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2024-03-29 18:23:08, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005541               4925 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D),
            transcript variant 2, mRNA.
ACCESSION   NM_005541 XM_929960
VERSION     NM_005541.3  GI:64085176
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4925)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   2  (bases 1 to 4925)
  AUTHORS   Brauer,H., Strauss,J., Wegner,W., Muller-Tidow,C., Horstmann,M. and
            Jucker,M.
  TITLE     Leukemia-associated mutations in SHIP1 inhibit its enzymatic
            activity, interaction with the GM-CSF receptor and Grb2, and its
            ability to inactivate PI3K/AKT signaling
  JOURNAL   Cell. Signal. 24 (11), 2095-2101 (2012)
   PUBMED   22820502
  REMARK    GeneRIF: SHIP1 mutant P1039S which does not reduce PI3K/AKT
            signaling anymore is located in a PXXP SH3 domain consensus binding
            motif.
REFERENCE   3  (bases 1 to 4925)
  AUTHORS   Bao,M., Hanabuchi,S., Facchinetti,V., Du,Q., Bover,L., Plumas,J.,
            Chaperot,L., Cao,W., Qin,J., Sun,S.C. and Liu,Y.J.
  TITLE     CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic
            cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl
  JOURNAL   J. Immunol. 189 (2), 786-792 (2012)
   PUBMED   22706086
  REMARK    GeneRIF: The CD2AP/SHIP1 complex and Cbl are recruited to blood
            dendritic cell (DC) antigen 2 (BDCA2) and Fc fragment of IgE high
            affinity I receptor (FcepsilonR1)gamma complex after BDCA2
            cross-linking in human primary plasmacytoid DCs.
REFERENCE   4  (bases 1 to 4925)
  AUTHORS   Liu,X.J., Yang,L., Wen,S.P., Yao,L., Yang,J.C. and Luo,J.M.
  TITLE     [Effect of SHIP mutation on invasion and migration of K562 leukemia
            cells]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 33 (1), 38-42 (2012)
   PUBMED   22575191
  REMARK    GeneRIF: Mutation in the PxxP domain of SHIP affects cell migration
            and invasion ability of K562 cells through increased MMP-9
            expression, FAK phosphorylation and NF-kappaB activation.
REFERENCE   5  (bases 1 to 4925)
  AUTHORS   Conde,C., Rambout,X., Lebrun,M., Lecat,A., Di Valentin,E.,
            Dequiedt,F., Piette,J., Gloire,G. and Legrand,S.
  TITLE     The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kappaB
            activation by disturbing the interaction of XIAP with RIP2
  JOURNAL   PLoS ONE 7 (7), E41005 (2012)
   PUBMED   22815893
  REMARK    GeneRIF: inositol phosphatase SHIP-1 inhibits NOD2-induced
            NF-kappaB activation by disturbing the interaction of XIAP with
            RIP2
REFERENCE   6  (bases 1 to 4925)
  AUTHORS   Ware,M.D., Rosten,P., Damen,J.E., Liu,L., Humphries,R.K. and
            Krystal,G.
  TITLE     Cloning and characterization of human SHIP, the 145-kD inositol
            5-phosphatase that associates with SHC after cytokine stimulation
  JOURNAL   Blood 88 (8), 2833-2840 (1996)
   PUBMED   8874179
REFERENCE   7  (bases 1 to 4925)
  AUTHORS   Drayer,A.L., Pesesse,X., De Smedt,F., Woscholski,R., Parker,P. and
            Erneux,C.
  TITLE     Cloning and expression of a human placenta inositol
            1,3,4,5-tetrakisphosphate and phosphatidylinositol
            3,4,5-trisphosphate 5-phosphatase
  JOURNAL   Biochem. Biophys. Res. Commun. 225 (1), 243-249 (1996)
   PUBMED   8769125
REFERENCE   8  (bases 1 to 4925)
  AUTHORS   Lioubin,M.N., Algate,P.A., Tsai,S., Carlberg,K., Aebersold,A. and
            Rohrschneider,L.R.
