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2024-04-24 17:04:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005302 3815 bp mRNA linear PRI 17-JUN-2013
DEFINITION Homo sapiens G protein-coupled receptor 37 (endothelin receptor
type B-like) (GPR37), mRNA.
ACCESSION NM_005302
VERSION NM_005302.3 GI:408968120
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3815)
AUTHORS Fujita-Jimbo,E., Yu,Z.L., Li,H., Yamagata,T., Mori,M., Momoi,T. and
Momoi,M.Y.
TITLE Mutation in Parkinson disease-associated, G-protein-coupled
receptor 37 (GPR37/PaelR) is related to autism spectrum disorder
JOURNAL PLoS ONE 7 (12), E51155 (2012)
PUBMED 23251443
REMARK GeneRIF: results suggested that some alleles in GPR37 were related
to the deleterious effect of ASD. GPR37 is associated with the
dopamine transporter to modulate dopamine uptake, and regulates
behavioral responses to dopaminergic drugs
REFERENCE 2 (bases 1 to 3815)
AUTHORS Marazziti,D., Di Pietro,C., Mandillo,S., Golini,E., Matteoni,R. and
Tocchini-Valentini,G.P.
TITLE Absence of the GPR37/PAEL receptor impairs striatal Akt and ERK2
phosphorylation, DeltaFosB expression, and conditioned place
preference to amphetamine and cocaine
JOURNAL FASEB J. 25 (6), 2071-2081 (2011)
PUBMED 21372109
REFERENCE 3 (bases 1 to 3815)
AUTHORS Dunham,J.H., Meyer,R.C., Garcia,E.L. and Hall,R.A.
TITLE GPR37 surface expression enhancement via N-terminal truncation or
protein-protein interactions
JOURNAL Biochemistry 48 (43), 10286-10297 (2009)
PUBMED 19799451
REMARK GeneRIF: GPR37 surface trafficking in heterologous cells can be
greatly enhanced by N-terminal truncation, coexpression with other
receptors, and coexpression with syntenin-1.
REFERENCE 4 (bases 1 to 3815)
AUTHORS Marazziti,D., Di Pietro,C., Golini,E., Mandillo,S., Matteoni,R. and
Tocchini-Valentini,G.P.
TITLE Induction of macroautophagy by overexpression of the Parkinson's
disease-associated GPR37 receptor
JOURNAL FASEB J. 23 (6), 1978-1987 (2009)
PUBMED 19218498
REMARK GeneRIF: Data show that GPR37 overexpression can induce cellular
autophagy, which may prevent the selective degeneration of
GPR37-expressing neurons, as reported for Parkinson's and related
neurodegenerative diseases.
REFERENCE 5 (bases 1 to 3815)
AUTHORS Wang,H.Q., Imai,Y., Inoue,H., Kataoka,A., Iita,S., Nukina,N. and
Takahashi,R.
TITLE Pael-R transgenic mice crossed with parkin deficient mice displayed
progressive and selective catecholaminergic neuronal loss
JOURNAL J. Neurochem. 107 (1), 171-185 (2008)
PUBMED 18691389
REMARK GeneRIF: Parkin-ko/Pael-R-tg mice represents an AR-JP mouse model
displaying chronic and selective loss of catecholaminergic neurons.
REFERENCE 6 (bases 1 to 3815)
AUTHORS Imai,Y., Soda,M., Hatakeyama,S., Akagi,T., Hashikawa,T.,
Nakayama,K.I. and Takahashi,R.
TITLE CHIP is associated with Parkin, a gene responsible for familial
Parkinson's disease, and enhances its ubiquitin ligase activity
JOURNAL Mol. Cell 10 (1), 55-67 (2002)
PUBMED 12150907
REFERENCE 7 (bases 1 to 3815)
AUTHORS Imai,Y., Soda,M., Inoue,H., Hattori,N., Mizuno,Y. and Takahashi,R.
TITLE An unfolded putative transmembrane polypeptide, which can lead to
endoplasmic reticulum stress, is a substrate of Parkin
JOURNAL Cell 105 (7), 891-902 (2001)
PUBMED 11439185
REFERENCE 8 (bases 1 to 3815)
AUTHORS Donohue,P.J., Shapira,H., Mantey,S.A., Hampton,L.L., Jensen,R.T.
and Battey,J.F.
TITLE A human gene encodes a putative G protein-coupled receptor highly
expressed in the central nervous system
JOURNAL Brain Res. Mol. Brain Res. 54 (1), 152-160 (1998)
PUBMED 9526070
REFERENCE 9 (bases 1 to 3815)
AUTHORS Marazziti,D., Golini,E., Gallo,A., Lombardi,M.S., Matteoni,R. and
Tocchini-Valentini,G.P.
TITLE Cloning of GPR37, a gene located on chromosome 7 encoding a
putative G-protein-coupled peptide receptor, from a human frontal
brain EST library
JOURNAL Genomics 45 (1), 68-77 (1997)
PUBMED 9339362
REFERENCE 10 (bases 1 to 3815)
AUTHORS Zeng,Z., Su,K., Kyaw,H. and Li,Y.
