2024-03-30 00:07:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004991 5533 bp mRNA linear PRI 16-JUN-2013 DEFINITION Homo sapiens MDS1 and EVI1 complex locus (MECOM), transcript variant 4, mRNA. ACCESSION NM_004991 VERSION NM_004991.3 GI:255683385 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5533) AUTHORS Senyuk,V., Zhang,Y., Liu,Y., Ming,M., Premanand,K., Zhou,L., Chen,P., Chen,J., Rowley,J.D., Nucifora,G. and Qian,Z. TITLE Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (14), 5594-5599 (2013) PUBMED 23509296 REMARK GeneRIF: EVI1 binds to the promoter of miR-9-3, leading to DNA hypermethylation of the promoter and repression of miR-9. REFERENCE 2 (bases 1 to 5533) AUTHORS Hwang,J.Y., Lee,S.H., Go,M.J., Kim,B.J., Kou,I., Ikegawa,S., Guo,Y., Deng,H.W., Raychaudhuri,S., Kim,Y.J., Oh,J.H., Kim,Y., Moon,S., Kim,D.J., Koo,H., Cha,M.J., Lee,M.H., Yun,J.Y., Yoo,H.S., Kang,Y.A., Cho,E.H., Kim,S.W., Oh,K.W., Kang,M.I., Son,H.Y., Kim,S.Y., Kim,G.S., Han,B.G., Cho,Y.S., Cho,M.C., Lee,J.Y. and Koh,J.M. TITLE Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture JOURNAL J. Med. Genet. 50 (4), 212-219 (2013) PUBMED 23349225 REFERENCE 3 (bases 1 to 5533) AUTHORS Steinleitner,K., Rampetsreiter,P., Koffel,R., Ramanathan,G., Mannhalter,C., Strobl,H. and Wieser,R. TITLE EVI1 and MDS1/EVI1 expression during primary human hematopoietic progenitor cell differentiation into various myeloid lineages JOURNAL Anticancer Res. 32 (11), 4883-4889 (2012) PUBMED 23155256 REMARK GeneRIF: EVI1 is expressed in human hematopoietic progenitor cells, but is down-regulated during differentiation REFERENCE 4 (bases 1 to 5533) AUTHORS Hancock,D.B., Artigas,M.S., Gharib,S.A., Henry,A., Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B., McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W., Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M., Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B., Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K., Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S., Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G., Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C., Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T., Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J., Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M., Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T., North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T., Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P., Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D., Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R., Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P., Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J. TITLE Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function JOURNAL PLoS Genet. 8 (12), E1003098 (2012) PUBMED 23284291 REFERENCE 5 (bases 1 to 5533) AUTHORS Haas,K., Kundi,M., Sperr,W.R., Esterbauer,H., Ludwig,W.D., Ratei,R., Koller,E., Gruener,H., Sauerland,C., Fonatsch,C., Valent,P. and Wieser,R. TITLE Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission duration JOURNAL Genes Chromosomes Cancer 47 (4), 288-298 (2008) PUBMED 18181178 REMARK GeneRIF: EVI1 and MDS1/EVI1 overexpression is associated with acute myeloid leukemia REFERENCE 6 (bases 1 to 5533) AUTHORS Aytekin,M., Vinatzer,U., Musteanu,M., Raynaud,S. and Wieser,R. TITLE Regulation of the expression of the oncogene EVI1 through the use of alternative mRNA 5'-ends JOURNAL Gene 356, 160-168 (2005) PUBMED 16014322 REMARK GeneRIF: The general expression patterns of the EVI1 5'-end variants in a panel of 20 human tissues were similar, while pronounced differences were noted in response to all-trans retinoic acid. REFERENCE 7 (bases 1 to 5533) AUTHORS Mochizuki,N., Shimizu,S., Nagasawa,T., Tanaka,H., Taniwaki,M., Yokota,J. and