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2024-04-24 14:45:54, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005378 2613 bp mRNA linear PRI 11-JUL-2013
DEFINITION Homo sapiens v-myc avian myelocytomatosis viral oncogene
neuroblastoma derived homolog (MYCN), mRNA.
ACCESSION NM_005378
VERSION NM_005378.4 GI:62750358
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2613)
AUTHORS Rushlow,D.E., Mol,B.M., Kennett,J.Y., Yee,S., Pajovic,S.,
Theriault,B.L., Prigoda-Lee,N.L., Spencer,C., Dimaras,H.,
Corson,T.W., Pang,R., Massey,C., Godbout,R., Jiang,Z.,
Zacksenhaus,E., Paton,K., Moll,A.C., Houdayer,C., Raizis,A.,
Halliday,W., Lam,W.L., Boutros,P.C., Lohmann,D., Dorsman,J.C. and
Gallie,B.L.
TITLE Characterisation of retinoblastomas without RB1 mutations: genomic,
gene expression, and clinical studies
JOURNAL Lancet Oncol. 14 (4), 327-334 (2013)
PUBMED 23498719
REMARK GeneRIF: Amplification of the MYCN oncogene might initiate
retinoblastoma in the presence of non-mutated RB1 genes. These
unilateral RB1(+/+)MYCN(A) retinoblastomas are characterised by
distinct histological features.
REFERENCE 2 (bases 1 to 2613)
AUTHORS Corvetta,D., Chayka,O., Gherardi,S., D'Acunto,C.W., Cantilena,S.,
Valli,E., Piotrowska,I., Perini,G. and Sala,A.
TITLE Physical interaction between MYCN oncogene and polycomb repressive
complex 2 (PRC2) in neuroblastoma: functional and therapeutic
implications
JOURNAL J. Biol. Chem. 288 (12), 8332-8341 (2013)
PUBMED 23362253
REMARK GeneRIF: Binding of MYCN to the CLU gene induces bivalent
epigenetic marks and recruitment of repressive proteins such as
histone deacetylases and Polycomb members.
REFERENCE 3 (bases 1 to 2613)
AUTHORS Villamon,E., Berbegall,A.P., Piqueras,M., Tadeo,I., Castel,V.,
Djos,A., Martinsson,T., Navarro,S. and Noguera,R.
TITLE Genetic instability and intratumoral heterogeneity in neuroblastoma
with MYCN amplification plus 11q deletion
JOURNAL PLoS ONE 8 (1), E53740 (2013)
PUBMED 23341988
REMARK GeneRIF: influence of MYCN amplification and 11q deletion in
neuroblastoma
REFERENCE 4 (bases 1 to 2613)
AUTHORS Wang,M., Zhou,C., Cai,R., Li,Y. and Gong,L.
TITLE Copy number gain of MYCN gene is a recurrent genetic aberration and
favorable prognostic factor in Chinese pediatric neuroblastoma
patients
JOURNAL Diagn Pathol 8, 5 (2013)
PUBMED 23320395
REMARK GeneRIF: Suggest MYCN plays an important role in neuroblastic tumor
differentiation and MYCN gain may define subgroup of tumors with
better outcome.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2613)
AUTHORS Inandiklioglu,N., Yilmaz,S., Demirhan,O., Erdogan,S. and Tanyeli,A.
TITLE Chromosome imbalances and alterations of AURKA and MYCN genes in
children with neuroblastoma
JOURNAL Asian Pac. J. Cancer Prev. 13 (11), 5391-5397 (2012)
PUBMED 23317189
REMARK GeneRIF: Amplifications of MYCN gene is associated with
neuroblastoma.
REFERENCE 6 (bases 1 to 2613)
AUTHORS Hagiwara,T., Nakaya,K., Nakamura,Y., Nakajima,H., Nishimura,S. and
Taya,Y.
TITLE Specific phosphorylation of the acidic central region of the N-myc
protein by casein kinase II
JOURNAL Eur. J. Biochem. 209 (3), 945-950 (1992)
PUBMED 1425701
REFERENCE 7 (bases 1 to 2613)
AUTHORS Armstrong,B.C. and Krystal,G.W.