TITLE A novel endothelin receptor type-B-like gene enriched in the brain
JOURNAL Biochem. Biophys. Res. Commun. 233 (2), 559-567 (1997)
PUBMED 9144577
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB475687.1, BC040007.1,
AF017262.1, DB517451.1 and DB495592.1.
On Oct 16, 2012 this sequence version replaced gi:31377788.
Summary: This gene is a member of the G protein-coupled receptor
family. The encoded protein contains seven transmembrane domains
and is found in cell and endoplasmic reticulum membranes. G
protein-coupled receptors are involved in translating outside
signals into G protein mediated intracellular effects. This gene
product interacts with Parkin and is involved in juvenile Parkinson
disease. [provided by RefSeq, Oct 2012].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC040007.1, AF017262.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-398 DB475687.1 3-400
399-2095 BC040007.1 1-1697
2096-2096 AF017262.1 1064-1064
2097-3355 BC040007.1 1699-2957
3356-3640 DB517451.1 175-459
3641-3815 DB495592.1 332-506
FEATURES Location/Qualifiers
source 1..3815
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q31"
gene 1..3815
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/note="G protein-coupled receptor 37 (endothelin receptor
type B-like)"
/db_xref="GeneID:2861"
/db_xref="HGNC:4494"
/db_xref="HPRD:03992"
/db_xref="MIM:602583"
exon 1..2072
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/inference="alignment:Splign:1.39.8"
variation 342
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="c"
/replace="t"
/db_xref="dbSNP:1557969"
variation 400
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="a"
/replace="g"
/db_xref="dbSNP:11542914"
variation 404
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="g"
/replace="t"
/db_xref="dbSNP:2239532"
variation 515
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542915"
variation 779
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="a"
/replace="g"
/db_xref="dbSNP:34961856"
variation 970
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="c"
/replace="t"
/db_xref="dbSNP:1003897"
variation 972
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="c"
/replace="t"
/db_xref="dbSNP:1003898"
misc_feature 1005..1007
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/note="upstream in-frame stop codon"
CDS 1050..2891
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/note="Parkin-associated endothelin receptor-like
receptor; probable G-protein coupled receptor 37;
ETBR-LP-1; endothelin B receptor-like protein 1"
/codon_start=1
/product="probable G-protein coupled receptor 37
precursor"
/protein_id="NP_005293.1"
/db_xref="GI:4885323"
/db_xref="CCDS:CCDS5792.1"
/db_xref="GeneID:2861"
/db_xref="HGNC:4494"
/db_xref="HPRD:03992"
/db_xref="MIM:602583"
/translation="
MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
"
sig_peptide 1050..1130
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 1131..2888
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/product="probable G-protein coupled receptor 37"
misc_feature 1899..2693
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/note="7 transmembrane receptor (rhodopsin family);
Region: 7tm_1; pfam00001"
/db_xref="CDD:200918"
exon 2073..3815
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/inference="alignment:Splign:1.39.8"
variation 2096
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="c"
/replace="t"
/db_xref="dbSNP:724356"
variation 2378
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/replace="c"
/replace="g"
/db_xref="dbSNP:3735270"
STS 2690..2888
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/standard_name="GPR37"
/db_xref="UniSTS:503668"
STS 3225..3331
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/standard_name="D7S532E"
/db_xref="UniSTS:55408"
STS 3226..3334
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/standard_name="HSC24E072"
/db_xref="UniSTS:82516"
polyA_signal 3333..3338
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
polyA_site 3356
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
polyA_signal 3389..3394
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
polyA_site 3419
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
STS 3708..3790
/gene="GPR37"
