2024-04-20 14:08:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004840 5282 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (ARHGEF6), mRNA. ACCESSION NM_004840 VERSION NM_004840.2 GI:47078220 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5282) AUTHORS Maiti,A.K. TITLE Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells JOURNAL Pharmacogenomics J. 10 (2), 94-104 (2010) PUBMED 19918261 REMARK GeneRIF: results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl(cos) cells. REFERENCE 2 (bases 1 to 5282) AUTHORS Eriguchi,M., Mizuta,H., Luo,S., Kuroda,Y., Hara,H. and Rubinsztein,D.C. TITLE alpha Pix enhances mutant huntingtin aggregation JOURNAL J. Neurol. Sci. 290 (1-2), 80-85 (2010) PUBMED 19969308 REMARK GeneRIF: These findings suggest that alpha Pix plays an important role in mutant huntingtin aggregation. REFERENCE 3 (bases 1 to 5282) AUTHORS Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T., Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A., Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M. and Kaibuchi,K. TITLE Mutation of ARHGAP9 in patients with coronary spastic angina JOURNAL J. Hum. Genet. 55 (1), 42-49 (2010) PUBMED 19911011 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 4 (bases 1 to 5282) AUTHORS Lim,J.W., Kim,K.H. and Kim,H. TITLE alphaPix interacts with Helicobacter pylori CagA to induce IL-8 expression in gastric epithelial cells JOURNAL Scand. J. Gastroenterol. 44 (10), 1166-1172 (2009) PUBMED 19672789 REMARK GeneRIF: The interaction of alphaPix with CagA activates PAK1, ERK and NF-kappaB, which induces IL-8 expression in H. pylori-infected gastric epithelial cells. REFERENCE 5 (bases 1 to 5282) AUTHORS Baek,H.Y., Lim,J.W. and Kim,H. TITLE Interaction between the Helicobacter pylori CagA and alpha-Pix in gastric epithelial AGS cells JOURNAL Ann. N. Y. Acad. Sci. 1096, 18-23 (2007) PUBMED 17405911 REMARK GeneRIF: phosphorylation of CagA induces the dephosphorylation of alpha-Pix, which may modulate cytoskeletal changes of gastric epithelial cells through PAK REFERENCE 6 (bases 1 to 5282) AUTHORS Yoshii,S., Tanaka,M., Otsuki,Y., Wang,D.Y., Guo,R.J., Zhu,Y., Takeda,R., Hanai,H., Kaneko,E. and Sugimura,H. TITLE alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase JOURNAL Oncogene 18 (41), 5680-5690 (1999) PUBMED 10523848 REFERENCE 7 (bases 1 to 5282) AUTHORS Yntema,H.G., Hamel,B.C., Smits,A.P., van Roosmalen,T., van den Helm,B., Kremer,H., Ropers,H.H., Smeets,D.F. and van Bokhoven,H. TITLE Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26 JOURNAL J. Med. Genet. 35 (10), 801-805 (1998) PUBMED 9783701 REFERENCE 8 (bases 1 to 5282) AUTHORS Ebinu,J.O., Bottorff,D.A., Chan,E.Y., Stang,S.L., Dunn,R.J. and Stone,J.C. TITLE RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs JOURNAL Science 280 (5366), 1082-1086 (1998) PUBMED 9582122 REFERENCE 9 (bases 1 to 5282) AUTHORS Manser,E., Loo,T.H., Koh,C.G., Zhao,Z.S., Chen,X.Q., Tan,L., Tan,I., Leung,T. and Lim,L. TITLE PAK kinases are directly coupled to the PIX family of nucleotide exchange factors JOURNAL Mol. Cell 1 (2), 183-192 (1998) PUBMED 9659915 REFERENCE 10 (bases 1 to 5282) AUTHORS Nomura,N., Nagase,T., Miyajima,N., Sazuka,T., Tanaka,A., Sato,S., Seki,N., Kawarabayasi,Y., Ishikawa,K. and Tabata,S. TITLE Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement) JOURNAL DNA Res. 1 (5), 251-262 (1994) PUBMED 7584048 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039856.1 and BC033768.1. This sequence is a reference standard in the RefSeqGene project. On May 7, 2004 this sequence version replaced gi:22027524. Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039856.1, BX537390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025098 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2951 BC039856.1 1-2951 2952-5282 BC033768.1 1123-3453 FEATURES Location/Qualifiers source 1..5282 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="X" /map="Xq26.3" gene 1..5282 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6" /db_xref="GeneID:9459" /db_xref="HGNC:685" /db_xref="HPRD:02226" /db_xref="MIM:300267" exon 1..627 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" misc_feature 412..414 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="upstream in-frame stop codon" CDS 463..2793 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="Rac/Cdc42 guanine exchange factor (GEF) 6; PAK-interacting exchange factor, alpha; PAK-interacting exchange factor alpha; rac/Cdc42 guanine nucleotide exchange factor 6" /codon_start=1 /product="rho guanine nucleotide exchange factor 6" /protein_id="NP_004831.1" /db_xref="GI:22027525" /db_xref="CCDS:CCDS14660.1" /db_xref="GeneID:9459" /db_xref="HGNC:685" /db_xref="HPRD:02226" /db_xref="MIM:300267" /translation="