Morishita,K. TITLE A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells JOURNAL Blood 96 (9), 3209-3214 (2000) PUBMED 11050005 REFERENCE 8 (bases 1 to 5533) AUTHORS Nucifora,G., Begy,C.R., Kobayashi,H., Roulston,D., Claxton,D., Pedersen-Bjergaard,J., Parganas,E., Ihle,J.N. and Rowley,J.D. TITLE Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (9), 4004-4008 (1994) PUBMED 8171026 REFERENCE 9 (bases 1 to 5533) AUTHORS Mitani,K., Ogawa,S., Tanaka,T., Miyoshi,H., Kurokawa,M., Mano,H., Yazaki,Y., Ohki,M. and Hirai,H. TITLE Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia JOURNAL EMBO J. 13 (3), 504-510 (1994) PUBMED 8313895 REFERENCE 10 (bases 1 to 5533) AUTHORS Morishita,K., Parganas,E., Douglass,E.C. and Ihle,J.N. TITLE Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts JOURNAL Oncogene 5 (7), 963-971 (1990) PUBMED 2115646 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC348381.1, AL700380.1, AK304098.1, CR541866.1, BC130520.1, BX647613.1 and AA043944.1. This sequence is a reference standard in the RefSeqGene project. On Aug 8, 2009 this sequence version replaced gi:195963413. Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]. Transcript Variant: This variant (4, also known as MDS1/EVI1) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. There are no publicly available full-length transcripts representing this variant, but it is supported by cloning evidence in PMID:11050005. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-160 DC348381.1 1-160 161-301 AL700380.1 99-239 302-486 AK304098.1 248-432 487-778 CR541866.1 84-375 779-3238 AK304098.1 725-3184 3239-4158 BC130520.1 2580-3499 4159-5525 BX647613.1 4098-5464 5526-5533 AA043944.1 3-10 c FEATURES Location/Qualifiers source 1..5533 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q26.2" gene 1..5533 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="MDS1 and EVI1 complex locus" /db_xref="GeneID:2122" /db_xref="HGNC:3498" /db_xref="MIM:165215" exon 1..440 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" misc_feature 131..133 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="upstream in-frame stop codon" variation 161..162 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="" /replace="ag" /db_xref="dbSNP:3832188" variation 222 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="a" /replace="g" /db_xref="dbSNP:1299563" variation 246..253 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="" /replace="gagagaga" /db_xref="dbSNP:71166260" CDS 404..4123 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="isoform c is encoded by transcript variant 4; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; oncogene EVI1; myelodysplasia syndrome-associated protein 1; zinc finger protein Evi1; AML1-EVI-1 fusion protein; ecotropic virus integration site 1 protein homolog" /codon_start=1 /product="MDS1 and EVI1 complex locus protein EVI1 isoform c" /protein_id="NP_004982.2" /db_xref="GI:255683386" /db_xref="GeneID:2122" /db_xref="HGNC:3498" /db_xref="MIM:165215" /translation="
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGAGLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV
" misc_feature 641..991 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317" /db_xref="CDD:197649" misc_feature 1232..1306 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc-finger double domain; Region: zf-H2C2_2; pfam13465" /db_xref="CDD:205643" misc_feature 1277..1342 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478" /db_xref="CDD:210117" misc_feature 1400..1480 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc-finger double domain; Region: zf-H2C2_2; pfam13465" /db_xref="CDD:205643" misc_feature 1451..1513 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478" /db_xref="CDD:210117" misc_feature 1532..1597 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478" /db_xref="CDD:210117" misc_feature 