="t"
/db_xref="dbSNP:368437949"
ORIGIN
actcgccacctcctcttccacccctgccaggcccagcagccaccacagcgcctgcttcctcggccctgaaatcatgcccctaggtctcctgtggctgggcctagccctgttgggggctctgcatgcccaggcccaggactccacctcagacctgatcccagccccacctctgagcaaggtccctctgcagcagaacttccaggacaaccaattccaggggaagtggtatgtggtaggcctggcagggaatgcaattctcagagaagacaaagacccgcaaaagatgtatgccaccatctatgagctgaaagaagacaagagctacaatgtcacctccgtcctgtttaggaaaaagaagtgtgactactggatcaggacttttgttccaggttgccagcccggcgagttcacgctgggcaacattaagagttaccctggattaacgagttacctcgtccgagtggtgagcaccaactacaaccagcatgctatggtgttcttcaagaaagtttctcaaaacagggagtacttcaagatcaccctctacgggagaaccaaggagctgacttcggaactaaaggagaacttcatccgcttctccaaatctctgggcctccctgaaaaccacatcgtcttccctgtcccaatcgaccagtgtatcgacggctgagtgcacaggtgccgccagctgccgcaccagcccgaacaccattgagggagctgggagaccctccccacagtgccacccatgcagctgctccccaggccaccccgctgatggagccccaccttgtctgctaaataaacatgtgccctcaggccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3934 -> Molecular function: GO:0002020 [protease binding] evidence: IEA
GeneID:3934 -> Molecular function: GO:0005215 [transporter activity] evidence: IEA
GeneID:3934 -> Molecular function: GO:0005506 [iron ion binding] evidence: ISS
GeneID:3934 -> Molecular function: GO:0036094 [small molecule binding] evidence: IEA
GeneID:3934 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
GeneID:3934 -> Biological process: GO:0006811 [ion transport] evidence: IEA
GeneID:3934 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:3934 -> Biological process: GO:0009615 [response to virus] evidence: IEA
GeneID:3934 -> Biological process: GO:0009635 [response to herbicide] evidence: IEA
GeneID:3934 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IEA
GeneID:3934 -> Biological process: GO:0015891 [siderophore transport] evidence: ISS
GeneID:3934 -> Biological process: GO:0031346 [positive regulation of cell projection organization] evidence: IEA
GeneID:3934 -> Biological process: GO:0031669 [cellular response to nutrient levels] evidence: IEA
GeneID:3934 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:3934 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IEA
GeneID:3934 -> Biological process: GO:0045087 [innate immune response] evidence: ISS
GeneID:3934 -> Biological process: GO:0070207 [protein homotrimerization] evidence: IEA
GeneID:3934 -> Biological process: GO:0070301 [cellular response to hydrogen peroxide] evidence: IEA
GeneID:3934 -> Biological process: GO:0071222 [cellular response to lipopolysaccharide] evidence: IEA
GeneID:3934 -> Biological process: GO:0071347 [cellular response to interleukin-1] evidence: IEA
GeneID:3934 -> Biological process: GO:0071356 [cellular response to tumor necrosis factor] evidence: IEA
GeneID:3934 -> Cellular component: GO:0005576 [extracellular region] evidence: ISS
GeneID:3934 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
GeneID:3934 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:3934 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
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@meso_cacase at
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