2024-04-27 02:04:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005163 3008 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1), transcript variant 1, mRNA. ACCESSION NM_005163 VERSION NM_005163.2 GI:62241010 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3008) AUTHORS Meng,Z.X., Li,S., Wang,L., Ko,H.J., Lee,Y., Jung,D.Y., Okutsu,M., Yan,Z., Kim,J.K. and Lin,J.D. TITLE Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation JOURNAL Nat. Med. 19 (5), 640-645 (2013) PUBMED 23563706 REMARK GeneRIF: Deptor is induced by the Baf60c-Six4 transcriptional complex and mediates activation of Akt and glycolytic metabolism by Baf60c in a cell-autonomous manner REFERENCE 2 (bases 1 to 3008) AUTHORS Riaz,A., Ilan,N., Vlodavsky,I., Li,J.P. and Johansson,S. TITLE Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence JOURNAL J. Biol. Chem. 288 (17), 12366-12375 (2013) PUBMED 23504323 REMARK GeneRIF: Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence. REFERENCE 3 (bases 1 to 3008) AUTHORS Farrer,R.G., Farrer,J.R. and DeVries,G.H. TITLE Platelet-derived growth factor-BB activates calcium/calmodulin-dependent and -independent mechanisms that mediate Akt phosphorylation in the neurofibromin-deficient human Schwann cell line ST88-14 JOURNAL J. Biol. Chem. 288 (16), 11066-11073 (2013) PUBMED 23457304 REMARK GeneRIF: the activation of the calcium/CaM/Akt pathway resulting from stimulation of overexpressed PDGF receptor-beta may contribute to the survival and tumorigenicity of MPNST cells. REFERENCE 4 (bases 1 to 3008) AUTHORS Novellasdemunt,L., Tato,I., Navarro-Sabate,A., Ruiz-Meana,M., Mendez-Lucas,A., Perales,J.C., Garcia-Dorado,D., Ventura,F., Bartrons,R. and Rosa,J.L. TITLE Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids JOURNAL J. Biol. Chem. 288 (15), 10640-10651 (2013) PUBMED 23457334 REMARK GeneRIF: amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked. REFERENCE 5 (bases 1 to 3008) AUTHORS Read,R.D., Fenton,T.R., Gomez,G.G., Wykosky,J., Vandenberg,S.R., Babic,I., Iwanami,A., Yang,H., Cavenee,W.K., Mischel,P.S., Furnari,F.B. and Thomas,J.B. TITLE A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma JOURNAL PLoS Genet. 9 (2), E1003253 (2013) PUBMED 23459592 REMARK GeneRIF: These results imply that, in glioblastoma cells, constitutive Akt signaling drives RIO kinase overexpression, which creates a feedforward loop that promotes and maintains oncogenic Akt activity through stimulation of mTor signaling REFERENCE 6 (bases 1 to 3008) AUTHORS Coffer,P.J. and Woodgett,J.R. TITLE Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families JOURNAL Eur. J. Biochem. 205 (3), 1217 (1992) PUBMED 1533586 REMARK Correction to:[Eur J Biochem. 1991 Oct 15;201(2):475-81. PMID: 1718748] REFERENCE 7 (bases 1 to 3008) AUTHORS Coffer,P.J. and Woodgett,J.R. TITLE Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families JOURNAL Eur. J. Biochem. 201 (2), 475-481 (1991) PUBMED 1718748 REMARK Erratum:[Eur J Biochem. 1992 May 1;205(3):1217. PMID: 1533586] REFERENCE 8 (bases 1 to 3008) AUTHORS Jones,P.F., Jakubowicz,T., Pitossi,F.J., Maurer,F. and Hemmings,B.A. TITLE Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (10), 4171-4175 (1991) PUBMED 1851997 REFERENCE 9 (bases 1 to 3008) AUTHORS Staal,S.P., Huebner,K., Croce,C.M., Parsa,N.Z. and Testa,J.R. TITLE The AKT1 proto-oncogene maps to human chromosome 14, band q32 JOURNAL Genomics 2 (1), 96-98 (1988) PUBMED 3384441 REFERENCE 10 (bases 1 to 3008) AUTHORS Staal,S.P. TITLE Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (14), 5034-5037 (1987) PUBMED 3037531 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK122894.1 and BC000479.2. This sequence is a reference standard in the RefSeqGene project. On Apr 6, 2005 this sequence version replaced gi:4885060. Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]. Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK122894.1, M63167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-996 AK122894.1 928-1923 997-3008 BC000479.2 718-2729 FEATURES Location/Qualifiers source 1..3008 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="14" /map="14q32.32" gene 1..3008 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="v-akt murine thymoma viral oncogene homolog 1" /db_xref="GeneID:207" /db_xref="HGNC:391" /db_xref="MIM:164730" exon 1..475 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 205 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="g" /replace="t" /db_xref="dbSNP:1130214" exon 476..600 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 509 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="g" /db_xref="dbSNP:34790457" variation 510 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="g" /db_xref="dbSNP:34757714" misc_feature 516..518 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="upstream in-frame stop codon" variation 547 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:28730786" CDS 555..1997 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /EC_number="2.7.11.1" /note="rac protein kinase alpha; RAC-PK-alpha; proto-oncogene c-Akt; PKB alpha; protein kinase B alpha" /codon_start=1 /product="RAC-alpha serine/threonine-protein kinase" /protein_id="NP_005154.2" /db_xref="GI:62241011" /db_xref="CCDS:CCDS9994.1" /db_xref="GeneID:207" /db_xref="HGNC:391" /db_xref="MIM:164730" /translation="
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