1619..1684 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478" /db_xref="CDD:210117" misc_feature 3167..3232 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478" /db_xref="CDD:210117" misc_feature 3206..3280 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc-finger double domain; Region: zf-H2C2_2; pfam13465" /db_xref="CDD:205643" misc_feature 3290..3364 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc-finger double domain; Region: zf-H2C2_2; pfam13465" /db_xref="CDD:205643" misc_feature 3338..3403 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478" /db_xref="CDD:210117" exon 441..778 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 779..913 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 914..1016 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 1017..1233 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 1234..1381 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" variation 1287 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="a" /replace="g" /db_xref="dbSNP:34896995" STS 1330..2537 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /standard_name="Evi1" /db_xref="UniSTS:256974" STS 1330..1796 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /standard_name="Evi1" /db_xref="UniSTS:256973" exon 1382..1535 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 1536..2892 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" variation 1678 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="a" /replace="g" /db_xref="dbSNP:35594969" variation 1721 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="g" /replace="t" /db_xref="dbSNP:199968662" STS 1981..2927 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /standard_name="Evi1" /db_xref="UniSTS:506889" variation 2600 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="c" /replace="t" /db_xref="dbSNP:2276719" exon 2893..2980 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 2981..3007 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 3008..3174 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" variation 3077 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="a" /replace="c" /db_xref="dbSNP:36043407" exon 3175..3252 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 3253..3422 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" variation 3344 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="c" /replace="t" /db_xref="dbSNP:34224062" exon 3423..3567 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 3568..3804 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 3805..3988 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" exon 3989..5533 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /inference="alignment:Splign:1.39.8" STS 4007..4226 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /standard_name="SHGC-77524" /db_xref="UniSTS:47700" STS 4524..4811 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /standard_name="SGC38138" /db_xref="UniSTS:74058" variation 4711 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="c" /replace="t" /db_xref="dbSNP:1048601" variation 5325 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" /replace="g" /replace="t" /db_xref="dbSNP:1048604" polyA_signal 5505..5510 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" polyA_site 5533 /gene="MECOM" /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3" ORIGIN
