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2024-04-26 07:44:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005109 4525 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens oxidative stress responsive 1 (OXSR1), mRNA.
ACCESSION NM_005109
VERSION NM_005109.2 GI:75709206
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4525)
AUTHORS Ponce-Coria,J., Gagnon,K.B. and Delpire,E.
TITLE Calcium-binding protein 39 facilitates molecular interaction
between Ste20p proline alanine-rich kinase and oxidative stress
response 1 monomers
JOURNAL Am. J. Physiol., Cell Physiol. 303 (11), C1198-C1205 (2012)
PUBMED 23034389
REMARK GeneRIF: SPAK and OSR1, which are often coexpressed in cells, can
form functional heterodimers.
REFERENCE 2 (bases 1 to 4525)
AUTHORS Sengupta,S., Tu,S.W., Wedin,K., Earnest,S., Stippec,S.,
Luby-Phelps,K. and Cobb,M.H.
TITLE Interactions with WNK (with no lysine) family members regulate
oxidative stress response 1 and ion co-transporter activity
JOURNAL J. Biol. Chem. 287 (45), 37868-37879 (2012)
PUBMED 22989884
REMARK GeneRIF: Data show that intracellular association between WNK1 and
oxidative stress-responsive 1 (OSR1) is required for stimulation of
OSR1 and Na(+), K(+), Cl(-)-Cotransporter NKCC1 and NKCC2
activities by osmotic stress.
REFERENCE 3 (bases 1 to 4525)
AUTHORS Chen,L.Y., Zhao,W.H., Tian,W., Guo,J., Jiang,F., Jin,L.J.,
Sun,Y.X., Chen,K.M., An,L.L., Li,G.D., Li,Q., Li,Y., Wu,C.,
Zhao,L., Wang,W.J., Zheng,G.Y., Li,B., Li,X.Q., Hu,J. and Tian,X.L.
TITLE STK39 is an independent risk factor for male hypertension in Han
Chinese
JOURNAL Int. J. Cardiol. 154 (2), 122-127 (2012)
PUBMED 20889219
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 4525)
AUTHORS Arion,D. and Lewis,D.A.
TITLE Altered expression of regulators of the cortical chloride
transporters NKCC1 and KCC2 in schizophrenia
JOURNAL Arch. Gen. Psychiatry 68 (1), 21-31 (2011)
PUBMED 20819979
REMARK GeneRIF: OXSR1 and WNK3 transcripts were substantially
overexpressed in subjects with schizophrenia relative to comparison
subjects.
REFERENCE 5 (bases 1 to 4525)
AUTHORS Lee,S.J., Cobb,M.H. and Goldsmith,E.J.
TITLE Crystal structure of domain-swapped STE20 OSR1 kinase domain
JOURNAL Protein Sci. 18 (2), 304-313 (2009)
PUBMED 19177573
REMARK GeneRIF: crystal structure of OSR1 kinase domain has been solved at
2.25 A; OSR1 forms a domain-swapped dimer in an inactive
conformation, in which P+1 loop and alphaEF helix are swapped
between dimer-related monomers
REFERENCE 6 (bases 1 to 4525)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
PUBMED 15302935
REFERENCE 7 (bases 1 to 4525)
AUTHORS Chen,W., Yazicioglu,M. and Cobb,M.H.
TITLE Characterization of OSR1, a member of the mammalian Ste20p/germinal
center kinase subfamily
JOURNAL J. Biol. Chem. 279 (12), 11129-11136 (2004)
PUBMED 14707132
REMARK GeneRIF: isolation and characterization of OSR1 (oxidative
stress-responsive 1), one of two human Fray homologs. OSR1 is a
58-kDa protein of 527 amino acids that is widely expressed in
mammalian tissues and cell lines
REFERENCE 8 (bases 1 to 4525)
AUTHORS Piechotta,K., Lu,J. and Delpire,E.
TITLE Cation chloride cotransporters interact with the stress-related
kinases Ste20-related proline-alanine-rich kinase (SPAK) and
oxidative stress response 1 (OSR1)
JOURNAL J. Biol. Chem. 277 (52), 50812-50819 (2002)
PUBMED 12386165
REMARK GeneRIF: interacts with cation chloride cotransporters
REFERENCE 9 (bases 1 to 4525)
AUTHORS Daigo,Y., Isomura,M., Nishiwaki,T., Tamari,M., Ishikawa,S., Kai,M.,
Murata,Y., Takeuchi,K., Yamane,Y., Hayashi,R., Minami,M.,
Fujino,M.A., Hojo,Y., Uchiyama,I., Takagi,T. and Nakamura,Y.
