GGRNA Home | Help | Advanced search

2024-03-30 00:07:33, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004991               5533 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens MDS1 and EVI1 complex locus (MECOM), transcript
            variant 4, mRNA.
ACCESSION   NM_004991
VERSION     NM_004991.3  GI:255683385
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5533)
  AUTHORS   Senyuk,V., Zhang,Y., Liu,Y., Ming,M., Premanand,K., Zhou,L.,
            Chen,P., Chen,J., Rowley,J.D., Nucifora,G. and Qian,Z.
  TITLE     Critical role of miR-9 in myelopoiesis and EVI1-induced
            leukemogenesis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (14), 5594-5599 (2013)
   PUBMED   23509296
  REMARK    GeneRIF: EVI1 binds to the promoter of miR-9-3, leading to DNA
            hypermethylation of the promoter and repression of miR-9.
REFERENCE   2  (bases 1 to 5533)
  AUTHORS   Hwang,J.Y., Lee,S.H., Go,M.J., Kim,B.J., Kou,I., Ikegawa,S.,
            Guo,Y., Deng,H.W., Raychaudhuri,S., Kim,Y.J., Oh,J.H., Kim,Y.,
            Moon,S., Kim,D.J., Koo,H., Cha,M.J., Lee,M.H., Yun,J.Y., Yoo,H.S.,
            Kang,Y.A., Cho,E.H., Kim,S.W., Oh,K.W., Kang,M.I., Son,H.Y.,
            Kim,S.Y., Kim,G.S., Han,B.G., Cho,Y.S., Cho,M.C., Lee,J.Y. and
            Koh,J.M.
  TITLE     Meta-analysis identifies a MECOM gene as a novel predisposing
            factor of osteoporotic fracture
  JOURNAL   J. Med. Genet. 50 (4), 212-219 (2013)
   PUBMED   23349225
REFERENCE   3  (bases 1 to 5533)
  AUTHORS   Steinleitner,K., Rampetsreiter,P., Koffel,R., Ramanathan,G.,
            Mannhalter,C., Strobl,H. and Wieser,R.
  TITLE     EVI1 and MDS1/EVI1 expression during primary human hematopoietic
            progenitor cell differentiation into various myeloid lineages
  JOURNAL   Anticancer Res. 32 (11), 4883-4889 (2012)
   PUBMED   23155256
  REMARK    GeneRIF: EVI1 is expressed in human hematopoietic progenitor cells,
            but is down-regulated during differentiation
REFERENCE   4  (bases 1 to 5533)
  AUTHORS   Hancock,D.B., Artigas,M.S., Gharib,S.A., Henry,A., Manichaikul,A.,
            Ramasamy,A., Loth,D.W., Imboden,M., Koch,B., McArdle,W.L.,
            Smith,A.V., Smolonska,J., Sood,A., Tang,W., Wilk,J.B., Zhai,G.,
            Zhao,J.H., Aschard,H., Burkart,K.M., Curjuric,I., Eijgelsheim,M.,
            Elliott,P., Gu,X., Harris,T.B., Janson,C., Homuth,G., Hysi,P.G.,
            Liu,J.Z., Loehr,L.R., Lohman,K., Loos,R.J., Manning,A.K.,
            Marciante,K.D., Obeidat,M., Postma,D.S., Aldrich,M.C.,
            Brusselle,G.G., Chen,T.H., Eiriksdottir,G., Franceschini,N.,
            Heinrich,J., Rotter,J.I., Wijmenga,C., Williams,O.D., Bentley,A.R.,
            Hofman,A., Laurie,C.C., Lumley,T., Morrison,A.C., Joubert,B.R.,
            Rivadeneira,F., Couper,D.J., Kritchevsky,S.B., Liu,Y., Wjst,M.,
            Wain,L.V., Vonk,J.M., Uitterlinden,A.G., Rochat,T., Rich,S.S.,
            Psaty,B.M., O'Connor,G.T., North,K.E., Mirel,D.B., Meibohm,B.,
            Launer,L.J., Khaw,K.T., Hartikainen,A.L., Hammond,C.J., Glaser,S.,
            Marchini,J., Kraft,P., Wareham,N.J., Volzke,H., Stricker,B.H.,
            Spector,T.D., Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R.,
            Heckbert,S.R., Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A.,
            Strachan,D.P., Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and
            London,S.J.
