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2020-10-24 06:47:22, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005347               3973 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein,
            78kDa) (HSPA5), mRNA.
ACCESSION   NM_005347
VERSION     NM_005347.4  GI:305855105
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3973)
  AUTHORS   Gray,M.J., Mhawech-Fauceglia,P., Yoo,E., Yang,W., Wu,E., Lee,A.S.
            and Lin,Y.G.
  TITLE     AKT inhibition mitigates GRP78 (glucose-regulated protein)
            expression and contribution to chemoresistance in endometrial
            cancers
  JOURNAL   Int. J. Cancer 133 (1), 21-30 (2013)
   PUBMED   23280503
  REMARK    GeneRIF: GRP78 is an important mediator in Endometrial Cancer (EC)
            cell survival and is associated with malignant disease.
            Furthermore, GRP78 contributes to cisplatin resistance, a critical
            aspect of disease progression in EC.
REFERENCE   2  (bases 1 to 3973)
  AUTHORS   Hammadi,M., Oulidi,A., Gackiere,F., Katsogiannou,M., Slomianny,C.,
            Roudbaraki,M., Dewailly,E., Delcourt,P., Lepage,G., Lotteau,S.,
            Ducreux,S., Prevarskaya,N. and Van Coppenolle,F.
  TITLE     Modulation of ER stress and apoptosis by endoplasmic reticulum
            calcium leak via translocon during unfolded protein response:
            involvement of GRP78
  JOURNAL   FASEB J. 27 (4), 1600-1609 (2013)
   PUBMED   23322163
  REMARK    GeneRIF: Expression of GRP78, an ER stress marker, increased
            following treatment with puromycin (a translocon opener) and was
            suppressed by anisomycin, confirming a primary role of translocon
            in ER stress induction.
REFERENCE   3  (bases 1 to 3973)
  AUTHORS   Liu,S., Li,K., Li,T., Xiong,X., Yao,S., Chen,Z., Wang,C. and
            Zhao,B.
  TITLE     Association between promoter polymorphisms of the GRP78 gene and
            risk of type 2 diabetes in a Chinese Han population
  JOURNAL   DNA Cell Biol. 32 (3), 119-124 (2013)
   PUBMED   23402331
  REMARK    GeneRIF: No associations of GRP78 polymorphisms with type 2
            diabetes were observed in genotypic analyses in a Chinese Han
            population.
REFERENCE   4  (bases 1 to 3973)
  AUTHORS   Ryu,J., Park,S.G., Lee,P.Y., Cho,S., Lee do,H., Kim,G.H., Kim,J.H.
            and Park,B.C.
  TITLE     Dimerization of pro-oncogenic protein Anterior Gradient 2 is
            required for the interaction with BiP/GRP78
  JOURNAL   Biochem. Biophys. Res. Commun. 430 (2), 610-615 (2013)
   PUBMED   23220234
  REMARK    GeneRIF: this study showed that dimerization of AGR2 attenuates ER
            stress induced cell death and its dimerization is required for the
            interaction with BiP/GRP78.
REFERENCE   5  (bases 1 to 3973)
  AUTHORS   Cloutier,P., Lavallee-Adam,M., Faubert,D., Blanchette,M. and
            Coulombe,B.
  TITLE     A newly uncovered group of distantly related lysine
            methyltransferases preferentially interact with molecular
            chaperones to regulate their activity
  JOURNAL   PLoS Genet. 9 (1), E1003210 (2013)
   PUBMED   23349634
  REMARK    GeneRIF: Evidence of trimethylation at Lys-585 by METTL21A
REFERENCE   6  (bases 1 to 3973)
  AUTHORS   Chao,C.C. and Lin-Chao,S.
  TITLE     A direct-repeat sequence of the human BiP gene is required for
            A23187-mediated inducibility and an inducible nuclear factor
            binding
  JOURNAL   Nucleic Acids Res. 20 (24), 6481-6485 (1992)
   PUBMED   1480470
REFERENCE   7  (bases 1 to 3973)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J. Infect. 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 3973)
  AUTHORS   Suzuki,C.K., Bonifacino,J.S., Lin,A.Y., Davis,M.M. and
            Klausner,R.D.
  TITLE     Regulating the retention of T-cell receptor alpha chain variants
            within the endoplasmic reticulum: Ca(2+)-dependent association with
            BiP
  JOURNAL   J. Cell Biol. 114 (2), 189-205 (1991)
   PUBMED   1649196
REFERENCE   9  (bases 1 to 3973)
  AUTHORS   Dana,R.C., Welch,W.J. and Deftos,L.J.
