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2019-03-24 20:08:09, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005401              13443 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens protein tyrosine phosphatase, non-receptor type 14
            (PTPN14), mRNA.
ACCESSION   NM_005401
VERSION     NM_005401.4  GI:294862265
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13443)
  AUTHORS   Huang,J.M., Nagatomo,I., Suzuki,E., Mizuno,T., Kumagai,T.,
            Berezov,A., Zhang,H., Karlan,B., Greene,M.I. and Wang,Q.
  TITLE     YAP modifies cancer cell sensitivity to EGFR and survivin
            inhibitors and is negatively regulated by the non-receptor type
            protein tyrosine phosphatase 14
  JOURNAL   Oncogene 32 (17), 2220-2229 (2013)
   PUBMED   22689061
  REMARK    GeneRIF: YAP forms a protein complex with PTPN14 through the WW
            domains of YAP and the PPXY motifs of PTPN14.
REFERENCE   2  (bases 1 to 13443)
  AUTHORS   Wang,W., Huang,J., Wang,X., Yuan,J., Li,X., Feng,L., Park,J.I. and
            Chen,J.
  TITLE     PTPN14 is required for the density-dependent control of YAP1
  JOURNAL   Genes Dev. 26 (17), 1959-1971 (2012)
   PUBMED   22948661
  REMARK    GeneRIF: that PTPN14 acts to suppress cell proliferation by
            promoting cell density-dependent cytoplasmic translocation of YAP1
REFERENCE   3  (bases 1 to 13443)
  AUTHORS   Benzinou,M., Clermont,F.F., Letteboer,T.G., Kim,J.H., Espejel,S.,
            Harradine,K.A., Arbelaez,J., Luu,M.T., Roy,R., Quigley,D.,
            Higgins,M.N., Zaid,M., Aouizerat,B.E., van Amstel,J.K., Giraud,S.,
            Dupuis-Girod,S., Lesca,G., Plauchu,H., Hughes,C.C., Westermann,C.J.
            and Akhurst,R.J.
  TITLE     Mouse and human strategies identify PTPN14 as a modifier of
            angiogenesis and hereditary haemorrhagic telangiectasia
  JOURNAL   Nat Commun 3, 616 (2012)
   PUBMED   22233626
  REMARK    GeneRIF: PTPN14 has a role in angiogenesis and/or arteriovenous
            fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1
            Erratum:[Nat Commun. 2012;3:1148]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13443)
  AUTHORS   Au,A.C., Hernandez,P.A., Lieber,E., Nadroo,A.M., Shen,Y.M.,
            Kelley,K.A., Gelb,B.D. and Diaz,G.A.
  TITLE     Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic
            function and choanal development in humans
  JOURNAL   Am. J. Hum. Genet. 87 (3), 436-444 (2010)
   PUBMED   20826270
  REMARK    GeneRIF: These results suggest a unique and conserved role for
            PTPN14 in the regulation of lymphatic development in mammals and a
            nonconserved role in choanal development in humans.
REFERENCE   5  (bases 1 to 13443)
  AUTHORS   Wyatt,L. and Khew-Goodall,Y.
  TITLE     PTP-Pez: a novel regulator of TGFbeta signaling
  JOURNAL   Cell Cycle 7 (15), 2290-2295 (2008)
   PUBMED   18677119
  REMARK    GeneRIF: Dysregulation of TGFbeta signaling as a possible link
            between Pez mutation and cancer progression.
            Review article
REFERENCE   6  (bases 1 to 13443)
  AUTHORS   Wadham,C., Gamble,J.R., Vadas,M.A. and Khew-Goodall,Y.
  TITLE     Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to
            the nucleus is associated with induction of cell proliferation
  JOURNAL   J. Cell. Sci. 113 (PT 17), 3117-3123 (2000)
   PUBMED   10934049
REFERENCE   7  (bases 1 to 13443)
  AUTHORS   Aoyama,K., Matsuda,T. and Aoki,N.
