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2024-04-26 04:05:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005257 3770 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens GATA binding protein 6 (GATA6), mRNA.
ACCESSION NM_005257
VERSION NM_005257.4 GI:386268026
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3770)
AUTHORS Tian,F., Li,D., Chen,J., Liu,W., Cai,L., Li,J., Jiang,P., Liu,Z.,
Zhao,X., Guo,F., Li,X. and Wang,S.
TITLE Aberrant expression of GATA binding protein 6 correlates with poor
prognosis and promotes metastasis in cholangiocarcinoma
JOURNAL Eur. J. Cancer 49 (7), 1771-1780 (2013)
PUBMED 23313142
REMARK GeneRIF: Data suggest that GATA6 was an independent prognostic
marker for overall survival and recurrence-free survival in
cholangiocarcinoma (CCA).
REFERENCE 2 (bases 1 to 3770)
AUTHORS Boopathi,E., Hypolite,J.A., Zderic,S.A., Gomes,C.M., Malkowicz,B.,
Liou,H.C., Wein,A.J. and Chacko,S.
TITLE GATA-6 and NF-kappaB activate CPI-17 gene transcription and
regulate Ca2+ sensitization of smooth muscle contraction
JOURNAL Mol. Cell. Biol. 33 (5), 1085-1102 (2013)
PUBMED 23275439
REMARK GeneRIF: The study characterized the CPI-17 promoter and identified
binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB).
REFERENCE 3 (bases 1 to 3770)
AUTHORS De Franco E, Shaw-Smith C, Flanagan SE, Shepherd MH, Hattersley AT
and Ellard S.
CONSRTM International NDM Consortium
TITLE GATA6 mutations cause a broad phenotypic spectrum of diabetes from
pancreatic agenesis to adult-onset diabetes without exocrine
insufficiency
JOURNAL Diabetes 62 (3), 993-997 (2013)
PUBMED 23223019
REMARK GeneRIF: mutation screening in 171 subjects with neonatal diabetes
of unknown genetic etiology: Data suggest that GATA6 mutations
account for a wide spectrum of neonatal diabetes; GATA6 mutations
appear to be the major cause of pancreatic agenesis.
REFERENCE 4 (bases 1 to 3770)
AUTHORS Huang,R.T., Xue,S., Xu,Y.J. and Yang,Y.Q.
TITLE Somatic mutations in the GATA6 gene underlie sporadic tetralogy of
Fallot
JOURNAL Int. J. Mol. Med. 31 (1), 51-58 (2013)
PUBMED 23175051
REMARK GeneRIF: This is the first report on the association of somatic
GATA6 loss-of-function mutation with increased susceptibility to
Tetralogy of Fallot.
REFERENCE 5 (bases 1 to 3770)
AUTHORS Wang,J., Luo,X.J., Xin,Y.F., Liu,Y., Liu,Z.M., Wang,Q., Li,R.G.,
Fang,W.Y., Wang,X.Z. and Yang,Y.Q.
TITLE Novel GATA6 mutations associated with congenital ventricular septal
defect or tetralogy of fallot
JOURNAL DNA Cell Biol. 31 (11), 1610-1617 (2012)
PUBMED 23020118
REMARK GeneRIF: Data indicate that two novel heterozygous GATA6 mutations,
p.D404Y and p.E460X, were identified in two families with
ventricular septal defect and tetralogy of Fallot, respectively.
REFERENCE 6 (bases 1 to 3770)
AUTHORS Takeda,M., Obayashi,K., Kobayashi,A. and Maeda,M.
TITLE A unique role of an amino terminal 16-residue region of long-type
GATA-6
JOURNAL J. Biochem. 135 (5), 639-650 (2004)
PUBMED 15173203
REFERENCE 7 (bases 1 to 3770)
AUTHORS Gao,X., Sedgwick,T., Shi,Y.B. and Evans,T.