TITLE Isolation and characterization of complementary DNA for N-cym, a
gene encoded by the DNA strand opposite to N-myc
JOURNAL Cell Growth Differ. 3 (6), 385-390 (1992)
PUBMED 1419902
REFERENCE 8 (bases 1 to 2613)
AUTHORS Fougerousse,F., Meloni,R., Roudaut,C. and Beckmann,J.S.
TITLE Dinucleotide repeat polymorphism at the human hemoglobin alpha-1
pseudo-gene (HBAP1)
JOURNAL Nucleic Acids Res. 20 (5), 1165 (1992)
PUBMED 1549498
REFERENCE 9 (bases 1 to 2613)
AUTHORS Blackwood,E.M. and Eisenman,R.N.
TITLE Max: a helix-loop-helix zipper protein that forms a
sequence-specific DNA-binding complex with Myc
JOURNAL Science 251 (4998), 1211-1217 (1991)
PUBMED 2006410
REFERENCE 10 (bases 1 to 2613)
AUTHORS Krystal,G.W., Armstrong,B.C. and Battey,J.F.
TITLE N-myc mRNA forms an RNA-RNA duplex with endogenous antisense
transcripts
JOURNAL Mol. Cell. Biol. 10 (8), 4180-4191 (1990)
PUBMED 1695323
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BU167361.1, BT007384.1,
AC010145.10 and AI962624.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 19, 2005 this sequence version replaced gi:34147496.
Summary: This gene is a member of the MYC family and encodes a
protein with a basic helix-loop-helix (bHLH) domain. This protein
is located in the nucleus and must dimerize with another bHLH
protein in order to bind DNA. Amplification of this gene is
associated with a variety of tumors, most notably neuroblastomas.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: BC002712.2, BT007384.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
ERS025086 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-300 BU167361.1 32-331
301-1695 BT007384.1 1-1395
1696-2576 AC010145.10 71443-72323
2577-2613 AI962624.1 1-37 c
FEATURES Location/Qualifiers
source 1..2613
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p24.3"
gene 1..2613
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="v-myc avian myelocytomatosis viral oncogene
neuroblastoma derived homolog"
/db_xref="GeneID:4613"
/db_xref="HGNC:7559"
/db_xref="HPRD:01278"
/db_xref="MIM:164840"
exon 1..183
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/inference="alignment:Splign:1.39.8"
variation 85
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:185713214"
misc_feature 97..99
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="upstream in-frame stop codon"
variation 124
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:188129461"
exon 184..1090
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/inference="alignment:Splign:1.39.8"
variation 263
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:200161041"
variation 272
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="c"
/db_xref="dbSNP:377590323"
variation 284
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:41264197"
variation 299
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:148277324"
CDS 301..1695
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="v-myc avian myelocytomatosis viral related
oncogene, neuroblastoma derived; pp65/67; neuroblastoma
MYC oncogene; oncogene NMYC; neuroblastoma-derived v-myc
avian myelocytomatosis viral related oncogene; class E
basic helix-loop-helix protein 37; v-myc myelocytomatosis
viral related oncogene, neuroblastoma derived"
/codon_start=1
/product="N-myc proto-oncogene protein"
/protein_id="NP_005369.2"
/db_xref="GI:19923312"
/db_xref="CCDS:CCDS1687.1"
/db_xref="GeneID:4613"
/db_xref="HGNC:7559"
/db_xref="HPRD:01278"
/db_xref="MIM:164840"
/translation="
MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
"
misc_feature 331..>903
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="Myc amino-terminal region; Region: Myc_N;
pfam01056"
/db_xref="CDD:110083"
misc_feature 472..474
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 484..486
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1081..1083
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK2; propagated from
UniProtKB/Swiss-Prot (P04198.2); phosphorylation site"
misc_feature 1081..1083
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:00277"
misc_feature 1081..1083
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:00279"
misc_feature 1087..1089
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK2; propagated from
UniProtKB/Swiss-Prot (P04198.2); phosphorylation site"
misc_feature 1087..1089
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:00277"
misc_feature 1087..1089
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
/db_xref="HPRD:00279"
misc_feature <1150..1410
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="Myc amino-terminal region; Region: Myc_N;
pfam01056"
/db_xref="CDD:110083"
misc_feature 1456..1596
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="Helix-loop-helix domain, found in specific DNA-
