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2024-04-26 17:24:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005406 6650 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens Rho-associated, coiled-coil containing protein kinase
1 (ROCK1), mRNA.
ACCESSION NM_005406 XM_001713904 XM_001722015 XM_001723570
VERSION NM_005406.2 GI:112382209
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6650)
AUTHORS Neill,T., Jones,H.R., Crane-Smith,Z., Owens,R.T., Schaefer,L. and
Iozzo,R.V.
TITLE Decorin induces rapid secretion of thrombospondin-1 in basal breast
carcinoma cells via inhibition of Ras homolog gene family, member
A/Rho-associated coiled-coil containing protein kinase 1
JOURNAL FEBS J. 280 (10), 2353-2368 (2013)
PUBMED 23350987
REMARK GeneRIF: Rapid secretion of TSP-1 from MDA-MB-231 cells depends on
ROCK1 inhibition.
REFERENCE 2 (bases 1 to 6650)
AUTHORS Schofield,A.V., Gamell,C., Suryadinata,R., Sarcevic,B. and
Bernard,O.
TITLE Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation
by Rho-associated coiled-coil kinase (rock) and cyclin-dependent
kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell
proliferation
JOURNAL J. Biol. Chem. 288 (11), 7907-7917 (2013)
PUBMED 23355470
REMARK GeneRIF: dual Rock and Cdk phosphorylation of Tppp1 inhibits its
regulation of the cell cycle to increase cell proliferation
REFERENCE 3 (bases 1 to 6650)
AUTHORS Cimino,D., De Pitta,C., Orso,F., Zampini,M., Casara,S., Penna,E.,
Quaglino,E., Forni,M., Damasco,C., Pinatel,E., Ponzone,R.,
Romualdi,C., Brisken,C., De Bortoli,M., Biglia,N., Provero,P.,
Lanfranchi,G. and Taverna,D.
TITLE miR148b is a major coordinator of breast cancer progression in a
relapse-associated microRNA signature by targeting ITGA5, ROCK1,
PIK3CA, NRAS, and CSF1
JOURNAL FASEB J. 27 (3), 1223-1235 (2013)
PUBMED 23233531
REMARK GeneRIF: miR-148b controls malignancy by coordinating a novel
pathway involving over 130 genes and, in particular, it directly
targets players of the integrin signaling, such as ITGA5, ROCK1,
PIK3CA/p110alpha, and NRAS, as well as CSF1
REFERENCE 4 (bases 1 to 6650)
AUTHORS Sun,J., Zhang,D., Zheng,Y., Zhao,Q., Zheng,M., Kovacevic,Z. and
Richardson,D.R.
TITLE Targeting the metastasis suppressor, NDRG1, using novel iron
chelators: regulation of stress fiber-mediated tumor cell migration
via modulation of the ROCK1/pMLC2 signaling pathway
JOURNAL Mol. Pharmacol. 83 (2), 454-469 (2013)
PUBMED 23188716
REMARK GeneRIF: NDRG1 inhibited an important regulatory pathway mediated
by ROCK1/pMLC2 pathway that modulates stress fiber assembly.
REFERENCE 5 (bases 1 to 6650)
AUTHORS Ryan,T., Shelton,M., Lambert,J.P., Malecova,B., Boisvenue,S.,
Ruel,M., Figeys,D., Puri,P.L. and Skerjanc,I.S.
TITLE Myosin phosphatase modulates the cardiac cell fate by regulating
the subcellular localization of Nkx2.5 in a Wnt/Rho-associated
protein kinase-dependent pathway
JOURNAL Circ. Res. 112 (2), 257-266 (2013)
PUBMED 23168335
REMARK GeneRIF: Rho-associated protein kinase and Wnt signaling regulates
Mypt1 and Nkx2.5 colocalization outside the cell nucleus.
REFERENCE 6 (bases 1 to 6650)
AUTHORS Fujisawa,K., Fujita,A., Ishizaki,T., Saito,Y. and Narumiya,S.
