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2020-10-24 07:24:58, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_005109               4525 bp    mRNA    linear   PRI 19-MAY-2013
DEFINITION  Homo sapiens oxidative stress responsive 1 (OXSR1), mRNA.
ACCESSION   NM_005109
VERSION     NM_005109.2  GI:75709206
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4525)
  AUTHORS   Ponce-Coria,J., Gagnon,K.B. and Delpire,E.
  TITLE     Calcium-binding protein 39 facilitates molecular interaction
            between Ste20p proline alanine-rich kinase and oxidative stress
            response 1 monomers
  JOURNAL   Am. J. Physiol., Cell Physiol. 303 (11), C1198-C1205 (2012)
   PUBMED   23034389
  REMARK    GeneRIF: SPAK and OSR1, which are often coexpressed in cells, can
            form functional heterodimers.
REFERENCE   2  (bases 1 to 4525)
  AUTHORS   Sengupta,S., Tu,S.W., Wedin,K., Earnest,S., Stippec,S.,
            Luby-Phelps,K. and Cobb,M.H.
  TITLE     Interactions with WNK (with no lysine) family members regulate
            oxidative stress response 1 and ion co-transporter activity
  JOURNAL   J. Biol. Chem. 287 (45), 37868-37879 (2012)
   PUBMED   22989884
  REMARK    GeneRIF: Data show that intracellular association between WNK1 and
            oxidative stress-responsive 1 (OSR1) is required for stimulation of
            OSR1 and Na(+), K(+), Cl(-)-Cotransporter NKCC1 and NKCC2
            activities by osmotic stress.
REFERENCE   3  (bases 1 to 4525)
  AUTHORS   Chen,L.Y., Zhao,W.H., Tian,W., Guo,J., Jiang,F., Jin,L.J.,
            Sun,Y.X., Chen,K.M., An,L.L., Li,G.D., Li,Q., Li,Y., Wu,C.,
            Zhao,L., Wang,W.J., Zheng,G.Y., Li,B., Li,X.Q., Hu,J. and Tian,X.L.
  TITLE     STK39 is an independent risk factor for male hypertension in Han
            Chinese
  JOURNAL   Int. J. Cardiol. 154 (2), 122-127 (2012)
   PUBMED   20889219
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4525)
  AUTHORS   Arion,D. and Lewis,D.A.
  TITLE     Altered expression of regulators of the cortical chloride
            transporters NKCC1 and KCC2 in schizophrenia
  JOURNAL   Arch. Gen. Psychiatry 68 (1), 21-31 (2011)
   PUBMED   20819979
  REMARK    GeneRIF: OXSR1 and WNK3 transcripts were substantially
            overexpressed in subjects with schizophrenia relative to comparison
            subjects.
REFERENCE   5  (bases 1 to 4525)
  AUTHORS   Lee,S.J., Cobb,M.H. and Goldsmith,E.J.
  TITLE     Crystal structure of domain-swapped STE20 OSR1 kinase domain
  JOURNAL   Protein Sci. 18 (2), 304-313 (2009)
   PUBMED   19177573
  REMARK    GeneRIF: crystal structure of OSR1 kinase domain has been solved at
            2.25 A; OSR1 forms a domain-swapped dimer in an inactive
            conformation, in which P+1 loop and alphaEF helix are swapped
            between dimer-related monomers
REFERENCE   6  (bases 1 to 4525)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4525)
  AUTHORS   Chen,W., Yazicioglu,M. and Cobb,M.H.
  TITLE     Characterization of OSR1, a member of the mammalian Ste20p/germinal
            center kinase subfamily
  JOURNAL   J. Biol. Chem. 279 (12), 11129-11136 (2004)
   PUBMED   14707132
  REMARK    GeneRIF: isolation and characterization of OSR1 (oxidative
            stress-responsive 1), one of two human Fray homologs. OSR1 is a
            58-kDa protein of 527 amino acids that is widely expressed in
            mammalian tissues and cell lines
REFERENCE   8  (bases 1 to 4525)
  AUTHORS   Piechotta,K., Lu,J. and Delpire,E.