  TITLE     p150Ship, a signal transduction molecule with inositol
            polyphosphate-5-phosphatase activity
  JOURNAL   Genes Dev. 10 (9), 1084-1095 (1996)
   PUBMED   8654924
REFERENCE   9  (bases 1 to 4925)
  AUTHORS   Kavanaugh,W.M., Pot,D.A., Chin,S.M., Deuter-Reinhard,M.,
            Jefferson,A.B., Norris,F.A., Masiarz,F.R., Cousens,L.S.,
            Majerus,P.W. and Williams,L.T.
  TITLE     Multiple forms of an inositol polyphosphate 5-phosphatase form
            signaling complexes with Shc and Grb2
  JOURNAL   Curr. Biol. 6 (4), 438-445 (1996)
   PUBMED   8723348
REFERENCE   10 (bases 1 to 4925)
  AUTHORS   Damen,J.E., Liu,L., Rosten,P., Humphries,R.K., Jefferson,A.B.,
            Majerus,P.W. and Krystal,G.
  TITLE     The 145-kDa protein induced to associate with Shc by multiple
            cytokines is an inositol tetraphosphate and phosphatidylinositol
            3,4,5-triphosphate 5-phosphatase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 93 (4), 1689-1693 (1996)
   PUBMED   8643691
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE247227.1, BM800110.1,
            U57650.1, U50040.1 and BC062985.1.
            On or before Sep 20, 2006 this sequence version replaced
            gi:113413517, gi:40254822.
            
            Summary: This gene is a member of the inositol
            polyphosphate-5-phosphatase (INPP5) family and encodes a protein
            with an N-terminal SH2 domain, an inositol phosphatase domain, and
            two C-terminal protein interaction domains. Expression of this
            protein is restricted to hematopoietic cells where its movement
            from the cytosol to the plasma membrane is mediated by tyrosine
            phosphorylation. At the plasma membrane, the protein hydrolyzes the
            5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and
            inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple
            signaling pathways. Overall, the protein functions as a negative
            regulator of myeliod cell proliferation and survival. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 1, resulting in a shorter protein
            (isoform b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099920.1, X98429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BE247227.1         4-83
            81-131              BM800110.1         77-127
            132-1961            U57650.1           491-2320
            1962-4113           U50040.1           1189-3340
            4114-4925           BC062985.1         1463-2274
FEATURES             Location/Qualifiers
     source          1..4925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..4925
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="inositol polyphosphate-5-phosphatase, 145kDa"
                     /db_xref="GeneID:3635"
                     /db_xref="HGNC:6079"
                     /db_xref="HPRD:09033"
                     /db_xref="MIM:601582"
     CDS             154..3720
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /EC_number="3.1.3.86"
                     /note="isoform b is encoded by transcript variant 2;
                     p150Ship; signaling inositol polyphosphate 5 phosphatase
                     SIP-145; phosphatidylinositol-3,4,5-trisphosphate
                     5-phosphatase 1; SH2 containing inositol phosphatase,
                     isoform b; SH2 domain-containing inositol phosphatase 1;
                     SH2 domain-containing inositol-5'-phosphatase 1; inositol
                     polyphosphate-5-phosphatase of 145 kDa; SH2
                     domain-containing inositol 5'-phosphatase 1;
                     phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1"
                     /codon_start=1
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     5-phosphatase 1 isoform b"
                     /protein_id="NP_005532.2"
                     /db_xref="GI:40254823"
                     /db_xref="GeneID:3635"
                     /db_xref="HGNC:6079"
                     /db_xref="HPRD:09033"
                     /db_xref="MIM:601582"
                     /translation="