TITLE Identification of the Rho-binding domain of p160ROCK, a
Rho-associated coiled-coil containing protein kinase
JOURNAL J. Biol. Chem. 271 (38), 23022-23028 (1996)
PUBMED 8798490
REFERENCE 7 (bases 1 to 6650)
AUTHORS Ishizaki,T., Maekawa,M., Fujisawa,K., Okawa,K., Iwamatsu,A.,
Fujita,A., Watanabe,N., Saito,Y., Kakizuka,A., Morii,N. and
Narumiya,S.
TITLE The small GTP-binding protein Rho binds to and activates a 160 kDa
Ser/Thr protein kinase homologous to myotonic dystrophy kinase
JOURNAL EMBO J. 15 (8), 1885-1893 (1996)
PUBMED 8617235
REFERENCE 8 (bases 1 to 6650)
AUTHORS Tsujimura,K., Tanaka,J., Ando,S., Matsuoka,Y., Kusubata,M.,
Sugiura,H., Yamauchi,T. and Inagaki,M.
TITLE Identification of phosphorylation sites on glial fibrillary acidic
protein for cdc2 kinase and Ca(2+)-calmodulin-dependent protein
kinase II
JOURNAL J. Biochem. 116 (2), 426-434 (1994)
PUBMED 7822264
REFERENCE 9 (bases 1 to 6650)
AUTHORS Tokui,T., Yamauchi,T., Yano,T., Nishi,Y., Kusagawa,M., Yatani,R.
and Inagaki,M.
TITLE Ca2(+)-calmodulin-dependent protein kinase II phosphorylates
various types of non-epithelial intermediate filament proteins
JOURNAL Biochem. Biophys. Res. Commun. 169 (3), 896-904 (1990)
PUBMED 2114109
REFERENCE 10 (bases 1 to 6650)
AUTHORS Inagaki,M., Gonda,Y., Nishizawa,K., Kitamura,S., Sato,C., Ando,S.,
Tanabe,K., Kikuchi,K., Tsuiki,S. and Nishi,Y.
TITLE Phosphorylation sites linked to glial filament disassembly in vitro
locate in a non-alpha-helical head domain
JOURNAL J. Biol. Chem. 265 (8), 4722-4729 (1990)
PUBMED 2155236
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK057038.1, U43195.1,
AU121527.1 and AC036178.11.
On or before Jun 10, 2008 this sequence version replaced
gi:169212958, gi:169212765, gi:169213116, gi:4885582.
Summary: This gene encodes a protein serine/threonine kinase that
is activated when bound to the GTP-bound form of Rho. The small
GTPase Rho regulates formation of focal adhesions and stress fibers
of fibroblasts, as well as adhesion and aggregation of platelets
and lymphocytes by shuttling between the inactive GDP-bound form
and the active GTP-bound form. Rho is also essential in cytokinesis
and plays a role in transcriptional activation by serum response
factor. This protein, a downstream effector of Rho, phosphorylates
and activates LIM kinase, which in turn, phosphorylates cofilin,
inhibiting its actin-depolymerizing activity. [provided by RefSeq,
Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-941 AK057038.1 2-942
942-5002 U43195.1 1-4061
5003-5444 AU121527.1 206-647
5445-6650 AC036178.11 18803-20008 c
FEATURES Location/Qualifiers
source 1..6650
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q11.1"
gene 1..6650
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Rho-associated, coiled-coil containing protein
kinase 1"
/db_xref="GeneID:6093"
/db_xref="HGNC:10251"
/db_xref="HPRD:03414"
/db_xref="MIM:601702"
exon 1..1034
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 28
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="c"
/db_xref="dbSNP:113927390"
variation 204
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="g"
/db_xref="dbSNP:113266015"
variation 239
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="g"
/db_xref="dbSNP:112002797"
variation 254
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="t"
/db_xref="dbSNP:111337504"
variation 406
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:113539923"
variation 514
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:113372301"
variation 515
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:112006560"
variation 577
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="g"
/db_xref="dbSNP:112807514"
misc_feature 885..887
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="upstream in-frame stop codon"
variation 914
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="t"
/db_xref="dbSNP:112883134"
CDS 942..5006
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/EC_number="2.7.11.1"
/note="p160-ROCK; renal carcinoma antigen NY-REN-35; Rho
kinase; p160 ROCK-1; rho-associated,
coiled-coil-containing protein kinase 1; rho-associated,
coiled-coil-containing protein kinase I"
