2024-03-30 00:30:40, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005166 2447 bp mRNA linear PRI 14-MAY-2013 DEFINITION Homo sapiens amyloid beta (A4) precursor-like protein 1 (APLP1), transcript variant 2, mRNA. ACCESSION NM_005166 VERSION NM_005166.3 GI:67782339 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2447) AUTHORS Baumkotter,F., Wagner,K., Eggert,S., Wild,K. and Kins,S. TITLE Structural aspects and physiological consequences of APP/APLP trans-dimerization JOURNAL Exp Brain Res 217 (3-4), 389-395 (2012) PUBMED 21952790 REMARK GeneRIF: [review] APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. Review article REFERENCE 2 (bases 1 to 2447) AUTHORS Lee,S., Xue,Y., Hu,J., Wang,Y., Liu,X., Demeler,B. and Ha,Y. TITLE The E2 domains of APP and APLP1 share a conserved mode of dimerization JOURNAL Biochemistry 50 (24), 5453-5464 (2011) PUBMED 21574595 REMARK GeneRIF: The 2.1 A resolution electron density map reveals phosphate ions that are bound to the protein surface. Mutational analysis shows that protein residues interacting with the phosphate ions are also involved in heparin binding. REFERENCE 3 (bases 1 to 2447) AUTHORS Radhakrishnan,K., Krieger,A., Dibue,M., Hescheler,J. and Schneider,T. TITLE APLP1 and Rab5A interact with the II-III loop of the voltage-gated Ca-channel Ca(v)2.3 and modulate its internalization differently JOURNAL Cell. Physiol. Biochem. 28 (4), 603-612 (2011) PUBMED 22178872 REMARK GeneRIF: APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel. REFERENCE 4 (bases 1 to 2447) AUTHORS Orcholski,M.E., Zhang,Q. and Bredesen,D.E. TITLE Signaling via amyloid precursor-like proteins APLP1 and APLP2 JOURNAL J. Alzheimers Dis. 23 (4), 689-699 (2011) PUBMED 21178287 REMARK GeneRIF: Both APLP1 and APLP2, form transcriptionally active triple protein complexes with Mint3 and transcriptional co-activators Taz andYap. REFERENCE 5 (bases 1 to 2447) AUTHORS Yanagida,K., Okochi,M., Tagami,S., Nakayama,T., Kodama,T.S., Nishitomi,K., Jiang,J., Mori,K., Tatsumi,S., Arai,T., Ikeuchi,T., Kasuga,K., Tokuda,T., Kondo,M., Ikeda,M., Deguchi,K., Kazui,H., Tanaka,T., Morihara,T., Hashimoto,R., Kudo,T., Steiner,H., Haass,C., Tsuchiya,K., Akiyama,H., Kuwano,R. and Takeda,M. TITLE The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system JOURNAL EMBO Mol Med 1 (4), 223-235 (2009) PUBMED 20049724 REMARK GeneRIF: Human cerebrospinal fluid contains three APLP1-derived Abeta-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM. REFERENCE 6 (bases 1 to 2447) AUTHORS Paliga,K., Peraus,G., Kreger,S., Durrwang,U., Hesse,L., Multhaup,G., Masters,C.L., Beyreuther,K. and Weidemann,A. TITLE Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid JOURNAL Eur. J. Biochem. 250 (2), 354-363 (1997) PUBMED 9428684 REFERENCE 7 (bases 1 to 2447) AUTHORS Bressler,S.L., Gray,M.D., Sopher,B.L., Hu,Q., Hearn,M.G., Pham,D.G., Dinulos,M.B., Fukuchi,K., Sisodia,S.S., Miller,M.A., Disteche,C.M. and Martin,G.M. TITLE cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein JOURNAL Hum. Mol. Genet. 5 (10), 1589-1598 (1996) PUBMED 8894693 REFERENCE 8 (bases 1 to 2447) AUTHORS Kim,T.W., Wu,K., Xu,J.L., McAuliffe,G., Tanzi,R.E., Wasco,W. and Black,I.B. TITLE Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density JOURNAL Brain Res. Mol. Brain Res. 32 (1), 36-44 (1995) PUBMED 7494461 REFERENCE 9 (bases 1 to 2447) AUTHORS Bush,A.I., Pettingell,W.H. Jr., de Paradis,M., Tanzi,R.E. and Wasco,W. TITLE The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily JOURNAL J. Biol. Chem. 269 (43), 26618-26621 (1994) PUBMED 7929392 REFERENCE 10 (bases 1 to 2447) AUTHORS Wasco,W., Brook,J.D. and Tanzi,R.E. TITLE The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19 JOURNAL Genomics 15 (1), 237-239 (1993) PUBMED 8432545 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AD000864.1, BC012889.1 and BQ219233.1. On Jun 15, 2005 this sequence version replaced gi:21361259. Summary: This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012889.1, U48437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082, ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-69 AD000864.1 3111-3179 70-2439 BC012889.1 1-2370 2440-2447 BQ219233.1 696-703 FEATURES Location/Qualifiers source 1..2447 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19q13.1" gene 1..2447 /gene="APLP1" /gene_synonym="APLP" /note="amyloid beta (A4) precursor-like protein 1" /db_xref="GeneID:333" /db_xref="HGNC:597" /db_xref="HPRD:00102" /db_xref="MIM:104775" exon 1..285 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" misc_feature 118..120 /gene="APLP1" /gene_synonym="APLP" /note="upstream in-frame stop codon" CDS 139..2091 /gene="APLP1" /gene_synonym="APLP" /note="isoform 2 precursor is encoded by transcript variant 2; amyloid-like protein 1; amyloid precursor-like protein 1; APLP-1" /codon_start=1 /product="amyloid-like protein 1 isoform 2 precursor" /protein_id="NP_005157.1" /db_xref="GI:4885065" /db_xref="GeneID:333" /db_xref="HGNC:597" /db_xref="HPRD:00102" /db_xref="MIM:104775" /translation="
MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
