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2019-03-20 12:33:56, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005255               4549 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens cyclin G associated kinase (GAK), mRNA.
ACCESSION   NM_005255 XM_938227 XM_943587 XM_943590 XM_943594 XM_943598
            XM_943600 XM_943603
VERSION     NM_005255.2  GI:157384970
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4549)
  AUTHORS   Li,N.N., Chang,X.L., Mao,X.Y., Zhang,J.H., Zhao,D.M., Tan,E.K. and
            Peng,R.
  TITLE     GWAS-linked GAK locus in Parkinson's disease in Han Chinese and
            meta-analysis
  JOURNAL   Hum. Genet. 131 (7), 1089-1093 (2012)
   PUBMED   22198721
  REMARK    GeneRIF: study demonstrated that the rs1564282 variant in GAK
            (PARK17) increases the risk of Parkinson's disease in Han Chinese
            patients from mainland China
REFERENCE   2  (bases 1 to 4549)
  AUTHORS   Naito,Y., Shimizu,H., Kasama,T., Sato,J., Tabara,H., Okamoto,A.,
            Yabuta,N. and Nojima,H.
  TITLE     Cyclin G-associated kinase regulates protein phosphatase 2A by
            phosphorylation of its B'gamma subunit
  JOURNAL   Cell Cycle 11 (3), 604-616 (2012)
   PUBMED   22262175
  REMARK    GeneRIF: GAK as a regulator of dephosphorylation events under the
            control of the PP2A B'gamma subunit.
REFERENCE   3  (bases 1 to 4549)
  AUTHORS   Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM,
            Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M,
            Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano
            AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T,
            Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle
            JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA,
            Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB,
            Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP, Young
            P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP and Bertram
            L.
  CONSRTM   23andMe  Genetic Epidemiology of Parkinson's Disease Consortium;
            International Parkinson's Disease Genomics Consortium; Parkinson's
            Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2)
  TITLE     Comprehensive research synopsis and systematic meta-analyses in
            Parkinson's disease genetics: The PDGene database
  JOURNAL   PLoS Genet. 8 (3), E1002548 (2012)
   PUBMED   22438815
REFERENCE   4  (bases 1 to 4549)
  AUTHORS   Do,C.B., Tung,J.Y., Dorfman,E., Kiefer,A.K., Drabant,E.M.,
            Francke,U., Mountain,J.L., Goldman,S.M., Tanner,C.M.,
            Langston,J.W., Wojcicki,A. and Eriksson,N.
  TITLE     Web-based genome-wide association study identifies two novel loci
            and a substantial genetic component for Parkinson's disease
  JOURNAL   PLoS Genet. 7 (6), E1002141 (2011)
   PUBMED   21738487
REFERENCE   5  (bases 1 to 4549)
  AUTHORS   Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M,
            Simon-Sanchez J, Schulte C, Lesage S, Sveinbjornsdottir S,
            Stefansson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T,
            Singleton AB and Wood NW.
  CONSRTM   International Parkinson Disease Genomics Consortium
  TITLE     Imputation of sequence variants for identification of genetic risks
            for Parkinson's disease: a meta-analysis of genome-wide association
            studies
  JOURNAL   Lancet 377 (9766), 641-649 (2011)
   PUBMED   21292315
REFERENCE   6  (bases 1 to 4549)
  AUTHORS   Zhao,X., Greener,T., Al-Hasani,H., Cushman,S.W., Eisenberg,E. and
            Greene,L.E.
  TITLE     Expression of auxilin or AP180 inhibits endocytosis by
            mislocalizing clathrin: evidence for formation of nascent pits
            containing AP1 or AP2 but not clathrin
  JOURNAL   J. Cell. Sci. 114 (PT 2), 353-365 (2001)
   PUBMED   11148137
REFERENCE   7  (bases 1 to 4549)
  AUTHORS   Umeda,A., Meyerholz,A. and Ungewickell,E.
  TITLE     Identification of the universal cofactor (auxilin 2) in clathrin
            coat dissociation
  JOURNAL   Eur. J. Cell Biol. 79 (5), 336-342 (2000)
   PUBMED   10887964
REFERENCE   8  (bases 1 to 4549)
  AUTHORS   Greener,T., Zhao,X., Nojima,H., Eisenberg,E. and Greene,L.E.