/codon_start=1
/product="rho-associated protein kinase 1"
/protein_id="NP_005397.1"
/db_xref="GI:4885583"
/db_xref="CCDS:CCDS11870.2"
/db_xref="GeneID:6093"
/db_xref="HGNC:10251"
/db_xref="HPRD:03414"
/db_xref="MIM:601702"
/translation="
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS
"
misc_feature 945..947
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (Q13464.1); acetylation site"
misc_feature 1035..2144
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Rho-associated coiled-coil containing protein
kinase; Region: STKc_ROCK; cd05596"
/db_xref="CDD:173687"
misc_feature order(1050..1052,1086..1088,1092..1094,1104..1106,
1113..1118,1125..1127,1143..1157,1164..1166,1362..1364,
2103..2111,2115..2120,2124..2126,2139..2141)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:173687"
misc_feature 1167..1955
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(1185..1190,1209..1211,1248..1250,1398..1409,
1419..1421,1545..1547,1554..1556,1584..1589,2043..2045)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173687"
misc_feature order(1185..1199,1209..1211,1248..1250,1254..1256,
1350..1352,1398..1403,1407..1409,1419..1421,1425..1427,
1533..1535,1539..1541,1545..1550,1554..1556,1584..1589,
1596..1598,1641..1658,1749..1751,1767..1769,1776..1778)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="active site"
/db_xref="CDD:173687"
misc_feature order(1197..1199,1419..1421,1425..1427,1533..1535,
1539..1541,1545..1547,1596..1598,1641..1658,1749..1751,
1767..1769,1776..1778)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173687"
misc_feature 1584..1658
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173687"
misc_feature 2043..3122
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13464.1);
Region: Interaction with FHOD1"
misc_feature 2121..2138
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="hydrophobic motif (HM); other site"
/db_xref="CDD:173687"
misc_feature 2406..2603
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Protein kinase C-related kinase homology region 1
(HR1) Rho-binding domain of Rho-associated coiled-coil
containing protein kinase 1; Region: HR1_ROCK1; cd11639"
/db_xref="CDD:212029"
misc_feature order(2427..2429,2436..2438,2445..2450,2457..2462,
2466..2471,2478..2483,2487..2492,2538..2543,2550..2552,
2559..2564,2571..2573)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="putative Rho binding site 1 [polypeptide binding];
other site"
/db_xref="CDD:212029"
misc_feature order(2451..2456,2460..2465,2472..2477,2481..2486,
2493..2498,2523..2528,2532..2534)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="putative Rho binding site 2 [polypeptide binding];
other site"
/db_xref="CDD:212029"
misc_feature 2880..2882
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q13464.1); acetylation site"
misc_feature 3786..3983
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Rho Binding; Region: Rho_Binding; pfam08912"
/db_xref="CDD:149849"
misc_feature 3933..3971
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13464.1);
Region: RHOA binding"
misc_feature 4254..4256
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13464.1); phosphorylation site"
misc_feature 4278..4283
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3; propagated from
UniProtKB/Swiss-Prot (Q13464.1); cleavage site"
misc_feature 4284..5003
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q13464.1);
Region: Auto-inhibitory"
misc_feature 4299..>4550
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Rok (Rho- associated kinase) pleckstrin homology
(PH) domain; Region: PH_ROK; cd01242"
/db_xref="CDD:176318"
misc_feature order(4299..4328,4353..4379,4383..4406,4437..4454,
4458..4472,4524..4544)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="PH-kinase core; other site"
/db_xref="CDD:176318"
misc_feature order(4320..4322,4326..4328,4356..4358,4362..4370)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="putative phosphoinositide binding site [chemical
binding]; other site"
/db_xref="CDD:176318"
misc_feature 4479..4481
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 4626..4766
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Protein kinase C conserved region 1 (C1) .
