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2024-04-24 03:18:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004874 4478 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens BCL2-associated athanogene 4 (BAG4), transcript
variant 1, mRNA.
ACCESSION NM_004874
VERSION NM_004874.3 GI:325910867
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4478)
AUTHORS Reuland,S.N., Smith,S.M., Bemis,L.T., Goldstein,N.B., Almeida,A.R.,
Partyka,K.A., Marquez,V.E., Zhang,Q., Norris,D.A. and Shellman,Y.G.
TITLE MicroRNA-26a is strongly downregulated in melanoma and induces cell
death through repression of silencer of death domains (SODD)
JOURNAL J. Invest. Dermatol. 133 (5), 1286-1293 (2013)
PUBMED 23190898
REMARK GeneRIF: MicroRNA-26a is strongly downregulated in melanoma and
induces cell death through repression of silencer of death domains
(SODD).
REFERENCE 2 (bases 1 to 4478)
AUTHORS Kelly,J.L., Novak,A.J., Fredericksen,Z.S., Liebow,M., Ansell,S.M.,
Dogan,A., Wang,A.H., Witzig,T.E., Call,T.G., Kay,N.E.,
Habermann,T.M., Slager,S.L. and Cerhan,J.R.
TITLE Germline variation in apoptosis pathway genes and risk of
non-Hodgkin's lymphoma
JOURNAL Cancer Epidemiol. Biomarkers Prev. 19 (11), 2847-2858 (2010)
PUBMED 20855536
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 4478)
AUTHORS Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B,
Yusuf S, Gerstein HC, Engert JC and Anand S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 4 (bases 1 to 4478)
AUTHORS Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt
TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M,
Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ,
Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S,
Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD,
Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE
and Hingorani AD.
CONSRTM ASCOT investigators; NORDIL investigators; BRIGHT Consortium
TITLE Gene-centric association signals for lipids and apolipoproteins
identified via the HumanCVD BeadChip
JOURNAL Am. J. Hum. Genet. 85 (5), 628-642 (2009)
PUBMED 19913121
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4478)
AUTHORS Tao,H.F., Hu,Q., Fang,J.L., Liu,A.G., Liu,S.Y., Zhang,L.Q. and
Hu,Y.
TITLE [Effects of SODD and survivin on leukemia cell apoptosis induced by
chemotherapeutic drugs]
JOURNAL Zhongguo Shi Yan Xue Ye Xue Za Zhi 15 (3), 501-505 (2007)
PUBMED 17605853
REMARK GeneRIF: Vincristine induces Jurkat cell apoptosis by
downregulating expression of SODD protein and priming the death
receptor pathway.
REFERENCE 6 (bases 1 to 4478)
AUTHORS Eichholtz-Wirth,H. and Sagan,D.
TITLE Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible
for radioresistance in human HT-R15 cells
JOURNAL Anticancer Res. 22 (1A), 235-240 (2002)
PUBMED 12017295
REMARK GeneRIF: Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is
responsible for radioresistance in human HT-R15 cells.
REFERENCE 7 (bases 1 to 4478)
AUTHORS Antoku,K., Maser,R.S., Scully,W.J. Jr., Delach,S.M. and
Johnson,D.E.
TITLE Isolation of Bcl-2 binding proteins that exhibit homology with
BAG-1 and suppressor of death domains protein
JOURNAL Biochem. Biophys. Res. Commun. 286 (5), 1003-1010 (2001)
PUBMED 11527400
REFERENCE 8 (bases 1 to 4478)
AUTHORS Frisch,S.M.
TITLE Evidence for a function of death-receptor-related,
death-domain-containing proteins in anoikis
JOURNAL Curr. Biol. 9 (18), 1047-1049 (1999)
PUBMED 10508612
REFERENCE 9 (bases 1 to 4478)
AUTHORS Jiang,Y., Woronicz,J.D., Liu,W. and Goeddel,D.V.