TITLE Characterization of a 1200-kb genomic segment of chromosome
3p22-p21.3
JOURNAL DNA Res. 6 (1), 37-44 (1999)
PUBMED 10231028
REFERENCE 10 (bases 1 to 4525)
AUTHORS Tamari,M., Daigo,Y. and Nakamura,Y.
TITLE Isolation and characterization of a novel serine threonine kinase
gene on chromosome 3p22-21.3
JOURNAL J. Hum. Genet. 44 (2), 116-120 (1999)
PUBMED 10083736
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AB017642.1, BC008726.2 and
BI090706.1.
On Sep 15, 2005 this sequence version replaced gi:4826877.
Summary: The product of this gene belongs to the Ser/Thr protein
kinase family of proteins. It regulates downstream kinases in
response to environmental stress, and may play a role in regulating
the actin cytoskeleton. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB017642.1, BC008726.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-17 AB017642.1 1-17
18-4360 BC008726.2 1-4343
4361-4519 AB017642.1 4361-4519
4520-4525 BI090706.1 405-410
FEATURES Location/Qualifiers
source 1..4525
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p22.2"
gene 1..4525
/gene="OXSR1"
/gene_synonym="OSR1"
/note="oxidative stress responsive 1"
/db_xref="GeneID:9943"
/db_xref="HGNC:8508"
/db_xref="HPRD:06809"
/db_xref="MIM:604046"
exon 1..412
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 43
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:35572366"
variation 79..81
/gene="OXSR1"
/gene_synonym="OSR1"
/replace=""
/replace="gga"
/db_xref="dbSNP:375761846"
variation 114
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:35995261"
variation 149
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:9819438"
misc_feature 157..159
/gene="OXSR1"
/gene_synonym="OSR1"
/note="upstream in-frame stop codon"
variation 160
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:459453"
variation 192
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2844429"
variation 242
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34526897"
CDS 343..1926
/gene="OXSR1"
/gene_synonym="OSR1"
/EC_number="2.7.11.1"
/note="oxidative stress-responsive 1 protein;
oxidative-stress responsive 1"
/codon_start=1
/product="serine/threonine-protein kinase OSR1"
/protein_id="NP_005100.1"
/db_xref="GI:4826878"
/db_xref="CCDS:CCDS2675.1"
/db_xref="GeneID:9943"
/db_xref="HGNC:8508"
/db_xref="HPRD:06809"
/db_xref="MIM:604046"
/translation="
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
"
misc_feature 385..1215
/gene="OXSR1"
/gene_synonym="OSR1"
/note="Catalytic domain of the Protein Serine/Threonine
Kinases, Oxidative stress response kinase and
Ste20-related proline alanine-rich kinase; Region:
STKc_OSR1_SPAK; cd06610"
/db_xref="CDD:173726"
misc_feature 391..1215
/gene="OXSR1"
/gene_synonym="OSR1"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(409..423,433..435,472..474,478..480,568..570,
616..627,634..639,646..648,778..780,784..795,799..801,
832..834,841..843,898..909,913..915,997..999,1024..1026)
/gene="OXSR1"
/gene_synonym="OSR1"
/note="active site"
/db_xref="CDD:173726"
misc_feature order(409..423,433..435,472..474,478..480,568..570,
616..627,634..639,646..648,784..786,790..795,799..801,
832..834)
/gene="OXSR1"
/gene_synonym="OSR1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173726"
misc_feature order(418..423,778..780,784..792,841..843,898..909,
913..915,997..999,1024..1026)
/gene="OXSR1"
/gene_synonym="OSR1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173726"
misc_feature order(829..870,889..915)
/gene="OXSR1"
/gene_synonym="OSR1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173726"
misc_feature 1357..1359
/gene="OXSR1"
/gene_synonym="OSR1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O95747.1); phosphorylation site"
misc_feature 1357..1359
/gene="OXSR1"
/gene_synonym="OSR1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/citation=[6]
misc_feature 1381..1383
/gene="OXSR1"
/gene_synonym="OSR1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O95747.1); phosphorylation site"
misc_feature 1621..1623
/gene="OXSR1"
/gene_synonym="OSR1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O95747.1); phosphorylation site"
misc_feature 1621..1623
/gene="OXSR1"
/gene_synonym="OSR1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1642..1737
/gene="OXSR1"
/gene_synonym="OSR1"
/note="Oxidative-stress-responsive kinase 1 C terminal;
Region: OSR1_C; pfam12202"
/db_xref="CDD:204847"
variation 351
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:457661"
exon 413..525
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 438
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55915229"
variation 452
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:138580801"
variation 453
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146175618"
exon 526..634
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 570
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141794705"