Cysteine-rich zinc binding domain. Some members of this
domain family bind phorbol esters and diacylglycerol, some
are reported to bind RasGTP. May occur in tandem
arrangement. Diacylglycerol (DAG) is a second...; Region:
C1; cd00029"
/db_xref="CDD:28911"
misc_feature order(4626..4628,4665..4667,4674..4676,4722..4724,
4731..4733,4746..4748,4755..4757)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="zinc binding sites [ion binding]; other site"
/db_xref="CDD:28911"
misc_feature order(4647..4649,4656..4661,4686..4703,4710..4712)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="putative DAG/PE binding site; other site"
/db_xref="CDD:28911"
misc_feature order(4656..4658,4662..4664)
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="putative RAS interaction site [polypeptide
binding]; other site"
/db_xref="CDD:28911"
misc_feature <4815..4895
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl00273"
/db_xref="CDD:206947"
exon 1035..1116
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 1117..1217
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 1218..1355
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 1356..1531
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 1484
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:111949403"
exon 1532..1616
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 1617..1761
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 1762..1900
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 1901..1992
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 1981
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:113763420"
exon 1993..2152
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 2141
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:113552696"
exon 2153..2213
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 2214..2302
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 2303..2351
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 2352..2487
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 2488..2579
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 2580..2826
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 2726
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="g"
/replace="t"
/db_xref="dbSNP:112165707"
exon 2827..2933
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 2934..3084
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 2988
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:112255811"
exon 3085..3245
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 3188
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:113104450"
exon 3246..3430
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 3431..3500
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 3501..3595
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 3596..3761
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 3762..3855
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
STS 3778..3943
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/standard_name="ROCK1"
/db_xref="UniSTS:504235"
exon 3856..3944
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 3945..4133
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 4134..4293
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 4160
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:113818979"
variation 4230
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:2292296"
exon 4294..4364
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 4365..4453
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 4454..4532