TITLE Prevention of constitutive TNF receptor 1 signaling by silencer of
death domains
JOURNAL Science 283 (5401), 543-546 (1999)
PUBMED 9915703
REMARK Erratum:[Science 1999 Mar 19;283(5409):1852]
REFERENCE 10 (bases 1 to 4478)
AUTHORS Takayama,S., Xie,Z. and Reed,J.C.
TITLE An evolutionarily conserved family of Hsp70/Hsc70 molecular
chaperone regulators
JOURNAL J. Biol. Chem. 274 (2), 781-786 (1999)
PUBMED 9873016
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC000800.1, AF095194.2,
AC084024.17 and BM683128.1.
On Mar 11, 2011 this sequence version replaced gi:14574569.
Summary: The protein encoded by this gene is a member of the
BAG1-related protein family. BAG1 is an anti-apoptotic protein that
functions through interactions with a variety of cell apoptosis and
growth related proteins including BCL-2, Raf-protein kinase,
steroid hormone receptors, growth factor receptors and members of
the heat shock protein 70 kDa family. This protein contains a BAG
domain near the C-terminus, which could bind and inhibit the
chaperone activity of Hsc70/Hsp70. This protein was found to be
associated with the death domain of tumor necrosis factor receptor
type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively
regulates downstream cell death signaling. The regulatory role of
this protein in cell death was demonstrated in epithelial cells
which undergo apoptosis while integrin mediated matrix contacts are
lost. Alternatively spliced transcript variants encoding distinct
isoforms have been identified. [provided by RefSeq, Mar 2011].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC038505.1, AF095194.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-244 BC000800.1 1-244
245-1712 AF095194.2 5-1472
1713-3992 AC084024.17 96207-98486
3993-4478 BM683128.1 1-486 c
FEATURES Location/Qualifiers
source 1..4478
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11.23"
gene 1..4478
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/note="BCL2-associated athanogene 4"
/db_xref="GeneID:9530"
/db_xref="HGNC:940"
/db_xref="HPRD:04861"
/db_xref="MIM:603884"
exon 1..552
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/inference="alignment:Splign:1.39.8"
variation 23
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:150735540"
variation 35..36
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="g"
/db_xref="dbSNP:34846134"
variation 89
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:7000184"
variation 90
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:113937856"
misc_feature 106..108
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/note="upstream in-frame stop codon"
variation 109
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:77568784"
variation 177
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:112343580"
variation 179
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:55962869"
variation 237
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:143677476"
variation 244
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:190213515"
variation 273
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:376268617"
CDS 283..1656
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/note="isoform 1 is encoded by transcript variant 1;
BAG-family molecular chaperone regulator-4; silencer of
death domains; BAG family molecular chaperone regulator 4;
bcl-2-associated athanogene 4"
/codon_start=1
/product="BAG family molecular chaperone regulator 4
isoform 1"
/protein_id="NP_004865.1"
/db_xref="GI:6631075"
/db_xref="CCDS:CCDS6104.1"
/db_xref="GeneID:9530"
/db_xref="HGNC:940"
/db_xref="HPRD:04861"
/db_xref="MIM:603884"
/translation="
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
"
misc_feature 1417..1650
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/note="BAG domains, present in regulator of Hsp70
proteins; Region: BAG; smart00264"
/db_xref="CDD:197613"
variation 297
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:61731143"
variation 353
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:369467061"
variation 355
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:61731142"
variation 479
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:35041562"
variation 507
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:369666639"
exon 553..660
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/inference="alignment:Splign:1.39.8"
variation 555
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:187647845"
variation 590
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:143482634"
variation 602
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:147141531"
exon 661..915
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/inference="alignment:Splign:1.39.8"
variation 670
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:377544370"
variation 677