  TITLE     Characterization of newly identified four isoforms for a putative
            cytosolic protein tyrosine phosphatase PTP36
  JOURNAL   Biochem. Biophys. Res. Commun. 266 (2), 523-531 (1999)
   PUBMED   10600535
REFERENCE   8  (bases 1 to 13443)
  AUTHORS   Ogata,M., Takada,T., Mori,Y., Uchida,Y., Miki,T., Okuyama,A.,
            Kosugi,A., Sawada,M., Oh-hora,M. and Hamaoka,T.
  TITLE     Regulation of phosphorylation level and distribution of PTP36, a
            putative protein tyrosine phosphatase, by cell-substrate adhesion
  JOURNAL   J. Biol. Chem. 274 (29), 20717-20724 (1999)
   PUBMED   10400706
REFERENCE   9  (bases 1 to 13443)
  AUTHORS   Ogata,M., Takada,T., Mori,Y., Oh-hora,M., Uchida,Y., Kosugi,A.,
            Miyake,K. and Hamaoka,T.
  TITLE     Effects of overexpression of PTP36, a putative protein tyrosine
            phosphatase, on cell adhesion, cell growth, and cytoskeletons in
            HeLa cells
  JOURNAL   J. Biol. Chem. 274 (18), 12905-12909 (1999)
   PUBMED   10212280
REFERENCE   10 (bases 1 to 13443)
  AUTHORS   Smith,A.L., Mitchell,P.J., Shipley,J., Gusterson,B.A., Rogers,M.V.
            and Crompton,M.R.
  TITLE     Pez: a novel human cDNA encoding protein tyrosine phosphatase- and
            ezrin-like domains
  JOURNAL   Biochem. Biophys. Res. Commun. 209 (3), 959-965 (1995)
   PUBMED   7733990
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA738908.1, AK291641.1,
            AL445305.11, AL603838.6 and AL929236.4.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 20, 2010 this sequence version replaced gi:34328898.
            
            Summary: The protein encoded by this gene is a member of the
            protein tyrosine phosphatase (PTP) family. PTPs are known to be
            signaling molecules that regulate a variety of cellular processes
            including cell growth, differentiation, mitotic cycle, and
            oncogenic transformation. This PTP contains an N-terminal
            noncatalytic domain similar to that of band 4.1 superfamily
            cytoskeleton-associated proteins, which suggested the membrane or
            cytoskeleton localization of this protein. It appears to regulate
            lymphatic development in mammals, and a loss of function mutation
            has been found in a kindred with a lymphedema-choanal atresia.
            [provided by RefSeq, Sep 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291641.1, X82676.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               DA738908.1         1-356
            357-627             AK291641.1         289-559
            628-827             AL445305.11        3979-4178           c
            828-2179            AK291641.1         760-2111
            2180-3197           AL603838.6         25863-26880         c
            3198-4391           AK291641.1         3130-4323
            4392-13443          AL929236.4         107756-116807       c
FEATURES             Location/Qualifiers
     source          1..13443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..13443
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="protein tyrosine phosphatase, non-receptor type 14"
                     /db_xref="GeneID:5784"
                     /db_xref="HGNC:9647"
                     /db_xref="HPRD:04402"
                     /db_xref="MIM:603155"
     exon            1..499
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     variation       357
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3806315"
     exon            500..827
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    564..566
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="upstream in-frame stop codon"
     CDS             654..4217
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /EC_number="3.1.3.48"
                     /note="cytoskeletal-associated protein tyrosine
                     phosphatase; protein-tyrosine phosphatase pez"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     14"
                     /protein_id="NP_005392.2"
                     /db_xref="GI:34328899"
                     /db_xref="CCDS:CCDS1514.1"
                     /db_xref="GeneID:5784"
                     /db_xref="HGNC:9647"
                     /db_xref="HPRD:04402"
                     /db_xref="MIM:603155"