  TITLE     Heat shock proteins bind calcitonin
  JOURNAL   Endocrinology 126 (1), 672-674 (1990)
   PUBMED   2294010
REFERENCE   10 (bases 1 to 3973)
  AUTHORS   Ting,J. and Lee,A.S.
  TITLE     Human gene encoding the 78,000-dalton glucose-regulated protein and
            its pseudogene: structure, conservation, and regulation
  JOURNAL   DNA 7 (4), 275-286 (1988)
   PUBMED   2840249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA549454.1, BC020235.1,
            X87949.1 and AA433933.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 3, 2010 this sequence version replaced gi:194097371.
            
            Summary: The protein encoded by this gene is a member of the heat
            shock protein 70 (HSP70) family. It is localized in the lumen of
            the endoplasmic reticulum (ER), and is involved in the folding and
            assembly of proteins in the ER. As this protein interacts with many
            ER proteins, it may play a key role in monitoring protein transport
            through the cell.[provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020235.1, X87949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088, ERS025098 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               DA549454.1         107-370
            265-2445            BC020235.1         208-2388
            2446-2579           X87949.1           2404-2537
            2580-2735           BC020235.1         2523-2678
            2736-3965           BC020235.1         2680-3909
            3966-3973           AA433933.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..3973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..3973
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="heat shock 70kDa protein 5 (glucose-regulated
                     protein, 78kDa)"
                     /db_xref="GeneID:3309"
                     /db_xref="HGNC:5238"
                     /db_xref="HPRD:00682"
                     /db_xref="MIM:138120"
     exon            1..383
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     variation       10..11
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35938784"
     STS             40..261
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /standard_name="PMC108893P1"
                     /db_xref="UniSTS:270143"
     misc_feature    73..75
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="upstream in-frame stop codon"
     variation       76
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34899577"
     variation       138
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35757312"
     variation       208
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11542737"
     CDS             262..2226
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="78 kDa glucose-regulated protein; immunoglobulin
                     heavy chain-binding protein; endoplasmic reticulum lumenal
                     Ca(2+)-binding protein grp78"
                     /codon_start=1
                     /product="78 kDa glucose-regulated protein precursor"
                     /protein_id="NP_005338.1"
                     /db_xref="GI:16507237"
                     /db_xref="CCDS:CCDS6863.1"
                     /db_xref="GeneID:3309"
                     /db_xref="HGNC:5238"
                     /db_xref="HPRD:00682"
                     /db_xref="MIM:138120"
                     /translation="
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
"
     sig_peptide     262..315
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     316..2223
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /product="78 kDa glucose-regulated protein"
     misc_feature    343..1437
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="Nucleotide-binding domain of human HSPA5 and
                     similar proteins; Region: HSPA5-like_NBD; cd10241"
                     /db_xref="CDD:212681"
     misc_feature    349..2166
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="Hsp70 protein; Region: HSP70; pfam00012"
                     /db_xref="CDD:200927"
     misc_feature    order(361..363,367..378,547..549,778..780,862..864,
                     931..948,952..954,1024..1029,1138..1140,1147..1152,
                     1348..1356,1360..1365,1432..1434)
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="nucleotide binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:212681"
     misc_feature    order(430..432,481..483,493..495,502..507,736..741,
                     1108..1110,1117..1122,1129..1131,1141..1143,1183..1185,
                     1189..1194)
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="putative NEF/HSP70 interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:212681"
     misc_feature    order(793..798,802..807,850..855,859..861,985..996)
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /note="SBD interface [polypeptide binding]; other site"
                     /db_xref="CDD:212681"
     misc_feature    1813..1815
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P11021.2); phosphorylation site"
     misc_feature    2212..2223
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P11021.2);
                     Region: Prevents secretion from ER"
     variation       270
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35866338"
     variation       364