" misc_feature 570..875 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="Akt pleckstrin homology (PH) domain; Region: PH_Akt; cd01241" /db_xref="CDD:176317" misc_feature order(594..596,600..602,621..623,627..635) /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="putative phosphoinositide binding site [chemical binding]; other site" /db_xref="CDD:176317" misc_feature 594..611 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P31749.2); Region: Inositol-(1,3,4,5)-tetrakisphosphate binding" misc_feature 594..596 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P31749.2); acetylation site" misc_feature 612..614 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P31749.2); acetylation site" misc_feature 621..629 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P31749.2); Region: Inositol-(1,3,4,5)-tetrakisphosphate binding" misc_feature 924..926 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 924..926 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 930..932 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, alternate; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 930..932 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 939..941 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, alternate; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 939..941 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1002..1778 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature 1014..1985 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="Catalytic domain of the Protein Serine/Threonine Kinase, Protein Kinase B; Region: STKc_PKB; cd05571" /db_xref="CDD:173662" misc_feature order(1020..1025,1029..1034,1044..1046,1083..1085, 1089..1091,1125..1127,1134..1136,1185..1187,1233..1244, 1254..1256,1260..1262,1272..1274,1374..1376,1380..1382, 1386..1391,1395..1397,1425..1430,1437..1439,1479..1502, 1575..1577,1593..1595,1602..1604,1866..1868,1878..1880) /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="active site" /db_xref="CDD:173662" misc_feature order(1020..1025,1029..1031,1044..1046,1083..1085, 1089..1091,1185..1187,1233..1244,1254..1256,1374..1376, 1380..1382,1386..1391,1395..1397,1425..1430,1866..1868) /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173662" misc_feature order(1032..1034,1125..1127,1134..1136,1254..1256, 1260..1262,1272..1274,1374..1376,1380..1382,1386..1388, 1437..1439,1479..1502,1575..1577,1593..1595,1602..1604, 1878..1880) /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173662" misc_feature 1080..1082 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine, by TNK2; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 1236..1244 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P31749.2); Region: Inhibitor binding" misc_feature 1425..1496 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="activation loop (A-loop); other site" /db_xref="CDD:173662" misc_feature 1476..1478 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="dephosphorylation site; modified site" /db_xref="HPRD:08912" misc_feature 1476..1478 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by PDPK1; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 1476..1478 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:03954" misc_feature 1476..1478 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:05556" misc_feature 1476..1478 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:13000" misc_feature 1476..1478 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1497..1499 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:01819" misc_feature 1530..1532 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:01819" misc_feature 1902..1904 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="turn motif phosphorylation site [posttranslational modification]; other site" /db_xref="CDD:173662" misc_feature 1902..1904 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1938..1940 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:02799" misc_feature 1959..1976 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /note="hydrophobic motif (HM); other site" /db_xref="CDD:173662" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="dephosphorylation site; modified site" /db_xref="HPRD:08912" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by MTOR, alternate; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:03842" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:03954" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:05556" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1971..1973 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /db_xref="HPRD:15245" misc_feature 1974..1976 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine; propagated from UniProtKB/Swiss-Prot (P31749.2); phosphorylation site" misc_feature 1974..1976 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 601..729 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 681 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:11555436" exon 730..841 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" exon 842..989 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 986 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:17846825" exon 990..1121 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 1054 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:11555433" exon 1122..1187 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 1154 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:61761191" variation 1158 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:2230506" exon 1188..1256 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" exon 1257..1382 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 1280 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="g" /db_xref="dbSNP:1130233" variation 1364 