  TITLE     Genome-wide joint meta-analysis of SNP and SNP-by-smoking
            interaction identifies novel loci for pulmonary function
  JOURNAL   PLoS Genet. 8 (12), E1003098 (2012)
   PUBMED   23284291
REFERENCE   5  (bases 1 to 5533)
  AUTHORS   Haas,K., Kundi,M., Sperr,W.R., Esterbauer,H., Ludwig,W.D.,
            Ratei,R., Koller,E., Gruener,H., Sauerland,C., Fonatsch,C.,
            Valent,P. and Wieser,R.
  TITLE     Expression and prognostic significance of different mRNA 5'-end
            variants of the oncogene EVI1 in 266 patients with de novo AML:
            EVI1 and MDS1/EVI1 overexpression both predict short remission
            duration
  JOURNAL   Genes Chromosomes Cancer 47 (4), 288-298 (2008)
   PUBMED   18181178
  REMARK    GeneRIF: EVI1 and MDS1/EVI1 overexpression is associated with acute
            myeloid leukemia
REFERENCE   6  (bases 1 to 5533)
  AUTHORS   Aytekin,M., Vinatzer,U., Musteanu,M., Raynaud,S. and Wieser,R.
  TITLE     Regulation of the expression of the oncogene EVI1 through the use
            of alternative mRNA 5'-ends
  JOURNAL   Gene 356, 160-168 (2005)
   PUBMED   16014322
  REMARK    GeneRIF: The general expression patterns of the EVI1 5'-end
            variants in a panel of 20 human tissues were similar, while
            pronounced differences were noted in response to all-trans retinoic
            acid.
REFERENCE   7  (bases 1 to 5533)
  AUTHORS   Mochizuki,N., Shimizu,S., Nagasawa,T., Tanaka,H., Taniwaki,M.,
            Yokota,J. and Morishita,K.
  TITLE     A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the
            MDS1/EVI1 gene and is transcriptionally activated in
            t(1;3)(p36;q21)-positive leukemia cells
  JOURNAL   Blood 96 (9), 3209-3214 (2000)
   PUBMED   11050005
REFERENCE   8  (bases 1 to 5533)
  AUTHORS   Nucifora,G., Begy,C.R., Kobayashi,H., Roulston,D., Claxton,D.,
            Pedersen-Bjergaard,J., Parganas,E., Ihle,J.N. and Rowley,J.D.
  TITLE     Consistent intergenic splicing and production of multiple
            transcripts between AML1 at 21q22 and unrelated genes at 3q26 in
            (3;21)(q26;q22) translocations
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (9), 4004-4008 (1994)
   PUBMED   8171026
REFERENCE   9  (bases 1 to 5533)
  AUTHORS   Mitani,K., Ogawa,S., Tanaka,T., Miyoshi,H., Kurokawa,M., Mano,H.,
            Yazaki,Y., Ohki,M. and Hirai,H.
  TITLE     Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22)
            causes blastic crisis in chronic myelocytic leukemia
  JOURNAL   EMBO J. 13 (3), 504-510 (1994)
   PUBMED   8313895
REFERENCE   10 (bases 1 to 5533)
  AUTHORS   Morishita,K., Parganas,E., Douglass,E.C. and Ihle,J.N.