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3189684"
     exon            384..615
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     variation       429
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11542736"
     exon            616..753
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     exon            754..866
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     exon            867..1257
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     variation       1030
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11542738"
     exon            1258..1495
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     variation       1295
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11542739"
     exon            1496..1663
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     exon            1664..3970
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /inference="alignment:Splign:1.39.8"
     STS             1759..2557
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /standard_name="HSPA5_988"
                     /db_xref="UniSTS:277334"
     variation       1888
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35356639"
     STS             2331..2540
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /standard_name="D2Wsu17e"
                     /db_xref="UniSTS:142375"
     STS             2357..2531
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /standard_name="D9S1138"
                     /db_xref="UniSTS:48897"
     variation       2364
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7922"
     variation       2446
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8759"
     polyA_signal    2553..2558
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
     polyA_site      2582
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
     variation       2814
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35228219"
     variation       2901
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35130081"
     variation       2971..2972
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:35875709"
     variation       2972..2973
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35204075"
     STS             3444..3536
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /standard_name="D10S275"
                     /db_xref="UniSTS:147992"
     variation       3505
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1140763"
     STS             3740..3917
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /standard_name="RH102504"
                     /db_xref="UniSTS:96838"
     variation       3789
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35189333"
     variation       3794
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12009"
     polyA_signal    3946..3951
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
     polyA_site      3970
                     /gene="HSPA5"
                     /gene_synonym="BIP; GRP78; MIF2"
ORIGIN      
gggctgggggagggtatataagccgagtaggcgacggtgaggtcgacgccggccaagacagcacagacagattgacctattggggtgtttcgcgagtgtgagagggaagcgccgcggcctgtatttctagacctgcccttcgcctggttcgtggcgccttgtgaccccgggcccctgccgcctgcaagtcggaaattgcgctgtgctcctgtgctacggcctgtggctggactgcctgctgctgcccaactggctggcaagatgaagctctccctggtggccgcgatgctgctgctgctcagcgcggcgcgggccgaggaggaggacaagaaggaggacgtgggcacggtggtcggcatcgacctggggaccacctactcctgcgtcggcgtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgcatcacgccgtcctatgtcgccttcactcctgaaggggaacgtctgattggcgatgccgccaagaaccagctcacctccaaccccgagaacacggtctttgacgccaagcggctcatcggccgcacgtggaatgacccgtctgtgcagcaggacatcaagttcttgccgttcaaggtggttgaaaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacatttgctcctgaagaaatttctgccatggttctcactaaaatgaaagaaaccgctgaggcttatttgggaaagaaggttacccatgcagttgttactgtaccagcctattttaatgatgcccaacgccaagcaaccaaagacgctggaactattgctggcctaaatgttatgaggatcatcaacgagcctacggcagctgctattgcttatggcctggataagagggagggggagaagaacatcctggtgtttgacctgggtggcggaaccttcgatgtgtctcttctcaccattgacaatggtgtcttcgaagttgtggccactaatggagatactcatctgggtggagaagactttgaccagcgtgtcatggaacacttcatcaaactgtacaaaaagaagacgggcaaagatgtcaggaaagacaatagagctgtgcagaaactccggcgcgaggtagaaaaggccaaacgggccctgtcttctcagcatcaagcaagaattgaaattgagtccttctatgaaggagaagacttttctgagaccctgactcgggccaaatttgaagagctcaacatggatctgttccggtctactatgaagcccgtccagaaagtgttggaagattctgatttgaagaagtctgatattgatgaaattgttcttgttggtggctcgactcgaattccaaagattcagcaactggttaaagagttcttcaatggcaaggaaccatcccgtggcataaacccagatgaagctgtagcgtatggtgctgctgtccaggctggtgtgctctctggtgatcaagatacaggtgacctggtactgcttgatgtatgtccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaacacagtggtgcctaccaagaagtctcagatcttttctacagcttctgataatcaaccaactgttacaatcaaggtctatgaaggtgaaagacccctgacaaaagacaatcatcttctgggtacatttgatctgactggaattcctcctgctcctcgtggggtcccacagattgaagtcacctttgagatagatgtgaatggtattcttcgagtgacagctgaagacaagggtacagggaacaaaaataagatcacaatcaccaatgaccagaatcgcctgacacctgaagaaatcgaaaggatggttaatgatgctgagaagtttgctgaggaagacaaaaagctcaaggagcgcattgatactagaaatgagttggaaagctatgcctattctctaaagaatcagattggagataaagaaaagctgggaggtaaactttcctctgaagataaggagaccatggaaaaagctgtagaagaaaagattgaatggctggaaagccaccaagatgctgacattgaagacttcaaagctaagaagaaggaactggaagaaattgttcaaccaattatcagcaaactctatggaagtgcaggccctcccccaactggtgaagaggatacagcagaaaaagatgagttgtagacactgatctgctagtgctgtaatattgtaaatactggactcaggaacttttgttaggaaaaaattgaaagaacttaagtctcgaatgtaattggaatcttcacctcagagtggagttgaaactgctatagcctaagcggctgtttactgcttttcattagcagttgctcacatgtctttgggtgggggggagaagaagaattggccatcttaaaaagcgggtaaaaaacctgggttagggtgtgtgttcaccttcaaaatgttctatttaacaactgggtcatgtgcatctggtgtaggaagttttttctaccataagtgacaccaataaatgtttgttatttacactggtctaatgtttgtgagaagcttctaattagatcaattacttattttaggaaatttaagactagatactcgtgtgtggggtgaggggagggagtatttggtatgttgggataaggaaacacttctatttaatgcttccagggatttttttttttttttttaaccctcctgggcccaagtgatccttccacctcagtctcccagctaattgagaccacaggcttgttaccaccatgctcggcttttgcattaatctaagaaaaggggagagaagttaatccacatctttactcaggcaaggggcatttcacagtgcccaagagtggggttttcttgaacatacttggtttcctatttccccttatctttctaaaactgcctttctggtggctttttttaaaattattactaatgatgcttttatagctgcttggattctctgagaaatgatggggagtgagtgatcactggtattaactttatacacttggatttcatttgtaactttaggatgtaaaggtatattgtgaaccctagctgtgtcagaatctccatccctgaaatttctcattagtggtactggggtgggatcttggatggtgacattgaaactacactaaatcccctcactatgaatgggttgttaaaggcaatggtttgtgtcaaaactggtttaggattacttagattgtgttcctgaagaaaagagtccaggtaaatggtatgatcaataaaggacaggctggtgctaacataaaatccaatattgtaatcctagcactttgggaggccaaggcgggtggatcacaaggtcaagagatagagaccatctttgccaacatggtgaaactccatctctactgaaaatacaaaaattagctgggcgtggtagtgcaagctgaaggctgaggcaggagaatcactcgaacccgggaggcagaggttgcagtgagccgagatcacaccactgtactccagcccggcactccagcctggcgacaagagtgagactccacctcaaaaaaaaaaaaaagaatccaatactgcccaaggataggtattttatagatgggcaactggctgaaaggttaattctctagggctagtagaactggatcccaacaccaaactcttaattagacctaggcctcagctgcactgcccgaaaagcatttgggcagaccctgagcagaatactggtctcaggccaagcccaatacagccattaaagatgacctacagtgctgtgtaccctggggcaatagggttaaatggtagttagcaactagggctagtcttcccttacctcaaaggctctcactaccgtggaccacctagtctgtaactctttctgaggagctgttactgaatattaaaaagatagacttcaactatgaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3309 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS
            GeneID:3309 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:3309 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:3309 -> Molecular function: GO:0016887 [ATPase activity] evidence: ISS
            GeneID:3309 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
            GeneID:3309 -> Molecular function: GO:0030674 [protein binding, bridging] evidence: NAS
            GeneID:3309 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
            GeneID:3309 -> Molecular function: GO:0043022 [ribosome binding] evidence: IEA
            GeneID:3309 -> Molecular function: GO:0051082 [unfolded protein binding] evidence: TAS
            GeneID:3309 -> Molecular function: GO:0051087 [chaperone binding] evidence: TAS
            GeneID:3309 -> Molecular function: GO:0051787 [misfolded protein binding] evidence: IDA
            GeneID:3309 -> Biological process: GO:0002576 [platelet degranulation] evidence: TAS
            GeneID:3309 -> Biological process: GO:0006200 [ATP catabolic process] evidence: ISS
            GeneID:3309 -> Biological process: GO:0006983 [ER overload response] evidence: IEA
            GeneID:3309 -> Biological process: GO:0006987 [activation of signaling protein activity involved in unfolded protein response] evidence: TAS
            GeneID:3309 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
            GeneID:3309 -> Biological process: GO:0021589 [cerebellum structural organization] evidence: IEA
            GeneID:3309 -> Biological process: GO:0021680 [cerebellar Purkinje cell layer development] evidence: IEA
            GeneID:3309 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
            GeneID:3309 -> Biological process: GO:0030433 [ER-associated protein catabolic process] evidence: TAS
            GeneID:3309 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IEA
            GeneID:3309 -> Biological process: GO:0030968 [endoplasmic reticulum unfolded protein response] evidence: TAS
            GeneID:3309 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IEA
            GeneID:3309 -> Biological process: GO:0042149 [cellular response to glucose starvation] evidence: IDA
            GeneID:3309 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
            GeneID:3309 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:3309 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:3309 -> Biological process: GO:0060904 [regulation of protein folding in endoplasmic reticulum] evidence: TAS
            GeneID:3309 -> Biological process: GO:0071353 [cellular response to interleukin-4] evidence: IEA
            GeneID:3309 -> Cellular component: GO:0005634 [nucleus] evidence: IMP
            GeneID:3309 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IMP
            GeneID:3309 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: TAS
            GeneID:3309 -> Cellular component: GO:0005788 [endoplasmic reticulum lumen] evidence: TAS
            GeneID:3309 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
            GeneID:3309 -> Cellular component: GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0008180 [COP9 signalosome] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0030176 [integral to endoplasmic reticulum membrane] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0030496 [midbody] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0034663 [endoplasmic reticulum chaperone complex] evidence: IDA
            GeneID:3309 -> Cellular component: GO:0042470 [melanosome] evidence: IEA

by @meso_cacase at DBCLS
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