" sig_peptide 139..252 /gene="APLP1" /gene_synonym="APLP" /inference="COORDINATES: ab initio prediction:SignalP:4.0" mat_peptide 253..2088 /gene="APLP1" /gene_synonym="APLP" /product="amyloid-like protein 1 isoform 2" misc_feature 301..771 /gene="APLP1" /gene_synonym="APLP" /note="amyloid A4; Region: A4_EXTRA; smart00006" /db_xref="CDD:128326" misc_feature 301..600 /gene="APLP1" /gene_synonym="APLP" /note="Amyloid A4 N-terminal heparin-binding; Region: APP_N; pfam02177" /db_xref="CDD:190234" misc_feature 601..771 /gene="APLP1" /gene_synonym="APLP" /note="Copper-binding of amyloid precursor, CuBD; Region: APP_Cu_bd; pfam12924" /db_xref="CDD:193397" misc_feature 610..672 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Copper-binding (By similarity)" misc_feature 637..639 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="Required for Cu(2+) reduction (By similarity); propagated from UniProtKB/Swiss-Prot (P51693.3); other site" misc_feature 748..771 /gene="APLP1" /gene_synonym="APLP" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Zinc-binding" misc_feature 988..1542 /gene="APLP1" /gene_synonym="APLP" /note="E2 domain of amyloid precursor protein; Region: APP_E2; pfam12925" /db_xref="CDD:205150" misc_feature 991..1053 /gene="APLP1" /gene_synonym="APLP" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: O-glycosylated at three sites" misc_feature 1066..1164 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Heparin-binding (By similarity)" misc_feature 1147..1149 /gene="APLP1" /gene_synonym="APLP" /experiment="experimental evidence, no additional details recorded" /note="glycosylation site" /citation=[6] misc_feature 1366..1461 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Heparin-binding (By similarity)" misc_feature 1462..1515 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Collagen-binding (By similarity)" misc_feature 1519..1521 /gene="APLP1" /gene_synonym="APLP" /experiment="experimental evidence, no additional details recorded" /note="glycosylation site" /citation=[6] misc_feature 1789..1791 /gene="APLP1" /gene_synonym="APLP" /experiment="experimental evidence, no additional details recorded" /note="glycosylation site" /citation=[6] misc_feature 1879..1947 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); transmembrane region" misc_feature 1918..2079 /gene="APLP1" /gene_synonym="APLP" /note="beta-amyloid precursor protein C-terminus; Region: APP_amyloid; pfam10515" /db_xref="CDD:151071" misc_feature 1948..1983 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Basolateral sorting signal (By similarity)" misc_feature 1996..2001 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="Cleavage, by caspase-3 (By similarity); propagated from UniProtKB/Swiss-Prot (P51693.3); cleavage site" mat_peptide 1999..2088 /gene="APLP1" /gene_synonym="APLP" /product="C30 (By similarity)" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3)" misc_feature 2032..2085 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Interaction with DAB1 (By similarity)" misc_feature 2044..2088 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Interaction with DAB2 (By similarity)" misc_feature 2056..2067 /gene="APLP1" /gene_synonym="APLP" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: Clathrin-binding (Potential)" misc_feature 2056..2067 /gene="APLP1" /gene_synonym="APLP" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P51693.3); Region: NPXY motif, contains endocytosis signal" variation 148 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:7249156" variation 155 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:11551001" variation 176 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:11550995" variation 193 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:113170155" variation 216 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:11550997" variation 250 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:11550999" exon 286..429 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 293 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:150327956" variation 312 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:11550994" variation 318 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:184150635" variation 327 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:368919721" variation 354 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:137921081" variation 356 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:142353985" variation 357 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:145927014" variation 361 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:139993081" variation 363 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:11551003" variation 383 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:201483792" variation 395 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:373971997" variation 397 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:375934057" variation 399 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:369825983" variation 401 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:11550996" exon 430..562 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 441 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:77209402" variation 454 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:144561889" variation 471 