/gene_synonym="EDNRBL; hET(B)R-LP; PAELR"
/standard_name="RH93211"
/db_xref="UniSTS:84115"
ORIGIN
ttagtgagtggtgaaccaccaggggatcccgtctccccacaaaccagtatctctccgaggaggaggcgaaggagtgggaggaggcaacgagccgagagtcgagcttcgcgggcgcgcgcagcggctggagcgcgggggcgaggccgggccacctccccttcccggccgcgcactgcctggcccgcggcggttccaggcaccacccttcccgtccgggctgagcccgctgtggcagtgactagctcccgcggctagcggcactgtccaccgacgagcggcgccctcttctcccccttctccccacgatttccttctctgcggcggcacgccgtccagcagcctgcttcgccccgtcgtcaactttgagctggaggagaagcaactttggcagtggccgcggggttggaatcccgcttctcctcggcagcagtaggctcgcaagtcgctggggttaggtggggcaagagtttcgccggcgcatcagcgctgcttcggactgtttgcaacgtgtttccagcgagctgggagcggggttgtgactgcgagtcgtctgggggagggggacttgtttttcttttcctctagagacctcggcttgcaactggatcaaacgctgtcgaaaggatgtaaataggcagagcaactgttaccaagaaggccaccacccccacccaaaggcagtgaggagtgtggggcttcgtctgggctcccccgagtctcaacagtaatcaacagtcaggtgttgattgcaacttttcaaggtcagccaccgggagtagcctattccctctaggaaccttggagggcataccttgctgggactcaacttggctgagaaatgcacaagatgccaaaggaggaaggattatagggggcgtgtgtgtgacccccaagaccgatcttccgctatcaccctaatctccggttccccgctacccgggcgggggtgagtatgtgacatgtgcctaactctcagcagcaacttcggcagcaggtgtcgatcctaactaagcaggagctgcggctgccgggtgtgccctcaccaagccatgcgagccccgggcgcgcttctcgcccgcatgtcgcggctactgcttctgctactgctcaaggtgtctgcctcttctgccctcggggtcgcccctgcgtccagaaacgaaacttgtctgggggagagctgtgcacctacagtgatccagcgccgcggcagggacgcctggggaccgggaaattctgcaagagacgttctgcgagcccgagcacccagggaggagcagggggcagcgtttcttgcgggaccctcctgggacctgccggcggccccgggccgtgacccggctgcaggcagaggggcggaggcgtcggcagccggacccccgggacctccaaccaggccacctggcccctggaggtggaaaggtgctcggggtcaggagccttctgaaactttggggagagggaaccccacggccctccagctcttccttcagatctcagaggaggaagagaagggtcccagaggcgctggcatttccgggcgtagccaggagcagagtgtgaagacagtccccggagccagcgatcttttttactggccaaggagagccgggaaactccagggttcccaccacaagcccctgtccaagacggccaatggactggcggggcacgaagggtggacaattgcactcccgggccgggcgctggcccagaatggatccttgggtgaaggaatccatgagcctgggggtccccgccggggaaacagcacgaaccggcgtgtgagactgaagaaccccttctacccgctgacccaggagtcctatggagcctacgcggtcatgtgtctgtccgtggtgatcttcgggaccggcatcattggcaacctggcggtgatgtgcatcgtgtgccacaactactacatgcggagcatctccaactccctcttggccaacctggccttctgggactttctcatcatcttcttctgccttccgctggtcatcttccacgagctgaccaagaagtggctgctggaggacttctcctgcaagatcgtgccctatatagaggtcgcttctctgggagtcaccactttcaccttatgtgctctgtgcatagaccgcttccgtgctgccaccaacgtacagatgtactacgaaatgatcgaaaactgttcctcaacaactgccaaacttgctgttatatgggtgggagctctattgttagcacttccagaagttgttctccgccagctgagcaaggaggatttggggtttagtggccgagctccggcagaaaggtgcattattaagatctctcctgatttaccagacaccatctatgttctagccctcacctacgacagtgcgagactgtggtggtattttggctgttacttttgtttgcccacgcttttcaccatcacctgctctctagtgactgcgaggaaaatccgcaaagcagagaaagcctgtacccgagggaataaacggcagattcaactagagagtcagatgaactgtacagtagtggcactgaccattttatatggattttgcattattcctgaaaatatctgcaacattgttactgcctacatggctacaggggtttcacagcagacaatggacctccttaatatcatcagccagttccttttgttctttaagtcctgtgtcaccccagtcctccttttctgtctctgcaaacccttcagtcgggccttcatggagtgctgctgctgttgctgtgaggaatgcattcagaagtcttcaacggtgaccagtgatgacaatgacaacgagtacaccacggaactcgaactctcgcctttcagtaccatacgccgtgaaatgtccacttttgcttctgtcggaactcattgctgaaggacagtacttggttgggtcagatttatttgtttgattttcatatcccgtgaaagtttttaattcatatttttccttatagggaaaaatgcaaaaaagaaacaataaagaaagaaatattaactactgtagaactgattttacaaattaatatttgtgctttgaaaaaaagtttctatttagttatttaagaagaatgagaaggccaatagttttagattattttatctggtatggtgctaatattttatttgaaaaaagttactgcaacttaacttaaaattgctaacgttttttcttcttttaaaaatacaattattgtatattgattatagcaatgtgattttgtaggttattttatatttgagttgtgattgaaagtatgttgtatatggtattgtgagatgatttgtacttggaagcattcacaaagtagcaccaaataaattacactttattctttaatgtcattgtcaatctacttttaaccaatattcaataaatcttctaattgccttaaagatacaattactggttctatgcacaatttaaaaccggccttactgttttataacgtattttcttttaaggcaggtaatcattatgttataaagaagtttttctaatagcagtattttatatgcatgattcataaaactatgttgtatgttaaaacaaagctgtatttttaatattcaggtatagatgtcaaattacttctgaatacttataaaatatgaataaatagcagagtaggaagaaagtttcttttttaaaaaattcacctctgaactagcacatagagctacagattttcccttggggaattatgggcagaatcaagaattttaaaatgcagttgtcatctgatttcctctgaacactgacctttgaagctttgtgaatcctacgtaaagcactctg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2861 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: IEA
GeneID:2861 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:2861 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
GeneID:2861 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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