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2024-04-21 01:21:41, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005223 3108 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens deoxyribonuclease I (DNASE1), mRNA.
ACCESSION NM_005223
VERSION NM_005223.3 GI:58331227
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3108)
AUTHORS Parsiegla,G., Noguere,C., Santell,L., Lazarus,R.A. and Bourne,Y.
TITLE The structure of human DNase I bound to magnesium and phosphate
ions points to a catalytic mechanism common to members of the DNase
I-like superfamily
JOURNAL Biochemistry 51 (51), 10250-10258 (2012)
PUBMED 23215638
REMARK GeneRIF: The novel structure of rhDNase I presented herein reveals
the precise location and coordination sphere of the Mg2+ ion bound
at subsite IVb along with the orientation of key side chains in the
active site.
REFERENCE 2 (bases 1 to 3108)
AUTHORS Hunsaker,T.L., Jefferson,H.S., Morrison,J.K., Franklin,A.J. and
Shewchuk,B.M.
TITLE POU1F1-mediated activation of hGH-N by deoxyribonuclease I
hypersensitive site II of the human growth hormone locus control
region
JOURNAL J. Mol. Biol. 415 (1), 29-45 (2012)
PUBMED 22094313
REMARK GeneRIF: POU1F1 binds to multiple sites at deoxyribonuclease I
hypersensitive site II.
REFERENCE 3 (bases 1 to 3108)
AUTHORS Thiyagarajan,D., Fismen,S., Seredkina,N., Jacobsen,S.,
Elung-Jensen,T., Kamper,A.L., Fenton,C.G., Rekvig,O.P. and
Mortensen,E.S.
TITLE Silencing of renal DNaseI in murine lupus nephritis imposes
exposure of large chromatin fragments and activation of Toll like
receptors and the Clec4e
JOURNAL PLoS ONE 7 (3), E34080 (2012)
PUBMED 22479529
REMARK GeneRIF: silencing of renal DNaseI gene expression initiates a
cascade of inflammatory signals including activation of Toll like
receptors and Clec4e, leading to progression of both murine and
human lupus nephritis
REFERENCE 4 (bases 1 to 3108)
AUTHORS Fujihara,J., Ueki,M., Yasuda,T., Iida,R., Soejima,M., Koda,Y.,
Kimura-Kataoka,K., Kato,H., Panduro,A., Tongu,M. and Takeshita,H.
TITLE Functional and genetic survey of all known single-nucleotide
polymorphisms within the human deoxyribonuclease I gene in
wide-ranging ethnic groups
JOURNAL DNA Cell Biol. 30 (4), 205-217 (2011)
PUBMED 21235399
REMARK GeneRIF: The genetic aspects of DNASE1 with regard to all the SNPs
in wide-ranging ethnic groups could be first demonstrated. Further,
there was no correlation of all the polymorphic SNPs other than
nonsynonymous ones with serum DNase I activity levels.
REFERENCE 5 (bases 1 to 3108)
AUTHORS Sofi,M.H., Qiao,Y., Ansel,K.M., Kubo,M. and Chang,C.H.
TITLE Induction and maintenance of IL-4 expression are regulated
differently by the 3' enhancer in CD4 T cells
JOURNAL J. Immunol. 186 (5), 2792-2799 (2011)
PUBMED 21282512
REMARK GeneRIF: In thymocyte-selected CD4 T cells (T-CD4 T cells) DNase I
hypersensitive sites at the 3'-enhancer region of interleukin-4
play an essential role during the induction of IL-4 expression.
REFERENCE 6 (bases 1 to 3108)
AUTHORS Shak,S., Capon,D.J., Hellmiss,R., Marsters,S.A. and Baker,C.L.
TITLE Recombinant human DNase I reduces the viscosity of cystic fibrosis
sputum
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (23), 9188-9192 (1990)
PUBMED 2251263
REFERENCE 7 (bases 1 to 3108)
AUTHORS Kabsch,W., Mannherz,H.G., Suck,D., Pai,E.F. and Holmes,K.C.
TITLE Atomic structure of the actin:DNase I complex
JOURNAL Nature 347 (6288), 37-44 (1990)
PUBMED 2395459
REFERENCE 8 (bases 1 to 3108)
AUTHORS Yasuda,T., Awazu,S., Sato,W., Iida,R., Tanaka,Y. and Kishi,K.