  TITLE     Cation chloride cotransporters interact with the stress-related
            kinases Ste20-related proline-alanine-rich kinase (SPAK) and
            oxidative stress response 1 (OSR1)
  JOURNAL   J. Biol. Chem. 277 (52), 50812-50819 (2002)
   PUBMED   12386165
  REMARK    GeneRIF: interacts with cation chloride cotransporters
REFERENCE   9  (bases 1 to 4525)
  AUTHORS   Daigo,Y., Isomura,M., Nishiwaki,T., Tamari,M., Ishikawa,S., Kai,M.,
            Murata,Y., Takeuchi,K., Yamane,Y., Hayashi,R., Minami,M.,
            Fujino,M.A., Hojo,Y., Uchiyama,I., Takagi,T. and Nakamura,Y.
  TITLE     Characterization of a 1200-kb genomic segment of chromosome
            3p22-p21.3
  JOURNAL   DNA Res. 6 (1), 37-44 (1999)
   PUBMED   10231028
REFERENCE   10 (bases 1 to 4525)
  AUTHORS   Tamari,M., Daigo,Y. and Nakamura,Y.
  TITLE     Isolation and characterization of a novel serine threonine kinase
            gene on chromosome 3p22-21.3
  JOURNAL   J. Hum. Genet. 44 (2), 116-120 (1999)
   PUBMED   10083736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB017642.1, BC008726.2 and
            BI090706.1.
            On Sep 15, 2005 this sequence version replaced gi:4826877.
            
            Summary: The product of this gene belongs to the Ser/Thr protein
            kinase family of proteins. It regulates downstream kinases in
            response to environmental stress, and may play a role in regulating
            the actin cytoskeleton. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017642.1, BC008726.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AB017642.1         1-17
            18-4360             BC008726.2         1-4343
            4361-4519           AB017642.1         4361-4519
            4520-4525           BI090706.1         405-410
FEATURES             Location/Qualifiers
     source          1..4525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..4525
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="oxidative stress responsive 1"
                     /db_xref="GeneID:9943"
                     /db_xref="HGNC:8508"
                     /db_xref="HPRD:06809"
                     /db_xref="MIM:604046"
     exon            1..412
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       43
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35572366"
     variation       79..81
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace=""
                     /replace="gga"
                     /db_xref="dbSNP:375761846"
     variation       114
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35995261"
     variation       149
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9819438"
     misc_feature    157..159
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="upstream in-frame stop codon"
     variation       160
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:459453"
     variation       192
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2844429"
     variation       242
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34526897"
     CDS             343..1926
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /EC_number="2.7.11.1"
                     /note="oxidative stress-responsive 1 protein;
                     oxidative-stress responsive 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase OSR1"
                     /protein_id="NP_005100.1"
                     /db_xref="GI:4826878"
                     /db_xref="CCDS:CCDS2675.1"
                     /db_xref="GeneID:9943"
                     /db_xref="HGNC:8508"
                     /db_xref="HPRD:06809"
                     /db_xref="MIM:604046"
                     /translation="
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
"
     misc_feature    385..1215
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinases, Oxidative stress response kinase and
                     Ste20-related proline alanine-rich kinase; Region:
                     STKc_OSR1_SPAK; cd06610"
                     /db_xref="CDD:173726"
     misc_feature    391..1215
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(409..423,433..435,472..474,478..480,568..570,
                     616..627,634..639,646..648,778..780,784..795,799..801,
                     832..834,841..843,898..909,913..915,997..999,1024..1026)
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="active site"
                     /db_xref="CDD:173726"
     misc_feature    order(409..423,433..435,472..474,478..480,568..570,
                     616..627,634..639,646..648,784..786,790..795,799..801,
                     832..834)
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173726"
     misc_feature    order(418..423,778..780,784..792,841..843,898..909,
                     913..915,997..999,1024..1026)
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173726"
     misc_feature    order(829..870,889..915)
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173726"
     misc_feature    1357..1359
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O95747.1); phosphorylation site"
     misc_feature    1357..1359
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /citation=[6]
     misc_feature    1381..1383
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O95747.1); phosphorylation site"
     misc_feature    1621..1623
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O95747.1); phosphorylation site"
     misc_feature    1621..1623
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1642..1737
