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2019-03-25 14:29:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004827               4445 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2
            (ABCG2), transcript variant 1, mRNA.
ACCESSION   NM_004827
VERSION     NM_004827.2  GI:62526032
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4445)
  AUTHORS   Samanta,S., Pursell,B. and Mercurio,A.M.
  TITLE     IMP3 protein promotes chemoresistance in breast cancer cells by
            regulating breast cancer resistance protein (ABCG2) expression
  JOURNAL   J. Biol. Chem. 288 (18), 12569-12573 (2013)
   PUBMED   23539627
  REMARK    GeneRIF: IMP3 binds to BCRP mRNA and regulates BCRP expression.
REFERENCE   2  (bases 1 to 4445)
  AUTHORS   Woodward,O.M., Tukaye,D.N., Cui,J., Greenwell,P.,
            Constantoulakis,L.M., Parker,B.S., Rao,A., Kottgen,M., Maloney,P.C.
            and Guggino,W.B.
  TITLE     Gout-causing Q141K mutation in ABCG2 leads to instability of the
            nucleotide-binding domain and can be corrected with small molecules
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (13), 5223-5228 (2013)
   PUBMED   23493553
  REMARK    GeneRIF: study found the Q141K mutation leads to instability in the
            nucleotide-binding domain,a defect that translates to decreased
            protein expression; the Q141K mutation does not interfere with the
            nucleotide-binding domain/intracellular loop
            interactions;identified critical residues involved in
            protein-protein interactions necessary for dimerization of ABCG2
REFERENCE   3  (bases 1 to 4445)
  AUTHORS   Hinohara,Y., Naito,M., Okada,R., Yin,G., Higashibata,T., Tamura,T.,
            Kawai,S., Morita,E., Wakai,K., Matsuo,H., Mori,A. and Hamajima,N.
  TITLE     No association between MTHFR C677T and serum uric acid levels among
            Japanese with ABCG2 126QQ and SLC22A12 258WW
  JOURNAL   Nagoya J Med Sci 75 (1-2), 93-100 (2013)
   PUBMED   23544272
  REMARK    GeneRIF: Report no association between serum uric acid and MTHFR
            C677T genotype, after the influences of ABCG2 Q126X and SLC22A12
            W258X were removed.
REFERENCE   4  (bases 1 to 4445)
  AUTHORS   Zhou,Q., Ruan,Z.R., Yuan,H., Xu,D.H. and Zeng,S.
  TITLE     ABCB1 gene polymorphisms, ABCB1 haplotypes and ABCG2 c.421c > A are
            determinants of inter-subject variability in rosuvastatin
            pharmacokinetics
  JOURNAL   Pharmazie 68 (2), 129-134 (2013)
   PUBMED   23469685
  REMARK    GeneRIF: ABCG2 c.421C > A is a determinant of inter-subject
            variability in rosuvastatin pharmacokinetics in healthy Chinese
            volunteers
REFERENCE   5  (bases 1 to 4445)
  AUTHORS   Li,H., Zhou,S., Li,T., Liu,Z., Wu,J., Zeng,G., Liu,C. and Gong,J.
  TITLE     Suppression of BCRP expression and restoration of sensitivity to
            chemotherapy in multidrug-resistant HCC cell line HEPG2/ADM by RNA
            interference
  JOURNAL   Hepatogastroenterology 59 (119), 2238-2242 (2012)
   PUBMED   23435138
  REMARK    GeneRIF: RNA interference knockdown of BCRP expression restored
            sensitivity to adriamycin chemotherapy in multidrug-resistant
            hepatocellular carcinoma cell line.
REFERENCE   6  (bases 1 to 4445)
  AUTHORS   Ross,D.D., Yang,W., Abruzzo,L.V., Dalton,W.S., Schneider,E.,
            Lage,H., Dietel,M., Greenberger,L., Cole,S.P. and Doyle,L.A.