  TITLE     Unique expression of the human Evi-1 gene in an endometrial
            carcinoma cell line: sequence of cDNAs and structure of
            alternatively spliced transcripts
  JOURNAL   Oncogene 5 (7), 963-971 (1990)
   PUBMED   2115646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC348381.1, AL700380.1,
            AK304098.1, CR541866.1, BC130520.1, BX647613.1 and AA043944.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Aug 8, 2009 this sequence version replaced gi:195963413.
            
            Summary: The protein encoded by this gene is a transcriptional
            regulator and oncoprotein that may be involved in hematopoiesis,
            apoptosis, development, and cell differentiation and proliferation.
            The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B,
            MAPK8, and MAPK9. This gene can undergo translocation with the AML1
            gene, resulting in overexpression of this gene and the onset of
            leukemia. Several transcript variants encoding a few different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2011].
            
            Transcript Variant: This variant (4, also known as MDS1/EVI1)
            differs in the 5' UTR and 5' coding region, and uses an alternate
            in-frame splice site in the central coding region, compared to
            variant 1. The encoded isoform (c) has a distinct N-terminus and is
            longer than isoform a. There are no publicly available full-length
            transcripts representing this variant, but it is supported by
            cloning evidence in PMID:11050005.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
                              [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               DC348381.1         1-160
            161-301             AL700380.1         99-239
            302-486             AK304098.1         248-432
            487-778             CR541866.1         84-375
            779-3238            AK304098.1         725-3184
            3239-4158           BC130520.1         2580-3499
            4159-5525           BX647613.1         4098-5464
            5526-5533           AA043944.1         3-10                c
FEATURES             Location/Qualifiers
     source          1..5533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..5533
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="MDS1 and EVI1 complex locus"
                     /db_xref="GeneID:2122"
                     /db_xref="HGNC:3498"
                     /db_xref="MIM:165215"
     exon            1..440
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    131..133
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="upstream in-frame stop codon"
     variation       161..162
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace=""
                     /replace="ag"
                     /db_xref="dbSNP:3832188"
     variation       222
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1299563"
     variation       246..253
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace=""
                     /replace="gagagaga"
                     /db_xref="dbSNP:71166260"
     CDS             404..4123
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="isoform c is encoded by transcript variant 4; MDS1
                     and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex
                     locus protein MDS1; oncogene EVI1; myelodysplasia
                     syndrome-associated protein 1; zinc finger protein Evi1;
                     AML1-EVI-1 fusion protein; ecotropic virus integration
                     site 1 protein homolog"
                     /codon_start=1
                     /product="MDS1 and EVI1 complex locus protein EVI1 isoform
                     c"
                     /protein_id="NP_004982.2"
                     /db_xref="GI:255683386"
                     /db_xref="GeneID:2122"
                     /db_xref="HGNC:3498"
                     /db_xref="MIM:165215"
                     /translation="
MRSKGRARKLATNNECVYGNYPEIPLEEMPDADGVASTPSLNIQEPCSPATSSEAFTPKEGSPYKAPIYIPDDIPIPAEFELRESNMPGAGLGIWTKRKIEVGEKFGPYVGEQRSNLKDPSYGWEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV
"
     misc_feature    641..991
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain; Region: SET; smart00317"
                     /db_xref="CDD:197649"
     misc_feature    1232..1306
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:205643"
     misc_feature    1277..1342
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     misc_feature    1400..1480
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:205643"
     misc_feature    1451..1513
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     misc_feature    1532..1597
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     misc_feature    1619..1684
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     misc_feature    3167..3232
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     misc_feature    3206..3280
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:205643"
     misc_feature    3290..3364
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc-finger double domain; Region: zf-H2C2_2;
                     pfam13465"
                     /db_xref="CDD:205643"
     misc_feature    3338..3403
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
                     /db_xref="CDD:210117"
     exon            441..778
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            779..913
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            914..1016
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            1017..1233
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            1234..1381
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     variation       1287
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34896995"
     STS             1330..2537
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /standard_name="Evi1"
                     /db_xref="UniSTS:256974"
     STS             1330..1796
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /standard_name="Evi1"
                     /db_xref="UniSTS:256973"
     exon            1382..1535
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            1536..2892
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     variation       1678
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35594969"
     variation       1721
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:199968662"
     STS             1981..2927
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /standard_name="Evi1"
                     /db_xref="UniSTS:506889"
     variation       2600
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2276719"
     exon            2893..2980
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            2981..3007
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            3008..3174
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     variation       3077
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:36043407"
     exon            3175..3252
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            3253..3422
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     variation       3344
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34224062"
     exon            3423..3567
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            3568..3804
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            3805..3988
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     exon            3989..5533
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /inference="alignment:Splign:1.39.8"
     STS             4007..4226
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /standard_name="SHGC-77524"
                     /db_xref="UniSTS:47700"
     STS             4524..4811
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /standard_name="SGC38138"
                     /db_xref="UniSTS:74058"
     variation       4711
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1048601"
     variation       5325
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1048604"
     polyA_signal    5505..5510
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
     polyA_site      5533
