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2024-04-24 16:38:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005308 2575 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens G protein-coupled receptor kinase 5 (GRK5), mRNA.
ACCESSION NM_005308
VERSION NM_005308.2 GI:51896033
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2575)
AUTHORS Li,H., Gan,W., Lu,L., Dong,X., Han,X., Hu,C., Yang,Z., Sun,L.,
Bao,W., Li,P., He,M., Sun,L., Wang,Y., Zhu,J., Ning,Q., Tang,Y.,
Zhang,R., Wen,J., Wang,D., Zhu,X., Guo,K., Zuo,X., Guo,X., Yang,H.,
Zhou,X., Zhang,X., Qi,L., Loos,R.J., Hu,F.B., Wu,T., Liu,Y.,
Liu,L., Yang,Z., Hu,R., Jia,W., Ji,L., Li,Y. and Lin,X.
CONSRTM DIAGRAM Consortium; AGEN-T2D Consortium
TITLE A genome-wide association study identifies GRK5 and RASGRP1 as type
2 diabetes loci in Chinese Hans
JOURNAL Diabetes 62 (1), 291-298 (2013)
PUBMED 22961080
REMARK GeneRIF: A genome-wide association study identifies GRK5 and
RASGRP1 as type 2 diabetes loci in Chinese Hans.
REFERENCE 2 (bases 1 to 2575)
AUTHORS So,C.H., Michal,A.M., Mashayekhi,R. and Benovic,J.L.
TITLE G protein-coupled receptor kinase 5 phosphorylates nucleophosmin
and regulates cell sensitivity to polo-like kinase 1 inhibition
JOURNAL J. Biol. Chem. 287 (21), 17088-17099 (2012)
PUBMED 22467873
REMARK GeneRIF: GRK5 phosphorylates Ser-4 in nucleophosmin and regulates
the sensitivity of cells to PLK1 inhibition.
REFERENCE 3 (bases 1 to 2575)
AUTHORS Michal,A.M., So,C.H., Beeharry,N., Shankar,H., Mashayekhi,R.,
Yen,T.J. and Benovic,J.L.
TITLE G Protein-coupled receptor kinase 5 is localized to centrosomes and
regulates cell cycle progression
JOURNAL J. Biol. Chem. 287 (9), 6928-6940 (2012)
PUBMED 22223642
REMARK GeneRIF: GRK5 is localized in the centrosome and regulates
microtubule nucleation and normal cell cycle progression.
REFERENCE 4 (bases 1 to 2575)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 5 (bases 1 to 2575)
AUTHORS Bychkov,E., Zurkovsky,L., Garret,M.B., Ahmed,M.R. and Gurevich,E.V.
TITLE Distinct cellular and subcellular distributions of G
protein-coupled receptor kinase and arrestin isoforms in the
striatum
JOURNAL PLoS ONE 7 (11), E48912 (2012)
PUBMED 23139825
REMARK GeneRIF: These data suggest cell type- and subcellular
compartment-dependent differences in GRK/arrestin-mediated
desensitization and signaling.
REFERENCE 6 (bases 1 to 2575)
AUTHORS Nagayama,Y., Tanaka,K., Hara,T., Namba,H., Yamashita,S.,
Taniyama,K. and Niwa,M.
TITLE Involvement of G protein-coupled receptor kinase 5 in homologous
desensitization of the thyrotropin receptor
JOURNAL J. Biol. Chem. 271 (17), 10143-10148 (1996)
PUBMED 8626574
REFERENCE 7 (bases 1 to 2575)
AUTHORS Bullrich,F., Druck,T., Kunapuli,P., Gomez,J., Gripp,K.W.,
Schlegelberger,B., Lasota,J., Aronson,M., Cannizzaro,L.A.,
Huebner,K. et al.
TITLE Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G
protein-coupled receptor kinases GRK5 and GRK6
JOURNAL Cytogenet. Cell Genet. 70 (3-4), 250-254 (1995)
PUBMED 7789183
REFERENCE 8 (bases 1 to 2575)
AUTHORS Kunapuli,P., Gurevich,V.V. and Benovic,J.L.