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="Oxidative-stress-responsive kinase 1 C terminal;
                     Region: OSR1_C; pfam12202"
                     /db_xref="CDD:204847"
     variation       351
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:457661"
     exon            413..525
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       438
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:55915229"
     variation       452
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138580801"
     variation       453
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146175618"
     exon            526..634
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       570
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141794705"
     variation       585
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139570170"
     exon            635..776
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       639
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56013125"
     variation       660
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375009566"
     variation       702
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35279632"
     variation       742
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370847117"
     exon            777..832
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       818
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189939988"
     exon            833..942
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       837
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376490943"
     variation       856
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2650093"
     variation       858
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371056877"
     variation       873
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2936811"
     variation       882..883
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3016004"
     variation       883
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:2936810"
     variation       884
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201145646"
     exon            943..1044
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       946
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148501279"
     variation       948
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151105173"
     variation       994
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145105894"
     exon            1045..1178
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1060
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374106391"
     exon            1179..1227
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     exon            1228..1293
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1244
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:375186809"
     variation       1253
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:6599079"
     variation       1266
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149444891"
     variation       1269
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367861836"
     variation       1275
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142820192"
     exon            1294..1416
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1331
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372927731"
     exon            1417..1452
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1434
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374794688"
     variation       1440
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369634764"
     exon            1453..1599
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1483
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369274667"
     variation       1488
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147400759"
     variation       1513
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201009720"
     variation       1526
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376982746"
     variation       1529
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369899701"
     variation       1557
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374066633"
     variation       1576
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:113919536"
     exon            1600..1664
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1615
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:35295772"
     variation       1625
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143136743"
     variation       1626
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149980508"
     exon            1665..1717
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1671
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375603924"
     variation       1672
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2588458"
     exon            1718..1786
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1765
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145431865"
     variation       1767
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185093662"
     variation       1773
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369269538"
     exon            1787..1851
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1811
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112280434"
     exon            1852..4523
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:1.39.8"
     variation       1864
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191643511"
     variation       1929