variation 585
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139570170"
exon 635..776
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 639
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:56013125"
variation 660
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375009566"
variation 702
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35279632"
variation 742
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370847117"
exon 777..832
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 818
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189939988"
exon 833..942
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 837
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376490943"
variation 856
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:2650093"
variation 858
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371056877"
variation 873
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2936811"
variation 882..883
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:3016004"
variation 883
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="t"
/db_xref="dbSNP:2936810"
variation 884
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201145646"
exon 943..1044
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 946
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148501279"
variation 948
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:151105173"
variation 994
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145105894"
exon 1045..1178
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1060
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374106391"
exon 1179..1227
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
exon 1228..1293
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1244
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="t"
/db_xref="dbSNP:375186809"
variation 1253
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:6599079"
variation 1266
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="t"
/db_xref="dbSNP:149444891"
variation 1269
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367861836"
variation 1275
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:142820192"
exon 1294..1416
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1331
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372927731"
exon 1417..1452
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1434
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374794688"
variation 1440
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369634764"
exon 1453..1599
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1483
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369274667"
variation 1488
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147400759"
variation 1513
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201009720"
variation 1526
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376982746"
variation 1529
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369899701"
variation 1557
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374066633"
variation 1576
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:113919536"
exon 1600..1664
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1615
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="t"
/db_xref="dbSNP:35295772"
variation 1625
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143136743"
variation 1626
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149980508"
exon 1665..1717
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1671
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375603924"
variation 1672
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2588458"
exon 1718..1786
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1765
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145431865"
variation 1767
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185093662"
variation 1773
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369269538"
exon 1787..1851
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1811
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112280434"
exon 1852..4523
/gene="OXSR1"
/gene_synonym="OSR1"
/inference="alignment:Splign:1.39.8"
variation 1864
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191643511"
variation 1929
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368493165"
variation 1944
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371027986"
variation 1947
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374272461"
variation 1970
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372701984"
variation 1971
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368455057"
variation 1979
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371503225"
variation 2034
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34465576"
variation 2035