TITLE Phospholipid-stimulated autophosphorylation activates the G
protein-coupled receptor kinase GRK5
JOURNAL J. Biol. Chem. 269 (14), 10209-10212 (1994)
PUBMED 8144599
REFERENCE 9 (bases 1 to 2575)
AUTHORS Kunapuli,P., Onorato,J.J., Hosey,M.M. and Benovic,J.L.
TITLE Expression, purification, and characterization of the G
protein-coupled receptor kinase GRK5
JOURNAL J. Biol. Chem. 269 (2), 1099-1105 (1994)
PUBMED 8288567
REFERENCE 10 (bases 1 to 2575)
AUTHORS Kunapuli,P. and Benovic,J.L.
TITLE Cloning and expression of GRK5: a member of the G protein-coupled
receptor kinase family
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (12), 5588-5592 (1993)
PUBMED 7685906
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC018116.1, L15388.1,
BC064506.1, CN290123.1 and BQ184611.1.
On Sep 7, 2004 this sequence version replaced gi:4885348.
Summary: This gene encodes a member of the guanine
nucleotide-binding protein (G protein)-coupled receptor kinase
subfamily of the Ser/Thr protein kinase family. The protein
phosphorylates the activated forms of G protein-coupled receptors
thus initiating their deactivation. It has also been shown to play
a role in regulating the motility of polymorphonuclear leukocytes
(PMNs). [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC064506.1, L15388.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-44 BC018116.1 97-140
45-92 L15388.1 32-79
93-179 BC064506.1 87-173
180-381 BC018116.1 270-471
382-2350 BC064506.1 376-2344
2351-2373 L15388.1 2335-2357
2374-2394 L15388.1 2360-2380
2395-2460 CN290123.1 557-622
2461-2467 CN290123.1 624-630
2468-2491 L15388.1 2453-2476
2492-2556 L15388.1 2478-2542
2557-2575 BQ184611.1 1-19 c
FEATURES Location/Qualifiers
source 1..2575
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26.11"
gene 1..2575
/gene="GRK5"
/gene_synonym="GPRK5"
/note="G protein-coupled receptor kinase 5"
/db_xref="GeneID:2869"
/db_xref="HGNC:4544"
/db_xref="HPRD:02926"
/db_xref="MIM:600870"
exon 1..285
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 6
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:113937734"
variation 22..27
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="gcggcg"
/db_xref="dbSNP:10527480"
variation 22..24
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="gcg"
/db_xref="dbSNP:367989827"
variation 24
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:28399015"
variation 30..35
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="ggcggc"
/db_xref="dbSNP:66517911"
variation 33..38
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="ggc"
/replace="ggcggc"
/db_xref="dbSNP:67855436"
variation 37..42
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="gcggcg"
/db_xref="dbSNP:66867624"
variation 37
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="cggcgg"
/db_xref="dbSNP:68139446"
variation 40
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="cggcgg"
/db_xref="dbSNP:67818984"
variation 45..50
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="ggcggc"
/db_xref="dbSNP:76422636"
misc_feature 93..95
/gene="GRK5"
/gene_synonym="GPRK5"
/note="upstream in-frame stop codon"
variation 180
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230347"
variation 195
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369362370"
variation 209
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112389603"
variation 226
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:376205003"
CDS 234..2006
/gene="GRK5"
/gene_synonym="GPRK5"
/EC_number="2.7.11.16"
/note="FP2025; g protein-coupled receptor kinase GRK5"
/codon_start=1
/product="G protein-coupled receptor kinase 5"
/protein_id="NP_005299.1"
/db_xref="GI:4885349"
/db_xref="CCDS:CCDS7612.1"
/db_xref="GeneID:2869"
/db_xref="HGNC:4544"
/db_xref="HPRD:02926"
/db_xref="MIM:600870"
/translation="
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
"
misc_feature 234..788
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P34947.1);
Region: N-terminal"
misc_feature 291..350
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P34947.1);
Region: Interaction with calmodulin"
misc_feature 390..758
/gene="GRK5"
/gene_synonym="GPRK5"
/note="Regulator of G protein signaling domain (RGS) found
in G protein-coupled receptor kinase 5 (GRK5); Region:
RGS_GRK5; cd08752"
/db_xref="CDD:188706"
misc_feature order(438..440,447..449,720..722,726..731,735..740)
/gene="GRK5"
/gene_synonym="GPRK5"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:188706"
misc_feature 786..1640
/gene="GRK5"
/gene_synonym="GPRK5"
/note="Catalytic domain of G protein-coupled Receptor
Kinase 4-like Protein Serine/Threonine Kinases; Region:
STKc_GRK4_like; cd05605"
/db_xref="CDD:173696"
misc_feature 789..1577
/gene="GRK5"
/gene_synonym="GPRK5"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(807..821,831..833,870..872,876..878,972..974,
1020..1025,1029..1031,1041..1043,1047..1049,1164..1166,
1170..1172,1176..1181,1185..1187,1215..1220,1227..1229,
1266..1283,1362..1364,1380..1382,1389..1391)
/gene="GRK5"
/gene_synonym="GPRK5"
/note="active site"
/db_xref="CDD:173696"
misc_feature order(807..821,831..833,870..872,876..878,1023..1031,
1185..1187,1218..1220)
/gene="GRK5"
/gene_synonym="GPRK5"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173696"
misc_feature order(819..821,1041..1043,1047..1049,1164..1166,
1170..1172,1176..1178,1227..1229,1266..1283,1362..1364,
1380..1382,1389..1391)
/gene="GRK5"
/gene_synonym="GPRK5"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173696"
misc_feature 1215..1283
/gene="GRK5"
/gene_synonym="GPRK5"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173696"
misc_feature 1395..1418
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P34947.1);
Region: Nuclear localization signal"
misc_feature 1578..1775
/gene="GRK5"
/gene_synonym="GPRK5"
/note="Protein kinase C terminal domain; Region:
Pkinase_C; cl11395"
/db_xref="CDD:209299"
misc_feature 1683..1685
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P34947.1); phosphorylation site"
misc_feature 1683..1685
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:02926"
misc_feature 1686..1688
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (P34947.1); phosphorylation site"
misc_feature 1686..1688
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[8]
/db_xref="HPRD:02926"
misc_feature 1869..1928
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P34947.1);
Region: Sufficient for membrane localization"
exon 286..381
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 288
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201715604"
variation 291
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:148368301"
variation 349
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:199919771"
variation 355
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:2230345"
variation 370
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377304963"
exon 382..494
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 389
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:150876579"
variation 419
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230346"
variation 436
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201278015"
variation 452
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139600136"
variation 453
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377486443"
variation 459
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:143531840"
variation 460
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35412666"
variation 464
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370653887"
variation 479
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:147153472"
variation 491
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375958071"
exon 495..572
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
exon 573..673
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 586
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201054122"
variation 589
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:55980792"
variation 597
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:55902633"
variation 605
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149657541"
variation 619
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:34679178"
variation 654
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:56254855"
variation 660
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:188222479"
exon 674..766
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 684
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:142641433"
variation 689
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375813764"
variation 710
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:189973518"
variation 749
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:45630572"
variation 755
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369078145"
variation 766
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:61733303"
exon 767..830
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 770
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375766891"
variation 772
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369944660"
variation 773
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:199673866"
variation 779
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:116686924"
exon 831..971
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 857
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:55719738"
variation 946
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:140965782"
variation 954
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:202120111"
variation 955
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:112871819"
exon 972..1162
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 980
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:368484124"
variation 993
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371156667"
variation 998
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:200748109"
variation 1035