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
" misc_feature 466..777 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cd00014" /db_xref="CDD:28898" misc_feature order(466..471,475..483,490..492,499..501,682..687, 694..696,703..705,709..711,751..756,763..768,772..777) /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="putative actin binding surface [polypeptide binding]; other site" /db_xref="CDD:28898" misc_feature 826..828 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 829..831 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 832..834 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 838..840 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q15052.2); phosphorylation site" misc_feature 838..840 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 892..894 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q15052.2); phosphorylation site" misc_feature 910..912 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q15052.2); phosphorylation site" misc_feature 910..912 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 946..1119 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="Src Homology 3 domain of alpha-Pak Interactive eXchange factor; Region: SH3_alphaPIX; cd12060" /db_xref="CDD:212993" misc_feature order(967..969,973..975,982..984,991..996,1039..1041, 1045..1053,1084..1086,1090..1092,1096..1101) /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="peptide ligand binding site [polypeptide binding]; other site" /db_xref="CDD:212993" misc_feature 1135..1137 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1186..1719 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; Region: RhoGEF; cd00160" /db_xref="CDD:29100" misc_feature order(1204..1206,1216..1218,1498..1500,1570..1575, 1582..1587,1591..1596,1603..1608,1615..1620,1627..1629, 1705..1707,1717..1719) /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:29100" misc_feature 1777..2109 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="Cool (cloned out of library)/Pix (PAK-interactive exchange factor) pleckstrin homology (PH) domain; Region: PH_Cool_Pix; cd01225" /db_xref="CDD:176301" misc_feature order(1798..1821,1861..1881,1885..1911,1942..1980, 2005..2025,2035..2052,2065..2100) /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /note="core domain; other site" /db_xref="CDD:176301" misc_feature 1924..1926 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2380..2382 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q15052.2); phosphorylation site" misc_feature 2407..2409 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2410..2412 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2512..2514 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q15052.2); phosphorylation site" misc_feature 2512..2514 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" variation 494 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /replace="c" /replace="t" /db_xref="dbSNP:35747426" exon 628..711 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 712..796 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 797..921 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" variation 824 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /replace="a" /replace="g" /db_xref="dbSNP:35106300" exon 922..1123 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1124..1194 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1195..1289 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1290..1385 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1386..1508 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" variation 1404 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /replace="c" /replace="t" /db_xref="dbSNP:34274521" exon 1509..1647 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1648..1707 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1708..1854 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1855..1941 