  TITLE     Atypical multidrug resistance: breast cancer resistance protein
            messenger RNA expression in mitoxantrone-selected cell lines
  JOURNAL   J. Natl. Cancer Inst. 91 (5), 429-433 (1999)
   PUBMED   10070941
REFERENCE   7  (bases 1 to 4445)
  AUTHORS   Miyake,K., Mickley,L., Litman,T., Zhan,Z., Robey,R., Cristensen,B.,
            Brangi,M., Greenberger,L., Dean,M., Fojo,T. and Bates,S.E.
  TITLE     Molecular cloning of cDNAs which are highly overexpressed in
            mitoxantrone-resistant cells: demonstration of homology to ABC
            transport genes
  JOURNAL   Cancer Res. 59 (1), 8-13 (1999)
   PUBMED   9892175
REFERENCE   8  (bases 1 to 4445)
  AUTHORS   Doyle,L.A., Yang,W., Abruzzo,L.V., Krogmann,T., Gao,Y., Rishi,A.K.
            and Ross,D.D.
  TITLE     A multidrug resistance transporter from human MCF-7 breast cancer
            cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (26), 15665-15670 (1998)
   PUBMED   9861027
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
REFERENCE   9  (bases 1 to 4445)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res. 58 (23), 5337-5339 (1998)
   PUBMED   9850061
REFERENCE   10 (bases 1 to 4445)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum. Mol. Genet. 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI598784.1, BC021281.2 and
            BC092408.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Apr 12, 2005 this sequence version replaced gi:4757849.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            this protein functions as a xenobiotic transporter which may play a
            major role in multi-drug resistance. It likely serves as a cellular
            defense mechanism in response to mitoxantrone and anthracycline
            exposure. Significant expression of this protein has been observed
            in the placenta, which may suggest a potential role for this
            molecule in placenta tissue. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021281.2, AF103796.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               BI598784.1         59-617
            560-2525            BC021281.2         560-2525
            2526-4445           BC092408.1         2371-4290
FEATURES             Location/Qualifiers
     source          1..4445
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22"
     gene            1..4445
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="ATP-binding cassette, sub-family G (WHITE), member
                     2"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:74"
                     /db_xref="MIM:603756"
     exon            1..474
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       18
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2231135"
     variation       72
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61225678"
     variation       232
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2231136"
     variation       259
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:3219192"
     variation       365
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111692024"
     variation       380
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111766106"
     variation       465
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45630471"
     misc_feature    467..469
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="upstream in-frame stop codon"
     exon            475..696
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     CDS             494..2461
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer resistance protein; placenta specific MDR
                     protein; ABC transporter; ATP-binding cassette transporter
                     G2; mitoxantrone resistance-associated protein;
                     placenta-specific ATP-binding cassette transporter; multi
                     drug resistance efflux transport ATP-binding cassette
                     sub-family G (WHITE) member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 2
                     isoform 1"
                     /protein_id="NP_004818.2"
                     /db_xref="GI:62526033"
                     /db_xref="CCDS:CCDS3628.1"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:74"
                     /db_xref="MIM:603756"
                     /translation="
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
"
     misc_feature    593..1297
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="ABCG transporters are involved in eye pigment (EP)
                     precursor transport, regulation of lipid-trafficking
                     mechanisms, and pleiotropic drug resistance (DR).  DR is a
                     well-described phenomenon occurring in fungi and shares
                     several similarities with processes...; Region: ABCG_EPDR;
                     cd03213"
                     /db_xref="CDD:72972"
     misc_feature    656..2440
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; Region: 3a01204; TIGR00955"
                     /db_xref="CDD:162130"
     misc_feature    731..754
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:72972"
     misc_feature    order(740..745,749..757,869..871,1121..1126,1220..1222)