  TITLE     Role of cyclin G-associated kinase in uncoating clathrin-coated
            vesicles from non-neuronal cells
  JOURNAL   J. Biol. Chem. 275 (2), 1365-1370 (2000)
   PUBMED   10625686
REFERENCE   9  (bases 1 to 4549)
  AUTHORS   Kimura,S.H., Tsuruga,H., Yabuta,N., Endo,Y. and Nojima,H.
  TITLE     Structure, expression, and chromosomal localization of human GAK
  JOURNAL   Genomics 44 (2), 179-187 (1997)
   PUBMED   9299234
REFERENCE   10 (bases 1 to 4549)
  AUTHORS   Kanaoka,Y., Kimura,S.H., Okazaki,I., Ikeda,M. and Nojima,H.
  TITLE     GAK: a cyclin G associated kinase contains a tensin/auxilin-like
            domain
  JOURNAL   FEBS Lett. 402 (1), 73-80 (1997)
   PUBMED   9013862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA680073.1, D88435.1, AC139887.3 and BC000816.1.
            On Sep 20, 2007 this sequence version replaced gi:4885250.
            
            Summary: In all eukaryotes, the cell cycle is governed by
            cyclin-dependent protein kinases (CDKs), whose activities are
            regulated by cyclins and CDK inhibitors in a diverse array of
            mechanisms that involve the control of phosphorylation and
            dephosphorylation of Ser, Thr or Tyr residues. Cyclins are
            molecules that possess a consensus domain called the 'cyclin box.'
            In mammalian cells, 9 cyclin species have been identified, and they
            are referred to as cyclins A through I. Cyclin G is a direct
            transcriptional target of the p53 tumor suppressor gene product and
            thus functions downstream of p53. GAK is an association partner of
            cyclin G and CDK5. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88435.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               DA680073.1         6-158
            154-217             DA680073.1         160-223
            218-3201            D88435.1           19-3002
            3202-3242           AC139887.3         128141-128181       c
            3243-3365           AC139887.3         126899-127021       c
            3366-3482           AC139887.3         121383-121499       c
            3483-3707           AC139887.3         113527-113751       c
            3708-3856           AC139887.3         112713-112861       c
            3857-4033           AC139887.3         111669-111845       c
            4034-4512           AC139887.3         111073-111551       c
            4513-4549           BC000816.1         1375-1411
FEATURES             Location/Qualifiers
     source          1..4549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16"
     gene            1..4549
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="cyclin G associated kinase"
                     /db_xref="GeneID:2580"
                     /db_xref="HGNC:4113"
                     /db_xref="MIM:602052"
     exon            1..344
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    125..127
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="upstream in-frame stop codon"
     CDS             200..4135
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /EC_number="2.7.11.1"
                     /note="auxilin-2"
                     /codon_start=1
                     /product="cyclin-G-associated kinase"
                     /protein_id="NP_005246.2"
                     /db_xref="GI:157384971"
                     /db_xref="CCDS:CCDS3340.1"
                     /db_xref="GeneID:2580"
                     /db_xref="HGNC:4113"
                     /db_xref="MIM:602052"
                     /translation="
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF
"
     misc_feature    203..205
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylserine; propagated from
                     UniProtKB/Swiss-Prot (O14976.2); acetylation site"
     misc_feature    245..247
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    350..1126
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    359..1126
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl09925"
                     /db_xref="CDD:213116"
     misc_feature    order(359..361,398..400,404..406,494..496,566..577,
                     584..586,590..592,716..718,722..724,728..733,737..739,
                     770..772,779..781,866..874)
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(359..361,398..400,404..406,494..496,566..577,
                     584..586,716..718,722..724,728..733,737..739,770..772)
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(584..586,590..592,716..718,722..724,728..730,
                     779..781,866..874)
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    order(767..787,866..874)
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173623"
     misc_feature    1565..1567
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    1907..2323
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="C2 domain of PTEN tumour-suppressor protein;
                     Region: PTEN_C2; pfam10409"
                     /db_xref="CDD:204476"