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:148450806" variation 506 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:376121334" variation 509 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:11550998" variation 562 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:202136254" exon 563..675 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 578 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:142596936" variation 584 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:200445460" variation 586 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:11551002" variation 589 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:373926480" variation 608 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:375779576" variation 618 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:369636374" variation 652 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:374105478" variation 656 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:370615323" variation 661 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:11551000" exon 676..809 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 699 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:376987069" variation 710 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:199660121" variation 711 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:111419351" variation 734 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:370111912" variation 735 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:201024631" variation 740 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:147904649" variation 741 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:139935642" variation 745 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:375567499" variation 781 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="t" /db_xref="dbSNP:145389825" variation 786 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:147667410" variation 794 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:142658251" variation 803 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:200704183" exon 810..988 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 811 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:150267124" variation 813 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:371660334" variation 823 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:375123845" variation 832 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:369442773" variation 836 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:367773519" variation 837 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:188024320" variation 842 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:145848376" variation 864 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:148987065" variation 884 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:79518176" variation 887 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:371298427" variation 917 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:376813918" variation 921 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:369846598" variation 945 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:200756165" variation 948 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:112608328" variation 952 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:372531049" variation 958 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:369421258" variation 969 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="t" /db_xref="dbSNP:373409117" variation 976 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:143738110" variation 982 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:199883121" exon 989..1119 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1001 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:377568407" variation 1060 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:371008485" variation 1064 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:11550993" variation 1074 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:230261" variation 1086 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:150106545" variation 1097 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:183994174" exon 1120..1194 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1140 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:373682820" variation 1154 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:144628787" variation 1155 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:138515969" variation 1181 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:200932079" exon 1195..1353 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1205 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:376217167" variation 1207 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:369275539" variation 1235 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:201351812" variation 1236 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:200399471" variation 1254 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:377257982" variation 1275 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:201787220" variation 1304 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:141378715" variation 1345 