gattgccatctgacaagatctccaaatcaaagtgataaatcgctccaaactttttttggcggcgctgagatgttggaggggcgtctagcgcgcatgtgcgaaggtgtccaaactgacaatgctggagagatagcgagtgtggattgagagaaagggagagagggagggagagagagtgaaagaagaaaatacagagagtgagtgtgtggaagagagagagaaacaggagagaaacaggagggagggagagagagagagagagagagagagagagagagagagagagagagagagagagagacaggagagagagggagggagcgagagggagagcaaaagaaggaaaggatccaagaaaaaaaagccccaaccacacaccagcggctgcaggactgggcacagcatgagatccaaaggcagggcaaggaaactggccacaaataatgagtgtgtatatggcaactaccctgaaatacctttggaagaaatgccagatgcagatggagtagccagcactccctccctcaatattcaagagccatgctctcctgccacatccagtgaagcattcactccaaaggagggttctccttacaaagcccccatctacatccctgatgatatccccattcctgctgagtttgaacttcgagagtcaaatatgcctggggcaggactaggaatatggaccaaaaggaagatcgaagtaggtgaaaagtttgggccttatgtgggagagcagaggtcaaacctgaaagaccccagttatggatgggagatcttagacgaattttacaatgtgaagttctgcatagatgccagtcaaccagatgttggaagctggctcaagtacattagattcgctggctgttatgatcagcacaaccttgttgcatgccagataaatgatcagatattctatagagtagttgcagacattgcgccgggagaggagcttctgctgttcatgaagagcgaagactatccccatgaaactatggcgccggatatccacgaagaacggcaatatcgctgcgaagactgtgaccagctctttgaatctaaggctgaactagcagatcaccaaaagtttccatgcagtactcctcactcagcattttcaatggttgaagaggactttcagcaaaaactcgaaagcgagaatgatctccaagagatacacacgatccaggagtgtaaggaatgtgaccaagtttttcctgatttgcaaagcctggagaaacacatgctgtcacatactgaagagagggaatacaagtgtgatcagtgtcccaaggcatttaactggaagtccaatttaattcgccaccagatgtcacatgacagtggaaagcactatgaatgtgaaaactgtgccaaggttttcacggaccctagcaaccttcagcggcacattcgctctcagcatgtcggtgcccgggcccatgcatgcccggagtgtggcaaaacgtttgccacttcgtcgggcctcaaacaacacaagcacatccacagcagtgtgaagccctttatctgtgaggtctgccataaatcctatactcagttttcaaacctttgccgtcataagcgcatgcatgctgattgcagaacccaaatcaagtgcaaagactgtggacaaatgttcagcactacgtcttccttaaataaacacaggaggttttgtgagggcaagaaccattttgcggcaggtggattttttggccaaggcatttcacttcctggaaccccagctatggataaaacgtccatggttaatatgagtcatgccaacccgggccttgctgactattttggcgccaataggcatcctgctggtcttacctttccaacagctcctggattttcttttagcttccctggtctgtttccttccggcttgtaccacaggcctcctttgatacctgctagttctcctgttaaaggactatcaagtactgaacagacaaacaaaagtcaaagtcccctcatgacacatcctcagatactgccagctacacaggatattttgaaggcactatctaaacacccatctgtaggggacaataagccagtggagctccagcccgagaggtcctctgaagagaggccctttgagaaaatcagtgaccagtcagagagtagtgaccttgatgatgtcagtacaccaagtggcagtgacctggaaacaacctcgggctctgatctggaaagtgacattgaaagtgataaagagaaatttaaagaaaatggtaaaatgttcaaagacaaagtaagccctcttcagaatctggcttcaataaataataagaaagaatacagcaatcattccattttctcaccatctttagaggagcagactgcggtgtcaggagctgtgaatgattctataaaggctattgcttctattgctgaaaaatactttggttcaacaggactggtggggctgcaagacaaaaaagttggagctttaccttacccttccatgtttcccctcccattttttccagcattctctcaatcaatgtacccatttcctgatagagacttgagatcgttacctttgaaaatggaaccccaatcaccaggtgaagtaaagaaactgcagaagggcagctctgagtccccctttgatctcaccactaagcgaaaggatgagaagcccttgactccagtcccctccaagcctccagtgacacctgccacaagccaagaccagcccctggatctaagtatgggcagtaggagtagagccagtgggacaaagctgactgagcctcgaaaaaaccacgtgtttgggggaaaaaaaggaagcaacgtcgaatcaagacctgcttcagatggttccttgcagcatgcaagacccactcctttctttatggaccctatttacagagtagagaaaagaaaactaactgacccacttgaagctttaaaagagaaatacttgaggccttctccaggattcttgtttcacccacaattccaactgcctgatcagagaacttggatgtcagctattgaaaacatggcagaaaagctagagagcttcagtgccctgaaacctgaggccagtgagctcttacagtcagtgccctctatgttcaacttcagggcgcctcccaatgccctgccagagaaccttctgcggaagggaaaggagcgctatacctgcagatactgtggcaagatttttccaaggtctgcaaacctaacacggcacttgagaacccacacaggagagcagccttacagatgcaaatactgtgacagatcatttagcatatcttctaacttgcaaaggcatgttcgcaacatccacaataaagagaagccatttaagtgtcacttatgtgataggtgttttggtcaacaaaccaatttagacagacacctaaagaaacatgagaatgggaacatgtccggtacagcaacatcgtcgcctcattctgaactggaaagtacaggtgcgattctggatgacaaagaagatgcttacttcacagaaattcgaaatttcattgggaacagcaaccatggcagccaatctcccaggaatgtggaggagagaatgaatggcagtcattttaaagatgaaaaggctttggtgaccagtcaaaattcagacttgctggatgatgaagaagttgaagatgaggtgttgttagatgaggaggatgaagacaatgatattactggaaaaacaggaaaggaaccagtgacaagtaatttacatgaaggaaaccctgaggatgactatgaagaaaccagtgccctggagatgagttgcaagacatccccagtgaggtataaagaggaagaatataaaagtggactttctgctctagatcatataaggcacttcacagatagcctcaaaatgaggaaaatggaagataatcaatattctgaagctgagctgtcttcttttagtacttcccatgtgccagaggaacttaagcagccgttacacagaaagtccaaatcgcaggcatatgctatgatgctgtcactgtctgacaaggagtccctccattctacatcccacagttcttccaacgtgtggcacagtatggccagggctgcggcggaatccagtgctatccagtccataagccacgtatgacgttatcaaggttgaccagagtgggaccaagtccaacagtagcatggctctttcatataggactatttacaagactgctgagcagaatgccttataaacctgcagggtcactcatctaaagtctagtgaccttaaactgaatgatttaaaaaagaaaagaaagaaaaaagaaactatttattctcgatattttgttttgcacagcaaaggcagctgctgacttctggaagatcaatcaatgcgacttaaagtgattcagtgaaaacaaaaaacttggtgggctgaaggcatcttccagtttaccccaccttagggtatgggtgggtgagaagggcagttgagatggcagcattgatatgaatgaacactccatagaaactgaattctcttttgtacaagatcacctgacatgattgggaacagttgcttttaattacagatttaatttttttcttcgttaaagttttatgtaatttaaccctttgaagacagaagtagttggatgaaatgcacagtcaattattatagaaactgataacagggagtacttgttcccccttttgccttcttaagtacattgtttaaaactagggaaaaagggtatgtgtatattgtaaactatggatgttaacactcaaagaggttaagtcagtgaagtaacctattcatcaccagtaccgctgtaccactaataaattgtttgccaaatccttgtaataacatcttaattttagacaatcatgtcactgtttttaatgtttatttttttgtgtgtgttgcgtgtatcatgtatttatttgttggcaaactattgtttgttgattaaaatagcactgttccagtcagccactactttatgacgtctgaggcacacccctttccgaatttcaaggaccaaggtgacccgacctgtgtatgagagtgccaaatggtgtttggcttttcttaacattcctttttgtttgtttgttttgttttccttcttaatgaactaaatacgaatagatgcaacttagtttttgtaatactgaaatcgattcaattgtataaacgattataatttctttcatggaagcatgattcttctgattaaaaactgtactccatattttatgctggttgtctgcaagcttgtgcgatgttatgttcatgttaatcctatttgtaaaatgaagtgttcccaaccttatgttaaaagagagaagtaaataacagactgtattcagttattttgccctttattgaggaaccagatttgttttctttttgtttgtaatctcattttgaaataatcagcaagttgaggtactttcttcaaatgctttgtacaatataaactgttatgcctttcagtgcattactatgggaggagcaactaaaaaataaagacttacaaaaaggagtattttt
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:2122 -> Molecular function: GO:0003677 [DNA binding] evidence: ISS GeneID:2122 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA GeneID:2122 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS GeneID:2122 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:2122 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA GeneID:2122 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA GeneID:2122 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA GeneID:2122 -> Biological process: GO:0001780 [neutrophil homeostasis] evidence: IEA GeneID:2122 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA GeneID:2122 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS GeneID:2122 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:2122 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA GeneID:2122 -> Biological process: GO:0009605 [response to external stimulus] evidence: IEA GeneID:2122 -> Biological process: GO:0009617 [response to bacterium] evidence: IEA GeneID:2122 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA GeneID:2122 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA GeneID:2122 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IDA GeneID:2122 -> Biological process: GO:0030900 [forebrain development] evidence: IEA GeneID:2122 -> Biological process: GO:0035115 [embryonic forelimb morphogenesis] evidence: IEA GeneID:2122 -> Biological process: GO:0035116 [embryonic hindlimb morphogenesis] evidence: IEA GeneID:2122 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA GeneID:2122 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: IMP GeneID:2122 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA GeneID:2122 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA GeneID:2122 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA GeneID:2122 -> Biological process: GO:0046329 [negative regulation of JNK cascade] evidence: IMP GeneID:2122 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IDA GeneID:2122 -> Biological process: GO:0060039 [pericardium development] evidence: IEA GeneID:2122 -> Biological process: GO:0071425 [hematopoietic stem cell proliferation] evidence: ISS GeneID:2122 -> Biological process: GO:0072001 [renal system development] evidence: IEA GeneID:2122 -> Cellular component: GO:0000118 [histone deacetylase complex] evidence: IDA GeneID:2122 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:2122 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA
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