TITLE Distinct functions are implicated for the GATA-4, -5, and -6
transcription factors in the regulation of intestine epithelial
cell differentiation
JOURNAL Mol. Cell. Biol. 18 (5), 2901-2911 (1998)
PUBMED 9566909
REFERENCE 8 (bases 1 to 3770)
AUTHORS Yoshida,T., Sato,R., Mahmood,S., Kawasaki,S., Futai,M. and Maeda,M.
TITLE GATA-6 DNA binding protein expressed in human gastric
adenocarcinoma MKN45 cells
JOURNAL FEBS Lett. 414 (2), 333-337 (1997)
PUBMED 9315713
REFERENCE 9 (bases 1 to 3770)
AUTHORS Huggon,I.C., Davies,A., Gove,C., Moscoso,G., Moniz,C., Foss,Y.,
Farzaneh,F. and Towner,P.
TITLE Molecular cloning of human GATA-6 DNA binding protein: high levels
of expression in heart and gut
JOURNAL Biochim. Biophys. Acta 1353 (2), 98-102 (1997)
PUBMED 9294001
REFERENCE 10 (bases 1 to 3770)
AUTHORS Suzuki,E., Evans,T., Lowry,J., Truong,L., Bell,D.W., Testa,J.R. and
Walsh,K.
TITLE The human GATA-6 gene: structure, chromosomal location, and
regulation of expression by tissue-specific and mitogen-responsive
signals
JOURNAL Genomics 38 (3), 283-290 (1996)
PUBMED 8975704
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X95701.1, CN280495.1,
AK223547.1, U66075.1, W19304.1, AU309820.1 and N91601.1.
This sequence is a reference standard in the RefSeqGene project.
On May 3, 2012 this sequence version replaced gi:40288196.
Summary: This gene is a member of a small family of zinc finger
transcription factors that play an important role in the regulation
of cellular differentiation and organogenesis during vertebrate
development. This gene is expressed during early embryogenesis and
localizes to endo- and mesodermally derived cells during later
embryogenesis and thereby plays an important role in gut, lung, and
heart development. Mutations in this gene are associated with
several congenital defects. [provided by RefSeq, Mar 2012].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: X95701.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025083, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-8 X95701.1 1-8
9-240 CN280495.1 1-232
241-991 AK223547.1 176-926
992-3150 U66075.1 624-2782
3151-3344 W19304.1 75-268
3345-3763 AU309820.1 8-426 c
3764-3770 N91601.1 2-8 c
FEATURES Location/Qualifiers
source 1..3770
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="18"
/map="18q11.1-q11.2"
gene 1..3770
/gene="GATA6"
/note="GATA binding protein 6"
/db_xref="GeneID:2627"
/db_xref="HGNC:4174"
/db_xref="HPRD:09043"
/db_xref="MIM:601656"
exon 1..240
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
variation 45
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:369911805"
variation 163
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:111419728"
variation 219
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:367668977"
exon 241..1412
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
misc_feature 245..247
/gene="GATA6"
/note="upstream in-frame stop codon"
variation 255
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:373655784"
CDS 278..2065
/gene="GATA6"
/note="GATA-binding factor 6"
/codon_start=1
/product="transcription factor GATA-6"
/protein_id="NP_005248.2"
/db_xref="GI:40288197"
/db_xref="CCDS:CCDS11872.1"
/db_xref="GeneID:2627"
/db_xref="HGNC:4174"
/db_xref="HPRD:09043"
/db_xref="MIM:601656"
/translation="
MALTDGGWCLPKRFGAAGADASDSRAFPAREPSTPPSPISSSSSSCSRGGERGPGGASNCGTPQLDTEAAAGPPARSLLLSSYASHPFGAPHGPSAPGVAGPGGNLSSWEDLLLFTDLDQAATASKLLWSSRGAKLSPFAPEQPEEMYQTLAALSSQGPAAYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYHLQGSGSGPANHAGGAGAHPGWPQASADSPPYGSGGGAAGGGAAGPGGAGSAAAHVSARFPYSPSPPMANGAAREPGGYAAAGSGGAGGVSGGGSSLAAMGGREPQYSSLSAARPLNGTYHHHHHHHHHHPSPYSPYVGAPLTPAWPAGPFETPVLHSLQSRAGAPLPVPRGPSADLLEDLSESRECVNCGSIQTPLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKTCSGNSNNSIPMTPTSTSSNSDDCSKNTSPTTQPTASGAGAPVMTGAGESTNPENSELKYSGQDGLYIGVSLASPAEVTSSVRPDSWCALALA
"
misc_feature 716..1420
/gene="GATA6"
/note="GATA-type transcription activator, N-terminal;
Region: GATA-N; pfam05349"
/db_xref="CDD:203237"
misc_feature 1079..1081