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:150801773" exon 1354..1482 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1355 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:368817415" variation 1356 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:139176114" variation 1359 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:201735866" variation 1378 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:149513227" variation 1381 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:200771936" variation 1390 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:376367676" variation 1395 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:2228998" variation 1420 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:3907232" variation 1434 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:374217287" variation 1437 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="t" /db_xref="dbSNP:149296980" variation 1447 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:35358477" variation 1474 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:367756339" exon 1483..1582 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1488 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:145426865" variation 1523 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:199987390" variation 1536 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:368465916" variation 1571 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:200760118" variation 1573 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:35586905" variation 1582 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:372591248" exon 1583..1690 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1593 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:148721665" variation 1651 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:142258705" variation 1671 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:373063120" exon 1691..1714 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1700 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="t" /db_xref="dbSNP:199626325" exon 1715..1785 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1718 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:374833360" variation 1765 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:151326608" variation 1781 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:368942763" exon 1786..1848 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1803 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:140582408" STS 1829..1901 /gene="APLP1" /gene_synonym="APLP" /standard_name="D1S357E" /db_xref="UniSTS:473117" exon 1849..1992 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 1858 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:144442676" variation 1878 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:371465275" variation 1884 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:2227909" variation 1896 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:368985958" variation 1911 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:376643850" variation 1916 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:140931671" variation 1949 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:369697025" variation 1955 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:144655560" variation 1965 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:138562956" variation 1968 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:148829251" variation 1976 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:143425453" variation 1983 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:374079392" variation 1984 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:148071646" exon 1993..2447 /gene="APLP1" /gene_synonym="APLP" /inference="alignment:Splign:1.39.8" variation 2001 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:188827215" variation 2002 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:141786487" variation 2032 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:147200750" variation 2046 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:368214878" STS 2070..2255 /gene="APLP1" /gene_synonym="APLP" /standard_name="RH66352" /db_xref="UniSTS:6834" variation 2083 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:373885022" variation 2092 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="c" /db_xref="dbSNP:138812813" variation 2100 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:2871778" variation 2129..2130 /gene="APLP1" /gene_synonym="APLP" /replace="" /replace="c" /db_xref="dbSNP:142204084" variation 2157..2158 /gene="APLP1" /gene_synonym="APLP" /replace="" /replace="a" /db_xref="dbSNP:35497017" variation 2181 /gene="APLP1" /gene_synonym="APLP" /replace="g" /replace="t" /db_xref="dbSNP:376060353" STS 2198..2408 /gene="APLP1" /gene_synonym="APLP" /standard_name="HSC0VF102" /db_xref="UniSTS:53563" STS 2214..2413 /gene="APLP1" /gene_synonym="APLP" /standard_name="SHGC-4198" /db_xref="UniSTS:62626" STS 2232..2432 /gene="APLP1" /gene_synonym="APLP" /standard_name="D19S237E" /db_xref="UniSTS:44617" STS 2296..2408 /gene="APLP1" /gene_synonym="APLP" /standard_name="D19S237E" /db_xref="UniSTS:147416" variation 2317..2320 /gene="APLP1" /gene_synonym="APLP" /replace="" /replace="attt" /db_xref="dbSNP:143741403" variation 2352 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="t" /db_xref="dbSNP:192826888" variation 2372 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="g" /db_xref="dbSNP:114782076" variation 2378 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="g" /db_xref="dbSNP:148319278" variation 2394 /gene="APLP1" /gene_synonym="APLP" /replace="c" /replace="t" /db_xref="dbSNP:1802912" polyA_signal 2421..2426 /gene="APLP1" /gene_synonym="APLP" variation 2438 /gene="APLP1" /gene_synonym="APLP" /replace="a" /replace="t" /db_xref="dbSNP:113053391" polyA_site 2442 /gene="APLP1" /gene_synonym="APLP" polyA_site 2447 /gene="APLP1" /gene_synonym="APLP" ORIGIN