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:72972"
     misc_feature    860..871
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:72972"
     misc_feature    1049..1078
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:72972"
     misc_feature    1109..1126
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="Walker B; other site"
                     /db_xref="CDD:72972"
     misc_feature    1133..1144
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="D-loop; other site"
                     /db_xref="CDD:72972"
     misc_feature    1208..1228
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:72972"
     misc_feature    1616..2251
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /note="ABC-2 type transporter; Region: ABC2_membrane;
                     pfam01061"
                     /db_xref="CDD:201578"
     misc_feature    1679..1741
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNQ0.3);
                     transmembrane region"
     misc_feature    1745..1747
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Not glycosylated; propagated from
                     UniProtKB/Swiss-Prot (Q9UNQ0.3); other site"
     misc_feature    1778..1840
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNQ0.3);
                     transmembrane region"
     misc_feature    1925..1987
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNQ0.3);
                     transmembrane region"
     misc_feature    2012..2074
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNQ0.3);
                     transmembrane region"
     misc_feature    2099..2161
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNQ0.3);
                     transmembrane region"
     misc_feature    2162..2164
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Not glycosylated; propagated from
                     UniProtKB/Swiss-Prot (Q9UNQ0.3); other site"
     misc_feature    2279..2281
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
     misc_feature    2384..2446
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UNQ0.3);
                     transmembrane region"
     variation       527
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2231137"
     variation       607
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12721640"
     exon            697..756
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     STS             738..1014
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /standard_name="ABCG2"
                     /db_xref="UniSTS:503454"
     exon            757..871
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       810..830
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199578838"
     variation       862
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2231139"
     exon            872..1024
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       914
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2231142"
     variation       989
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1061017"
     exon            1025..1182
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     STS             1028..1177
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /standard_name="ABCG2"
                     /db_xref="UniSTS:519123"
     variation       1057
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3116439"
     variation       1109
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12721643"
     variation       1116
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1061018"
     exon            1183..1334
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       1235
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3116448"
     variation       1277
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200473953"
     variation       1298
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34678167"
     exon            1335..1436
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     exon            1437..1687
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       1492
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34881799"
     variation       1493
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3201997"
     variation       1591
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35622453"
     exon            1688..1770
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     exon            1771..1860
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     exon            1861..1985
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     exon            1986..2140
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       2075
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45605536"
     variation       2084
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201584210"
     variation       2107
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34156107"
     variation       2117
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35965584"
     exon            2141..2230
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       2204
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:9282571"
     exon            2231..2313