TITLE Human genetically polymorphic deoxyribonuclease: purification,
characterization, and multiplicity of urine deoxyribonuclease I
JOURNAL J. Biochem. 108 (3), 393-398 (1990)
PUBMED 2277032
REFERENCE 9 (bases 1 to 3108)
AUTHORS Kishi,K., Yasuda,T., Ikehara,Y., Sawazaki,K., Sato,W. and Iida,R.
TITLE Human serum deoxyribonuclease I (DNase I) polymorphism: pattern
similarities among isozymes from serum, urine, kidney, liver, and
pancreas
JOURNAL Am. J. Hum. Genet. 47 (1), 121-126 (1990)
PUBMED 2349940
REFERENCE 10 (bases 1 to 3108)
AUTHORS Kishi,K., Yasuda,T., Awazu,S. and Mizuta,K.
TITLE Genetic polymorphism of human urine deoxyribonuclease I
JOURNAL Hum. Genet. 81 (3), 295-297 (1989)
PUBMED 2921043
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC006111.4, AJ298844.1 and
AI378682.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 29, 2005 this sequence version replaced gi:21361253.
Summary: This gene encodes a member of the DNase family. This
protein is stored in the zymogen granules of the nuclear envelope
and functions by cleaving DNA in an endonucleolytic manner. At
least six autosomal codominant alleles have been characterized,
DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented
in this record. Mutations in this gene have been associated with
systemic lupus erythematosus (SLE), an autoimmune disease. A
recombinant form of this protein is used to treat the one of the
symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in
sputum and reducing its viscosity. Alternate transcriptional splice
variants of this gene have been observed but have not been
thoroughly characterized. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ298844.1, AB188152.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1964 AC006111.4 110681-112644
1965-2964 AJ298844.1 920-1919
2965-3108 AI378682.1 4-147 c
FEATURES Location/Qualifiers
source 1..3108
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..3108
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="deoxyribonuclease I"
/db_xref="GeneID:1773"
/db_xref="HGNC:2956"
/db_xref="HPRD:00509"
/db_xref="MIM:125505"
exon 1..2106
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 58
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="g"
/db_xref="dbSNP:375300757"
variation 76
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:185414501"
variation 102
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:191253928"
variation 177
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:182709234"
variation 205
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:146695354"
variation 206
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:185968354"
variation 214..216
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="aga"
/db_xref="dbSNP:374703381"
variation 216
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:369554733"
STS 234..370
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/standard_name="SHGC-57870"
/db_xref="UniSTS:72932"
variation 259
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:74005841"
variation 297
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:139048434"
variation 311
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:45564535"
variation 315
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:192125454"
variation 318
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:143982736"
variation 337
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:112878652"
variation 366
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:183334678"
variation 461..462
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="g"
/db_xref="dbSNP:34767593"
variation 475
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:146437886"
variation 510
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:1140198"
variation 529
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:188077048"
variation 536
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:45606645"
variation 570
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:45626736"
variation 599
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:192063399"
variation 637
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:111733271"
variation 655
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:372687630"
variation 666
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="g"
/replace="t"
/db_xref="dbSNP:183150984"
STS 695..783
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 745..814
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
variation 793
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:1139162"
variation 794
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:1140203"
variation 798
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:1140204"
variation 810
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:1139163"
variation 821
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:370760517"
variation 825
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:1140205"
variation 829
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:1140206"
variation 837
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:1139164"
variation 855
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:377138914"
variation 869..870
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="aa"
/db_xref="dbSNP:151141356"
variation 870
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="aa"
/db_xref="dbSNP:371427033"
variation 901
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:112301944"
variation 902..903
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="aa"
/db_xref="dbSNP:71133649"
variation 925..926
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="g"
/db_xref="dbSNP:369953113"
variation 941
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:77563984"
variation 942
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:79356805"
variation 943
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:113601432"
variation 1170
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:113086912"
variation 1172
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:148986688"
variation 1177
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:188117528"
variation 1188
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:78677316"
variation 1237
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:192745107"
