2024-04-26 17:55:46, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_005047 3504 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 (PSMD5), transcript variant 1, mRNA. ACCESSION NM_005047 VERSION NM_005047.3 GI:394025670 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3504) AUTHORS Shim,S.M., Lee,W.J., Kim,Y., Chang,J.W., Song,S. and Jung,Y.K. TITLE Role of S5b/PSMD5 in proteasome inhibition caused by TNF-alpha/NFkappaB in higher eukaryotes JOURNAL Cell Rep 2 (3), 603-615 (2012) PUBMED 22921402 REMARK GeneRIF: the critical role of S5b/PSMD5 in negative regulation of proteasome by TNF-alpha/NFkappaB and provide insights into proteasome inhibition in human disease. REFERENCE 2 (bases 1 to 3504) AUTHORS Roelofs,J., Park,S., Haas,W., Tian,G., McAllister,F.E., Huo,Y., Lee,B.H., Zhang,F., Shi,Y., Gygi,S.P. and Finley,D. TITLE Chaperone-mediated pathway of proteasome regulatory particle assembly JOURNAL Nature 459 (7248), 861-865 (2009) PUBMED 19412159 REFERENCE 3 (bases 1 to 3504) AUTHORS Kaneko,T., Hamazaki,J., Iemura,S., Sasaki,K., Furuyama,K., Natsume,T., Tanaka,K. and Murata,S. TITLE Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones JOURNAL Cell 137 (5), 914-925 (2009) PUBMED 19490896 REFERENCE 4 (bases 1 to 3504) AUTHORS Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J., Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and Kim,N.S. TITLE Transcriptome analysis of human gastric cancer JOURNAL Mamm. Genome 16 (12), 942-954 (2005) PUBMED 16341674 REFERENCE 5 (bases 1 to 3504) AUTHORS Listovsky,T., Oren,Y.S., Yudkovsky,Y., Mahbubani,H.M., Weiss,A.M., Lebendiker,M. and Brandeis,M. TITLE Mammalian Cdh1/Fzr mediates its own degradation JOURNAL EMBO J. 23 (7), 1619-1626 (2004) PUBMED 15029244 REFERENCE 6 (bases 1 to 3504) AUTHORS Seeger,M., Ferrell,K., Frank,R. and Dubiel,W. TITLE HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation JOURNAL J. Biol. Chem. 272 (13), 8145-8148 (1997) PUBMED 9079628 REFERENCE 7 (bases 1 to 3504) AUTHORS Coux,O., Tanaka,K. and Goldberg,A.L. TITLE Structure and functions of the 20S and 26S proteasomes JOURNAL Annu. Rev. Biochem. 65, 801-847 (1996) PUBMED 8811196 REMARK Review article REFERENCE 8 (bases 1 to 3504) AUTHORS Deveraux,Q., Jensen,C. and Rechsteiner,M. TITLE Molecular cloning and expression of a 26 S protease subunit enriched in dileucine repeats JOURNAL J. Biol. Chem. 270 (40), 23726-23729 (1995) PUBMED 7559544 REFERENCE 9 (bases 1 to 3504) AUTHORS Deveraux,Q., Ustrell,V., Pickart,C. and Rechsteiner,M. TITLE A 26 S protease subunit that binds ubiquitin conjugates JOURNAL J. Biol. Chem. 269 (10), 7059-7061 (1994) PUBMED 8125911 REFERENCE 10 (bases 1 to 3504) AUTHORS Kanayama,H.O., Tamura,T., Ugai,S., Kagawa,S., Tanahashi,N., Yoshimura,T., Tanaka,K. and Ichihara,A. TITLE Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms JOURNAL Eur. J. Biochem. 206 (2), 567-578 (1992) PUBMED 1317798 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023459.1, D31889.1 and BC014478.1. On Jul 7, 2012 this sequence version replaced gi:25777613. Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014478.1, D31889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-113 HY023459.1 2-114 114-3433 D31889.1 1-3320 3434-3504 BC014478.1 3325-3395 FEATURES Location/Qualifiers source 1..3504 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q33.2" gene 1..3504 /gene="PSMD5" /gene_synonym="S5B" /note="proteasome (prosome, macropain) 26S subunit, non-ATPase, 5" /db_xref="GeneID:5711" /db_xref="HGNC:9563" /db_xref="HPRD:05121" /db_xref="MIM:604452" exon 1..285 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" misc_feature 11..13 /gene="PSMD5" /gene_synonym="S5B" /note="upstream in-frame stop codon" CDS 113..1627 /gene="PSMD5" /gene_synonym="S5B" /note="isoform 1 is encoded by transcript variant 1; 26S protease subunit S5 basic; 26S proteasome subunit S5B; 26S proteasome non-ATPase regulatory subunit 5" /codon_start=1 /product="26S proteasome non-ATPase regulatory subunit 5 isoform 1" /protein_id="NP_005038.1" /db_xref="GI:4826952" /db_xref="CCDS:CCDS6824.1" /db_xref="GeneID:5711" /db_xref="HGNC:9563" /db_xref="HPRD:05121" /db_xref="MIM:604452" /translation="
MAAQALALLREVARLEAPLEELRALHSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLLQAMEPVHVARNLRVDLQRGLIHPDDSVKILTLSQIGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRISLTQAGLEALFESNLLDDLKSVMKTNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGRQYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAVMDSPQQICERYPIFVEKVFEMIESQDPTMIGVAVDTVGILGSNVEGKQVLQKTGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPEQQTDDLLRMTESWFSSLSRDPLELFRGISSQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSEGPYYVKPVSTTAVEGAE
" misc_feature 116..118 /gene="PSMD5" /gene_synonym="S5B" /experiment="experimental evidence, no additional details recorded" /note="N-acetylalanine; propagated from UniProtKB/Swiss-Prot (Q16401.3); acetylation site" misc_feature 188..1624 /gene="PSMD5" /gene_synonym="S5B" /note="Proteasome non-ATPase 26S subunit; Region: Proteasom_PSMB; pfam10508" /db_xref="CDD:192608" exon 286..430 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 431..544 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 545..673 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 674..783 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 784..926 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 927..1118 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 1119..1228 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" exon 1229..1369 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" variation 1294 /gene="PSMD5" /gene_synonym="S5B" /replace="c" /replace="t" /db_xref="dbSNP:1060817" exon 1370..3480 /gene="PSMD5" /gene_synonym="S5B" /inference="alignment:Splign:1.39.8" STS 1704..1921 /gene="PSMD5" /gene_synonym="S5B" /standard_name="SHGC-31585" /db_xref="UniSTS:6895" STS 1724..1856 /gene="PSMD5" /gene_synonym="S5B" /standard_name="STS-D31889" /db_xref="UniSTS:29367" STS 2531..2711 /gene="PSMD5" /gene_synonym="S5B" /standard_name="RH25302" /db_xref="UniSTS:19105" STS 2531..2711 /gene="PSMD5" /gene_synonym="S5B" /standard_name="RH35526" /db_xref="UniSTS:85782" variation 2847 /gene="PSMD5" /gene_synonym="S5B" /replace="a" /replace="g" /db_xref="dbSNP:6602" variation 3078 /gene="PSMD5" /gene_synonym="S5B" /replace="c" /replace="t" /db_xref="dbSNP:10384" polyA_signal 3161..3166 /gene="PSMD5" /gene_synonym="S5B" polyA_site 3180 /gene="PSMD5" /gene_synonym="S5B" polyA_signal 3441..3446 /gene="PSMD5" /gene_synonym="S5B" polyA_site 3480 /gene="PSMD5" /gene_synonym="S5B" ORIGIN
ggcagccccatagccatctcagggacaaggaggctgtgatcagatctcgcgaggttcaggaaagcgccccgggaactgggccgctgggccagcccctgcgtcggggggcaagatggcagcccaggctttggcgctgctgagagaggtagcgaggctggaagcgccgctggaggagctacgcgcgcttcactccgtgctgcaggcagtgccgctcaacgagcttcgccagcaagcggcggagctgcgcctcggcccgctcttctccctgcttaacgagaaccatagggaaaagactactttgtgtgtatccattctggagagattgctccaagctatggaaccggttcacgtggcccggaacctcagggttgacctgcagaggggactaattcaccctgatgattctgtaaaaatcctcactctttcccagattggaagaattgttgaaaattctgatgctgttactgagattctaaataatgctgaattactaaaacaaattgtttattgcattggtggagagaatctatctgtagcaaaagcggctatcaaatccctgtcaagaatatcactaacccaagctggactggaggctttatttgaaagcaatctgctggatgatttgaaaagtgtaatgaaaacaaatgacattgttcgatacagggtgtatgagctaattatagagatttcttccgtgtcaccagaatctttaaactactgtaccacaagtggattggtaacccagctcctgagagagctgactggtgaggatgtgttggtcagagccacctgtatagaaatggtgacatcactggcatatactcatcatgggcgacaatatcttgctcaagaaggagtaattgaccaaatttctaatataattgttggggcagattcagaccctttctctagcttctatctgccaggattcgtgaagttttttggaaacctggctgtcatggatagtcctcaacagatctgtgagcgttatcctatctttgtggaaaaagtctttgaaatgatagaaagtcaggaccccactatgattggtgtagctgtagacacagttggaatcttgggatccaatgttgaaggaaaacaggttttacagaaaacaggaactcgctttgaacgcttgcttatgagaataggacatcaatcaaagaatgccccagtggagctaaaaattagatgtttggatgcaatttcatctcttctgtacttaccacctgagcagcagactgatgaccttctgaggatgacagaatcctggttttcttctttatctcgggatccactggagctcttccgtggcattagtagtcagcccttccctgaactacactgtgctgccttaaaagtgtttacggccattgcaaaccaaccctgggctcagaaacttatgtttaacagtccaggttttgtagaatatgtggtggaccggtctgtggagcatgacaaagcttcaaaggatgccaaatatgaactagtgaaagcacttgccaattccaagacaattgcagaaatctttgggaacccaaattatttgaggctcagaacttacctgagtgaagggccatactatgtgaaacctgtttccacgacagcagtagaaggagccgaatgatttcttctagagctcatgtagaggaccacgttttgaccaaaacttctcctaaggcatttgactccatctatatttcacaaaagagacttcctttccccaagaattatcatggaatgtcagatgttactttgttaccaacactgttatatttctacattgaaatgcaaagtggaactaggagtttggaatgcattaagagcagacaagcttggtcataatagatccagtgtttttcagattcctttcactgccttaatctttgcaacagggtggaagtttttttcttccctcaaaattttcatggacatgcaatcttatctaaaagcctgcttcagggctgggcgcggtggctaacacctataattcccagcactttgggaggccaagatgggcaaatcacttgagtctaggagttcaagaccagcctggccaatatggcaaaaccctgtctctactaaaaatataaaatcagccaggcatggtggcgcacacctataatctcagctactcaggaggctgaggcacgagaatcgcttgagcctgggaggcagaggttgcagtgagctgagatcttgccactgcacaccagcctgggcaacacagcaagactctgtctcaaaaataaatgaataaaataaaaacctgccaccaaattatttctggattctcttcactatctttttttttctttttggtcctttttccatttctgattccactttcaaagtcttggatatattctttgaaaaatgagtagtatggaatattaagattatgttccttatactcagaatactttttatgagctctcttgtttttttgttactattattcctttgaaaaaaagacaaaatatctaaaaaatgtttatagtgttcatgtaattttttttgctgtttaccaatgaactttgccctgttgtggttttgggggatcagaaggattcctaaactgtcatttcatttattggtaggtcatgattgctgagggttttgctttggatttttcatacctataaagtcaatcttgagttgatcagagaaagggaaacttactcctaataaacagactcagaacagaagggacatatgcataaatcaggataccatctcattaatttacaaaggataatctttcttttcattgacaacacctacacccacctgttttccagtgttcttctctctaaacagcaaagccaaagcactctgcacaccaaatcacctgttcagaggtttatgcatgagcatatttcttttaggccgtggtgaagttgataaaccacccctgctttgtaacaaaattattttaaagtgactggaattatctagtccccagattgatcatctcccctggcaacgtgactctgttttttgtgtgtgtttccatgctgactagtcccctactgttaatatcactactaattaggctataaccaggtctttcctggcctgagaaatattctcttaaaatgacctttgttttaatctcattcatgatgttgattttttttcaatgtggtgcaatatatacaataaaatttgtcataactattttaagtgtacagttcagtatattacatatgttcataagttgtacaaccatcaccaccatccatcttcagaattattttcatcttatacaattgaaactgtattcattaaacaataactgtctattccctcttttccccagcctctggcaaccaccattctgcttcatgacattgattttattcacttaacatcagattttggggggatgccctctctcctatgtatggtctacacattctgattttttttttagattgaataaaatttgtaaatcattattttcatttcataagtaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5711 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5711 -> Molecular function: GO:0044183 [protein binding involved in protein folding] evidence: IEA GeneID:5711 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:5711 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS GeneID:5711 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:5711 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS GeneID:5711 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS GeneID:5711 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS GeneID:5711 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5711 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS GeneID:5711 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:5711 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:5711 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:5711 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:5711 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS GeneID:5711 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS GeneID:5711 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS GeneID:5711 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:5711 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:5711 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:5711 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5711 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5711 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5711 -> Biological process: GO:0070682 [proteasome regulatory particle assembly] evidence: TAS GeneID:5711 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS GeneID:5711 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5711 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5711 -> Cellular component: GO:0008540 [proteasome regulatory particle, base subcomplex] evidence: IDA GeneID:5711 -> Cellular component: GO:0022624 [proteasome accessory complex] evidence: ISS
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