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 4533..4794
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 4795..5002
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
exon 5003..6650
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/inference="alignment:Splign:1.39.8"
variation 5024
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="c"
/replace="t"
/db_xref="dbSNP:1045148"
variation 5401
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:56110438"
variation 6514
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
/replace="a"
/replace="g"
/db_xref="dbSNP:12372"
polyA_signal 6624..6629
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
polyA_site 6650
/gene="ROCK1"
/gene_synonym="P160ROCK; ROCK-I"
ORIGIN
gctggttccccttccgagcgtccgcgccccgcatgcgcagtctgccccggcggtctccgtttgtttgaacaggaaggcggacatattagtccctctcagcccccctcgccccaccccccaggcattcgccgccgcgactcgccctttccccggctgggaccgcagcccctcccagaagctcccccatcagcagccgccgggacccaactatcgtcttcctcttcgcccgctctccagcctttcctctgctaagtctccatcgggcatcgacctcgccctgccccaccggacaccgtagcagcagccccagcagcgacgggacaaaatgggagagtgaggctgtcctgcgtggaccagctcgtggccgagactgatcggtgcgtcgggccgggccgagtagagccggggacgcggggctagaccgtctacagcgcctctgagcggagcgggcccggcccgtggcccgagcggcggccgcagctggcacagctcctcacccgccctttgctttcgcctttcctcttctccctcccttgttgcccggagggagtctccaccctgcttctctttctctacccgctcctgcccatctcgggacggggacccctccatggcgacggcggccggggcccgctagactgaagcacctcgccggagcgacgaggctggtggcgacggcgctgtcggctgtcgtgaggggctgccgggtgggatgcgactttgggcgtccgagcggctgtgggtcgctgttgcccccggcccggggtctggagagcggaggtcccctcagtgaggggaagacgggggaaccgggcgcacctggtgaccctgaggttccggctcctccgccccgcggctgcgaacccaccgcggaggaagttggttgaaattgctttccgctgctggtgctggtaagagggcattgtcacagcagcagcaacatgtcgactggggacagttttgagactcgatttgaaaaaatggacaacctgctgcgggatcccaaatcggaagtgaattcggattgtttgctggatggattggatgctttggtatatgatttggattttcctgccttaagaaaaaacaaaaatattgacaactttttaagcagatataaagacacaataaataaaatcagagatttacgaatgaaagctgaagattatgaagtagtgaaggtgattggtagaggtgcatttggagaagttcaattggtaaggcataaatccaccaggaaggtatatgctatgaagcttctcagcaaatttgaaatgataaagagatctgattctgcttttttctgggaagaaagggacatcatggcttttgccaacagtccttgggttgttcagcttttttatgcattccaagatgatcgttatctctacatggtgatggaatacatgcctggtggagatcttgtaaacttaatgagcaactatgatgtgcctgaaaaatgggcacgattctatactgcagaagtagttcttgcattggatgcaatccattccatgggttttattcacagagatgtgaagcctgataacatgctgctggataaatctggacatttgaagttagcagattttggtacttgtatgaagatgaataaggaaggcatggtacgatgtgatacagcggttggaacacctgattatatttcccctgaagtattaaaatcccaaggtggtgatggttattatggaagagaatgtgactggtggtcggttggggtatttttatacgaaatgcttgtaggtgatacacctttttatgcagattctttggttggaacttacagtaaaattatgaaccataaaaattcacttacctttcctgatgataatgacatatcaaaagaagcaaaaaaccttatttgtgccttccttactgacagggaagtgaggttagggcgaaatggtgtagaagaaatcaaacgacatctcttcttcaaaaatgaccagtgggcttgggaaacgctccgagacactgtagcaccagttgtacccgatttaagtagtgacattgatactagtaattttgatgacttggaagaagataaaggagaggaagaaacattccctattcctaaagctttcgttggcaatcaactaccttttgtaggatttacatattatagcaatcgtagatacttatcttcagcaaatcctaatgataacagaactagctccaatgcagataaaagcttgcaggaaagtttgcaaaaaacaatctataagctggaagaacagctgcataatgaaatgcagttaaaagatgaaatggagcagaagtgcagaacctcaaacataaaactagacaagataatgaaagaattggatgaagagggaaatcaaagaagaaatctagaatctacagtgtctcagattgagaaggagaaaatgttgctacagcatagaattaatgagtaccaaagaaaagctgaacaggaaaatgagaagagaagaaatgtagaaaatgaagtttctacattaaaggatcagttggaagacttaaagaaagtcagtcagaattcacagcttgctaatgagaagctgtcccagttacaaaagcagctagaagaagccaatgacttacttaggacagaatcggacacagctgtaagattgaggaagagtcacacagagatgagcaagtcaattagtcagttagagtccctgaacagagagttgcaagagagaaatcgaattttagagaattctaagtcacaaacagacaaagattattaccagctgcaagctatattagaagctgaacgaagagacagaggtcatgattctgagatgattggagaccttcaagctcgaattacatctttacaagaggaggtgaagcatctcaaacataatctcgaaaaagtggaaggagaaagaaaagaggctcaagacatgcttaatcactcagaaaaggaaaagaataatttagagatagatttaaactacaaacttaaatcattacaacaacggttagaacaagaggtaaatgaacacaaagtaaccaaagctcgtttaactgacaaacatcaatctattgaagaggcaaagtctgtggcaatgtgtgagatggaaaaaaagctgaaagaagaaagagaagctcgagagaaggctgaaaatcgggttgttcagattgagaaacagtgttccatgctagacgttgatctgaagcaatctcagcagaaactagaacatttgactggaaataaagaaaggatggaggatgaagttaagaatctaaccctgcaactggagcaggaatcaaataagcggctgttgttacaaaatgaattgaagactcaagcatttgaggcagacaatttaaaaggtttagaaaagcagatgaaacaggaaataaatactttattggaagcaaagagattattagaatttgagttagctcagcttacgaaacagtatagaggaaatgaaggacagatgcgggagctacaagatcagcttgaagctgagcaatatttctcgacactttataaaacccaggtaaaggaacttaaagaagaaattgaagaaaaaaacagagaaaatttaaagaaaatacaggaactacaaaatgaaaaagaaactcttgctactcagttggatctagcagaaacaaaagctgagtctgagcagttggcgcgaggccttctggaagaacagtattttgaattgacgcaagaaagcaagaaagctgcttcaagaaatagacaagagattacagataaagatcacactgttagtcggcttgaagaagcaaacagcatgctaaccaaagatattgaaatattaagaagagagaatgaagagctaacagagaaaatgaagaaggcagaggaagaatataaactggagaaggaggaggagatcagtaatcttaaggctgcctttgaaaagaatatcaacactgaacgaacccttaaaacacaggctgttaacaaattggcagaaataatgaatcgaaaagattttaaaattgatagaaagaaagctaatacacaagatttgagaaagaaagaaaaggaaaatcgaaagctgcaactggaactcaaccaagaaagagagaaattcaaccagatggtagtgaaacatcagaaggaactgaatgacatgcaagcgcaattggtagaagaatgtgcacataggaatgagcttcagatgcagttggccagcaaagagagtgatattgagcaattgcgtgctaaacttttggacctctcggattctacaagtgttgctagttttcctagtgctgatgaaactgatggtaacctcccagagtcaagaattgaaggttggctttcagtaccaaatagaggaaatatcaaacgatatggctggaagaaacagtatgttgtggtaagcagcaaaaaaattttgttctataatgacgaacaagataaggagcaatccaatccatctatggtattggacatagataaactgtttcacgttagacctgtaacccaaggagatgtgtatagagctgaaactgaagaaattcctaaaatattccagatactatatgcaaatgaaggtgaatgtagaaaagatgtagagatggaaccagtacaacaagctgaaaaaactaatttccaaaatcacaaaggccatgagtttattcctacactctaccactttcctgccaattgtgatgcctgtgccaaacctctctggcatgtttttaagccaccccctgccctagagtgtcgaagatgccatgttaagtgccacagagatcacttagataagaaagaggacttaatttgtccatgtaaagtaagttatgatgtaacatcagcaagagatatgctgctgttagcatgttctcaggatgaacaaaaaaaatgggtaactcatttagtaaagaaaatccctaagaatccaccatctggttttgttcgtgcttcccctcgaacgctttctacaagatccactgcaaatcagtctttccggaaagtggtcaaaaatacatctggaaaaactagttaaccatgtgactgagtgccctgtggaatcgtgtgggatgctacctgataaaccaggcttctttaaccatgcagagcagacaggctgtttctttgacacaaatatcacaggcttcagggttaagattgctgtttttctgtccttgctttggcacaacacactgagggttttttttattgcgggtttgcctacaggtagattagattaattattactatgtaatgcaagtacagttgggggaaagcttaggtagatatattttttttaaaaggtgctgcctttttggatttataagaaaatgcctgtcagtcgtgatagaacagagttttcctcatatgagtaagaggaagggactttcactttcaagtggaacagccatcactatcaagatcagctcatggaaggagtaaagaaaatatctcaaaatgagacaaactgaagttttgttttttttttaatgacttaagtttttgtgctcttgcaagactatacaaaactattttaagaaagcagtgatatcacttgaacttcagtgccctcactgtagaatttaaaagccttactgttgattgcccatgttggacttgatggagaaattaaatatctttcattatgctttacaaaatactgtatatgtttcagcaagtttggggaatgggagaggacaaaaaaaagttacatttaatctatgcatttttgccaagccatattgagttattttactactagagacattaggaaactaactgtacaaaagaaccaagtttaaaagcattttgtggggtacatcatttctataattgtataatgtatttctttgtggttttaaatgataaagacattaagttaacaaacatataagaaatgtatgcactgtttgaaatgtaaattattcttagaacactttcaatgggggttgcattgtccttttagtgccttaatttgagataattattttactgccatgagtaagtatagaaatttcaaaaaatgtattttcaaaaaattatgtgtgtcagtgagtttttcattgataattggtttaatttaaaatatttagaggtttgttggactttcataaattgagtacaatctttgcatcaaactacctgctacaataatgactttataaaactgcaaaaaatgtagaaggttgcaccaacataaaaaggaaatatggcaatacatccatgatgttttccagttaacataggaattaccagataaatactgttaaactcttgtccagtaacaagagttgattcatatggacagtatgatttattgtttatttttttaaccaaatacctcctcagtaatttataatggctttgcagtaatgtgtatcagataagaagcactggaaaaccgatcgtctctaggatgatatgcatgtttcaagtggtattgaaagccgcactgatggatatgtaataataaacatatctgttattaatatactaatgactctgtgctcatttaatgagaaataaaagtaatttatggatgggtatctttaatttttactgcaatgtgttttctcatggctgaaatgaatggaaaacatacttcaaattagtctctgattgtatataaatgtttgtgaaattccatggttagattaaagtgtatttttaaaagataaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6093 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