ggggcggggctggcggcgccggcgcagcccgggggcggcgggaggaggaggtggcggcggtggcgctgggagctcctgtcaccgctggggccgggccgggcgggagtgcaggggacgtgagggcgcaagggccgggacatggggcccgccagccccgctgctcgcggtctaagtcgccgcccgggccagccgccgctgccgctgctgctgccactattgctgctgcttctgcgcgcgcagcccgccatcgggagcctggccggtgggagccccggcgcggccgaggccccggggtcggcccaggtggctggactatgcgggcgcctaacccttcaccgggacctgcgcaccggccgctgggaaccagacccacagcgctctcgacgctgtctccgggacccgcagcgcgtgctggagtactgcagacagatgtacccggagctgcagattgcacgtgtggagcaggctacgcaggccatccccatggagcgctggtgcgggggttcccggagcggcagctgcgcccacccccaccaccaggttgtgcccttccgctgcctgcctggtgaatttgtgagtgaggccctgctggtgcctgaaggctgccggttcttgcaccaggagcgcatggaccaatgtgagagttcaacccggaggcatcaggaggcacaggaggcctgcagctcccagggcctcatcctgcacggctcgggcatgctcttaccctgtggctcggatcggttccgtggtgtggagtatgtgtgctgtccccctccagggacccccgacccatctgggacagcagttggtgacccctccacccggtcctggcccccggggagcagagtagagggggctgaggacgaggaagaggaggaatccttcccacagccagtagatgattacttcgtggagcctccgcaggctgaagaggaagaggaaacggtcccacccccaagctcccatacacttgcagtggtcggcaaagtcactcccaccccgaggcccacagacggtgtggatatttactttggcatgcctggggaaatcagtgagcacgaggggttcctgagggccaagatggacctggaggagcgtaggatgcgccagattaatgaggtgatgcgtgaatgggccatggcagacaaccagtccaagaacctgcctaaagccgacagacaggccctgaatgagcacttccagtccattctgcagactctggaggagcaggtgtctggtgagcgacagcgcctggtggaaacccacgccacccgcgtcatcgcccttatcaacgaccagcgccgggctgccttggagggcttcctggcagccctgcaggcagatccgcctcaggcggagcgtgtcctgttggccctgcggcgctacctgcgtgcggagcagaaggaacagaggcacacgctgcgccactaccagcatgtggccgccgtggatcccgagaaggcacagcagatgcgcttccaggtgcatacccaccttcaagtgattgaggagagggtgaatcagagcctgggcctgcttgaccagaacccccacctggctcaggagctgcggccccaaatccaggaactcctccactctgaacacctgggtcccagtgaattggaagcccctgcccctgggggcagcagcgaggacaagggtgggctgcagcctccagattccaaggatgacacccccatgacccttccaaaagggtccacagaacaagatgctgcatcccctgagaaagagaagatgaacccgctggaacagtatgagcgaaaggtgaatgcgtctgttccaaggggtttccctttccactcatcggagattcagagggatgagctggcaccagctgggacaggggtgtcccgtgaggctgtgtcgggtctgctgatcatgggagcgggcggaggctccctcatcgtcctctccatgctgctcctgcgcaggaagaagccctacggggctatcagccatggcgtggtggaggtggaccccatgctgaccctggaggagcagcagctccgcgaactgcagcggcacggctatgagaaccccacttaccgcttcctggaggaacgaccctgacccggcccccttcaccccttcagccgagcccagacctcccctcttcctggagccccagaaccccaactcccagcctagggcagcagggagtcttgaagtgatcatttcacacccttttgtgagacggctggaaattcttatttcccctttccaattccaaaattccatccctaagaattcccagatagtcccagcagcctccccacgtggcacctcctcaccttaatttattttttaagtttatttatggctctttaaggtgaccgccaccttggtcctagtgtctattccctggaattcaccctctcatgtttccctactaacatcccaataaagtcctcttccctaccaggcca
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:333 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:333 -> Molecular function: GO:0008201 [heparin binding] evidence: IEA GeneID:333 -> Molecular function: GO:0031694 [alpha-2A adrenergic receptor binding] evidence: IPI GeneID:333 -> Molecular function: GO:0031695 [alpha-2B adrenergic receptor binding] evidence: IPI GeneID:333 -> Molecular function: GO:0031696 [alpha-2C adrenergic receptor binding] evidence: IPI GeneID:333 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:333 -> Molecular function: GO:0046914 [transition metal ion binding] evidence: IEA GeneID:333 -> Biological process: GO:0006378 [mRNA polyadenylation] evidence: IEA GeneID:333 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA GeneID:333 -> Biological process: GO:0006897 [endocytosis] evidence: IEA GeneID:333 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:333 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA GeneID:333 -> Biological process: GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] evidence: IC GeneID:333 -> Biological process: GO:0007399 [nervous system development] evidence: TAS GeneID:333 -> Biological process: GO:0009887 [organ morphogenesis] evidence: TAS GeneID:333 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA GeneID:333 -> Biological process: GO:0030818 [negative regulation of cAMP biosynthetic process] evidence: IDA GeneID:333 -> Biological process: GO:0030900 [forebrain development] evidence: IEA GeneID:333 -> Biological process: GO:0071874 [cellular response to norepinephrine stimulus] evidence: IDA GeneID:333 -> Cellular component: GO:0005604 [basement membrane] evidence: TAS GeneID:333 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA GeneID:333 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:333 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA GeneID:333 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
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