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTESVVSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ
"
     misc_feature    154..459
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="Src homology 2 (SH2) domain found in SH2-containing
                     inositol-5'-phosphatase (SHIP) and SLAM-associated protein
                     (SAP); Region: SH2_SHIP; cd10343"
                     /db_xref="CDD:198206"
     misc_feature    order(187..189,244..246,307..309,313..315)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]; other site"
                     /db_xref="CDD:198206"
     misc_feature    order(307..312,346..351,364..366,373..375,421..429)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="hydrophobic binding pocket [polypeptide binding];
                     other site"
                     /db_xref="CDD:198206"
     misc_feature    520..537
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92835.2);
                     Region: SH3-binding 1"
     misc_feature    1360..2280
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="Catalytic inositol polyphosphate 5-phosphatase
                     (INPP5c) domain of SH2 domain containing inositol
                     polyphosphate 5-phosphatase-1 and related proteins;
                     Region: INPP5c_SHIP1-INPP5D; cd09100"
                     /db_xref="CDD:197334"
     misc_feature    order(1384..1386,1390..1392,1507..1509,1708..1713,
                     1771..1773,1780..1785,1909..1911,1915..1917,1921..1923,
                     2080..2085,2149..2151,2167..2169,2248..2253)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="putative active site [active]"
                     /db_xref="CDD:197334"
     misc_feature    order(1384..1386,1507..1509,1771..1773,1909..1911,
                     1915..1917,2167..2169,2248..2253)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197334"
     misc_feature    order(1507..1509,1708..1713,1771..1773,1780..1785,
                     1921..1923,2080..2085,2149..2151,2248..2250)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="putative PI/IP binding site [chemical binding];
                     other site"
                     /db_xref="CDD:197334"
     misc_feature    order(1507..1509,2248..2250)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="putative Mg binding site [ion binding]; other site"
                     /db_xref="CDD:197334"
     misc_feature    order(1771..1773,1915..1917,2251..2253)
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /note="putative phosphate binding site [ion binding];
                     other site"
                     /db_xref="CDD:197334"
     misc_feature    2743..2745
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2884..2895
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92835.2);
                     Region: NPXY motif 1"
     misc_feature    2893..2895
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (Q92835.2); phosphorylation site"
     misc_feature    2893..2895
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3055..3072
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92835.2);
                     Region: SH3-binding 2"
     misc_feature    3196..3240
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92835.2);
                     Region: Interaction with DAB2 (By similarity)"
     misc_feature    3205..3216
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92835.2);
                     Region: NPXY motif 2"
     misc_feature    3214..3216
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    3268..3303
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92835.2);
                     Region: SH3-binding 3"
     variation       1191
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1135174"
     variation       1191
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:17419775"
     STS             4621..4895
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /standard_name="RH68049"
                     /db_xref="UniSTS:63658"
     STS             4681..4867
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
                     /standard_name="RH68337"
                     /db_xref="UniSTS:6352"
