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2024-03-29 23:19:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005204               3013 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 8
            (MAP3K8), transcript variant 1, mRNA.
ACCESSION   NM_005204
VERSION     NM_005204.3  GI:346644791
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Gkirtzimanaki,K., Gkouskou,K.K., Oleksiewicz,U., Nikolaidis,G.,
            Vyrla,D., Liontos,M., Pelekanou,V., Kanellis,D.C., Evangelou,K.,
            Stathopoulos,E.N., Field,J.K., Tsichlis,P.N., Gorgoulis,V.,
            Liloglou,T. and Eliopoulos,A.G.
  TITLE     TPL2 kinase is a suppressor of lung carcinogenesis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (16), E1470-E1479 (2013)
   PUBMED   23533274
  REMARK    GeneRIF: TPL2 was found to antagonize oncogene-induced cell
            transformation and survival through a pathway involving p53
            downstream of cJun N-terminal kinase (JNK) and be required for
            optimal p53 response to genotoxic stress.
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Tunca,B., Tezcan,G., Cecener,G., Egeli,U., Zorluoglu,A.,
            Yilmazlar,T., Ak,S., Yerci,O., Ozturk,E., Umut,G. and Evrensel,T.
  TITLE     Overexpression of CK20, MAP3K8 and EIF5A correlates with poor
            prognosis in early-onset colorectal cancer patients
  JOURNAL   J. Cancer Res. Clin. Oncol. 139 (4), 691-702 (2013)
   PUBMED   23322277
  REMARK    GeneRIF: Overexpression of MAP3K8 is associated with early-onset
            colorectal cancer.
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Kim,G., Khanal,P., Lim,S.C., Yun,H.J., Ahn,S.G., Ki,S.H. and
            Choi,H.S.
  TITLE     Interleukin-17 induces AP-1 activity and cellular transformation
            via upregulation of tumor progression locus 2 activity
  JOURNAL   Carcinogenesis 34 (2), 341-350 (2013)
   PUBMED   23125217
  REMARK    GeneRIF: High TPL2 expression is associated with tumor progression.
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Ballester,A., Tobena,R., Lisbona,C., Calvo,V. and Alemany,S.
  TITLE     Cot kinase regulation of IL-2 production in Jurkat T cells
  JOURNAL   J. Immunol. 159 (4), 1613-1618 (1997)
   PUBMED   9257820
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Salmeron,A., Ahmad,T.B., Carlile,G.W., Pappin,D., Narsimhan,R.P.
            and Ley,S.C.
  TITLE     Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel
            MAP kinase kinase kinase
  JOURNAL   EMBO J. 15 (4), 817-826 (1996)
   PUBMED   8631303
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Aoki,M., Hamada,F., Sugimoto,T., Sumida,S., Akiyama,T. and
            Toyoshima,K.
  TITLE     The human cot proto-oncogene encodes two protein serine/threonine
            kinases with different transforming activities by alternative
            initiation of translation
  JOURNAL   J. Biol. Chem. 268 (30), 22723-22732 (1993)
   PUBMED   8226782
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Chan,A.M., Chedid,M., McGovern,E.S., Popescu,N.C., Miki,T. and
            Aaronson,S.A.
  TITLE     Expression cDNA cloning of a serine kinase transforming gene
  JOURNAL   Oncogene 8 (5), 1329-1333 (1993)
   PUBMED   8479752
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Aoki,M., Akiyama,T., Miyoshi,J. and Toyoshima,K.
  TITLE     Identification and characterization of protein products of the cot
            oncogene with serine kinase activity
  JOURNAL   Oncogene 6 (9), 1515-1519 (1991)
   PUBMED   1833717
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Miyoshi,J., Higashi,T., Mukai,H., Ohuchi,T. and Kakunaga,T.
  TITLE     Structure and transforming potential of the human cot oncogene
            encoding a putative protein kinase
  JOURNAL   Mol. Cell. Biol. 11 (8), 4088-4096 (1991)
   PUBMED   2072910
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB271664.1, DA308072.1,
            BC104833.1, AL161651.13 and AA156603.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Sep 14, 2011 this sequence version replaced gi:22035597.