                     /translation="
MPFGLKLRRTRRYNVLSKNCFVTRIRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHVQCGEHYSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVSGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQIPMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDLTSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI
"
     misc_feature    723..1313
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="Band 4.1 homologues; Region: B41; smart00295"
                     /db_xref="CDD:197635"
     misc_feature    726..962
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="FERM N-terminal domain; Region: FERM_N; pfam09379"
                     /db_xref="CDD:204220"
     misc_feature    978..1313
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="FERM central domain; Region: FERM_M; pfam00373"
                     /db_xref="CDD:201187"
     misc_feature    1293..1562
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl00273"
                     /db_xref="CDD:206947"
     misc_feature    order(1305..1328,1335..1355,1362..1376,1425..1439,
                     1449..1463,1482..1496,1521..1547)
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="PH-like core; other site"
                     /db_xref="CDD:176275"
     misc_feature    2109..2111
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15678.2); phosphorylation site"
     misc_feature    2109..2111
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2403..2405
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    2424..2426
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15678.2); phosphorylation site"
     misc_feature    2433..2435
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15678.2); phosphorylation site"
     misc_feature    2577..2579
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q15678.2); phosphorylation site"
     misc_feature    3378..4190
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="Protein tyrosine phosphatase, catalytic domain;
                     Region: PTPc; smart00194"
                     /db_xref="CDD:197567"
     misc_feature    3456..4190
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="Protein tyrosine phosphatases (PTP) catalyze the
                     dephosphorylation of phosphotyrosine peptides; they
                     regulate phosphotyrosine levels in signal transduction
                     pathways. The depth of the active site cleft renders the
                     enzyme specific for phosphorylated Tyr; Region: PTPc;
                     cd00047"
                     /db_xref="CDD:28929"
     misc_feature    order(3888..3890,4011..4016,4023..4025,4032..4037)
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /note="active site"
                     /db_xref="CDD:28929"
     misc_feature    4014..4034
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15678.2);
                     Region: Substrate (By similarity)"
     misc_feature    4014..4034
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15678.2);
                     Region: Substrate binding (By similarity)"
     exon            828..997
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            998..1095
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1096..1163
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1164..1234
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1235..1322
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1323..1411
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1412..1499
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     variation       1499
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35027429"
     exon            1500..1582
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1583..1640
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1641..1719
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            1720..3197
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     variation       2260
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79745253"
     exon            3198..3341
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            3342..3560
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            3561..3689
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            3690..3924