GeneID:6093 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:6093 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6093 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:6093 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA
GeneID:6093 -> Molecular function: GO:0017048 [Rho GTPase binding] evidence: IEA
GeneID:6093 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:6093 -> Biological process: GO:0003383 [apical constriction] evidence: IEA
GeneID:6093 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:6093 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:6093 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:6093 -> Biological process: GO:0006939 [smooth muscle contraction] evidence: TAS
GeneID:6093 -> Biological process: GO:0007159 [leukocyte cell-cell adhesion] evidence: IDA
GeneID:6093 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:6093 -> Biological process: GO:0007266 [Rho protein signal transduction] evidence: TAS
GeneID:6093 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:6093 -> Biological process: GO:0016525 [negative regulation of angiogenesis] evidence: IMP
GeneID:6093 -> Biological process: GO:0022614 [membrane to membrane docking] evidence: IDA
GeneID:6093 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: IEA
GeneID:6093 -> Biological process: GO:0030155 [regulation of cell adhesion] evidence: TAS
GeneID:6093 -> Biological process: GO:0032060 [bleb assembly] evidence: IEA
GeneID:6093 -> Biological process: GO:0032956 [regulation of actin cytoskeleton organization] evidence: TAS
GeneID:6093 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IEA
GeneID:6093 -> Biological process: GO:0045616 [regulation of keratinocyte differentiation] evidence: IMP
GeneID:6093 -> Biological process: GO:0050900 [leukocyte migration] evidence: IDA
GeneID:6093 -> Biological process: GO:0050901 [leukocyte tethering or rolling] evidence: IDA
GeneID:6093 -> Biological process: GO:0051492 [regulation of stress fiber assembly] evidence: TAS
GeneID:6093 -> Biological process: GO:0051893 [regulation of focal adhesion assembly] evidence: TAS
GeneID:6093 -> Biological process: GO:2000114 [regulation of establishment of cell polarity] evidence: TAS
GeneID:6093 -> Biological process: GO:2000145 [regulation of cell motility] evidence: TAS
GeneID:6093 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IEA
GeneID:6093 -> Cellular component: GO:0001726 [ruffle] evidence: ISS
GeneID:6093 -> Cellular component: GO:0005814 [centriole] evidence: IEA
GeneID:6093 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:6093 -> Cellular component: GO:0005856 [cytoskeleton] evidence: ISS
GeneID:6093 -> Cellular component: GO:0005886 [plasma membrane] evidence: ISS
GeneID:6093 -> Cellular component: GO:0030027 [lamellipodium] evidence: ISS
GeneID:6093 -> Cellular component: GO:0032059 [bleb] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005397 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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