binding proteins that act as transcription factors; 60-100
amino acids long. A DNA-binding basic region is followed
by two alpha-helices separated by a variable loop region;
HLH forms homo- and heterodimers; Region: HLH; cd00083"
/db_xref="CDD:28964"
misc_feature order(1465..1473,1477..1479,1546..1548,1555..1557)
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="DNA binding region [nucleotide binding]"
/db_xref="CDD:28964"
misc_feature 1468..1470
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="E-box/N-box specificity site; other site"
/db_xref="CDD:28964"
misc_feature order(1486..1491,1498..1503,1507..1512,1558..1560,
1567..1569,1579..1581,1585..1590)
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:28964"
misc_feature 1597..1662
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P04198.2);
Region: Leucine-zipper"
variation 305
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:370558211"
variation 308
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:373683425"
variation 318
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:199929021"
variation 323
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:371517719"
variation 330
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:201009439"
variation 369
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:141260022"
variation 390
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:35648249"
variation 411
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="c"
/db_xref="dbSNP:374745691"
variation 507
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:41264199"
variation 517
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:113994115"
variation 531
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:121913667"
variation 546
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:148975024"
variation 579
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:151113760"
exon 1091..2605
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/inference="alignment:Splign:1.39.8"
variation 1108
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:376496392"
variation 1131
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:373661257"
variation 1132
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:201115523"
variation 1204
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:144939456"
variation 1205
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:140581169"
variation 1222
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:370751156"
variation 1235
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:200236475"
variation 1284
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:374105854"
variation 1299
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:138606824"
variation 1314
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:367962377"
variation 1315
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:372079635"
variation 1322
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:144648016"
variation 1361
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:185639773"
variation 1362
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:201114632"
variation 1390
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:143438192"
variation 1393
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:140276895"
variation 1394
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="c"
/db_xref="dbSNP:150742977"
variation 1445
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:121913666"
variation 1477
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="c"
/db_xref="dbSNP:104893647"
variation 1478
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:104893646"
variation 1481
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:104893648"
variation 1516
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:200482512"
variation 1521
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:190053841"
variation 1554
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:140567920"
variation 1680
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:150023769"
variation 1684
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/db_xref="dbSNP:144531796"
variation 1697
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:141392135"
variation 1749
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="g"
/replace="t"
/db_xref="dbSNP:192196240"
variation 1752
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:144532405"
variation 1753
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="c"
/db_xref="dbSNP:62116683"
variation 1783
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:148464851"
variation 1788
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:371145074"
variation 1797