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368493165"
     variation       1944
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371027986"
     variation       1947
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374272461"
     variation       1970
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372701984"
     variation       1971
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368455057"
     variation       1979
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371503225"
     variation       2034
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34465576"
     variation       2035
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147089627"
     variation       2280
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183838469"
     variation       2281
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188171498"
     variation       2298
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2298417"
     variation       2361
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34362848"
     variation       2532
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1444243"
     variation       2539
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180736107"
     variation       2553
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371179657"
     variation       2556
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115133372"
     variation       2572
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147719146"
     variation       2611
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184759246"
     variation       2768
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2298418"
     variation       2807
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12107638"
     variation       2820
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35799757"
     variation       2823
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35716483"
     STS             2851..3019
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="SHGC-76840"
                     /db_xref="UniSTS:81897"
     STS             2860..3143
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="D3S2942E"
                     /db_xref="UniSTS:150925"
     variation       2888
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35508927"
     variation       2895
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36086192"
     variation       2921
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373502892"
     variation       2953
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34304095"
     variation       3075
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149355587"
     variation       3151
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190322725"
     variation       3163
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145619504"
     variation       3244..3245
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35890394"
     variation       3277
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182088221"
     STS             3548..3723
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="SHGC-76846"
                     /db_xref="UniSTS:57567"
     variation       3676
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186733245"
     variation       3698..3701
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace=""
                     /replace="agat"
                     /db_xref="dbSNP:199787905"
     variation       3721..3722
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35539377"
     variation       3723
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149830"
     variation       3735
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:36014521"
     variation       3753..3754
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:370302841"
     variation       3753
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201681558"
     variation       3757
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:36124466"
     variation       3776
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2623811"
     variation       3807
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138763538"
     variation       3814
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141800606"
     variation       3882
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370770366"
     variation       3962
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34969268"
     variation       3966
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181301603"
     variation       4006
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35385989"
     variation       4034
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:114471798"
     STS             4115..4345
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="T03494"
                     /db_xref="UniSTS:18289"
     variation       4127
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146256440"
     STS             4228..4387
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="WIAF-1617"
                     /db_xref="UniSTS:63655"
     variation       4285
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73827649"
     STS             4320..4410
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="D3S2887E"
                     /db_xref="UniSTS:27749"
     STS             4324..4469
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /standard_name="RH47460"
                     /db_xref="UniSTS:22356"
     variation       4361
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2011"
     variation       4405