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:200072822"
variation 1037
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:374267230"
variation 1073
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230348"
variation 1083
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368432841"
variation 1093
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372032697"
variation 1108
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146569660"
variation 1125
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:140946236"
variation 1130
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375192069"
variation 1143
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145397190"
variation 1144
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:2230349"
variation 1154
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368066639"
exon 1163..1200
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1175
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:369898706"
variation 1180
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:374620668"
variation 1190
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377042285"
exon 1201..1290
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1244
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149427927"
variation 1249
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:143794689"
variation 1262
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372602377"
variation 1274
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375799877"
exon 1291..1499
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1316
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:116059103"
variation 1320
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372256166"
variation 1332
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:374812456"
variation 1345
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:367798791"
variation 1370
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:372655409"
variation 1385
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138476092"
variation 1392
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:202089063"
variation 1409
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200876105"
variation 1429
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:143962659"
variation 1430
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:377193545"
variation 1431
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147170538"
variation 1445
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:140383080"
variation 1472
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141164889"
variation 1487
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:73437341"
exon 1500..1637
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1507
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:77323445"
variation 1515
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149580250"
variation 1539
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200344195"
variation 1575
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139222578"
variation 1607
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149959928"
variation 1637
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144561152"
exon 1638..1775
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1642
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:369268255"
variation 1662
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372941824"
variation 1673
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:200359403"
variation 1692
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:139931883"
variation 1697
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143343212"
variation 1706
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375647738"
variation 1715
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146588150"
variation 1718
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149159651"
variation 1719
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200119606"
variation 1721
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:368864312"
variation 1772
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200305868"
exon 1776..1907
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1802
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:372801210"
variation 1834
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371520487"
variation 1835
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:142293372"
variation 1854
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199631074"
variation 1857
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:374258738"
variation 1868
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:185837625"
exon 1908..2558
/gene="GRK5"
/gene_synonym="GPRK5"
/inference="alignment:Splign:1.39.8"
variation 1930
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141365148"
variation 1933
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:372911829"
variation 1947
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:147119258"