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:142866857"
STS 1826..2169
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/standard_name="D2S2719"
/db_xref="UniSTS:52755"
variation 1930
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:374300561"
variation 1941
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1048"
variation 1942..1943
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace=""
/replace="gacggt"
/db_xref="dbSNP:376446365"
variation 1945
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:922"
STS 1961..2363
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/standard_name="MARC_10471-10472:999704936:1"
/db_xref="UniSTS:267151"
variation 2049
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="g"
/db_xref="dbSNP:79703814"
variation 2089
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:141300189"
variation 2418..2419
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace=""
/replace="ta"
/db_xref="dbSNP:371336742"
variation 2424
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:184691461"
variation 2458
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="a"
/replace="c"
/db_xref="dbSNP:2515691"
variation 2481
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
/replace="c"
/replace="t"
/db_xref="dbSNP:15260"
polyA_signal 2582..2587
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
polyA_signal 2597..2602
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
polyA_site 2605
/gene="MYCN"
/gene_synonym="bHLHe37; MODED; N-myc; NMYC; ODED"
ORIGIN
gtcatctgtctggacgcgctgggtggatgcggggggctcctgggaactgtgttggagccgagcaagcgctagccaggcgcaagcgcgcacagactgtagccatccgaggacacccccgcccccccggcccacccggagacacccgcgcagaatcgcctccggatcccctgcagtcggcgggagtgttggaggtcggcgccggcccccgccttccgcgccccccacgggaaggaagcacccccggtattaaaacgaacggggcggaaagaagccctcagtcgccggccgggaggcgagccgatgccgagctgctccacgtccaccatgccgggcatgatctgcaagaacccagacctcgagtttgactcgctacagccctgcttctacccggacgaagatgacttctacttcggcggccccgactcgacccccccgggggaggacatctggaagaagtttgagctgctgcccacgcccccgctgtcgcccagccgtggcttcgcggagcacagctccgagcccccgagctgggtcacggagatgctgcttgagaacgagctgtggggcagcccggccgaggaggacgcgttcggcctggggggactgggtggcctcacccccaacccggtcatcctccaggactgcatgtggagcggcttctccgcccgcgagaagctggagcgcgccgtgagcgagaagctgcagcacggccgcgggccgccaaccgccggttccaccgcccagtccccgggagccggcgccgccagccctgcgggtcgcgggcacggcggggctgcgggagccggccgcgccggggccgccctgcccgccgagctcgcccacccggccgccgagtgcgtggatcccgccgtggtcttcccctttcccgtgaacaagcgcgagccagcgcccgtgcccgcagccccggccagtgccccggcggcgggccctgcggtcgcctcgggggcgggtattgccgccccagccggggccccgggggtcgcccctccgcgcccaggcggccgccagaccagcggcggcgaccacaaggccctcagtacctccggagaggacaccctgagcgattcagatgatgaagatgatgaagaggaagatgaagaggaagaaatcgacgtggtcactgtggagaagcggcgttcctcctccaacaccaaggctgtcaccacattcaccatcactgtgcgtcccaagaacgcagccctgggtcccgggagggctcagtccagcgagctgatcctcaaacgatgccttcccatccaccagcagcacaactatgccgccccctctccctacgtggagagtgaggatgcacccccacagaagaagataaagagcgaggcgtccccacgtccgctcaagagtgtcatccccccaaaggctaagagcttgagcccccgaaactctgactcggaggacagtgagcgtcgcagaaaccacaacatcctggagcgccagcgccgcaacgaccttcggtccagctttctcacgctcagggaccacgtgccggagttggtaaagaatgagaaggccgccaaggtggtcattttgaaaaaggccactgagtatgtccactccctccaggccgaggagcaccagcttttgctggaaaaggaaaaattgcaggcaagacagcagcagttgctaaagaaaattgaacacgctcggacttgctagacgcttctcaaaactggacagtcactgccactttgcacattttgattttttttttaaacaaacattgtgttgacattaagaatgttggtttactttcaaatcggtcccctgtcgagttcggctctgggtgggcagtaggaccaccagtgtggggttctgctgggaccttggagagcctgcatcccaggatgctgggtggccctgcagcctcctccacctcacctccatgacagcgctaaacgttggtgacggttgggagcctctggggctgttgaagtcaccttgtgtgttccaagtttccaaacaacagaaagtcattccttctttttaaaatggtgcttaagttccagcagatgccacataaggggtttgccatttgatacccctggggaacatttctgtaaataccattgacacatccgccttttgtatacatcctgggtaatgagaggtggcttttgcggccagtattagactggaagttcatacctaagtactgtaataatacctcaatgtttgaggagcatgttttgtatacaaatatattgttaatctctgttatgtactgtactaattcttacactgcctgtatactttagtatgacgctgatacataactaaatttgatacttatattttcgtatgaaaatgagttgtgaaagttttgagtagatattactttatcactttttgaactaagaaacttttgtaaagaaatttactatatatatatgcctttttcctagcctgtttcttcctgttaatgtatttgttcatgtttggtgcatagaactgggtaaatgcaaagttctgtgtttaatttcttcaaaatgtatatatttagtgctgcatcttatagcactttgaaatacctcatgtttatgaaaataaatagcttaaaattaaatgaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4613 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:4613 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:4613 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4613 -> Molecular function: GO:0046983 [protein dimerization activity] evidence: IEA
GeneID:4613 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS
GeneID:4613 -> Cellular component: GO:0000785 [chromatin] evidence: TAS
GeneID:4613 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
by
@meso_cacase at
DBCLS
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