/gene="GATA6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q92908.2); phosphorylation site"
misc_feature 1442..1594
/gene="GATA6"
/note="Zinc finger DNA binding domain; binds specifically
to DNA consensus sequence [AT]GATA[AG] promoter elements;
a subset of family members may also bind protein;
zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
Region: ZnF_GATA; cd00202"
/db_xref="CDD:29259"
misc_feature order(1445..1447,1454..1456,1508..1510,1517..1519)
/gene="GATA6"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:29259"
misc_feature order(1472..1477,1481..1483,1508..1540,1589..1591)
/gene="GATA6"
/note="DNA-binding region [nucleotide binding]; DNA
binding site"
/db_xref="CDD:29259"
misc_feature 1604..1759
/gene="GATA6"
/note="Zinc finger DNA binding domain; binds specifically
to DNA consensus sequence [AT]GATA[AG] promoter elements;
a subset of family members may also bind protein;
zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
Region: ZnF_GATA; cd00202"
/db_xref="CDD:29259"
misc_feature order(1607..1609,1616..1618,1670..1672,1679..1681)
/gene="GATA6"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:29259"
misc_feature order(1634..1639,1643..1645,1670..1702,1748..1750,
1754..1759)
/gene="GATA6"
/note="DNA-binding region [nucleotide binding]; DNA
binding site"
/db_xref="CDD:29259"
variation 293
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:139750927"
variation 320
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:116262672"
variation 339
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:139666654"
variation 430
/gene="GATA6"
/replace="g"
/replace="t"
/db_xref="dbSNP:200519946"
variation 460
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:377217497"
variation 462..463
/gene="GATA6"
/replace=""
/replace="t"
/db_xref="dbSNP:36041440"
variation 480
/gene="GATA6"
/replace="a"
/replace="t"
/db_xref="dbSNP:200483324"
variation 499
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:374402554"
variation 559
/gene="GATA6"
/replace="a"
/replace="t"
/db_xref="dbSNP:374591296"
variation 629
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:368297251"
variation 647
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:372228686"
variation 694
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:374959006"
variation 759
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:35248194"
variation 810
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:387906815"
variation 828
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:387906816"
variation 869
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:387906814"
variation 1128
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:185325359"
variation 1256
/gene="GATA6"
/replace="a"
/replace="c"
/db_xref="dbSNP:4299243"
variation 1304
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:142601402"
exon 1413..1579
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
variation 1495
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:371894991"
variation 1540
/gene="GATA6"
/replace="a"
/replace="c"
/db_xref="dbSNP:375015752"
exon 1580..1705
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
variation 1589
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:144512170"
variation 1597
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:146624465"
variation 1627
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:61731977"
variation 1631
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:387906817"
variation 1643
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:387906818"
variation 1644
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:387906819"
variation 1651
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:143026087"
variation 1652
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:151176879"
variation 1673
/gene="GATA6"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:387906813"
variation 1676
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:387906820"
exon 1706..1793