variation 1962
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138518818"
variation 1967
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:202208716"
variation 1984
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:142571352"
STS 1995..2233
/gene="GRK5"
/gene_synonym="GPRK5"
/standard_name="STS-L15388"
/db_xref="UniSTS:51357"
variation 1995
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375507983"
variation 2020
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369872846"
variation 2190
/gene="GRK5"
/gene_synonym="GPRK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:12721548"
STS 2258..2446
/gene="GRK5"
/gene_synonym="GPRK5"
/standard_name="RH69017"
/db_xref="UniSTS:21210"
variation 2479
/gene="GRK5"
/gene_synonym="GPRK5"
/replace=""
/replace="a"
/replace="aa"
/db_xref="dbSNP:5788355"
polyA_signal 2535..2540
/gene="GRK5"
/gene_synonym="GPRK5"
polyA_site 2557
/gene="GRK5"
/gene_synonym="GPRK5"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
gggacacagagggaggaagaagcggcggcggcggcggcggcggcggcggctcctctttgcagagggggaaactcttgggctgagagcaggaataatgcggtaggcaaggcgggctgctggctcccccggctccggcagcagcggcggcagcccgagcagcggcagcagcagcggcagcaccccaggcgctgacagccccgccggccggctccgttgctgaccgccgactgtcaatggagctggaaaacatcgtggccaacacggtcttgctgaaagccagggaagggggcggaggaaagcgcaaagggaaaagcaagaagtggaaagaaatcctgaagttccctcacattagccagtgtgaagacctccgaaggaccatagacagagattactgcagtttatgtgacaagcagccaatcgggaggctgcttttccggcagttttgtgaaaccaggcctgggctggagtgttacattcagttcctggactccgtggcagaatatgaagttactccagatgaaaaactgggagagaaagggaaggaaattatgaccaagtacctcaccccaaagtcccctgttttcatagcccaagttggccaagacctggtctcccagacggaggagaagctcctacagaagccgtgcaaagaactcttttctgcctgtgcacagtctgtccacgagtacctgaggggagaaccattccacgaatatctggacagcatgttttttgaccgctttctccagtggaagtggttggaaaggcaaccggtgaccaaaaacactttcaggcagtatcgagtgctaggaaaagggggcttcggggaggtctgtgcctgccaggttcgggccacgggtaaaatgtatgcctgcaagcgcttggagaagaagaggatcaaaaagaggaaaggggagtccatggccctcaatgagaagcagatcctcgagaaggtcaacagtcagtttgtggtcaacctggcctatgcctacgagaccaaggatgcactgtgcttggtcctgaccatcatgaatgggggtgacctgaagttccacatctacaacatgggcaaccctggcttcgaggaggagcgggccttgttttatgcggcagagatcctctgcggcttagaagacctccaccgtgagaacaccgtctaccgagatctgaaacctgaaaacatcctgttagatgattatggccacattaggatctcagacctgggcttggctgtgaagatccccgagggagacctgatccgcggccgggtgggcactgttggctacatggctccagaggtcctgaacaaccagaggtacggcctgagccccgactactggggccttggctgcctcatctatgagatgatcgagggccagtcgccgttccgcggccgcaaggagaaggtgaagcgggaggaggtggaccgccgggtcctggagacggaggaggtgtactcccacaagttctccgaggaggccaagtccatctgcaagatgctgctcacgaaagatgcgaagcagaggctgggctgccaggaggagggggctgcagaggtcaagagacaccccttcttcaggaacatgaacttcaagcgcttagaagccgggatgttggaccctcccttcgttccagacccccgcgctgtgtactgtaaggacgtgctggacatcgagcagttctccactgtgaagggcgtcaatctggaccacacagacgacgacttctactccaagttctccacgggctctgtgtccatcccatggcaaaacgagatgatagaaacagaatgctttaaggagctgaacgtgtttggacctaatggtaccctcccgccagatctgaacagaaaccaccctccggaaccgcccaagaaagggctgctccagagactcttcaagcggcagcatcagaacaattccaagagttcgcccagctccaagaccagttttaaccaccacataaactcaaaccatgtcagctcgaactccaccggaagcagctagtttcggctctggcctccaagtccacagtggaaccagcccagacccttctccttagaagtggaagtagtggagcccctgctctggtggggctgccaggggagaccccgggagccggggaaggaggccgtccatcccgtcgacgtagaacctcgaggtttctcaaagaaatttccactcaggtctgttttccgaggcggccccggccggggtggattggatttgtctttggtgaacattgcaatagaaatccaattggatacgacaacttgcacgtattttaatagcgtcataactagaactgaattttgtctttatgatttttaaagaaaagttttgtaaatttctctactgtctcagtttacattttgtatatttgtatttaaatgaaagtgagactttgagggtgtatattttctgtgcagccactgttaagccatgtgttccaaggcattttagcggggagggggttatcaaaaaaaaaaaaatgtgactcaagacttccagagcctcaaatgagaaaatgtctttattaaatgtagaaagtgatccataaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2869 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:2869 -> Molecular function: GO:0004703 [G-protein coupled receptor kinase activity] evidence: IEA
GeneID:2869 -> Molecular function: GO:0005080 [protein kinase C binding] evidence: TAS
GeneID:2869 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2869 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:2869 -> Molecular function: GO:0005543 [phospholipid binding] evidence: TAS
GeneID:2869 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2869 -> Biological process: GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2869 -> Biological process: GO:0007217 [tachykinin receptor signaling pathway] evidence: IDA
GeneID:2869 -> Biological process: GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] evidence: TAS
GeneID:2869 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
GeneID:2869 -> Biological process: GO:0038032 [termination of G-protein coupled receptor signaling pathway] evidence: IEA
GeneID:2869 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:2869 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
GeneID:2869 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:2869 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:2869 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005299 -> EC 2.7.11.16
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.