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:371334530"
variation 681
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:375515884"
variation 697
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:192353336"
variation 706
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:377654190"
variation 756
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:374977832"
variation 792
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:17853839"
variation 799
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:140270832"
variation 802
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:375790383"
variation 826
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:367677262"
variation 832
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:143334197"
variation 836
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:61754115"
variation 840
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:372261481"
variation 859
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:139408020"
variation 877
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:150045830"
variation 905
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:200494674"
exon 916..1170
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/inference="alignment:Splign:1.39.8"
variation 955
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:145302681"
variation 964
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:369685431"
variation 975
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:190953663"
variation 998
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:111978086"
variation 1007
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:202100571"
variation 1008
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:140078461"
variation 1024
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:143665459"
variation 1057
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:201302425"
variation 1065
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:146791444"
variation 1079
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:376249751"
exon 1171..4464
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/inference="alignment:Splign:1.39.8"
variation 1173
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:147569371"
variation 1204
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:140547293"
variation 1220
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:140266447"
variation 1235
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:143644289"
variation 1254
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:151234579"
variation 1270
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:201044060"
variation 1286
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:199793591"
variation 1377
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:201309879"
variation 1412
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:376216479"
variation 1415
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:140388982"
variation 1416
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:377644522"
variation 1451
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:371081339"
variation 1455
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:376393739"
variation 1471
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:150352965"
STS 1481..1610
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/standard_name="SGC34731"
/db_xref="UniSTS:22143"
STS 1504..2250
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/standard_name="BAG4_88"
/db_xref="UniSTS:277023"
variation 1516
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:10725"
variation 1530
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:200905499"
variation 1572
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:374076675"
variation 1663
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:187571848"
variation 1745
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:377003478"
variation 1748
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:111385150"
variation 1769
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:80041165"
variation 1851
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:193259612"
STS 1955..2143
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/standard_name="RH78257"
/db_xref="UniSTS:21968"
variation 1969
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:1043782"
STS 2036..2161
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/standard_name="SHGC-30117"
/db_xref="UniSTS:1122"
variation 2065
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:3313"
variation 2163
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:144321800"
variation 2259..2260
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="g"
/db_xref="dbSNP:371085485"
variation 2365
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:76098501"
variation 2367