     misc_feature    2507..2509
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    2675..2677
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    2684..2686
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    2699..2701
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    3014..3016
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    3485..3487
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    3725..3727
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    3752..3754
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O14976.2); phosphorylation site"
     misc_feature    <3977..4111
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; Region: DnaJ;
                     cd06257"
                     /db_xref="CDD:99751"
     misc_feature    order(4022..4030,4064..4066,4073..4078,4085..4090)
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /note="HSP70 interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:99751"
     exon            345..406
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            407..466
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            467..581
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       557
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1141284"
     exon            582..724
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            725..850
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            851..940
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            941..1076
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            1077..1189
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            1190..1280
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            1281..1404
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       1396
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2279181"
     exon            1405..1454
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            1455..1603
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            1604..1726
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       1656
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1802538"
     exon            1727..1860
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            1861..2055
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       1957
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35964990"
     exon            2056..2173
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       2137
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41333249"
     exon            2174..2253
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            2254..2447
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            2448..2594
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       2535
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1056673"
     exon            2595..3071
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       2817
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1141285"
     exon            3072..3242
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       3202
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1064207"
     exon            3243..3365
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       3308
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77455473"
     variation       3334
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1026738"
     exon            3366..3482
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            3483..3707
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            3708..3856
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     exon            3857..4033
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     variation       3993
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2306242"
     variation       4017..4018
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76111882"
     variation       4018
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8093"
     exon            4034..4531
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /inference="alignment:Splign:1.39.8"
     STS             4069..4530
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /standard_name="GAK__6772"
                     /db_xref="UniSTS:466196"
     variation       4088
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1134921"
     STS             4277..4532
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /standard_name="WI-20233"
                     /db_xref="UniSTS:57018"
     STS             4281..4494
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /standard_name="SHGC-68043"
                     /db_xref="UniSTS:53741"
     variation       4412
                     /gene="GAK"
                     /gene_synonym="DNAJ26; DNAJC26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6964"
ORIGIN      