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
exon 1794..1897
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
variation 1803
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:140212942"
variation 1844
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:113144042"
variation 1849
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:199684979"
variation 1879
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:146949786"
variation 1882
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:117646477"
variation 1886
/gene="GATA6"
/replace="a"
/replace="c"
/db_xref="dbSNP:369809143"
exon 1898..3770
/gene="GATA6"
/inference="alignment:Splign:1.39.8"
variation 1926
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:368858287"
variation 1940
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:146243018"
variation 1949
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:138641332"
variation 1982
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:11545246"
variation 2000
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:149569288"
variation 2002
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:200788504"
variation 2026
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:142079702"
variation 2031
/gene="GATA6"
/replace="g"
/replace="t"
/db_xref="dbSNP:201707559"
STS 2105..2329
/gene="GATA6"
/standard_name="RH79922"
/db_xref="UniSTS:87343"
variation 2106
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:115585611"
variation 2137
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:1941084"
variation 2142
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:1941083"
variation 2148
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:369787804"
variation 2163
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:193273091"
variation 2294
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:76974536"
STS 2353..3230
/gene="GATA6"
/standard_name="GATA6_V53"
/db_xref="UniSTS:277273"
variation 2390
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:185025662"
variation 2391
/gene="GATA6"
/replace="a"
/replace="t"
/db_xref="dbSNP:9965366"
variation 2627
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:140220180"
variation 2681
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:372507351"
variation 2691
/gene="GATA6"
/replace="g"
/replace="t"
/db_xref="dbSNP:145348592"
variation 2734
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:377023636"
STS 2922..3032
/gene="GATA6"
/standard_name="RH91359"
/db_xref="UniSTS:92742"
variation 3036
/gene="GATA6"
/replace="g"
/replace="t"
/db_xref="dbSNP:137914072"
variation 3083
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:369346950"
variation 3102
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:111636900"
variation 3240
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:113511738"
variation 3265
/gene="GATA6"
/replace="c"
/replace="g"
/db_xref="dbSNP:188999183"
variation 3266
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:181762297"
variation 3290
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:141065612"
variation 3358
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:111924382"
variation 3366
/gene="GATA6"
/replace="a"
/replace="t"
/db_xref="dbSNP:184146092"
variation 3578
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:188721277"
variation 3632
/gene="GATA6"
/replace=""
/replace="c"
/db_xref="dbSNP:35257471"
variation 3646
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:111786565"
variation 3670
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:138957832"
variation 3690
/gene="GATA6"
/replace="c"
/replace="t"
/db_xref="dbSNP:80191140"
variation 3708
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:180688081"
variation 3735
/gene="GATA6"
/replace="a"
/replace="g"
/db_xref="dbSNP:186176517"
ORIGIN