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3"
ORIGIN      
gattgccatctgacaagatctccaaatcaaagtgataaatcgctccaaactttttttggcggcgctgagatgttggaggggcgtctagcgcgcatgtgcgaaggtgtccaaactgacaatgctggagagatagcgagtgtggattgagagaaagggagagagggagggagagagagtgaaagaagaaaatacagagagtgagtgtgtggaagagagagagaaacaggagagaaacaggagggagggagagagagagagagagagagagagagagagagagagagagagagagagagagagacaggagagagagggagggagcgagagggagagcaaaagaaggaaaggatccaagaaaaaaaagccccaaccacacaccagcggctgcaggactgggcacagcatgagatccaaaggcagggcaaggaaactggccacaaataatgagtgtgtatatggcaactaccctgaaatacctttggaagaaatgccagatgcagatggagtagccagcactccctccctcaatattcaagagccatgctctcctgccacatccagtgaagcattcactccaaaggagggttctccttacaaagcccccatctacatccctgatgatatccccattcctgctgagtttgaacttcgagagtcaaatatgcctggggcaggactaggaatatggaccaaaaggaagatcgaagtaggtgaaaagtttgggccttatgtgggagagcagaggtcaaacctgaaagaccccagttatggatgggagatcttagacgaattttacaatgtgaagttctgcatagatgccagtcaaccagatgttggaagctggctcaagtacattagattcgctggctgttatgatcagcacaaccttgttgcatgccagataaatgatcagatattctatagagtagttgcagacattgcgccgggagaggagcttctgctgttcatgaagagcgaagactatccccatgaaactatggcgccggatatccacgaagaacggcaatatcgctgcgaagactgtgaccagctctttgaatctaaggctgaactagcagatcaccaaaagtttccatgcagtactcctcactcagcattttcaatggttgaagaggactttcagcaaaaactcgaaagcgagaatgatctccaagagatacacacgatccaggagtgtaaggaatgtgaccaagtttttcctgatttgcaaagcctggagaaacacatgctgtcacatactgaagagagggaatacaagtgtgatcagtgtcccaaggcatttaactggaagtccaatttaattcgccaccagatgtcacatgacagtggaaagcactatgaatgtgaaaactgtgccaaggttttcacggaccctagcaaccttcagcggcacattcgctctcagcatgtcggtgcccgggcccatgcatgcccggagtgtggcaaaacgtttgccacttcgtcgggcctcaaacaacacaagcacatccacagcagtgtgaagccctttatctgtgaggtctgccataaatcctatactcagttttcaaacctttgccgtcataagcgcatgcatgctgattgcagaacccaaatcaagtgcaaagactgtggacaaatgttcagcactacgtcttccttaaataaacacaggaggttttgtgagggcaagaaccattttgcggcaggtggattttttggccaaggcatttcacttcctggaaccccagctatggataaaacgtccatggttaatatgagtcatgccaacccgggccttgctgactattttggcgccaataggcatcctgctggtcttacctttccaacagctcctggattttcttttagcttccctggtctgtttccttccggcttgtaccacaggcctcctttgatacctgctagttctcctgttaaaggactatcaagtactgaacagacaaacaaaagtcaaagtcccctcatgacacatcctcagatactgccagctacacaggatattttgaaggcactatctaaacacccatctgtaggggacaataagccagtggagctccagcccgagaggtcctctgaagagaggccctttgagaaaatcagtgaccagtcagagagtagtgaccttgatgatgtcagtacaccaagtggcagtgacctggaaacaacctcgggctctgatctggaaagtgacattgaaagtgataaagagaaatttaaagaaaatggtaaaatgttcaaagacaaagtaagccctcttcagaatctggcttcaataaataataagaaagaatacagcaatcattccattttctcaccatctttagaggagcagactgcggtgtcaggagctgtgaatgattctataaaggctattgcttctattgctgaaaaatactttggttcaacaggactggtggggctgcaagacaaaaaagttggagctttaccttacccttccatgtttcccctcccattttttccagcattctctcaatcaatgtacccatttcctgatagagacttgagatcgttacctttgaaaatggaaccccaatcaccaggtgaagtaaagaaactgcagaagggcagctctgagtccccctttgatctcaccactaagcgaaaggatgagaagcccttgactccagtcccctccaagcctccagtgacacctgccacaagccaagaccagcccctggatctaagtatgggcagtaggagtagagccagtgggacaaagctgactgagcctcgaaaaaaccacgtgtttgggggaaaaaaaggaagcaacgtcgaatcaagacctgcttcagatggttccttgcagcatgcaagacccactcctttctttatggaccctatttacagagtagagaaaagaaaactaactgacccacttgaagctttaaaagagaaatacttgaggccttctccaggattcttgtttcacccacaattccaactgcctgatcagagaacttggatgtcagctattgaaaacatggcagaaaagctagagagcttcagtgccctgaaacctgaggccagtgagctcttacagtcagtgccctctatgttcaacttcagggcgcctcccaatgccctgccagagaaccttctgcggaagggaaaggagcgctatacctgcagatactgtggcaagatttttccaaggtctgcaaacctaacacggcacttgagaacccacacaggagagcagccttacagatgcaaatactgtgacagatcatttagcatatcttctaacttgcaaaggcatgttcgcaacatccacaataaagagaagccatttaagtgtcacttatgtgataggtgttttggtcaacaaaccaatttagacagacacctaaagaaacatgagaatgggaacatgtccggtacagcaacatcgtcgcctcattctgaactggaaagtacaggtgcgattctggatgacaaagaagatgcttacttcacagaaattcgaaatttcattgggaacagcaaccatggcagccaatctcccaggaatgtggaggagagaatgaatggcagtcattttaaagatgaaaaggctttggtgaccagtcaaaattcagacttgctggatgatgaagaagttgaagatgaggtgttgttagatgaggaggatgaagacaatgatattactggaaaaacaggaaaggaaccagtgacaagtaatttacatgaaggaaaccctgaggatgactatgaagaaaccagtgccctggagatgagttgcaagacatccccagtgaggtataaagaggaagaatataaaagtggactttctgctctagatcatataaggcacttcacagatagcctcaaaatgaggaaaatggaagataatcaatattctgaagctgagctgtcttcttttagtacttcccatgtgccagaggaacttaagcagccgttacacagaaagtccaaatcgcaggcatatgctatgatgctgtcactgtctgacaaggagtccctccattctacatcccacagttcttccaacgtgtggcacagtatggccagggctgcggcggaatccagtgctatccagtccataagccacgtatgacgttatcaaggttgaccagagtgggaccaagtccaacagtagcatggctctttcatataggactatttacaagactgctgagcagaatgccttataaacctgcagggtcactcatctaaagtctagtgaccttaaactgaatgatttaaaaaagaaaagaaagaaaaaagaaactatttattctcgatattttgttttgcacagcaaaggcagctgctgacttctggaagatcaatcaatgcgacttaaagtgattcagtgaaaacaaaaaacttggtgggctgaaggcatcttccagtttaccccaccttagggtatgggtgggtgagaagggcagttgagatggcagcattgatatgaatgaacactccatagaaactgaattctcttttgtacaagatcacctgacatgattgggaacagttgcttttaattacagatttaatttttttcttcgttaaagttttatgtaatttaaccctttgaagacagaagtagttggatgaaatgcacagtcaattattatagaaactgataacagggagtacttgttcccccttttgccttcttaagtacattgtttaaaactagggaaaaagggtatgtgtatattgtaaactatggatgttaacactcaaagaggttaagtcagtgaagtaacctattcatcaccagtaccgctgtaccactaataaattgtttgccaaatccttgtaataacatcttaattttagacaatcatgtcactgtttttaatgtttatttttttgtgtgtgttgcgtgtatcatgtatttatttgttggcaaactattgtttgttgattaaaatagcactgttccagtcagccactactttatgacgtctgaggcacacccctttccgaatttcaaggaccaaggtgacccgacctgtgtatgagagtgccaaatggtgtttggcttttcttaacattcctttttgtttgtttgttttgttttccttcttaatgaactaaatacgaatagatgcaacttagtttttgtaatactgaaatcgattcaattgtataaacgattataatttctttcatggaagcatgattcttctgattaaaaactgtactccatattttatgctggttgtctgcaagcttgtgcgatgttatgttcatgttaatcctatttgtaaaatgaagtgttcccaaccttatgttaaaagagagaagtaaataacagactgtattcagttattttgccctttattgaggaaccagatttgttttctttttgtttgtaatctcattttgaaataatcagcaagttgaggtactttcttcaaatgctttgtacaatataaactgttatgcctttcagtgcattactatgggaggagcaactaaaaaataaagacttacaaaaaggagtattttt
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2122 -> Molecular function: GO:0003677 [DNA binding] evidence: ISS
            GeneID:2122 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:2122 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
            GeneID:2122 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2122 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
            GeneID:2122 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:2122 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:2122 -> Biological process: GO:0001780 [neutrophil homeostasis] evidence: IEA
            GeneID:2122 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:2122 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
            GeneID:2122 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:2122 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
            GeneID:2122 -> Biological process: GO:0009605 [response to external stimulus] evidence: IEA
            GeneID:2122 -> Biological process: GO:0009617 [response to bacterium] evidence: IEA
            GeneID:2122 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
            GeneID:2122 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
            GeneID:2122 -> Biological process: GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] evidence: IDA
            GeneID:2122 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
            GeneID:2122 -> Biological process: GO:0035115 [embryonic forelimb morphogenesis] evidence: IEA
            GeneID:2122 -> Biological process: GO:0035116 [embryonic hindlimb morphogenesis] evidence: IEA
            GeneID:2122 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
            GeneID:2122 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: IMP
            GeneID:2122 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:2122 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:2122 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IEA
            GeneID:2122 -> Biological process: GO:0046329 [negative regulation of JNK cascade] evidence: IMP
            GeneID:2122 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IDA
            GeneID:2122 -> Biological process: GO:0060039 [pericardium development] evidence: IEA
            GeneID:2122 -> Biological process: GO:0071425 [hematopoietic stem cell proliferation] evidence: ISS
            GeneID:2122 -> Biological process: GO:0072001 [renal system development] evidence: IEA
            GeneID:2122 -> Cellular component: GO:0000118 [histone deacetylase complex] evidence: IDA
            GeneID:2122 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:2122 -> Cellular component: GO:0016607 [nuclear speck] evidence: IDA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.