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:79588397"
variation 2388..2389
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="t"
/db_xref="dbSNP:72159699"
variation 2442
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:184097066"
variation 2443..2449
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="ataaaat"
/db_xref="dbSNP:144659234"
variation 2451
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:112471179"
variation 2491
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:4579494"
variation 2547
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:78509021"
variation 2556
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:142140385"
variation 2650..2651
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="t"
/db_xref="dbSNP:34203247"
variation 2667
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:113784638"
variation 2691
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:187833453"
STS 2709..2797
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/standard_name="D8S1432E"
/db_xref="UniSTS:151221"
STS 2725..2930
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/standard_name="RH25151"
/db_xref="UniSTS:88759"
variation 2788
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:142541037"
variation 2909
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:192460147"
variation 3006
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="g"
/db_xref="dbSNP:184086295"
variation 3077
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:143366565"
variation 3153
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:60530611"
variation 3208
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:188766347"
variation 3242
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:372784467"
variation 3372
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:113567191"
variation 3390
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:372560655"
variation 3434..3437
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="ttac"
/db_xref="dbSNP:370930659"
variation 3577
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:192014496"
variation 3610..3611
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace=""
/replace="c"
/db_xref="dbSNP:36118987"
variation 3619
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:184563970"
variation 3676
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:190199472"
variation 3732
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:76228049"
variation 3773
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:35866749"
variation 3948
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:182385280"
variation 4030
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="g"
/db_xref="dbSNP:187376240"
variation 4314
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="c"
/replace="t"
/db_xref="dbSNP:138231001"
variation 4324
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="c"
/db_xref="dbSNP:189383231"
variation 4368
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="a"
/replace="t"
/db_xref="dbSNP:180939735"
polyA_signal 4430..4435
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
variation 4448
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
/replace="g"
/replace="t"
/db_xref="dbSNP:142725480"
polyA_site 4464
/gene="BAG4"
/gene_synonym="BAG-4; SODD"
ORIGIN
aggtaagaggaaactccattggataaatggcgaggaaacgtatactccctcttaaggaacacggtgtcttccttcgtctccgggttcccgagaccccagagtcactgacctccgtccctcagctttcggggttcggcagcagaaggggcgggcccgggcctgggattggctggcgtcgtccgacccccttcgctgctctccattcgcaatcgcccgcgggcgcctgcgcgatgggtcggccgtggggagcggggcgggaagcgcttcagggcagcggatcccatgtcggccctgaggcgctcgggctacggccccagtgacggtccgtcctacggccgctactacgggcctgggggtggagatgtgccggtacacccacctccacccttatatcctcttcgccctgaacctccccagcctcccatttcctggcgggtgcgcgggggcggcccggcggagaccacctggctgggagaaggcggaggaggcgatggctactatccctcgggaggcgcctggccagagcctggtcgagccggaggaagccaccaggagcagccaccatatcctagctacaattctaactattggaattctactgcgagatctagggctccttacccaagtacatatcctgtaagaccagaattgcaaggccagagtttgaattcttatacaaatggagcgtatggtccaacataccccccaggccctggggcaaatactgcctcatactcaggggcttattatgcacctggttatactcagaccagttactccacagaagttccaagtacttaccgttcatctggcaacagcccaactccagtctctcgttggatctatccccagcaggactgtcagactgaagcaccccctcttagggggcaggttccaggatatccgccttcacagaaccctggaatgaccctgccccattatccttatggagatggtaatcgtagtgttccacaatcaggaccgactgtacgaccacaagaagatgcgtgggcttctcctggtgcttatggaatgggtggccgttatccctggccttcatcagcgccctcagcaccacccggcaatctctacatgactgaaagtacttcaccatggcctagcagtggctctccccagtcacccccttcacccccagtccagcagcccaaggattcttcatacccctatagccaatcagatcaaagcatgaaccggcacaactttccttgcagtgtccatcagtacgaatcctcggggacagtgaacaatgatgattcagatcttttggattcccaagtccagtatagtgctgagcctcagctgtatggtaatgccaccagtgaccatcccaacaatcaagatcaaagtagcagtcttcctgaagaatgtgtaccttcagatgaaagtactcctccgagtattaaaaaaatcatacatgtgctggagaaggtccagtatcttgaacaagaagtagaagaatttgtaggaaaaaagacagacaaagcatactggcttctggaagaaatgctaaccaaggaacttttggaactggattcagttgaaactgggggccaggactctgtacggcaggccagaaaagaggctgtttgtaagattcaggccatactggaaaaattagaaaaaaaaggattatgaaaggatttagaacaaagtggaagcctgttactaacttgaccaaagaacacttgatttggttaattaccctctttttgaaatgcctgttgatgacaagaagcaatacattccagctttcctttgattttatacttgaaaaactggcaaaggaatggaagaatattttagtcatgagttgttttcagttttcagacgaatgaatgtaataggaaactatggagttaccaatattgccaagtagactcactccttaaaaaatttatggatatctacaagctgcttcttaccagcaggagggaaacacacttcacacaacaggcttatcagaaacctaccagatgaaactggatataatctgagacaaacaggatgtgtttttttaaacatctggatatcttgtcacatttttgtacattgtgactgctttcaacatatacttcatgtgtaattatagcttagactttagccttcttggacttctgttttgttttgttatttgcagtttacaaatatagtattattctctacttcttggtacattttgtagtaatatgtttaatataattattcaagagactatattgacagccagatagtatggcagttctgaaaaaatttatatcttttcaccacttgaatatactgcaatgtgtagtgagtaaattgtctccctttttctatagatcattaggttagagtttttttcttcttttttttttttttttttttttaccacttctgctgttcatggtagtagtggaaggtaaatttggaaatggcattgacataaaatgaaaatgtttacggacacttttcttttttgcttttttattgtatttggataaagatccacttaaaagttatctgttttttcctgttttttttttttttccccaaagtgtagttatgttttcactattgctgcttctatagagggcattgtgatagagagttacagatgaaacattaaatgccacagtgagtagaaataattactacaaaaagtaataaatatgattacttggtaatatcattctccatctaaaatactagtttcacctgtgagcagatttcagctcagtttatagttaaaaacaatgagggtaaaatgggattcatgctcagggaatgaatcagccatagttagagtgggaaattattattttcttcatttaaaggtagattttatgtttatttccctaaattgcataagataaaattgtctgtttaataaaaagacatttattaccattattaacagtcattttagagccaaatttaagaaaaggatattgaaagggtctttattggccttgtttgggtaactctatgctgttagatagaagagacttaggtaaataactttttatgtctgaggtgagtacacaatattggttcttggaaaaatagctgtttcttcataagatacccaagtgataattttttttcccctagactgtcaggcctatgagtaaatactaaatctattagctgtccccactcataaaccaaaccaaaccaatacaaacagatgaggagaggaaatgtagtaaaaatactggctgggtcttatgattgggatgagtgattttataagataatatggtgataattttattctaggattttatttttggcctaatataggaatgtttaaaaaaggcttttctatgaaaattagaaatttatacttgaaattaaaagtctagaagggggaggaccttaaagctaagctaccagtaagacaatgaataattcagaagagaacactattcttttactgactgagtgcccaagatgccaatttccatgaagtcttgatttatatatatgtacacatgttatgcacatacatgtttgttttctaacagttattttttaagcttttgagataattttagacttacagaagagttgtaaaagtagtagagttcttgtatactctgcacccaccttgcccttatgttaacatcttacgtaacaatagaacatttgtcaaaattaagaaattaaccttgatataatactaactaaagtagaaagtttaaaaagtagagattttagtcttttcactaatgtccttttactgttccaagacccagccttgcatttagctatcatgcctacgtcctgtcttccagtctgtgacagtgtatcataacaggggatacctgatgttgtaatgtatttctggtgttgttaaccttgatcactatgctaaggtggtgtctgctaggattcgctactgtaaacttactgtgttttccttgtaattattgaatatttgctggagatacccggagactatgcaaatgtcccgtttctgcttaaacttttgctcattttactatccattggcagatcttgcttgtggcagttactactgtggtgttctaatggtgattttctatttctctcaatccttctacatttattattggaattcttctgtaaggaagagttgtcagttctggatttatatttttaactataataagatattcaggataagtatagatttagaacttaaagatgttaaatcatgttaaaattattccaaataccaatatcaaagaaaactaagttggtaatctatctcagaaaatatatgaacttaagaaggaaaatagtatttatgatttgtagaattggttcaacttttgacttaatactgactttggactgaattcaaagttttcttgaaatttcacatctggactttttaaagtgtctacatttatattactttggggatcattttgtcaaagtcttgaataaagttacccagtcctggcatgataaacacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9530 -> Molecular function: GO:0005057 [receptor signaling protein activity] evidence: TAS
GeneID:9530 -> Molecular function: GO:0051087 [chaperone binding] evidence: IEA
GeneID:9530 -> Biological process: GO:0006457 [protein folding] evidence: TAS
GeneID:9530 -> Biological process: GO:0010763 [positive regulation of fibroblast migration] evidence: IEA
GeneID:9530 -> Biological process: GO:0030838 [positive regulation of actin filament polymerization] evidence: IEA
GeneID:9530 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IEA
GeneID:9530 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:9530 -> Biological process: GO:0045785 [positive regulation of cell adhesion] evidence: IEA
GeneID:9530 -> Biological process: GO:0051496 [positive regulation of stress fiber assembly] evidence: IEA
GeneID:9530 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IEA
GeneID:9530 -> Biological process: GO:0071356 [cellular response to tumor necrosis factor] evidence: IDA
GeneID:9530 -> Biological process: GO:0071364 [cellular response to epidermal growth factor stimulus] evidence: IEA
GeneID:9530 -> Biological process: GO:0072659 [protein localization to plasma membrane] evidence: IEA
GeneID:9530 -> Biological process: GO:0097178 [ruffle assembly] evidence: IEA
GeneID:9530 -> Biological process: GO:2001145 [negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity] evidence: IEA
GeneID:9530 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9530 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:9530 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:9530 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:9530 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
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@meso_cacase at
DBCLS
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