     polyA_signal    4892..4897
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
     polyA_site      4915
                     /gene="INPP5D"
                     /gene_synonym="hp51CN; SHIP; SHIP-1; SHIP1; SIP-145"
ORIGIN      
aaacaggaagtcagtcagttaagctggtggcagcagccgaggccaccaagaggcaacgggcggcaggttgcagtggaggggcctccgctcccctcggtggtgtgtgggtcctgggggtgcctgccggcccggccgaggaggcccacgcccaccatggtcccctgctggaaccatggcaacatcacccgctccaaggcggaggagctgctttccaggacaggcaaggacgggagcttcctcgtgcgtgccagcgagtccatctcccgggcatacgcgctctgcgtgctgtatcggaattgcgtttacacttacagaattctgcccaatgaagatgataaattcactgttcaggcatccgaaggcgtctccatgaggttcttcaccaagctggaccagctcatcgagttttacaagaaggaaaacatggggctggtgacccatctgcaataccctgtgccgctggaggaagaggacacaggcgacgaccctgaggaggacacagaaagtgtcgtgtctccacccgagctgcccccaagaaacatcccgctgactgccagctcctgtgaggccaaggaggttcctttttcaaacgagaatccccgagcgaccgagaccagccggccgagcctctccgagacattgttccagcgactgcaaagcatggacaccagtgggcttccagaagagcatcttaaggccatccaagattatttaagcactcagctcgcccaggactctgaatttgtgaagacagggtccagcagtcttcctcacctgaagaaactgaccacactgctctgcaaggagctctatggagaagtcatccggaccctcccatccctggagtctctgcagaggttatttgaccagcagctctccccgggcctccgtccacgtcctcaggttcctggtgaggccaatcccatcaacatggtgtccaagctcagccaactgacaagcctgttgtcatccattgaagacaaggtcaaggccttgctgcacgagggtcctgagtctccgcaccggccctcccttatccctccagtcacctttgaggtgaaggcagagtctctggggattcctcagaaaatgcagctcaaagtcgacgttgagtctgggaaactgatcattaagaagtccaaggatggttctgaggacaagttctacagccacaagaaaatcctgcagctcattaagtcacagaaatttctgaataagttggtgatcttggtggaaacagagaaggagaagatcctgcggaaggaatatgtttttgctgactccaaaaagagagaaggcttctgccagctcctgcagcagatgaagaacaagcactcagagcagccggagcccgacatgatcaccatcttcatcggcacctggaacatgggtaacgccccccctcccaagaagatcacgtcctggtttctctccaaggggcagggaaagacgcgggacgactctgcggactacatcccccatgacatttacgtgatcggcacccaagaggaccccctgagtgagaaggagtggctggagatcctcaaacactccctgcaagaaatcaccagtgtgacttttaaaacagtcgccatccacacgctctggaacatccgcatcgtggtgctggccaagcctgagcacgagaaccggatcagccacatctgtactgacaacgtgaagacaggcattgcaaacacactggggaacaagggagccgtgggggtgtcgttcatgttcaatggaacctccttagggttcgtcaacagccacttgacttcaggaagtgaaaagaaactcaggcgaaaccaaaactatatgaacattctccggttcctggccctgggcgacaagaagctgagtccctttaacatcactcaccgcttcacgcacctcttctggtttggggatcttaactaccgtgtggatctgcctacctgggaggcagaaaccatcatccagaaaatcaagcagcagcagtacgcagacctcctgtcccacgaccagctgctcacagagaggagggagcagaaggtcttcctacacttcgaggaggaagaaatcacgtttgccccaacctaccgttttgagagactgactcgggacaaatacgcctacaccaagcagaaagcgacagggatgaagtacaacttgccttcctggtgtgaccgagtcctctggaagtcttatcccctggtgcacgtggtgtgtcagtcttatggcagtaccagcgacatcatgacgagtgaccacagccctgtctttgccacatttgaggcaggagtcacttcccagtttgtctccaagaacggtcccgggactgttgacagccaaggacagattgagtttctcaggtgctatgccacattgaagaccaagtcccagaccaaattctacctggagttccactcgagctgcttggagagttttgtcaagagtcaggaaggagaaaatgaagaaggaagtgagggggagctggtggtgaagtttggtgagactcttccaaagctgaagcccattatctctgaccctgagtacctgctagaccagcacatcctcatcagcatcaagtcctctgacagcgacgaatcctatggcgagggctgcattgcccttcggttagaggccacagaaacgcagctgcccatctacacgcctctcacccaccatggggagttgacaggccacttccagggggagatcaagctgcagacctctcagggcaagacgagggagaagctctatgactttgtgaagacggagcgtgatgaatccagtgggccaaagaccctgaagagcctcaccagccacgaccccatgaagcagtgggaagtcactagcagggcccctccgtgcagtggctccagcatcactgaaatcatcaaccccaactacatgggagtggggccctttgggccaccaatgcccctgcacgtgaagcagaccttgtcccctgaccagcagcccacagcctggagctacgaccagccgcccaaggactccccgctggggccctgcaggggagaaagtcctccgacacctcccggccagccgcccatatcacccaagaagtttttaccctcaacagcaaaccggggtctccctcccaggacacaggagtcaaggcccagtgacctggggaagaacgcaggggacacgctgcctcaggaggacctgccgctgacgaagcccgagatgtttgagaaccccctgtatgggtccctgagttccttccctaagcctgctcccaggaaggaccaggaatcccccaaaatgccgcggaaggaacccccgccctgcccggaacccggcatcttgtcgcccagcatcgtgctcaccaaagcccaggaggctgatcgcggcgaggggcccggcaagcaggtgcccgcgccccggctgcgctccttcacgtgctcatcctctgccgagggcagggcggccggcggggacaagagccaagggaagcccaagaccccggtcagctcccaggccccggtgccggccaagaggcccatcaagccttccagatcggaaatcaaccagcagaccccgcccaccccgacgccgcggccgccgctgccagtcaagagcccggcggtgctgcacctccagcactccaagggccgcgactaccgcgacaacaccgagctcccgcatcacggcaagcaccggccggaggaggggccaccagggcctctaggcaggactgccatgcagtgaagccctcagtgagctgccactgagtcgggagcccagaggaacggcgtgaagccactggaccctctcccgggacctcctgctggctcctcctgcccagcttcctatgcaaggctttgtgttttcaggaaagggcctagcttctgtgtggcccacagagttcactgcctgtgagacttagcaccaagtgctgaggctggaagaaaaacgcacaccagacgggcaacaaacagtctgggtccccagctcgctcttggtacttgggaccccagtgcctcgttgagggcgccattctgaagaaaggaactgcagcgccgatttgagggtggagatatagataataataatattaataataataatggccacatggatcgaacactcatgatgtgccaagtgctgtgctaagtgctttacgaacattcgtcatatcaggatgacctcgagagctgaggctctagccacctaaaaccacgtgcccaaacccaccagtttaaaacggtgtgtgttcggaggggtgaaagcattaagaagcccagtgccctcctggagtgagacaagggctcggccttaaggagctgaagagtctgggtagcttgtttagggtacaagaagcctgttctgtccagcttcagtgacacaagctgctttagctaaagtcccgcgggttccggcatggctaggctgagagcagggatctacctggcttctcagttctttggttggaaggagcaggaaatcagctcctattctccagtggagagatctggcctcagcttgggctagagatgccaaggcctgtgccaggttccctgtgccctcctcgaggtgggcagccatcaccagccacagttaagccaagccccccaacatgtattccatcgtgctggtagaagagtctttgctgttgctcccgaaagccgtgctctccagcctggctgccagggagggtgggcctcttggttccaggctcttgaaatagtgcagccttttcttcctatctctgtggctttcagctctgcttccttggttattaggagaatagatgggtgatgtctttccttatgttgctttttcaacatagcagaattaatgtagggagctaaatccagtggtgtgtgtgaatgcagaagggaatgcaccccacattcccatgatggaagtctgcgtaaccaataaattgtgcctttctcactcaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3635 -> Molecular function: GO:0004445 [inositol-polyphosphate 5-phosphatase activity] evidence: IEA
            GeneID:3635 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3635 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
            GeneID:3635 -> Molecular function: GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] evidence: IEA
            GeneID:3635 -> Molecular function: GO:0051425 [PTB domain binding] evidence: IEA
            GeneID:3635 -> Biological process: GO:0006644 [phospholipid metabolic process] evidence: TAS
            GeneID:3635 -> Biological process: GO:0006661 [phosphatidylinositol biosynthetic process] evidence: TAS
            GeneID:3635 -> Biological process: GO:0006796 [phosphate-containing compound metabolic process] evidence: TAS
            GeneID:3635 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:3635 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:3635 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:3635 -> Biological process: GO:0008340 [determination of adult lifespan] evidence: IEA
            GeneID:3635 -> Biological process: GO:0009968 [negative regulation of signal transduction] evidence: IEA
            GeneID:3635 -> Biological process: GO:0016064 [immunoglobulin mediated immune response] evidence: IEA
            GeneID:3635 -> Biological process: GO:0030889 [negative regulation of B cell proliferation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IEA
            GeneID:3635 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:3635 -> Biological process: GO:0043647 [inositol phosphate metabolic process] evidence: TAS
            GeneID:3635 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:3635 -> Biological process: GO:0045409 [negative regulation of interleukin-6 biosynthetic process] evidence: IEA
            GeneID:3635 -> Biological process: GO:0045579 [positive regulation of B cell differentiation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0045648 [positive regulation of erythrocyte differentiation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0045656 [negative regulation of monocyte differentiation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0045659 [negative regulation of neutrophil differentiation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0045671 [negative regulation of osteoclast differentiation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0045779 [negative regulation of bone resorption] evidence: IEA
            GeneID:3635 -> Biological process: GO:0046856 [phosphatidylinositol dephosphorylation] evidence: IEA
            GeneID:3635 -> Biological process: GO:0050777 [negative regulation of immune response] evidence: IEA
            GeneID:3635 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
            GeneID:3635 -> Biological process: GO:0050900 [leukocyte migration] evidence: TAS
            GeneID:3635 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:3635 -> Cellular component: GO:0016020 [membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005532 -> EC 3.1.3.86

by @meso_cacase at DBCLS
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