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147089627"
variation 2280
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183838469"
variation 2281
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188171498"
variation 2298
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2298417"
variation 2361
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34362848"
variation 2532
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1444243"
variation 2539
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:180736107"
variation 2553
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371179657"
variation 2556
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115133372"
variation 2572
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147719146"
variation 2611
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184759246"
variation 2768
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:2298418"
variation 2807
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:12107638"
variation 2820
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35799757"
variation 2823
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35716483"
STS 2851..3019
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="SHGC-76840"
/db_xref="UniSTS:81897"
STS 2860..3143
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="D3S2942E"
/db_xref="UniSTS:150925"
variation 2888
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35508927"
variation 2895
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:36086192"
variation 2921
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373502892"
variation 2953
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:34304095"
variation 3075
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149355587"
variation 3151
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:190322725"
variation 3163
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145619504"
variation 3244..3245
/gene="OXSR1"
/gene_synonym="OSR1"
/replace=""
/replace="c"
/db_xref="dbSNP:35890394"
variation 3277
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:182088221"
STS 3548..3723
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="SHGC-76846"
/db_xref="UniSTS:57567"
variation 3676
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186733245"
variation 3698..3701
/gene="OXSR1"
/gene_synonym="OSR1"
/replace=""
/replace="agat"
/db_xref="dbSNP:199787905"
variation 3721..3722
/gene="OXSR1"
/gene_synonym="OSR1"
/replace=""
/replace="t"
/db_xref="dbSNP:35539377"
variation 3723
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149830"
variation 3735
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:36014521"
variation 3753..3754
/gene="OXSR1"
/gene_synonym="OSR1"
/replace=""
/replace="t"
/db_xref="dbSNP:370302841"
variation 3753
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201681558"
variation 3757
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:36124466"
variation 3776
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:2623811"
variation 3807
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138763538"
variation 3814
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141800606"
variation 3882
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370770366"
variation 3962
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:34969268"
variation 3966
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181301603"
variation 4006
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35385989"
variation 4034
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="t"
/db_xref="dbSNP:114471798"
STS 4115..4345
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="T03494"
/db_xref="UniSTS:18289"
variation 4127
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146256440"
STS 4228..4387
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="WIAF-1617"
/db_xref="UniSTS:63655"
variation 4285
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:73827649"
STS 4320..4410
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="D3S2887E"
/db_xref="UniSTS:27749"
STS 4324..4469
/gene="OXSR1"
/gene_synonym="OSR1"
/standard_name="RH47460"
/db_xref="UniSTS:22356"
variation 4361
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2011"
variation 4405
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:76267410"
variation 4427
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141700131"
variation 4463
/gene="OXSR1"
/gene_synonym="OSR1"
/replace="c"
/replace="g"
/db_xref="dbSNP:189918848"
polyA_signal 4502..4507
/gene="OXSR1"
/gene_synonym="OSR1"
polyA_site 4523
/gene="OXSR1"
/gene_synonym="OSR1"
/note="17 a nucleotides"
ORIGIN