            
            Summary: This gene is an oncogene that encodes a member of the
            serine/threonine protein kinase family. The encoded protein
            localizes to the cytoplasm and can activate both the MAP kinase and
            JNK kinase pathways. This protein was shown to activate IkappaB
            kinases, and thus induce the nuclear production of NF-kappaB. This
            protein was also found to promote the production of TNF-alpha and
            IL-2 during T lymphocyte activation. This gene may also utilize a
            downstream in-frame translation start codon, and thus produce an
            isoform containing a shorter N-terminus. The shorter isoform has
            been shown to display weaker transforming activity. Alternate
            splicing results in multiple transcript variants that encode the
            same protein. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025083, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DB271664.1         1-26
            27-374              DA308072.1         1-348
            375-2163            BC104833.1         1-1789
            2164-2597           AL161651.13        143575-144008
            2598-3013           AA156603.1         3-418               c
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.23"
     gene            1..3013
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="mitogen-activated protein kinase kinase kinase 8"
                     /db_xref="GeneID:1326"
                     /db_xref="HGNC:6860"
                     /db_xref="HPRD:01863"
                     /db_xref="MIM:191195"
     exon            1..358
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       77
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8176952"
     variation       164
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:8176953"
     variation       168
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8176954"
     variation       214
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372356298"
     variation       278
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369075210"
     variation       352
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1269691"
     exon            359..589
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       374
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375770295"
     variation       412
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143510730"
     variation       434
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:182932469"
     variation       457
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3751450"
     variation       458
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8176962"
     variation       473
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142989322"
     variation       542
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1126481"
     misc_feature    586..588
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="upstream in-frame stop codon"
     exon            590..948
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     CDS             613..2016
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /EC_number="2.7.11.25"
                     /note="cot (cancer Osaka thyroid) oncogene; Ewing sarcoma
                     transformant; proto-oncogene serine/threoine protein
                     kinase; proto-oncogene c-Cot; tumor progression locus 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     8"
                     /protein_id="NP_005195.2"
                     /db_xref="GI:22035598"
                     /db_xref="CCDS:CCDS7166.1"
                     /db_xref="GeneID:1326"
                     /db_xref="HGNC:6860"
                     /db_xref="HPRD:01863"
                     /db_xref="MIM:191195"
                     /translation="
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
"
     misc_feature    700..702
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="Region: alternative start codon"
     misc_feature    850..852
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (P41279.2); phosphorylation site"
     misc_feature    1039..1767
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl09925"
                     /db_xref="CDD:213116"
     misc_feature    order(1042..1056,1066..1068,1105..1107,1111..1113,
                     1183..1185,1231..1242,1252..1254,1258..1260,1369..1371,
                     1375..1377,1381..1386,1420..1422,1429..1431,1477..1488)
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(1042..1056,1066..1068,1105..1107,1111..1113,
                     1183..1185,1231..1242,1252..1254,1369..1371,1375..1377,
                     1381..1386,1420..1422)
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    1048..1770
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(1054..1056,1252..1254,1258..1260,1369..1371,
                     1375..1377,1381..1383,1429..1431,1477..1488)
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    order(1417..1437,1477..1488)
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173623"
     misc_feature    1810..1812
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P41279.2); phosphorylation site"
     misc_feature    1810..1812
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01261"
     misc_feature    1849..1851
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01261"
     misc_feature    1939..1941
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P41279.2); phosphorylation site"
     variation       654
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372120772"
     variation       694
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150579938"
     variation       706
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139640494"
     variation       709
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374430565"
     variation       771
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77186746"
     variation       781