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="g" /db_xref="dbSNP:2230508" exon 1383..1511 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" STS 1408..1488 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /standard_name="PMC15397P1" /db_xref="UniSTS:271279" variation 1505 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="c" /db_xref="dbSNP:17846831" exon 1512..1726 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 1624 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:11555432" variation 1716 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="c" /db_xref="dbSNP:11555431" exon 1727..1814 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 1733 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:11555434" exon 1815..1917 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" exon 1918..2989 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /inference="alignment:Splign:1.39.8" variation 1935 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="g" /replace="t" /db_xref="dbSNP:11555435" variation 2046 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="g" /db_xref="dbSNP:11555430" variation 2107 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:17846821" variation 2118 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:17846826" variation 2246 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="g" /db_xref="dbSNP:61761249" variation 2265 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:34558581" variation 2320 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:1130245" variation 2365 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="c" /db_xref="dbSNP:34865723" variation 2388 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="g" /replace="t" /db_xref="dbSNP:35416681" STS 2506..2763 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /standard_name="RH69160" /db_xref="UniSTS:12879" variation 2542 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="g" /replace="t" /db_xref="dbSNP:1804268" variation 2551 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:1130295" variation 2701 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:1130443" STS 2706..2828 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /standard_name="RH101916" /db_xref="UniSTS:96251" STS 2742..2971 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /standard_name="STS-AA041305" /db_xref="UniSTS:79362" variation 2783..2784 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="" /replace="ttgaccttttcgac" /replace="ttgacctttttgac" /db_xref="dbSNP:3840005" STS 2811..2966 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /standard_name="RH47592" /db_xref="UniSTS:42837" variation 2815 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:3803305" variation 2850 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:17846828" variation 2857 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="a" /replace="g" /db_xref="dbSNP:17846829" variation 2966 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" /replace="c" /replace="t" /db_xref="dbSNP:1130526" polyA_signal 2970..2975 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" polyA_site 2989 /gene="AKT1" /gene_synonym="AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA" ORIGIN
taattatgggtctgtaaccaccctggactgggtgctcctcactgacggacttgtctgaacctctctttgtctccagcgcccagcactgggcctggcaaaacctgagacgcccggtacatgttggccaaatgaatgaaccagattcagaccggcaggggcgctgtggtttaggaggggcctggggtttctcccaggaggtttttgggcttgcgctggagggctctggactcccgtttgcgccagtggcctgcatcctggtcctgtcttcctcatgtttgaatttctttgctttcctagtctggggagcagggaggagccctgtgccctgtcccaggatccatgggtaggaacaccatggacagggagagcaaacggggccatctgtcaccaggggcttagggaaggccgagccagcctgggtcaaagaagtcaaaggggctgcctggaggaggcagcctgtcagctggtgcatcagaggctgtggccaggccagctgggctcggggagcgccagcctgagaggagcgcgtgagcgtcgcgggagcctcgggcaccatgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaagacctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggagcggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgccagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtggaccactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggacaaccgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttccggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaagcccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcactttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatcctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgcgtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccacgaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcccgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagccctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctcatgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatcaaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtgctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtacgagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctcatcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctttcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaaggagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaagctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgaggagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgtgtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcctgaggcggcggtggactgcgctggacgatagcttggagggatggagaggcggcctcgtgccatgatctgtatttaatggtttttatttctcgggtgcatttgagagaagccacgctgtcctctcgagcccagatggaaagacgtttttgtgctgtgggcagcaccctcccccgcagcggggtagggaagaaaactatcctgcgggttttaatttatttcatccagtttgttctccgggtgtggcctcagccctcagaacaatccgattcacgtagggaaatgttaaggacttctgcagctatgcgcaatgtggcattggggggccgggcaggtcctgcccatgtgtcccctcactctgtcagccagccgccctgggctgtctgtcaccagctatctgtcatctctctggggccctgggcctcagttcaacctggtggcaccagatgcaacctcactatggtatgctggccagcaccctctcctgggggtggcaggcacacagcagccccccagcactaaggccgtgtctctgaggacgtcatcggaggctgggcccctgggatgggaccagggatgggggatgggccagggtttacccagtgggacagaggagcaaggtttaaatttgttattgtgtattatgttgttcaaatgcattttgggggtttttaatctttgtgacaggaaagccctcccccttccccttctgtgtcacagttcttggtgactgtcccaccgggagcctccccctcagatgatctctccacggtagcacttgaccttttcgacgcttaacctttccgctgtcgccccaggccctccctgactccctgtgggggtggccatccctgggcccctccacgcctcctggccagacgctgccgctgccgctgcaccacggcgtttttttacaacattcaactttagtatttttactattataatataatatggaaccttccctccaaattcttcaataaaagttgcttttcaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:207 