variation 1267
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:138402929"
variation 1268
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:377615324"
variation 1291
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:373681390"
variation 1295
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:143935824"
variation 1414
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:17136470"
variation 1447
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:45522434"
variation 1456
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:184248735"
variation 1484
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:148306760"
variation 1623
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:189145229"
variation 1658
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:17136471"
variation 1751
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:191478517"
variation 1757
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:367673030"
variation 1768
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:141780167"
variation 1787..1790
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="agaa"
/db_xref="dbSNP:140316269"
variation 1788..1791
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace=""
/replace="gaaa"
/db_xref="dbSNP:60523329"
variation 1799
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:45479597"
variation 1824
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:184630383"
variation 1833
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:150593833"
variation 1929
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:189467610"
variation 1936
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:181422861"
variation 1956
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:186863250"
variation 1968
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:370353478"
variation 2076
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:7190521"
STS 2081..2580
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/standard_name="GDB:545412"
/db_xref="UniSTS:157584"
variation 2083
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:373772014"
misc_feature 2084..2086
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="upstream in-frame stop codon"
exon 2107..2254
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2107
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:374609613"
CDS 2108..2956
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/EC_number="3.1.21.1"
/note="Dornase alfa; human urine deoxyribonuclease I;
DNase I, lysosomal; deoxyribonuclease-1"
/codon_start=1
/product="deoxyribonuclease-1 precursor"
/protein_id="NP_005214.2"
/db_xref="GI:21361254"
/db_xref="CCDS:CCDS10507.1"
/db_xref="GeneID:1773"
/db_xref="HGNC:2956"
/db_xref="HPRD:00509"
/db_xref="MIM:125505"
/translation="
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
"
sig_peptide 2108..2173
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 2174..2953
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/product="deoxyribonuclease-1"
misc_feature 2177..2950
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="Deoxyribonuclease 1; Region: DNase1; cd10282"
/db_xref="CDD:197337"
misc_feature order(2192..2197,2201..2203,2213..2215,2288..2290,
2294..2302,2396..2401,2405..2407,2504..2506,2573..2575,
2582..2584,2675..2677,2681..2683,2696..2698,2792..2794,
2804..2809,2924..2929)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="putative active site [active]"
/db_xref="CDD:197337"
misc_feature order(2192..2194,2288..2290,2405..2407,2573..2575,
2675..2677,2681..2683,2807..2809,2924..2929)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="putative catalytic site [active]"
/db_xref="CDD:197337"
misc_feature order(2192..2194,2288..2290,2924..2926)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="putative Mg binding site IVb [ion binding]; other
site"
/db_xref="CDD:197337"
misc_feature order(2198..2200,2573..2575,2675..2677,2681..2683,
2927..2929)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="putative phosphate binding site [ion binding];
other site"
/db_xref="CDD:197337"
misc_feature 2198..2200
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="actin binding site [polypeptide binding]; other
site"
/db_xref="CDD:197337"
misc_feature order(2201..2203,2213..2215,2294..2302,2396..2401,
2405..2407,2504..2506,2573..2575,2582..2584,2675..2677,
2681..2683,2696..2698,2804..2806,2927..2929)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:197337"
misc_feature order(2468..2470,2507..2509)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="Ca binding site II [ion binding]; other site"
/db_xref="CDD:197337"
misc_feature order(2675..2677,2807..2809,2927..2929)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="putative Mg binding site IVa [ion binding]; other
site"
/db_xref="CDD:197337"
misc_feature order(2687..2689,2765..2767)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="metal binding site III [ion binding]; metal-binding
site"
/db_xref="CDD:197337"
misc_feature order(2774..2776,2780..2782)
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/note="Ca binding site I [ion binding]; other site"
/db_xref="CDD:197337"
variation 2113
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="g"
/replace="t"
/db_xref="dbSNP:8176927"
variation 2114
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:200484716"
variation 2115
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:61741279"
variation 2120
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:121912990"
variation 2125
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:367607486"
variation 2148
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:148015097"
variation 2149
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:199538085"
variation 2167
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:371362495"
variation 2173
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:373820749"
variation 2182
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:201161491"
variation 2183
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:141673463"
variation 2198
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:77254040"
variation 2203
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:8176930"
variation 2212
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:34907394"
variation 2215
