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2024-04-17 05:25:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004885 2056 bp mRNA linear PRI 06-MAY-2013
DEFINITION Homo sapiens neuropeptide FF receptor 2 (NPFFR2), transcript
variant 1, mRNA.
ACCESSION NM_004885
VERSION NM_004885.2 GI:221316653
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2056)
AUTHORS Mouledous,L., Froment,C., Dauvillier,S., Burlet-Schiltz,O.,
Zajac,J.M. and Mollereau,C.
TITLE GRK2 protein-mediated transphosphorylation contributes to loss of
function of mu-opioid receptors induced by neuropeptide FF (NPFF2)
receptors
JOURNAL J. Biol. Chem. 287 (16), 12736-12749 (2012)
PUBMED 22375000
REMARK GeneRIF: These data show that NPFF-induced heterologous
desensitization of MOP receptor signaling is mediated by GRK2 and
could involve transphosphorylation within the heteromeric receptor
complex.
REFERENCE 2 (bases 1 to 2056)
AUTHORS Hunt,S.C., Hasstedt,S.J., Xin,Y., Dalley,B.K., Milash,B.A.,
Yakobson,E., Gress,R.E., Davidson,L.E. and Adams,T.D.
TITLE Polymorphisms in the NPY2R gene show significant associations with
BMI that are additive to FTO, MC4R, and NPFFR2 gene effects
JOURNAL Obesity (Silver Spring) 19 (11), 2241-2247 (2011)
PUBMED 21818152
REMARK GeneRIF: Four genetic loci were strongly and independently
associated with obesity, NPY2R, NPFFR2, MC4R, and FTO.
REFERENCE 3 (bases 1 to 2056)
AUTHORS Lyubimov,Y., Engstrom,M., Wurster,S., Savola,J.M., Korpi,E.R. and
Panula,P.
TITLE Human kisspeptins activate neuropeptide FF2 receptor
JOURNAL Neuroscience 170 (1), 117-122 (2010)
PUBMED 20600636
REMARK GeneRIF: Besides regulation of reproduction, kisspeptins have a
potential to mediate physiological effects on autonomic regulation
and nociception in humans via the NPFF2R pathways.
REFERENCE 4 (bases 1 to 2056)
AUTHORS Talmont,F., Mouledous,L., Piedra-Garcia,L., Schmitt,M., Bihel,F.,
Bourguignon,J.J., Zajac,J.M. and Mollereau,C.
TITLE Pharmacological characterization of the mouse NPFF2 receptor
JOURNAL Peptides 31 (2), 215-220 (2010)
PUBMED 19944730
REMARK GeneRIF: species-related differences in the binding properties of
NPFF(2) receptors
REFERENCE 5 (bases 1 to 2056)
AUTHORS Goncharuk,V. and Jhamandas,J.H.
TITLE Neuropeptide FF2 receptor distribution in the human brain. An
immunohistochemical study
JOURNAL Peptides 29 (9), 1544-1553 (2008)
PUBMED 18565622
REMARK GeneRIF: we identified hFF2 positive neurons in the forebrain and
medulla oblongata of individuals who died suddenly.
REFERENCE 6 (bases 1 to 2056)
AUTHORS Engstrom,M., Brandt,A., Wurster,S., Savola,J.M. and Panula,P.
TITLE Prolactin releasing peptide has high affinity and efficacy at
neuropeptide FF2 receptors
JOURNAL J. Pharmacol. Exp. Ther. 305 (3), 825-832 (2003)
PUBMED 12606605
REFERENCE 7 (bases 1 to 2056)
AUTHORS Bonini,J.A., Jones,K.A., Adham,N., Forray,C., Artymyshyn,R.,
Durkin,M.M., Smith,K.E., Tamm,J.A., Boteju,L.W., Lakhlani,P.P.,
Raddatz,R., Yao,W.J., Ogozalek,K.L., Boyle,N., Kouranova,E.V.,
Quan,Y., Vaysse,P.J., Wetzel,J.M., Branchek,T.A., Gerald,C. and
Borowsky,B.