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150001848"
     variation       787
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117396201"
     variation       788
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146728212"
     variation       802
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377410996"
     variation       834
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:55962705"
     variation       840
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370656437"
     variation       842
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:549474"
     variation       846
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1042058"
     variation       855
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145696701"
     exon            949..1116
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       955
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368515552"
     variation       987
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112441933"
     variation       988
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201540136"
     variation       996
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375673139"
     variation       1014
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376205657"
     variation       1030
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201892819"
     variation       1048
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369295837"
     variation       1049
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143041571"
     variation       1053
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200843234"
     variation       1054
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3751449"
     variation       1084
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368789124"
     variation       1107
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143662794"
     exon            1117..1378
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       1126
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:151108315"
     variation       1169
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373057774"
     variation       1185
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201649487"
     variation       1199
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142650056"
     variation       1207
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146749791"
     variation       1242
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377297760"
     variation       1253
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3087944"
     exon            1379..1485
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       1443
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373977741"
     variation       1445
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139293295"
     exon            1486..1638
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       1503
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:66989210"
     variation       1527
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:8177062"
     variation       1560
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114464695"
     exon            1639..1885
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       1668
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:137991584"
     variation       1740
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149450278"
     variation       1741
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143874924"
     variation       1750
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368578451"
     variation       1761
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201275234"
     variation       1765
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77316331"
     variation       1781
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138733925"
     variation       1782
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141896473"
     variation       1787
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371438608"
     variation       1808
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:374373740"
     variation       1812
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146241749"
     variation       1834
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200350013"
     variation       1881
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139333853"
     exon            1886..3013
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /inference="alignment:Splign:1.39.8"
     variation       1892
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143676953"
     variation       1893
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150841663"
     variation       1897
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374109727"
     variation       1906
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375251313"
     variation       1908
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369517029"
     variation       1909
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145710720"
     variation       1924
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190610498"
     variation       1926
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372877014"
     variation       1950
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375876692"
     variation       1951
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139316352"
     variation       1956
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8177034"
     variation       1959
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368281659"
     variation       1970
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372679892"
     variation       1979
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376945200"
     variation       2053
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:76259773"
     STS             2068..2273
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /standard_name="SHGC-35244"