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS GeneID:207 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:207 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: TAS GeneID:207 -> Molecular function: GO:0005080 [protein kinase C binding] evidence: IEA GeneID:207 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:207 -> Molecular function: GO:0005524 [ATP binding] evidence: IC GeneID:207 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA GeneID:207 -> Molecular function: GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] evidence: IDA GeneID:207 -> Molecular function: GO:0016301 [kinase activity] evidence: IDA GeneID:207 -> Molecular function: GO:0019899 [enzyme binding] evidence: ISS GeneID:207 -> Molecular function: GO:0030235 [nitric-oxide synthase regulator activity] evidence: IMP GeneID:207 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:207 -> Molecular function: GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] evidence: IDA GeneID:207 -> Molecular function: GO:0071889 [14-3-3 protein binding] evidence: IPI GeneID:207 -> Biological process: GO:0000060 [protein import into nucleus, translocation] evidence: IMP GeneID:207 -> Biological process: GO:0001649 [osteoblast differentiation] evidence: IEA GeneID:207 -> Biological process: GO:0001893 [maternal placenta development] evidence: IEA GeneID:207 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IDA GeneID:207 -> Biological process: GO:0005978 [glycogen biosynthetic process] evidence: IEA GeneID:207 -> Biological process: GO:0005979 [regulation of glycogen biosynthetic process] evidence: IMP GeneID:207 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA GeneID:207 -> Biological process: GO:0006412 [translation] evidence: IEA GeneID:207 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA GeneID:207 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS GeneID:207 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA GeneID:207 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: IMP GeneID:207 -> Biological process: GO:0006469 [negative regulation of protein kinase activity] evidence: ISS GeneID:207 -> Biological process: GO:0006809 [nitric oxide biosynthetic process] evidence: TAS GeneID:207 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:207 -> Biological process: GO:0006924 [activation-induced cell death of T cells] evidence: IMP GeneID:207 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA GeneID:207 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:207 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:0007281 [germ cell development] evidence: IEA GeneID:207 -> Biological process: GO:0007568 [aging] evidence: IEA GeneID:207 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS GeneID:207 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS GeneID:207 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: IMP GeneID:207 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:0008637 [apoptotic mitochondrial changes] evidence: IEA GeneID:207 -> Biological process: GO:0009408 [response to heat] evidence: TAS GeneID:207 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:207 -> Biological process: GO:0010507 [negative regulation of autophagy] evidence: IMP GeneID:207 -> Biological process: GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] evidence: IMP GeneID:207 -> Biological process: GO:0010765 [positive regulation of sodium ion transport] evidence: IEA GeneID:207 -> Biological process: GO:0010907 [positive regulation of glucose metabolic process] evidence: IMP GeneID:207 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: IMP GeneID:207 -> Biological process: GO:0010975 [regulation of neuron projection development] evidence: ISS GeneID:207 -> Biological process: GO:0015758 [glucose transport] evidence: IEA GeneID:207 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS GeneID:207 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:207 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:207 -> Biological process: GO:0016310 [phosphorylation] evidence: IDA GeneID:207 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IEA GeneID:207 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA GeneID:207 -> Biological process: GO:0030030 [cell projection organization] evidence: IEA GeneID:207 -> Biological process: GO:0030154 [cell differentiation] evidence: TAS GeneID:207 -> Biological process: GO:0030163 [protein catabolic process] evidence: IEA GeneID:207 -> Biological process: GO:0030168 [platelet activation] evidence: TAS GeneID:207 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IDA GeneID:207 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IMP GeneID:207 -> Biological process: GO:0030334 [regulation of cell migration] evidence: TAS GeneID:207 -> Biological process: GO:0031018 [endocrine pancreas development] evidence: TAS GeneID:207 -> Biological process: GO:0031295 [T cell costimulation] evidence: TAS GeneID:207 -> Biological process: GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] evidence: IDA GeneID:207 -> Biological process: GO:0031999 [negative regulation of fatty acid beta-oxidation] evidence: IMP GeneID:207 -> Biological process: GO:0032094 [response to food] evidence: IEA GeneID:207 -> Biological process: GO:0032270 [positive regulation of cellular protein metabolic process] evidence: ISS GeneID:207 -> Biological process: GO:0032287 [peripheral nervous system myelin maintenance] evidence: IEA GeneID:207 -> Biological process: GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] evidence: IEA GeneID:207 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP GeneID:207 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: ISS GeneID:207 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IDA GeneID:207 -> Biological process: GO:0034405 [response to fluid shear stress] evidence: IMP GeneID:207 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: IDA GeneID:207 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:0042593 [glucose homeostasis] evidence: IEA GeneID:207 -> Biological process: GO:0042640 [anagen] evidence: IEA GeneID:207 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA GeneID:207 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA GeneID:207 -> Biological process: GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: ISS GeneID:207 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IEA GeneID:207 -> Biological process: GO:0043536 [positive regulation of blood vessel endothelial cell migration] evidence: IDA GeneID:207 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:207 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:207 -> Biological process: GO:0045429 [positive regulation of nitric oxide biosynthetic process] evidence: IMP GeneID:207 -> Biological process: GO:0045600 [positive regulation of fat cell differentiation] evidence: IMP GeneID:207 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: IMP GeneID:207 -> Biological process: GO:0045725 [positive regulation of glycogen biosynthetic process] evidence: NAS GeneID:207 -> Biological process: GO:0045792 [negative regulation of cell size] evidence: IEA GeneID:207 -> Biological process: GO:0045861 [negative regulation of proteolysis] evidence: IMP GeneID:207 -> Biological process: GO:0045907 [positive regulation of vasoconstriction] evidence: IEA GeneID:207 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA GeneID:207 -> Biological process: GO:0046209 [nitric oxide metabolic process] evidence: TAS GeneID:207 -> Biological process: GO:0046326 [positive regulation of glucose import] evidence: IMP GeneID:207 -> Biological process: GO:0046329 [negative regulation of JNK cascade] evidence: IEA GeneID:207 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: TAS GeneID:207 -> Biological process: GO:0046889 [positive regulation of lipid biosynthetic process] evidence: IMP GeneID:207 -> Biological process: GO:0048009 [insulin-like growth factor receptor signaling pathway] evidence: IMP GeneID:207 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS GeneID:207 -> Biological process: GO:0050999 [regulation of nitric-oxide synthase activity] evidence: TAS GeneID:207 -> Biological process: GO:0051000 [positive regulation of nitric-oxide synthase activity] evidence: IMP GeneID:207 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IDA GeneID:207 -> Biological process: GO:0051146 [striated muscle cell differentiation] evidence: IEA GeneID:207 -> Biological process: GO:0060644 [mammary gland epithelial cell differentiation] evidence: TAS GeneID:207 -> Biological process: GO:0060709 [glycogen cell differentiation involved in embryonic placenta development] evidence: IEA GeneID:207 -> Biological process: GO:0060716 [labyrinthine layer blood vessel development] evidence: IEA GeneID:207 -> Biological process: GO:0070141 [response to UV-A] evidence: IDA GeneID:207 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA GeneID:207 -> Biological process: GO:0071456 [cellular response to hypoxia] evidence: IEA GeneID:207 -> Biological process: GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] evidence: IMP GeneID:207 -> Biological process: GO:0090201 [negative regulation of release of cytochrome c from mitochondria] evidence: ISS GeneID:207 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:207 -> Biological process: GO:1901976 [regulation of cell cycle checkpoint] evidence: TAS GeneID:207 -> Biological process: GO:1902176 [negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress] evidence: NAS GeneID:207 -> Biological process: GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS GeneID:207 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:207 -> Cellular component: GO:0005634 [nucleus] evidence: TAS GeneID:207 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:207 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:207 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS GeneID:207 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS GeneID:207 -> Cellular component: GO:0005819 [spindle] evidence: IEA GeneID:207 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:207 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:207 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:207 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:207 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IDA GeneID:207 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_005154 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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