gacccacagcctggcacccttcggcgagcgctgtttgtttagggctcggtgagtccaatcaggagcccaggctgcagttttccggcagagcagtaagaggcgcctcctctctcctttttattcaccagcagcgcggcgcagaccccggactcgcgctcgcccgctggcgccctcggcttctctccgcgcctgggagcaccctccgccgcggccgttctccatgcgcagcgcccgcccgaggagctagacgtcagcttggagcggcgccggaccgtggatggccttgactgacggcggctggtgcttgccgaagcgcttcggggccgcgggtgcggacgccagcgactccagagcctttccagcgcgggagccctccacgccgccttcccccatctcttcctcgtcctcctcctgctcccggggcggagagcggggccccggcggcgccagcaactgcgggacgcctcagctcgacacggaggcggcggccggacccccggcccgctcgctgctgctcagttcctacgcttcgcatcccttcggggctccccacggaccttcggcgcctggggtcgcgggccccgggggcaacctgtcgagctgggaggacttgctgctgttcactgacctcgaccaagccgcgaccgccagcaagctgctgtggtccagccgcggcgccaagctgagccccttcgcacccgagcagccggaggagatgtaccagaccctcgccgctctctccagccagggtccggccgcctacgacggcgcgcccggcggcttcgtgcactctgcggccgcggcggcagcagccgcggcggcggccagctccccggtctacgtgcccaccacccgcgtgggttccatgctgcccggcctaccgtaccacctgcaggggtcgggcagtgggccagccaaccacgcgggcggcgcgggcgcgcaccccggctggcctcaggcctcggccgacagccctccatacggcagcggaggcggcgcggctggcggcggggccgcggggcctggcggcgctggctcagccgcggcgcacgtctcggcgcgcttcccctactctcccagcccgcccatggccaacggcgccgcgcgggagccgggaggctacgcggcggcgggcagtgggggcgcgggaggcgtgagcggcggcggcagtagcctggcggccatgggcggccgcgagccccagtacagctcgctgtcggccgcgcggccgctgaacgggacgtaccaccaccaccaccaccaccaccaccaccatccgagcccctactcgccctacgtgggggcgccactgacgcctgcctggcccgccggacccttcgagaccccggtgctgcacagcctgcagagccgcgccggagccccgctcccggtgccccggggtcccagtgcagacctgctggaggacctgtccgagagccgcgagtgcgtgaactgcggctccatccagacgccgctgtggcggcgggacggcaccggccactacctgtgcaacgcctgcgggctctacagcaagatgaacggcctcagccggcccctcatcaagccgcagaagcgcgtgccttcatcacggcggcttggattgtcctgtgccaactgtcacaccacaactaccaccttatggcgcagaaacgccgagggtgaacccgtgtgcaatgcttgtggactctacatgaaactccatggggtgcccagaccacttgctatgaaaaaagagggaattcaaaccaggaaacgaaaacctaagaacataaataaatcaaagacttgctctggtaatagcaataattccattcccatgactccaacttccacctcttctaactcagatgattgcagcaaaaatacttcccccacaacacaacctacagcctcaggggcgggtgccccggtgatgactggtgcgggagagagcaccaatcccgagaacagcgagctcaagtattcgggtcaagatgggctctacataggcgtcagtctcgcctcgccggccgaagtcacgtcctccgtgcgaccggattcctggtgcgccctggccctggcctgagcccacgccgccaggaggcagggagggctccgccgcgggcctcactccactcgtgtctgcttttgtgcagcggtccagacagtggcgactgcgctgacagaacgtgattctcgtgcctttattttgaaagagatgtttttcccaagaggcttgctgaaagagtgagagaagatggaagggaagggccagtgcaactgggcgcttgggccactccagccagcccgcctccggggcggaccctgctccacttccagaagccaggactaggacctgggccttgcctgctatggaatattgagagagattttttaaaaaagattttgcattttgtccaaaatcatgtgcttcttctgatcaattttggttgttccagaatttcttcataccttttccacatccagatttcatgtgcgttcatggagaagatcacttgaggccatttggtacacatctctggaggctgagtcggttcatgaggtctcttatcaaaaatattactcagtttgcaagactgcattgtaactttaacatacactgtgactgacgtttctcaaagttcatattgtgtggctgatctgaagtcagtcggaatttgtaaacagggtagcaaacaagatatttttcttccatgtatacaataatttttttaaaaagtgcaatttgcgttgcagcaatcagtgttaaatcatttgcataagatttaacagcattttttataatgaatgtaaacattttaacttaatggtacttaaaataatttaaaagaaaaatgttaacttagacattcttatgcttcttttacaactacatcccattttatatttccaattgttaaagaaaaatatttcaagaacaaatcttctctcaggaaaattgcctttctctatttgttaagaatttttatacaagaacaccaatataccccctttattttactgtggaatatgtgctggaaaaattgcaacaacactttactacctaacggatagcatttgtaaatactctaggtatctgtaaacactctgatgaagtctgtatagtgtgactaacccacaggcaggttggtttacattaatttttttttttgaatgggatgtcctatggaaacctatttcaccagagttttaaaaataaaaagggtattgttttgtcttctgtacagtgagttccttcccttttcaaagctttctttttatgctgtatgtgactatagatattcatataaaacaagtgcacgtgaagtttgcaaaatgctttaaggccttcctttcaaagcatagtccttttggagccgttttgtaccttttataccttggcttatttgaagttgacacatggggttagttactactctccatgtgcattggggacagtttttataagtgggaaggactcagtattattatatttgagatgataagcattttgtttgggaacaatgcttaaaaatattccagaaagttcagattttttttctttgtgaatgaaatatattctggcccacgaacagggcgatttcctttcagttttttccttttgcaacgtgccttgaagtctcaaagctcacctgaggttgcagacgttacccccaacagaagataggtagaaatgattccagtggcctctttgtattttcttcattgttgagtagatttcaggaaatcaggaggtgtttcacaatacagaatgatggcctttaactgtg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2627 -> Molecular function: GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] evidence: IEA
GeneID:2627 -> Molecular function: GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] evidence: IMP
GeneID:2627 -> Molecular function: GO:0001103 [RNA polymerase II repressing transcription factor binding] evidence: IEA