                     /db_xref="UniSTS:59219"
     variation       2146
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3034"
     variation       2154
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:181810063"
     variation       2155
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187247240"
     variation       2331
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191999092"
     variation       2397
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182628550"
     variation       2446..2447
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace=""
                     /replace="aa"
                     /db_xref="dbSNP:201417879"
     variation       2447..2448
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:143503665"
     variation       2447
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:8177035"
     variation       2534
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186978828"
     STS             2565..2872
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /standard_name="SHGC-78707"
                     /db_xref="UniSTS:95584"
     variation       2631..2632
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35579124"
     variation       2646
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3802631"
     variation       2693
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190217524"
     variation       2749
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369084396"
     variation       2846
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182807011"
     variation       2895
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8177036"
     variation       2908
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8177037"
     polyA_signal    2945..2950
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
     polyA_site      2969
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
     variation       2970
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8177038"
     variation       2975
                     /gene="MAP3K8"
                     /gene_synonym="c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8177039"
ORIGIN      
accctgcaaccgggcagtctctttctgtttacggagagaaaggggaaatggaaaagtcggggaggcggtggctggcgtccgctgcgccgcccctgggcaggctcagacgccgtgagtcaggggcagagcagggcggtctgagcgtgcgggcgacgcgggtctcactcgtccgctccgctctggactgcgcgccacgctctggggtccggcgccctggttcctgcttctgccgctgccgccgccggatcccagtggcccggcgtgctcggctcccacaggcctgcagccagcatcgcaccgaaccttcggggggccgcggctggagcgctcggccggcgtgggagcgccaaggccgcagatgcaatcttcttaccgcgaagaagccaggggaataggtagccacatcttgtttgcagataagaaaggaagctaacgcagtatctgcaaagccaggagtctgactcagtacttttctcactcatgcatacaaagcagctaaaaatgacacagcttatttaccatgcccctgacactgcactgagcactttatgagcttgaactctgttaatcctcacgaccacctcatgagactctccagaaagagcaacagtaatggagtacatgagcactggaagtgacaataaagaagagattgatttattaattaaacatttaaatgtgtctgatgtaatagacattatggaaaatctttatgcaagtgaagagccagcagtttatgaacccagtctaatgaccatgtgtcaagacagtaatcaaaacgatgagcgttctaagtctctgctgcttagtggccaagaggtaccatggttgtcatcagtcagatatggaactgtggaggatttgcttgcttttgcaaaccatatatccaacactgcaaagcatttttatggacaacgaccacaggaatctggaattttattaaacatggtcatcactccccaaaatggacgttaccaaatagattccgatgttctcctgatcccctggaagctgacttacaggaatattggttctgattttattcctcggggcgcctttggaaaggtatacttggcacaagatataaagacgaagaaaagaatggcgtgtaaactgatcccagtagatcaatttaagccatctgatgtggaaatccaggcttgcttccggcacgagaacatcgcagagctgtatggcgcagtcctgtggggtgaaactgtccatctctttatggaagcaggcgagggagggtctgttctggagaaactggagagctgtggaccaatgagagaatttgaaattatttgggtgacaaagcatgttctcaagggacttgattttctacactcaaagaaagtgatccatcatgatattaaacctagcaacattgttttcatgtccacaaaagctgttttggtggattttggcctaagtgttcaaatgaccgaagatgtctattttcctaaggacctccgaggaacagagatttacatgagcccagaggtcatcctgtgcaggggccattcaaccaaagcagacatctacagcctgggggccacgctcatccacatgcagacgggcaccccaccctgggtgaagcgctaccctcgctcagcctatccctcctacctgtacataatccacaagcaagcacctccactggaagacattgcagatgactgcagtccagggatgagagagctgatagaagcttccctggagagaaaccccaatcaccgcccaagagccgcagacctactaaaacatgaggccctgaacccgcccagagaggatcagccacgctgtcagagtctggactctgccctcttggagcgcaagaggctgctgagtaggaaggagctggaacttcctgagaacattgctgattcttcgtgcacaggaagcaccgaggaatctgagatgctcaagaggcaacgctctctctacatcgacctcggcgctctggctggctacttcaatcttgttcggggaccaccaacgcttgaatatggctgaaggatgccatgtttgctctaaattaagacagcattgatctcctggaggctggttctgctgcctctacacaggggccctgtacagtgaatggtgccattttcgaaggagcagtgtgacctcctgtgacccatgaatgtgcctccaagcggccctgtgtgtttgacatgtgaagctatttgatatgcaccaggtctcaaggttctcatttctcaggtgacgtgattctaaggcaggaatttgagagttcacagaaggatcgtgtctgctgactgtttcattcactgtgcactttgctcaaaattttaaaaataccaatcacaaggataatagagtagcctaaaattactattcttggttcttatttaagtatggaatattcattttactcagaatagctgttttgtgtatattggtgtatattatataactctttgagcctttattggtaaattctggtatacattgaattcattataatttgggtgactagaacaacttgaagattgtagcaataagctggactagtgtcctaaaaatggctaactgatgaattagaagccatctgacagcaggccactagtgacagtttcttttgtgttcctatggaaacattttatactgtacatgctatgctgaagacattcaaaacgtgatgttttgaatgtggataaaactgtgtaaaccacataatttttgtacatcccaaaggatgagaatgtgacctttaagaaaaatgaaaacttttgtaaattattgatgattttgtaattcttatgactaaattttcttttaagcatttgtatattaaaatagcatactgtgtatgttttatatcaaatgccttcatgaatctttcatacatatatatatttgtaacattgtaaagtatgtgagtagtcttatgtaaagtatgtttttacattatgcaaataaaacccaatacttttgtccaatgtggttggtcaaatcaactgaataaattcagtattttgcctta
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1326 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IEA
            GeneID:1326 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS
            GeneID:1326 -> Molecular function: GO:0004709 [MAP kinase kinase kinase activity] evidence: IEA
            GeneID:1326 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:1326 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:1326 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
            GeneID:1326 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:1326 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS
            GeneID:1326 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:1326 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005195 -> EC 2.7.11.25

by @meso_cacase at DBCLS
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