TITLE Identification and characterization of two G protein-coupled
receptors for neuropeptide FF
JOURNAL J. Biol. Chem. 275 (50), 39324-39331 (2000)
PUBMED 11024015
REFERENCE 8 (bases 1 to 2056)
AUTHORS Elshourbagy,N.A., Ames,R.S., Fitzgerald,L.R., Foley,J.J.,
Chambers,J.K., Szekeres,P.G., Evans,N.A., Schmidt,D.B.,
Buckley,P.T., Dytko,G.M., Murdock,P.R., Milligan,G., Groarke,D.A.,
Tan,K.B., Shabon,U., Nuthulaganti,P., Wang,D.Y., Wilson,S.,
Bergsma,D.J. and Sarau,H.M.
TITLE Receptor for the pain modulatory neuropeptides FF and AF is an
orphan G protein-coupled receptor
JOURNAL J. Biol. Chem. 275 (34), 25965-25971 (2000)
PUBMED 10851242
REFERENCE 9 (bases 1 to 2056)
AUTHORS Parker,R.M., Copeland,N.G., Eyre,H.J., Liu,M., Gilbert,D.J.,
Crawford,J., Couzens,M., Sutherland,G.R., Jenkins,N.A. and
Herzog,H.
TITLE Molecular cloning and characterisation of GPR74 a novel G-protein
coupled receptor closest related to the Y-receptor family
JOURNAL Brain Res. Mol. Brain Res. 77 (2), 199-208 (2000)
PUBMED 10837915
REFERENCE 10 (bases 1 to 2056)
AUTHORS Cikos,S., Gregor,P. and Koppel,J.
TITLE Sequence and tissue distribution of a novel G-protein-coupled
receptor expressed prominently in human placenta
JOURNAL Biochem. Biophys. Res. Commun. 256 (2), 352-356 (1999)
PUBMED 10079187
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF119815.1, AC106051.3 and
CN285250.1.
On Jan 24, 2009 this sequence version replaced gi:4758819.
Summary: This gene encodes a member of a subfamily of
G-protein-coupled neuropeptide receptors. This protein is activated
by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may
function in pain modulation and regulation of the opioid system.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Jan 2009].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF119815.1, AK308069.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1207 AF119815.1 1-1207
1208-1494 AC106051.3 21245-21531
1495-1916 AF119815.1 1495-1916
1917-2006 CN285250.1 579-668
2007-2056 AC106051.3 22044-22093
FEATURES Location/Qualifiers
source 1..2056
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q21"
gene 1..2056
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/note="neuropeptide FF receptor 2"
/db_xref="GeneID:10886"
/db_xref="HGNC:4525"
/db_xref="MIM:607449"
exon 1..397
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="alignment:Splign:1.39.8"
variation 51
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:368090354"
variation 76
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:200594451"
misc_feature 90..92
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/note="upstream in-frame stop codon"
variation 95
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="g"
/replace="t"
/db_xref="dbSNP:182167830"
CDS 99..1667
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/note="isoform 1 is encoded by transcript variant 1; G
protein-coupled receptor 74; neuropeptide FF 2; G-protein
coupled receptor 74; G-protein coupled receptor HLWAR77;
neuropeptide G-protein coupled receptor"
/codon_start=1
/product="neuropeptide FF receptor 2 isoform 1"
/protein_id="NP_004876.2"
/db_xref="GI:221316654"
/db_xref="CCDS:CCDS3551.1"
/db_xref="GeneID:10886"
/db_xref="HGNC:4525"
/db_xref="MIM:607449"
/translation="
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
"
misc_feature 540..602
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
misc_feature 591..>929
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/note="Olfactory receptor; Region: 7tm_4; cl10458"
/db_xref="CDD:209142"
misc_feature 606..1403
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/note="7 transmembrane receptor (rhodopsin family);
Region: 7tm_1; pfam00001"
/db_xref="CDD:200918"
misc_feature 651..713
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
misc_feature 762..824
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
misc_feature 885..947
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
misc_feature 1056..1118
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
misc_feature 1230..1292
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
misc_feature 1338..1400
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9Y5X5.2);
transmembrane region"
variation 125
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:138152531"
variation 159
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:113510276"
variation 174
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:71655703"
variation 179
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:201446563"
variation 202
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:112634901"
variation 203
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:115834666"
variation 210
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:371571027"
variation 231
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:372016830"
variation 250
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:146044348"
variation 273
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:112931663"
variation 291
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:141779896"
variation 303
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace=""
/replace="a"
/db_xref="dbSNP:35424833"
variation 305
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:148447621"
variation 311
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:61733658"
variation 312
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:150945821"
variation 316
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201021581"
variation 328
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:139488490"
variation 344
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:375027040"
variation 348
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:370639476"
variation 349
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:375344185"
variation 352
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:368084766"
variation 379
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:200424723"
variation 391
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:200084669"
exon 398..732
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="alignment:Splign:1.39.8"
variation 404
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:147754873"
variation 424
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:368846467"
variation 433
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:142617960"