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:76267410"
     variation       4427
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141700131"
     variation       4463
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189918848"
     polyA_signal    4502..4507
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
     polyA_site      4523
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="17 a nucleotides"
ORIGIN      
ttggcccgtgcgtggggctggggtggagggcgggacagaggggctgggcccaggcaaagcttctgtcgctgctgctgcggaggccgaggacaggacgtgggctgggccgggcagtgccggactcggaggagcaggaggcgaggtccgccggagctctgagcccccgctgctctgccgcgcggtgaccccgcgccccggcgccgtccgacccgtggctgttccgagacgattggtgggggcgcggcggcggcggcggcggctgttgggggtggggagacgcgcggcgaggagacgagcgaggtcagcgagtttgagggaggaccgcgagccgctgccgccgtcatgtccgaggactcgagcgccctgccctggtccatcaacagggacgattacgagctgcaggaggtgatcgggagtggagcaactgctgtagtccaagcagcttattgtgcccctaaaaaggagaaagtggcaatcaaacggataaaccttgagaaatgtcaaactagcatggatgaactcctgaaagaaattcaagccatgagtcaatgccatcatcctaatattgtatcttactacacatcttttgtggtaaaagatgagctgtggcttgtcatgaagctgctaagtggaggttctgttctggatattattaagcacattgtggcaaaaggggaacacaaaagtggagtcctagatgaatctaccattgctacgatactccgagaagtactggaagggctggaatatctgcataaaaatggacagatccacagagatgtgaaagctggaaacattcttcttggagaagatggctcagtacagattgcagactttggggttagtgcttttttagcaactggtggtgatattacccgaaataaagtgagaaagacctttgttggcaccccttgttggatggcacctgaagttatggaacaggtccgtggttatgatttcaaagctgatatttggagttttggaattacagcaattgaattggctacaggggcggctccttatcataaatatccaccaatgaaggttttaatgctgacactgcagaacgatcctccttctttggaaactggtgttcaagataaagaaatgctgaaaaaatatggaaaatcatttagaaaaatgatttcattgtgccttcaaaaagatccagaaaaaagaccaacagcagcagaactattaaggcacaaatttttccagaaagcaaagaataaagaatttcttcaagaaaaaacattgcagagagcaccaaccatttctgaaagagcaaaaaaggttcggagagtaccaggttccagtgggcgtcttcataagacagaggatggaggctgggagtggagtgatgatgaatttgatgaagaaagtgaggaagggaaagcagcaatttcacaactcaggtctccccgagtgaaagaatcaatatcaaattctgagctctttccaacaactgatcctgtgggtactttgctccaagttccagaacagatctctgctcatctacctcagccagctgggcagattgctacacagccaactcaagtctctctcccacccaccgcagagccagcaaaaacagctcaggctttgtcttcaggatcaggttcacaagaaaccaagatcccaatcagtctagtactaagattaaggaattccaaaaaagaactaaatgatattcgatttgaatttactcctgggagagatacagcagagggtgtctctcaggaactcatttctgctggcctggtcgacggaagggatttagtaatagtggcagctaatttgcagaaaattgtggaagaacctcagtcaaatcgatctgtcactttcaaactggcatctggtgtcgaaggctcagatattcctgatgatggtaaactgataggatttgcccagctcagcatcagctaaaccacaaccctggaagaggcggcctaaggagattccacacatgcgtatctctgttgcttctattggcctaaacccactactgccaaagaacccagcaacaaacctcccggctaggagctttagaagtctttatgttcttcctgccatcattcctccttttcccacagggaaagaaaagttggatcactagtggccagcatccccagagttccgttagtaaacttacttcatatgtcccctgtcttcctccatctgagaagtggcccatgtgcttcaaggcccaggagggagatctgtcagctcattcttgccttactccaatgatggcccaggtggaaaagtagcagctgtatcgggcttcctcatcctgcctgttcccccacacctgccaggatatggacatcttgggatatctctttaccactgaagtagaattgattgttcagctggagcccagagaatttaatttaatgttttttctttgtacctgatgtgaattctagcaacctttgttaggaaaaagcacagcctcagatggaggcagcctaaactgtgttcttgttttgttcatggtgtttctaagcgttttgctgaagctgctctcaggcacccccttcttcattgctctctccagaaagggttgctagccttaacttcagctggtgcaaaacatctgactgtagccgaacttcagccatcagatccttcaaagtggaactttggattgtttttacagacaacatcgagtaatggcttgtaaatgtgaattttgccagaggtggtttttgaacaggaaaatcataattcatatcattggagaagtatttattttcaaatatcaaattgaagaaaaactcaatcctcccatgaaaatcagttcgcctggcctccaagtcgtgaggaaatgggtatgcaaggctgagatttctacagcaataaaggagacacacactgggccagagaggcctgccttctgcctgctctcctgcactgaccctttggagggggtctctgtgtgctgaagctaactcaagatggaaagtgaaaccacatgtgccgtgacctttaggttttatgagtagacagtgttcatttgattttctacagaaataatataaattattctttaggtttaaaaaagagcactcataatgcaatatgtgaataatcagtgaggttgatttttcttttttcctaccgtttcatagtctttgtctaactgctagtaaccctaccgagttttatatatgagtgggatactcaatctggccttaaaaagatacacaaagatgggctgtgggtccctggaaagggggagagttgccctttacagaatcactcgagccctttccagcactgttggtctgatgaacaaggttgttttaccttattttctcttggaacatatctgaaaaccttccccacaaataacttgtcacaccttttgtttcattctgagtctttagttttagtcatgggctttcttcacctgctctaggtgcaaaggcatgttgggaaagagatggatgttggggaggaagagaggagatggatttcagttgggagttaggaggagagtaggtgagatgatcagacaccggagttcaacgtcccagcagtcttggtaaaaggagggagcctgctgagccaggagggagaaaagaagattgaccagcttgctagaaaaatacttagcttttctttttctttttttgtggaggggggacggagaggaacaaggatggggaggtaggaatgaggtatagaaaagagatagcatcttctttggcacaagactagtggcttaccgcttaccttagagttttgttttttttttttcaaacccatcaaaatctacttatttatgaatccaaggggtggcagcatcactctgttctagcattctttgtggagatggtctggtgcctagctgggagtgagcagcagcccatcccctgttcactttctctagcccatcattacctgtgaactgcagtggggcagtcatggcaaatagaattgggctggggtttctccttcttttcagttcattgtttgccctgctaggaattagaagacagacaccatgtcccaggacagtgttacttcttctgcatgatgtgtggtagactccctttgctggcttgtgcagtgatactgagaaaatacatgaacagaaactgcccaggtggaacagcacgtaacctagtgagtgactgtactcctttctaggaatgctgattcagagtgcacctctttgactaggtcccaggatccccttgtccctggagtagggactaactatagcacaaagtaatatgtgccaatgctatttgtgaaatgtttggtctttctaaacgactaaaggatttgttgggtttttgcttaagttttgaaccaaatcctagagccagctgataatatttaataatctggaggagagaataatgatgtaccaataagtggagattcctccttatgatgtatgctaggttatggaagatgtaaaatattcaactttttcctcctttttttggactttgtattttactgcatgttttcttcatttttaatcaataaagagtaaattgtccttaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9943 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
            GeneID:9943 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:9943 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:9943 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:9943 -> Biological process: GO:0006979 [response to oxidative stress] evidence: IEA
            GeneID:9943 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
            GeneID:9943 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_005100 -> EC 2.7.11.1

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.