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     variation       3905
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1135352"
     exon            3925..4088
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     exon            4089..13443
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /inference="alignment:Splign:1.39.8"
     STS             4212..4344
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="STS-X82676"
                     /db_xref="UniSTS:21364"
     STS             4218..4365
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="SHGC-76337"
                     /db_xref="UniSTS:64565"
     variation       5823
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1060349"
     variation       8230
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1472441"
     variation       8512
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1472442"
     variation       8518
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1472443"
     variation       9879
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1472439"
     variation       10166
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1472440"
     variation       10493
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200638209"
     STS             11345..11534
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="D1S1425"
                     /db_xref="UniSTS:149621"
     STS             11389..11495
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       12441
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11546021"
     STS             13215..13340
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="A009Q27"
                     /db_xref="UniSTS:949"
     STS             13215..13340
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="G32781"
                     /db_xref="UniSTS:117361"
     STS             13299..13425
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
                     /standard_name="D1S2195"
                     /db_xref="UniSTS:4899"
     polyA_signal    13416..13421
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
     polyA_site      13439
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
     polyA_site      13443
                     /gene="PTPN14"
                     /gene_synonym="PEZ; PTP36"
ORIGIN      
actcgcacggccccttcctccctcctctcccggccgctcgcatttcctgccgctctggctctcccggcccctcaaagttctttccaactttttctcggcggagtgagcgcagcgggcgcagactcgggggcaggttgctgtgcttctccgggctcagccgcctgctctcctggctcaggtcctcggggagccctagacagacatcaagtggccactggcgctccttcccctcccagctgagccatcctccccggcctcctcgggcgggacagccccgtgcttaggtttttctccttttctcccccggtgcgcctctgctcggactctcgcgccgggatcgcggcggaaacctccctcccctttcgcctcctgcggctccttcccttcgcccctcctccgccagtcactggaatcaattccgtggggaatcggctccgccgccgcgaaggacagcctttccgcgcgggactccggggcgccacgggggccatgtaagcagctatcttccagagggccacactgggcatggacacccttttccctgcctggaggagcacaggtgatagtgtaattttccagtcacgaaactgctaaggccatctcaggggcgtgtgcgccaggataggcgggcggcgtccgaggaccacatagccatgccttttggtctgaagctccgccggacacggcgctacaacgtcctgagcaagaactgctttgtcacacggattcgcctgctggacagcaatgttatcgagtgcacgctgtcggtggaaagcacagggcaagaatgcctggaggctgtggcccagaggctggagctgcgagagacgcactactttggcctttggtttctcagcaagagccagcaagcacgatgggtggagctggagaaacctctgaagaaacatctggacaaattcgctaatgagcctttgcttttctttggagtcatgttctatgtgccaaatgtgtcatggcttcagcaagaggccacaagatatcagtattacctgcaagtcaaaaaagatgtgcttgaagggcgattacgatgtacattggaccaggtgattcggctagccggcctagctgtgcaagctgattttggagactataatcagtttgattctcaagatttcctcagagagtatgtgctatttcctatggatttggccctggaagaggctgttctggaggagctgacccagaaggtagcccaagaacacaaagcccacagtggaatcctgccagcagaagctgaactgatgtacatcaatgaagttgaacgtttggatggatttggacaggaaatcttccctgtaaaggacaatcatggaaactgtgtacaccttggcattttctttatggggattttcgtgaggaacagaattggaagacaagcggtaatatacaggtggaatgacatggggaatatcactcataacaagtcgaccattctagtggagctcatcaacaaagaagagactgccctctttcacacggatgatatcgaaaatgccaagtatatttctcggttgtttgccacacgacacaagttttacaaacaaaacaaaatctgcactgaacagtcaaattctccaccccccatcagacgccagcccacctggagccgatcctctctgcccaggcagcagccgtacatcctgcctcccgttcacgtccagtgtggtgagcactactcggaaacgcacacctcgcaagacagcatttttcatgggaatgaagaagccttgtattgcaactctcacaacagcctggacttaaattatttaaatggcactgtcaccaatggcagcgtgtgtagcgttcacagcgtcaactccctcaactgctcgcaaagtttcatccaggcctcccctgtatcctccaacctcagtatccctgggagtgacatcatgcgggccgactacatcccgagccaccggcacagcgcgatcatcgtgccctcgtacaggccaacccccgattatgagacagtcatgcgccagatgaagagggggatcctgcatacagacagccagagccagtctctgagaaacctcaacattatcaacacccatgcctacaaccagccagaggatctggtgtacagccaaccggagatgcgggagaggcacccctacactgtcccttatgggccacagggggtctacagcaacaaacttgtcagtccatctgaccagaggaacccaaagaataatgtggtaccaagcaagccgggggcaagcgccatctcgcacacggtgagcaccccagagctggccaacatgcagctgcagggcagccataactacagcacggcccacatgcttaagaactatctcttcaggccaccgcccccctacccacggccacgacctgccaccagcaccccagacctggccagccaccgccacaagtacgtcagcggcagcagcccggacctggtgacccggaaggtgcagctctcggtgaagaccttccaagaggacagctctccggtggttcatcagtctctccaggaggtgagcgagcccctcacggccaccaagcaccacggcactgtgaacaagcgccacagcctggaggtgatgaacagcatggtgcggggcatggaggccatgacgctcaagtcgctccacctccccatggctcgccgcaacacgctccgggagcagggaccgcccgaggaggggtcaggcagccacgaggtcccccagctccctcagtatcaccacaagaagaccttctctgatgccactatgctaatccacagcagcgagagtgaggaggaggaggaggaggctccagaatcggtgccccagatccccatgctccgggagaagatggagtacagtgcccagctgcaggcggccctggcccgcatccccaacaagcccccgcctgagtaccccggtccaaggaagagtgtgagcaatggggctctgaggcaggaccaagccagccttcctcccgccatggccagagccagggtgctgaggcatgggccagccaaggccatcagcatgtctcggactgacccgccggctgtcaacggggcctctctcggcccatccatctcggaacccgacctgactagtgtgaaggagcgggtcaaaaaagagcctgtgaaggagagacctgtgtctgaaatgttttccctggaagacagcattatagagagagagatgatgatcaggaatctagagaagcagaagatggcaggcctggaggcacagaagaggccgctgatgttggcagcattgaatgggctctcggtggctcgagtctcagggcgggaagagaatcgagttgatgccacccgggttcccatggacgagaggttcagaaccctgaagaagaaactagaagagggaatggtgttcacagaatatgagcaaattccaaagaaaaaggcgaatggcattttcagcacagcagctctgccagaaaacgccgagcgcagccgaatccgtgaagttgtcccctatgaggagaatcgagtagagctgataccaaccaaagaaaataacacaggatacattaatgcctcccacatcaaggtggtggttggcggggcagaatggcactacatagccacccaggggcccctgccacacacgtgccacgacttctggcagatggtgtgggagcagggagtgaatgtgattgccatggtcactgcagaggaggagggtggacgaaccaaaagccaccgatactggcccaaactaggttcaaagcacagctcagccacctatggcaagttcaaggtcaccacgaagtttcgaacggattctgtttgctatgcaaccacgggcttgaaggtcaagcaccttttgtctgggcaagaaaggacggtgtggcatttacaatatactgactggccagatcacggctgtccagaagatgtccaaggatttttatcctacttggaggagatccagtcggtccgtcgccataccaacagcatgctggaaggcaccaagaaccggcacccgcccatcgtggtccactgtagtgctggggtgggaaggaccggcgtgctcattctttctgagctgatgatctactgcttggaacataacgaaaaggtggaagtgcccatgatgctgaggctcctcagggagcagaggatgttcatgatccagactatcgctcagtacaagtttgtctaccaagtcctcatccagttcctccaaaactccagactcatttaatcaccccaatccagctcctggaggagggacccagctccatcgcgctggaggagagtcacctccagacaacatctgctccccccacaggggtgcaggtggctggcagcaaacaggctctctgaagacagtagccaagattattcacacataccatgtattattttatatgagataatttatttttttcccctttggaataacttttgtgaattattataatgcagtttccctagtaatatagtacttttcatttgaaccacatcttgactgatctgtattgtaatatatgtcagcaggtaaggttgcctgctggatcattttgaggacagaggcatgagggagcacatctcttgtgaagttgcagccagatttgtaaccaaccctgaaattcatcagcttaattcatttatcagcttgattcattcatcattcattgcttatatccaaagcaaagacggtaagaaaatgaattcatcctgaaatataaagaaaagggtctgaaggaacaaacacgattctcttatattttggggctcatgagccttgatagacagtttcctctcgtcttcatttccacccctcatcctcagtagtctcctctcccccacgccccaccccaacttcccccccaagcttgagttaaagacagaatagctaaagacagtgctgcctttacaatgcagtaattgccatctttggggccgaaagacaagctctgtgttgtgcttttcttgaccaccccttatcctgggctctggagcttgtgtttccctgctggcgact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//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5784 -> Molecular function: GO:0003712 [transcription cofactor activity] evidence: IMP
            GeneID:5784 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IMP
            GeneID:5784 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5784 -> Molecular function: GO:0030971 [receptor tyrosine kinase binding] evidence: IPI
            GeneID:5784 -> Biological process: GO:0001946 [lymphangiogenesis] evidence: IMP
            GeneID:5784 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:5784 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:5784 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: TAS
            GeneID:5784 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IMP
            GeneID:5784 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: IMP
            GeneID:5784 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: TAS
            GeneID:5784 -> Biological process: GO:0046825 [regulation of protein export from nucleus] evidence: IDA
            GeneID:5784 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:5784 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:5784 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005392 -> EC 3.1.3.48

by @meso_cacase at DBCLS
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