variation 444
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:146896505"
variation 459
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201647370"
variation 488
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:147934711"
variation 489
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:201045074"
variation 505
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:200033565"
variation 512
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:148970744"
variation 548
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:376287922"
variation 582
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:143711179"
variation 618
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:148112426"
variation 621
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:77812923"
variation 623
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:200268318"
variation 629
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:371873043"
variation 657
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:144971184"
variation 692
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:186834987"
variation 699
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:202241077"
variation 719
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:376456096"
exon 733..832
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="alignment:Splign:1.39.8"
variation 752
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:141870844"
variation 792
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:77060411"
variation 809
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:372779938"
variation 811
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:199522429"
exon 833..2056
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/inference="alignment:Splign:1.39.8"
variation 847
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:61733659"
variation 849
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:377571805"
variation 852
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:371534224"
variation 881
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:375450983"
variation 883
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:201155248"
variation 898
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:180800404"
variation 930
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:371070897"
variation 945
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:375107454"
variation 950
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:368051849"
variation 955
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="g"
/replace="t"
/db_xref="dbSNP:149509872"
variation 970
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:143977785"
variation 971
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:141010660"
variation 1022
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:370050336"
variation 1023
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:200830127"
variation 1055
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="g"
/replace="t"
/db_xref="dbSNP:144234360"
variation 1061
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:147777418"
variation 1066
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:61734660"
variation 1069
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:375879750"
variation 1079
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:374367425"
variation 1092
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:144936999"
variation 1168
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:151314267"
variation 1193
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:367856737"
variation 1194
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:372789219"
variation 1211
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:374596680"
variation 1269
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:140574905"
variation 1302
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:368305828"
variation 1303
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:150453445"
variation 1306
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:150345262"
variation 1317
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:371971346"
variation 1334
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:377325352"
variation 1340
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:149158376"
variation 1345
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:182458784"
variation 1373
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:145038184"
variation 1374
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:199813244"
variation 1400
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="g"
/replace="t"
/db_xref="dbSNP:374891307"
variation 1415
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:138820836"
variation 1419
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:369247696"
variation 1425
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:141913034"
variation 1429
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:183198628"
variation 1482
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:145611919"
variation 1504
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:148058374"
variation 1527
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:190387826"
variation 1567
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:375841399"
variation 1588
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:201706126"
variation 1591
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:369070481"
variation 1596
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:141753805"
variation 1602
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:150557185"
variation 1647
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:138572984"
variation 1696
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:200556570"
variation 1700
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:200069388"
variation 1701
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:6823634"
variation 1823
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:182451166"
variation 1860
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="t"
/db_xref="dbSNP:375586970"
polyA_signal 1891..1896
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
polyA_site 1916
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/note="This is an internal polyA site. The 3'-most polyA
site has not been determined."