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:143327739"
variation 2220
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:369619441"
variation 2224
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200404670"
variation 2233
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:144058317"
variation 2237
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:370054136"
variation 2243
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:147546841"
variation 2244
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:140187838"
exon 2255..2343
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2264
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:143865851"
variation 2268
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:144227093"
variation 2278
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:148748335"
variation 2286
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:142318540"
variation 2287
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:45545238"
variation 2293
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:150984053"
variation 2314
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:139896401"
variation 2332
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:146770039"
exon 2344..2427
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2348
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:140530129"
variation 2368
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:140382618"
variation 2374
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:1133037"
variation 2391
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:190768401"
variation 2407
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:144007099"
variation 2414
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200188411"
variation 2416
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="g"
/replace="t"
/db_xref="dbSNP:144874248"
variation 2426
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176928"
exon 2428..2543
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2438
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:143058517"
variation 2445
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:199986334"
variation 2446
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:370998464"
variation 2457
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="g"
/replace="t"
/db_xref="dbSNP:34923865"
variation 2465
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:141801594"
variation 2476
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:147083287"
variation 2486
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176919"
variation 2492
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:144059899"
variation 2502
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:76397583"
variation 2505
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:150621329"
variation 2522
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:138676148"
variation 2534
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:374554105"
variation 2535
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:139615062"
exon 2544..2656
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2552
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:368307903"
variation 2567
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:1799891"
variation 2569
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:372063579"
variation 2577
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:143407371"
variation 2583
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:146238243"
variation 2584
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:377278126"
variation 2590
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201205627"
STS 2604..2727
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/standard_name="RH69144"
/db_xref="UniSTS:67308"
variation 2605
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:201942334"
variation 2606
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:139424576"
variation 2608
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:59621760"
variation 2609
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:371345873"
variation 2610
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:150933932"
variation 2621
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:140745748"
variation 2632
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:112247144"
variation 2635
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:8176938"
variation 2654
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:199540176"
exon 2657..2811
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2660
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:74892550"
variation 2663
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:147093089"
variation 2674
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:8175352"
variation 2675
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:142644209"
variation 2682
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:146236198"
variation 2685
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:143371936"
variation 2686
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:34984360"
variation 2725
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:375047779"
variation 2726
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:148373909"
variation 2731
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176920"
variation 2762
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:34186031"
variation 2764
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:368229366"
variation 2769
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:138354028"
variation 2770
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:373492852"
variation 2776
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:142828788"
variation 2793
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200620452"
variation 2799
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176940"
variation 2802
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:146249371"
variation 2805
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:199826318"
variation 2810
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="t"
/db_xref="dbSNP:139254891"
variation 2811
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:375616517"
exon 2812..2908