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 1942..2020 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2021..2166 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2167..2292 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2293..2313 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2314..2407 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2408..2497 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2498..2597 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2598..2652 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" exon 2653..5272 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /inference="alignment:Splign:1.39.8" STS 2824..3083 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="G10668" /db_xref="UniSTS:77943" STS 2828..3027 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="SHGC-31468" /db_xref="UniSTS:54087" STS 4467..4578 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="G18212" /db_xref="UniSTS:5291" STS 4584..4665 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="PMC155158P3" /db_xref="UniSTS:271329" variation 4946 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /replace="c" /replace="t" /db_xref="dbSNP:1061274" STS 4984..5146 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="RH25247" /db_xref="UniSTS:3145" STS 4989..5118 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="RH17397" /db_xref="UniSTS:14296" STS 5058..5164 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="RH77692" /db_xref="UniSTS:38000" STS 5112..5242 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /standard_name="SGC30410" /db_xref="UniSTS:79299" variation 5208 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" /replace="a" /replace="t" /db_xref="dbSNP:9670" polyA_signal 5251..5256 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" polyA_site 5272 /gene="ARHGEF6" /gene_synonym="alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA" ORIGIN
ctcatttccaaggtcccctgaagtgctggctcacctctgtttcccaaagcacttgcttgcttgtctctcctccctccccagcatccttttcactttcttcccttataacttcttgcactctgtgtgcgtgtgtgtgtatgcgtgtgtgcatgtgcgtttcttctttttttttatcctaacgaatttgttttgcaggttttgaaaaggaaaaaccagcgttatccaggattgttaaattaattcttatctgtttccacatcttggaccgtgatctctgtggttttaaaatcccatattttgagtgggttccgctgttgtttaagaaaagttgctttaaacctttgctctgcaagcacccgaagagaactcataaaaaggaagacaacagcagatgcaatcgcggatgtggcttagtccttgcagctgccccagagtgctgtttggagtgtaccgtcctcagtaatgaatccagaagaacaaatcgtgacatggcttatatctttgggagttttagagtcccctaaaaagaccatctgtgatccggaggagtttttaaagtcctcgctgaaaaatggggtagttctgtgcaaactgatcaacagactcatgcctggctctgtggaaaagttttgtctggatccccaaactgaagctgactgcatcaacaacatcaatgacttcctgaaaggatgtgcaaccctccaagtggaaatatttgatcctgatgacctttattcaggggtcaatttctccaaggtactgagtactcttttagctgtcaacaaagcaacagaagatcagctatcagaaagaccatgtggacgttcctcttctcttagtgctgctaatacttctcagacaaacccacagggagcagtttctagcacagtttcagggctgcaaaggcagtcaaagacagtggagatgacggaaaatggaagtcatcagttgatagtaaaagcaagattcaactttaagcagactaatgaggatgaactgtcagtttgtaagggggacatcatttacgtcacacgagttgaagaaggaggctggtgggaaggcacattaaatgggagaacaggctggttccccagtaattatgtccgtgaaattaaatccagtgagagacctctctccccaaaagccgtcaaaggatttgaaactgctccacttaccaagaattattatactgtggtgttacagaacatcctggacactgaaaaagaatatgctaaagaacttcagtctcttcttgttacttacttaagacccctgcagtccaataacaatctgagtactgtggaggttacatctttactgggaaacttcgaggaagtatgcacatttcaacagacactctgccaagccttggaagaatgttcaaagtttccagaaaaccagcacaaagtaggaggttgtctactgagtctcatgcctcattttaaatctatgtatctggcttactgtgcaaaccatccttcagctgtaaatgtgctcactcagcacagtgatgagttggaacaattcatggaaaatcaaggtgcatcgagcccaggtatcctcattttaacaacaaacctcagcaaaccattcatgcgactggagaaatatgttactctcttgcaagagttagaacggcatatggaggatactcatccagatcatcaggatattctgaaagcaatcgtagcattcaaaactctcatggggcaatgtcaagatctgaggaagagaaaacagctggagttacagatactgtccgaacctattcaggcatgggaaggagaagatattaaaaacttgggaaatgtgatttttatgtcacaagtaatggtgcagtatggagcatgtgaggaaaaagaggagcggtaccttatgttattttcaaatgtcctgataatgttatctgcaagtcctcggatgagtggctttatctatcagggaaaaataccaatagcaggaacggtggtgactagattagatgaaattgaagggaatgactgcacatttgaaatcactggtaacacagtggagagaattgtggtccattgtaacaacaaccaggacttccaggaatggttggagcagctgaacagactgatcagaggacctgcctcttgcagttcattatccaaaacctcatcgtcatcatgtagtgctcattcttcttttagctctaccggacagccccgaggacccttggagcctcctcaaattataaaaccgtggagtttaagttgtctacgacctgcacctccacttagaccatcagcagcactaggttataaagagaggatgtcttatatcttaaaggagtctagtaaaagccctaaaacgatgaagaaatttcttcataaaaggaagactgagagaaaaccatcggaggaggaatatgtgattaggaaaagtacagctgctctggaagaggatgctcaaatccttaaagtgatcgaagcctactgcaccagcgcaaattttcaacaaggccatggctcaagtactcgaaaagattccattccacaagtcctactccctgaggaagagaaactcatcattgaagaaaccagaagcaacggccagaccatcatggaagaaaagagccttgttgatactgtttacgccttgaaggacgaggtcagagaactgaagcaggaaaataaaagaatgaagcaatgcctggaagaagaactgaaatcaagaagggacctagaaaagctggtgcggaggcttttgaagcaaacagatgagtgtattcgaggcgagtccagtagcaagacctcaattcttccataaccatcactgtgccactgggtggagtgtgccttcagggcatcttgaaatgtcccgctgaatgatttgactcagtttgctcacttctttggcttttgttttgtgtttgagtctctctctctctctccctctctcttctctttctctccccgctgtgtgcatatgtgtgtgcgtgcacgtgcgcgcttgggcatttgctgttgtttggttattggttggttgttcattttttttttcaacaggtgaaaaagcaggaagtggtggtagagatggcctcagagtcttttccattcagtaagaaagagaaagggaatgcaggccagttacttaaaaggtcttcagattgccttcagttcacagtgcctctgcaacagccattgccctcaggtcacattctttgggctggctgcccttgcaaagcagctggccaaggcttattaaatgtgaacccaacttttccccagggctttcctgtacctgcaagcctcttagtacttaatttaccgaaggcaaatcttccagactatggcttgagtaggatgaaagacaaacacatctgcccaatgatccagctgcccttccttagaccatcacatgcctcccctcaatcacaggttttaaaattactgccctatgttgtctataagaccaagaaaactgtagtacccttattccttttgtgtcatgtaaattgtaactcaggggggcagaagctctggtcacccacaccaacaccaaatccatcagcaaattctactggacaatcctcccttttagtagcagagttgaccgccttttcccattgcatgataggtttctttccctcattctgcctagtgtgtaagttttctatttccccagtacttttagccaaccttaccaagtggtgtgtaaactagtatgtatgtgctttgcttactttttaaaaaaatgtagttagactgtgaggagttactttatgtacgttgcatattcaaactgtgatgttttatccttcaaaacaatctgcattaagaagatattgtgccctactagacagctttcattcactttattactctctcatatatgctgtgagaagttgtaatattaattggcctctttgggtgggactctaagcagtatttgcagaaatatgcttctggtccaacttgtacatccagaacaaaagggcccctctagtagctgtgtgctggattattcaggactgattaactcaagttgctcattgaatcacatcatccactttatcccagaaactagaactgtgagaaaccaggtttagaagacagtcacagaacagcacacatccaaattcagcgccattgaaagttggcctaaggctcagtgccactcacccctccctccccaaaagacaagagaaatttggccagatggggaaggtcactggaaattgaggccaaagggctgatcagaattgcctttataatatatttgatggatgcctataaatgtgggttttgcaaatattgtttaaaaaccaaacttgaagccaggcatggtggcccacacctgtggtcccagctactcaggaggctgaggtgggaggatcatttgagcccaggaggtcaaggctgcagtgagctgtgatgacaccactgcactccaacctaggtaacagagagacacctctgtctctgaaaaaacaaaacttgaagtttgaaacccccagcttgctgaggagccctttttatttttggtactgagagtctcaaggtcccatagctacatggtacagggctgttgtctgcttgctgcacagcagaaattacaccatccacaggaaatggactatttttgcagtccaacatcagccaaccacacacagccgtgtttggaagctgaagagtaaagaaatttctaggaatggctgttgttctgttttttagcacagccatttagatataacatccttcacttaaaaattaaaaacatcagtactaccaccaccaccaacaacatcaacacagatcttcacatctgcccattctgtggttagtcaatggcttgcaataaatgtgcaaactgcatctataggaaacatttttgtgattacggaatactttagttgattgctgaaaatattgaaaggtcttcattttacagtgatgagtacatatgcatgtttcggggacttggcccttctgatgaggggccctcggtactctggataacgaagcttgtgcagagtggtaaccatgcttacacactaaactataatataaaggaaatgaagccatgttaatctgagagcagtgtcgccatagttgtgttgtttacaatactctataaatgggttcctgttgccctgtaattaaactgctgcccgtagaggcctttcagttccttttctgtccttccccttcttaacacaagctcaaattttctaacttgtttttattttgaagacttttaaaatggacattttcaatacataaaaataaacagtgctttataaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9459 -> Molecular function: GO:0005089 [Rho guanyl-nucleotide exchange factor activity] evidence: NAS GeneID:9459 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: NAS GeneID:9459 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:9459 -> Molecular function: GO:0005543 [phospholipid binding] evidence: IEA GeneID:9459 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS GeneID:9459 -> Biological process: GO:0007254 [JNK cascade] evidence: NAS GeneID:9459 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS GeneID:9459 -> Biological process: GO:0030032 [lamellipodium assembly] evidence: ISS GeneID:9459 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS GeneID:9459 -> Biological process: GO:0035023 [regulation of Rho protein signal transduction] evidence: IEA GeneID:9459 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS GeneID:9459 -> Biological process: GO:0043547 [positive regulation of GTPase activity] evidence: NAS GeneID:9459 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS GeneID:9459 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: TAS GeneID:9459 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:9459 -> Cellular component: GO:0005622 [intracellular] evidence: IC GeneID:9459 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:9459 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:9459 -> Cellular component: GO:0030027 [lamellipodium] evidence: ISS
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