ttggcccgtgcgtggggctggggtggagggcgggacagaggggctgggcccaggcaaagcttctgtcgctgctgctgcggaggccgaggacaggacgtgggctgggccgggcagtgccggactcggaggagcaggaggcgaggtccgccggagctctgagcccccgctgctctgccgcgcggtgaccccgcgccccggcgccgtccgacccgtggctgttccgagacgattggtgggggcgcggcggcggcggcggcggctgttgggggtggggagacgcgcggcgaggagacgagcgaggtcagcgagtttgagggaggaccgcgagccgctgccgccgtcatgtccgaggactcgagcgccctgccctggtccatcaacagggacgattacgagctgcaggaggtgatcgggagtggagcaactgctgtagtccaagcagcttattgtgcccctaaaaaggagaaagtggcaatcaaacggataaaccttgagaaatgtcaaactagcatggatgaactcctgaaagaaattcaagccatgagtcaatgccatcatcctaatattgtatcttactacacatcttttgtggtaaaagatgagctgtggcttgtcatgaagctgctaagtggaggttctgttctggatattattaagcacattgtggcaaaaggggaacacaaaagtggagtcctagatgaatctaccattgctacgatactccgagaagtactggaagggctggaatatctgcataaaaatggacagatccacagagatgtgaaagctggaaacattcttcttggagaagatggctcagtacagattgcagactttggggttagtgcttttttagcaactggtggtgatattacccgaaataaagtgagaaagacctttgttggcaccccttgttggatggcacctgaagttatggaacaggtccgtggttatgatttcaaagctgatatttggagttttggaattacagcaattgaattggctacaggggcggctccttatcataaatatccaccaatgaaggttttaatgctgacactgcagaacgatcctccttctttggaaactggtgttcaagataaagaaatgctgaaaaaatatggaaaatcatttagaaaaatgatttcattgtgccttcaaaaagatccagaaaaaagaccaacagcagcagaactattaaggcacaaatttttccagaaagcaaagaataaagaatttcttcaagaaaaaacattgcagagagcaccaaccatttctgaaagagcaaaaaaggttcggagagtaccaggttccagtgggcgtcttcataagacagaggatggaggctgggagtggagtgatgatgaatttgatgaagaaagtgaggaagggaaagcagcaatttcacaactcaggtctccccgagtgaaagaatcaatatcaaattctgagctctttccaacaactgatcctgtgggtactttgctccaagttccagaacagatctctgctcatctacctcagccagctgggcagattgctacacagccaactcaagtctctctcccacccaccgcagagccagcaaaaacagctcaggctttgtcttcaggatcaggttcacaagaaaccaagatcccaatcagtctagtactaagattaaggaattccaaaaaagaactaaatgatattcgatttgaatttactcctgggagagatacagcagagggtgtctctcaggaactcatttctgctggcctggtcgacggaagggatttagtaatagtggcagctaatttgcagaaaattgtggaagaacctcagtcaaatcgatctgtcactttcaaactggcatctggtgtcgaaggctcagatattcctgatgatggtaaactgataggatttgcccagctcagcatcagctaaaccacaaccctggaagaggcggcctaaggagattccacacatgcgtatctctgttgcttctattggcctaaacccactactgccaaagaacccagcaacaaacctcccggctaggagctttagaagtctttatgttcttcctgccatcattcctccttttcccacagggaaagaaaagttggatcactagtggccagcatccccagagttccgttagtaaacttacttcatatgtcccctgtcttcctccatctgagaagtggcccatgtgcttcaaggcccaggagggagatctgtcagctcattcttgccttactccaatgatggcccaggtggaaaagtagcagctgtatcgggcttcctcatcctgcctgttcccccacacctgccaggatatggacatcttgggatatctctttaccactgaagtagaattgattgttcagctggagcccagagaatttaatttaatgttttttctttgtacctgatgtgaattctagcaacctttgttaggaaaaagcacagcctcagatggaggcagcctaaactgtgttcttgttttgttcatggtgtttctaagcgttttgctgaagctgctctcaggcacccccttcttcattgctctctccagaaagggttgctagccttaacttcagctggtgcaaaacatctgactgtagccgaacttcagccatcagatccttcaaagtggaactttggattgtttttacagacaacatcgagtaatggcttgtaaatgtgaattttgccagaggtggtttttgaacaggaaaatcataattcatatcattggagaagtatttattttcaaatatcaaattgaagaaaaactcaatcctcccatgaaaatcagttcgcctggcctccaagtcgtgaggaaatgggtatgcaaggctgagatttctacagcaataaaggagacacacactgggccagagaggcctgccttctgcctgctctcctgcactgaccctttggagggggtctctgtgtgctgaagctaactcaagatggaaagtgaaaccacatgtgccgtgacctttaggttttatgagtagacagtgttcatttgattttctacagaaataatataaattattctttaggtttaaaaaagagcactcataatgcaatatgtgaataatcagtgaggttgatttttcttttttcctaccgtttcatagtctttgtctaactgctagtaaccctaccgagttttatatatgagtgggatactcaatctggccttaaaaagatacacaaagatgggctgtgggtccctggaaagggggagagttgccctttacagaatcactcgagccctttccagcactgttggtctgatgaacaaggttgttttaccttattttctcttggaacatatctgaaaaccttccccacaaataacttgtcacaccttttgtttcattctgagtctttagttttagtcatgggctttcttcacctgctctaggtgcaaaggcatgttgggaaagagatggatgttggggaggaagagaggagatggatttcagttgggagttaggaggagagtaggtgagatgatcagacaccggagttcaacgtcccagcagtcttggtaaaaggagggagcctgctgagccaggagggagaaaagaagattgaccagcttgctagaaaaatacttagcttttctttttctttttttgtggaggggggacggagaggaacaaggatggggaggtaggaatgaggtatagaaaagagatagcatcttctttggcacaagactagtggcttaccgcttaccttagagttttgttttttttttttcaaacccatcaaaatctacttatttatgaatccaaggggtggcagcatcactctgttctagcattctttgtggagatggtctggtgcctagctgggagtgagcagcagcccatcccctgttcactttctctagcccatcattacctgtgaactgcagtggggcagtcatggcaaatagaattgggctggggtttctccttcttttcagttcattgtttgccctgctaggaattagaagacagacaccatgtcccaggacagtgttacttcttctgcatgatgtgtggtagactccctttgctggcttgtgcagtgatactgagaaaatacatgaacagaaactgcccaggtggaacagcacgtaacctagtgagtgactgtactcctttctaggaatgctgattcagagtgcacctctttgactaggtcccaggatccccttgtccctggagtagggactaactatagcacaaagtaatatgtgccaatgctatttgtgaaatgtttggtctttctaaacgactaaaggatttgttgggtttttgcttaagttttgaaccaaatcctagagccagctgataatatttaataatctggaggagagaataatgatgtaccaataagtggagattcctccttatgatgtatgctaggttatggaagatgtaaaatattcaactttttcctcctttttttggactttgtattttactgcatgttttcttcatttttaatcaataaagagtaaattgtccttaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9943 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
GeneID:9943 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:9943 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:9943 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:9943 -> Biological process: GO:0006979 [response to oxidative stress] evidence: IEA
GeneID:9943 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
GeneID:9943 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_005100 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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