gaggccgcggcggaggggacggggctaggccgggtcgccgcctgacgcgacgcgtcctcacgggcgcctacgtcacggcgtcgaggcggaagatggtgcacctccgggccggcggttgctgagctgacccggacggcgagggagcgggagcccgagcccgaccactccggctgccgcggggtgcggcgcagccaccgccatgtcgctgctgcagtcggcgctcgacttcttggcgggtccaggctccctgggcggtgcttccggccgcgaccagagtgacttcgtggggcagacggtggaactgggcgagctgcggctgcgggtgcggcgggtcctggccgaaggagggtttgcatttgtgtatgaagctcaagatgtggggagtggcagagagtatgcattaaagaggctattatccaatgaagaggaaaagaacagagccatcattcaagaagtttgcttcatgaaaaagctttccggccacccgaacattgtccagttttgttctgcagcgtctataggaaaagaggagtcagacacggggcaggctgagttcctcttgctcacagagctctgtaaagggcagctggtggaatttttgaagaaaatggaatctcgaggccccctttcgtgcgacacggttctgaagatcttctaccagacgtgccgcgccgtgcagcacatgcaccggcagaagccgcccatcatccacagggacctcaaggttgagaacttgttgcttagtaaccaagggaccattaagctgtgtgactttggcagtgccacgaccatctcgcactaccctgactacagctggagcgcccagaggcgagccctggtggaggaagagatcacgaggaatacaacaccaatgtatagaacaccagaaatcatagacttgtattccaacttcccgatcggcgagaagcaggatatctgggccctgggctgcatcttgtacctgctgtgcttccggcagcacccttttgaggatggagcgaaacttcgaatagtcaatgggaagtactcgatccccccgcacgacacgcagtacacggtcttccacagcctcatccgcgccatgctgcaggtgaacccggaggagcggctgtccatcgccgaggtggtgcaccagctgcaggagatcgcggccgcccgcaacgtgaaccccaagtctcccatcacagagctcctggagcagaatggaggctacgggagcgccacactgtcccgagggccaccccctcccgtgggccccgctggcagtggctacagtggaggcctggcgctggcggagtacgaccagccgtatggcggcttcctggacattctgcggggtgggacagagcggctcttcaccaacctcaaggacacctcctccaaggtcatccagtccgtcgctaattatgcaaagggtgacctggacatatcttacatcacatccagaattgcagtgatgtcattcccagcagaaggtgtggagtcagcgctcaaaaacaacatcgaagatgtgcggttgttcctggactccaagcacccagggcactatgccgtctacaacctgtccccgaggacctaccggccctccaggttccacaaccgggtctccgagtgtggctgggcagcacggcgggccccacacctgcacaccctgtacaacatctgcaggaacatgcacgcctggctgcggcaggaccacaagaacgtctgcgtcgtgcactgcatggacgggagagccgcgtctgctgtggccgtctgctccttcctgtgcttctgccgtctcttcagcaccgcggaggccgccgtgtacatgttcagcatgaagcgctgcccaccaggcatctggccatcccacaaaaggtacatcgagtacatgtgtgacatggtggcggaggagcccatcacaccccacagcaagcccatcctggtgagggccgtggtcatgacacccgtgccgctgttcagcaagcagaggagcggctgcaggcccttctgcgaggtctacgtgggggacgagcgtgtggccagcacctcccaggagtacgacaagatgcgggactttaagattgaagatggcaaagcggtgattcccctgggcgtcacggtgcaaggagacgtgctcatcgtcatctatcacgcccggtccactctgggcggccggctgcaggccaagatggcatccatgaagatgttccagattcagttccacacggggtttgtgcctcggaacgccaccactgtgaaatttgccaagtatgacctggacgcgtgtgacattcaagaaaaatacccggatttatttcaagtgaacctggaagtggaggtggagcccagggacaggccgagccgggaagccccaccatgggagaactcgagcatgagggggctgaaccccaaaatcctgttttccagccgggaggagcagcaagacattctgtctaagtttgggaagccggagcttccccggcagcctggctccacggctcagtatgatgctggggcagggtccccggaagccgaacccacagactctgactcaccgccaagcagcagcgcggacgccagtcgcttcctgcacacgctggactggcaggaagagaaggaggcagagactggtgcagaaaatgcctcttccaaggagagcgagtctgccctgatggaggacagagacgagagtgaggtgtcagatgaagggggatccccgatctccagcgagggccaggaacccagggccgacccagagccccccggcctggcagcagggctggtgcagcaggacttggtttttgaggtggagacaccggctgtgctgccagagcctgtgccacaggaagacggggtcgacctcctgggcctgcactccgaggtgggcgcagggccagctgtacccccgcaggcctgcaaggccccctccagcaacaccgacctgctcagctgcctccttgggccccctgaggccgcctcccaggggcccccggaggatctgctcagcgaggacccgctgctcctggcaagcccggcccctcccctgagcgtgcagagcaccccaagaggagggccccctgccgctgctgacccctttggcccgcttctgccgtcttcaggcaacaactcccagccctgctccaatcctgatctcttcggcgaatttctcaattcggactctgtgaccgtcccaccatccttcccgtctgcccacagtgctccgcccccatcctgcagcgccgacttcctgcacctgggggatctgccaggagagcccagcaagatgacagcctcgtccagcaacccagacctgctgggaggatgggctgcctggaccgagactgcagcatcggcagtggcccccacgccagccacagaaggccccctcttctctcctggaggtcagccggccccttgtggctctcaggccagctggaccaagtctcagaacccggacccatttgctgaccttggcgacctcagctccggcctccaaggctcaccagctggattccctcctgggggcttcattcccaaaacggccaccacgcccaaaggcagcagctcctggcagacaagtcggccgccagcccagggcgcctcatggccccctcaggccaagccgccccccaaagcctgcacacagccaaggcctaactatgcctcgaacttcagtgtgatcggggcgcgggaggagcggggggtccgcgcacccagctttgctcaaaagccaaaagtctctgagaacgactttgaagatctgttgtccaatcaaggcttctcctccaggtctgacaagaaagggccaaagaccattgcagagatgaggaagcaggacctggctaaagacacggacccactcaagctgaagctcctggactggattgagggcaaggagcggaacatccgggccctgctgtccacgctgcacacagtgctgtgggacggggagagccgctggacgcccgtgggcatggccgacctggtggctccggagcaagtgaagaagcactatcgccgcgcggtgctggctgtgcaccccgacaaggctgcggggcagccgtacgagcagcacgccaagatgatcttcatggagctgaatgacgcctggtcggagtttgagaaccagggctcccggcccctcttctgaggccgcagtggtggtggctgcgcacacagctccacaggttgggagccgtcgtgggacctgggtccccaccgtgaggaccccgtgggcgacagcaggtgtggccagggtggggctccgagccccgggtcaccgcccgcccagcgttccaggcacatgaagagaaagcattccaaagcctctgattgttgtttcctttttctcctcccgaaggaacagctgattcatgctcctcccgcaattgtcacgtctgtgatttatttggtgtttcgggcgtggcctctggagccccggcacgtggtgggccacgctgctggcgctcatgggccctggtgtttgcaccgcactttgtaatcagtcccgtggttgtctgtacagaattaaactattttccgatgaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2580 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
            GeneID:2580 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2580 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:2580 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:2580 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:2580 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
            GeneID:2580 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
            GeneID:2580 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005246 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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