GeneID:2627 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:2627 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:2627 -> Molecular function: GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:2627 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2627 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:2627 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:2627 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
GeneID:2627 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
GeneID:2627 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:2627 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
GeneID:2627 -> Biological process: GO:0001889 [liver development] evidence: IEA
GeneID:2627 -> Biological process: GO:0003148 [outflow tract septum morphogenesis] evidence: IMP
GeneID:2627 -> Biological process: GO:0003309 [type B pancreatic cell differentiation] evidence: IEA
GeneID:2627 -> Biological process: GO:0003310 [pancreatic A cell differentiation] evidence: IEA
GeneID:2627 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
GeneID:2627 -> Biological process: GO:0006644 [phospholipid metabolic process] evidence: IEA
GeneID:2627 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:2627 -> Biological process: GO:0007493 [endodermal cell fate determination] evidence: IEA
GeneID:2627 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:2627 -> Biological process: GO:0008584 [male gonad development] evidence: IEP
GeneID:2627 -> Biological process: GO:0014898 [cardiac muscle hypertrophy in response to stress] evidence: IEA
GeneID:2627 -> Biological process: GO:0032911 [negative regulation of transforming growth factor beta1 production] evidence: IMP
GeneID:2627 -> Biological process: GO:0032912 [negative regulation of transforming growth factor beta2 production] evidence: IMP
GeneID:2627 -> Biological process: GO:0035239 [tube morphogenesis] evidence: IEA
GeneID:2627 -> Biological process: GO:0042493 [response to drug] evidence: IMP
GeneID:2627 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:2627 -> Biological process: GO:0043627 [response to estrogen stimulus] evidence: IEA
GeneID:2627 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IDA
GeneID:2627 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:2627 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:2627 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
GeneID:2627 -> Biological process: GO:0048645 [organ formation] evidence: IEA
GeneID:2627 -> Biological process: GO:0051145 [smooth muscle cell differentiation] evidence: IMP
GeneID:2627 -> Biological process: GO:0051891 [positive regulation of cardioblast differentiation] evidence: IEA
GeneID:2627 -> Biological process: GO:0055007 [cardiac muscle cell differentiation] evidence: IEA
GeneID:2627 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: IEA
GeneID:2627 -> Biological process: GO:0060430 [lung saccule development] evidence: IEA
GeneID:2627 -> Biological process: GO:0060486 [Clara cell differentiation] evidence: IEA
GeneID:2627 -> Biological process: GO:0060510 [Type II pneumocyte differentiation] evidence: IEA
GeneID:2627 -> Biological process: GO:0060575 [intestinal epithelial cell differentiation] evidence: IDA
GeneID:2627 -> Biological process: GO:0060947 [cardiac vascular smooth muscle cell differentiation] evidence: IMP
GeneID:2627 -> Biological process: GO:0070848 [response to growth factor stimulus] evidence: IDA
GeneID:2627 -> Biological process: GO:0071158 [positive regulation of cell cycle arrest] evidence: IDA
GeneID:2627 -> Biological process: GO:0071371 [cellular response to gonadotropin stimulus] evidence: IEA
GeneID:2627 -> Biological process: GO:0071456 [cellular response to hypoxia] evidence: IDA
GeneID:2627 -> Biological process: GO:0071773 [cellular response to BMP stimulus] evidence: IEA
GeneID:2627 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:2627 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:2627 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
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