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2815
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201517407"
variation 2819
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:200149984"
variation 2824
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:149928907"
variation 2837
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201571412"
variation 2838
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:1053874"
variation 2842
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201756002"
variation 2843
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:8176939"
variation 2846
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:148684969"
variation 2854
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201975812"
variation 2859
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200538894"
variation 2883
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:142079857"
variation 2886
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:201413861"
variation 2887
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="c"
/db_xref="dbSNP:147763166"
variation 2889
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:368045366"
variation 2892
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:8176924"
variation 2902
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:139583800"
variation 2908
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:145084753"
exon 2909..3098
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/inference="alignment:Splign:1.39.8"
variation 2953
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:373403207"
variation 2964
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:369410727"
variation 2967
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:373124509"
variation 2973
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:8176937"
variation 2983
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200822160"
variation 3002
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:200262659"
variation 3003
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="t"
/db_xref="dbSNP:370964436"
variation 3041
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="c"
/replace="g"
/db_xref="dbSNP:149669139"
variation 3042
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:144464337"
polyA_signal 3071..3076
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
variation 3083
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
/replace="a"
/replace="g"
/db_xref="dbSNP:200677183"
polyA_site 3098
/gene="DNASE1"
/gene_synonym="DNL1; DRNI"
ORIGIN
acgtgcagggctgtccttggagggccagcacagccccttccaagtgggcaagacccaggggtggctcaaaagatagctgtgccctagccctggaacctctgaatgttgatttttgtagcaaaaaaggacttgcagatgtgagtaaaggctgttgagataaggacatcctccctgctctctgggaggaccccaaatgcaggtgcacagatcttaagaagaagaggcagagactggggtgatgcagccacaactaaggaaagccaaggattgctggcagcctgcagaaactggagggcaaggagcatcccccaaccgcccggagcctccaggaggcgcaaggtcctactgactccctgacttcagacgtccagtctccggaattttgagaggatccatttctgttattttaagcaaccaaacttgtggtagtttcaccagtctcaggaaatgaatacgaatggaaagtcaaagattccaagaaatgagtggcggggtgcggtggctcacacttgtaatcccagcatttgcgggaagattgcttgggctcaggacttggagaccttgtgtctgtgagaaacttaaaaaataggctgggtgcgatggctcacgcctgtaatcccagcactttgggaggccgaggcaggcggatcacaaggtcacgagtttgagaccagtgtgaccaacatggtgaaaccctgtctctactaaaaatacaaaaattagccgggtgtggtggtgcgtgcctgtaatcccagctactcgggaggctgaggcagaagaattgcttgaacccaggaagcagaggttgcagtgagccgagatagtattactgcactccaggctgggcagcagagcaagattccgcctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaactgagcatggtagcatgcacctgtggtcctggctacgccggaggattgcctgaagccaggagttcaagaccagtctggacaaaagagcaagaccccatctctaccaaaaaaatttaaaaattagccaggcatggtgccgtacccatagtcttagctactcaggaggctgaggagggaggattatctgagccctggcggttgaggctataatgagccatgattgtgccactgcactccagccttggcaacacagtgtgagaccctgtctcaaaaacaataaaaacccaaaacaaaagaaccaagaaattactggacctgaggcctggcctttagctgctgccctgcccttgtgacctggtcactcgggatcccctgggcctaaacacacagcctattgtctacctcaagaaggctccccactgcttggctggcaattggggtgggctttgcaggccccacctgtcctggccccacggcgctggtgctgcaggcccccaccactgcttgttccgagctccccagcctcctgcagagttgcctgcacctgatggcgatgaatcaggaaggcaggcgtgtcctgggccacagagcagtcatggctgtcagccaccagggggctccatttgcaactttggatgtggctttggcctctttgtccaaagtgaccttggggcccccagacaagagacagggagactggagcccagccccaccctcccgcacatacctggcccatccctgccctatcctggaagatgggggccaccacacgtgcaagggacacgggataggaacctttggccttgttatcagacattttaaaactaagtgcaaacgtgattatcaggtgcagtttttacagcagcaagaaacctgtgcttacagaaagaaacacgtgctagcaacccacctatgcggaaagccacacagagccattgttttctgcactctcaggtgacggctcacatttgccccagggaaggtcacagctgcctgaacttttaaaactcccagacacgcactgcctgtgcaggatccggagcccagcagcactgccagggccttgaagtgcttcttcagagacctttcttcatagactacttttttttctttaagcagcaaaaggagaaaattgtcatcaaaggatattccagattcttgacagcattctcgtcatctctgaggacatcaccatcatctcaggatgaggggcatgaagctgctgggggcgctgctggcactggcggccctactgcagggggccgtgtccctgaagatcgcagccttcaacatccagacatttggggagaccaagatgtccaatgccaccctcgtcagctacattgtgcagatcctgagccgctatgacatcgccctggtccaggaggtcagagacagccacctgactgccgtggggaagctgctggacaacctcaatcaggatgcaccagacacctatcactacgtggtcagtgagccactgggacggaacagctataaggagcgctacctgttcgtgtacaggcctgaccaggtgtctgcggtggacagctactactacgatgatggctgcgagccctgcgggaacgacaccttcaaccgagagccagccattgtcaggttcttctcccggttcacagaggtcagggagtttgccattgttcccctgcatgcggccccgggggacgcagtagccgagatcgacgctctctatgacgtctacctggatgtccaagagaaatggggcttggaggacgtcatgttgatgggcgacttcaatgcgggctgcagctatgtgagaccctcccagtggtcatccatccgcctgtggacaagccccaccttccagtggctgatccccgacagcgctgacaccacagctacacccacgcactgtgcctatgacaggatcgtggttgcagggatgctgctccgaggcgccgttgttcccgactcggctcttccctttaacttccaggctgcctatggcctgagtgaccaactggcccaagccatcagtgaccactatccagtggaggtgatgctgaagtgagcagcccctccccacaccagttgaactgcaggaagagaggacccatcctgccacaggacccagaaaaaaagcccaacacacactcgggttaagaaatacctttaaatttaggtaaataaagctcaaggaggtggggctgtcaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1773 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
GeneID:1773 -> Molecular function: GO:0004530 [deoxyribonuclease I activity] evidence: IEA
GeneID:1773 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1773 -> Biological process: GO:0006308 [DNA catabolic process] evidence: IEA
GeneID:1773 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:1773 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:1773 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005214 -> EC 3.1.21.1
by
@meso_cacase at
DBCLS
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