variation 1919
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="c"
/db_xref="dbSNP:187924887"
variation 1936
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="g"
/replace="t"
/db_xref="dbSNP:983345"
variation 1957
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:74469526"
variation 1958
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:191821492"
variation 1975
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="t"
/db_xref="dbSNP:184062275"
variation 1976
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="c"
/replace="g"
/db_xref="dbSNP:149091069"
variation 1978
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="a"
/replace="g"
/db_xref="dbSNP:187929278"
variation 2014
/gene="NPFFR2"
/gene_synonym="GPR74; HLWAR77; NPFF2; NPGPR"
/replace="g"
/replace="t"
/db_xref="dbSNP:371343125"
ORIGIN
tctggagccaagtaatggtgatactgatgcttccttttctttgccgcgctcggattctgagtttcacaagaatgtacctgggtgccccttagcgggatatgaatagcttcttcggaaccccagcggccagctggtgcctcctggaaagtgacgtctcatctgcaccggacaaggaggcggggagggagcgcagagcactcagcgtccagcagcgcggcgggccagcctggagcggaagcctggagtggagcaggcagtccgcgggggacagacgtcggctgggattgagccggcagactgcgaaaagtagctggagccggagcagggacagaacctgttgctgcagacgggcttggtggattctggttcctgccgccgacagggctcgccgggagaggttcatcatgaatgagaaatgggacacaaactcttcagaaaactggcatcccatctggaatgtcaatgacacaaagcatcatctgtactcagatattaatattacctatgtgaactactatcttcaccagcctcaagtggcagcaatcttcattatttcctactttctgatcttctttttgtgcatgatgggaaatactgtggtttgctttattgtaatgaggaacaaacatatgcacacagtcactaatctcttcatcttaaacctggccataagtgatttactagttggcatattctgcatgcctataacactgctggacaatattatagcaggatggccatttggaaacacgatgtgcaagatcagtggattggtccagggaatatctgtcgcagcttcagtctttacgttagttgcaattgctgtagataggttccagtgtgtggtctacccttttaaaccaaagctcactatcaagacagcgtttgtcattattatgatcatctgggtcctagccatcaccattatgtctccatctgcagtaatgttacatgtgcaagaagaaaaatattaccgagtgagactcaactcccagaataaaaccagtccagtctactggtgccgggaagactggccaaatcaggaaatgaggaagatctacaccactgtgctgtttgccaacatctacctggctcccctctccctcattgtcatcatgtatggaaggattggaatttcactcttcagggctgcagttcctcacacaggcaggaagaaccaggagcagtggcacgtggtgtccaggaagaagcagaagatcattaagatgctcctgattgtggccctgctttttattctctcatggctgcccctgtggactctaatgatgctctcagactacgctgacctttctccaaatgaactgcagatcatcaacatctacatctacccttttgcacactggctggcattcggcaacagcagtgtcaatcccatcatttatggtttcttcaacgagaatttccgccgtggtttccaagaagctttccagctccagctctgccaaaaaagagcaaagcctatggaagcttatgccctaaaagctaaaagccatgtgctcataaacacatctaatcagcttgtccaggaatctacatttcaaaaccctcatggggaaaccttgctttataggaaaagtgctgaaaaaccccaacaggaattagtgatggaagaattaaaagaaactactaacagcagtgagatttaaaaagagctagtgtgataatcctaactctactacgcattatatatttaaatccattgctttttgtggctttgcacttcaaatttttcaaagaatgttctaaataaaacatttactgaaagccctctctggcaaaaaaattaaaaataaacaaaaatggtcataagatcataaacaatcttatgttgtataaaaatacgtagagtgacttagacatgtttgcatgaataaatatatttctagagaacagtttacaaagcctcatctttccaaacttaaccatttgtgtatgcgtcaaatcaagcctgcacgcgtgcgtgcatgtgtgtgtgtattttccccaaatggtgatgatgagcagtgctttgcatgaaactagattttatcaattt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10886 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS
GeneID:10886 -> Molecular function: GO:0008188 [neuropeptide receptor activity] evidence: IEA
GeneID:10886 -> Molecular function: GO:0031628 [opioid receptor binding] evidence: IEA
GeneID:10886 -> Biological process: GO:0007186 [G-protein coupled receptor signaling pathway] evidence: TAS
GeneID:10886 -> Biological process: GO:0009582 [detection of abiotic stimulus] evidence: TAS
GeneID:10886 -> Biological process: GO:0043408 [regulation of MAPK cascade] evidence: IEA
GeneID:10886 -> Biological process: GO:0045761 [regulation of adenylate cyclase activity] evidence: IEA
GeneID:10886 -> Biological process: GO:2000479 [regulation of cAMP-dependent protein kinase activity] evidence: IEA
GeneID:10886 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:10886 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:10886 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:10886 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IDA
by
@meso_cacase at
DBCLS
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