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       2261
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:34264773"
     exon            2314..4431
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /inference="alignment:Splign:1.39.8"
     variation       2351
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34783571"
     STS             2369..2518
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /standard_name="SHGC-24753"
                     /db_xref="UniSTS:64270"
     STS             2475..3180
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /standard_name="ABCG2_1993"
                     /db_xref="UniSTS:280425"
     polyA_site      2527
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_signal    2626..2631
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
     polyA_site      2646
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /experiment="experimental evidence, no additional details
                     recorded"
     STS             2666..2819
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /standard_name="RH18379"
                     /db_xref="UniSTS:62742"
     variation       2678
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45566442"
     variation       2868
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1138276"
     STS             3130..3290
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /standard_name="SHGC-67418"
                     /db_xref="UniSTS:66120"
     variation       3242
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1448782"
     variation       3527
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1448784"
     variation       4373
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201773725"
     polyA_signal    4405..4410
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
     variation       4425
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45510401"
     polyA_site      4431
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; EST157481; GOUT1; MRX; MXR; MXR1; UAQTL1"
ORIGIN      
gtcagcgctgcctgagctcgtcccctggatgtccgggtctccccaggcggccacccgccggctcccatcgtgacctccagccgcagcgcctcccacgccggccgccgcgcgaggggagcgctcgggcgcgccgggtgtggttgggggaaggggttgtgccgcgcgcgggctgcgtgctgtgcccactcaaaaggttccgggcgcgcaggagggaagaggcagtgcccgccactcccactgagattgagagacgcggcaaggaggcagcctgtggaggaactgggtaggatttaggaacgcaccgtgcacatgcttggtggtcttgttaagtggaaactgctgctttagagtttgtttggaaggtccgggtgactcatcccaacatttacatccttaattgttaaagcgctgcctccgagcgcacgcatcctgagatcctgagcctttggttaagaccgagctctattaagctgaaaagataaaaactctccagatgtcttccagtaatgtcgaagtttttatcccagtgtcacaaggaaacaccaatggcttccccgcgacagcttccaatgacctgaaggcatttactgaaggagctgtgttaagttttcataacatctgctatcgagtaaaactgaagagtggctttctaccttgtcgaaaaccagttgagaaagaaatattatcgaatatcaatgggatcatgaaacctggtctcaacgccatcctgggacccacaggtggaggcaaatcttcgttattagatgtcttagctgcaaggaaagatccaagtggattatctggagatgttctgataaatggagcaccgcgacctgccaatttcaaatgtaattcaggttacgtggtacaagatgatgttgtgatgggcactctgacggtgagagaaaacttacagttctcagcagctcttcggcttgcaacaactatgacgaatcatgaaaaaaacgaacggattaacagggtcattcaagagttaggtctggataaagtggcagactccaaggttggaactcagtttatccgtggtgtgtctggaggagaaagaaaaaggactagtataggaatggagcttatcactgatccttccatcttgttcttggatgagcctacaactggcttagactcaagcacagcaaatgctgtccttttgctcctgaaaaggatgtctaagcagggacgaacaatcatcttctccattcatcagcctcgatattccatcttcaagttgtttgatagcctcaccttattggcctcaggaagacttatgttccacgggcctgctcaggaggccttgggatactttgaatcagctggttatcactgtgaggcctataataaccctgcagacttcttcttggacatcattaatggagattccactgctgtggcattaaacagagaagaagactttaaagccacagagatcatagagccttccaagcaggataagccactcatagaaaaattagcggagatttatgtcaactcctccttctacaaagagacaaaagctgaattacatcaactttccgggggtgagaagaagaagaagatcacagtcttcaaggagatcagctacaccacctccttctgtcatcaactcagatgggtttccaagcgttcattcaaaaacttgctgggtaatccccaggcctctatagctcagatcattgtcacagtcgtactgggactggttataggtgccatttactttgggctaaaaaatgattctactggaatccagaacagagctggggttctcttcttcctgacgaccaaccagtgtttcagcagtgtttcagccgtggaactctttgtggtagagaagaagctcttcatacatgaatacatcagcggatactacagagtgtcatcttatttccttggaaaactgttatctgatttattacccatgaggatgttaccaagtattatatttacctgtatagtgtacttcatgttaggattgaagccaaaggcagatgccttcttcgttatgatgtttacccttatgatggtggcttattcagccagttccatggcactggccatagcagcaggtcagagtgtggtttctgtagcaacacttctcatgaccatctgttttgtgtttatgatgattttttcaggtctgttggtcaatctcacaaccattgcatcttggctgtcatggcttcagtacttcagcattccacgatatggatttacggctttgcagcataatgaatttttgggacaaaacttctgcccaggactcaatgcaacaggaaacaatccttgtaactatgcaacatgtactggcgaagaatatttggtaaagcagggcatcgatctctcaccctggggcttgtggaagaatcacgtggccttggcttgtatgattgttattttcctcacaattgcctacctgaaattgttatttcttaaaaaatattcttaaatttccccttaattcagtatgatttatcctcacataaaaaagaagcactttgattgaagtattcaatcaagtttttttgttgttttctgttcccttgccatcacactgttgcacagcagcaattgttttaaagagatacatttttagaaatcacaacaaactgaattaaacatgaaagaacccaagacatcatgtatcgcatattagttaatctcctcagacagtaaccatggggaagaaatctggtctaatttattaatctaaaaaaggagaattgaattctggaaactcctgacaagttattactgtctctggcatttgtttcctcatctttaaaatgaataggtaggttagtagcccttcagtcttaatactttatgatgctatggtttgccattatttaataaatgacaaatgtattaatgctatactggaaatgtaaaattgaaaatatgttggaaaaaagattctgtcttatagggtaaaaaaagccaccgtgatagaaaaaaaatctttttgataagcacattaaagttaatagaacttactgatattcctgtctagtggtataatatctcaggaatcttggctgagggtttggaactgtgggtagagtagagggccaggagtccagtaatagaattcttgcaccatttctggaacattctagctctgggaggtcacgtaaccttcttggggtagttcagtggtttagtggtttataatccaggtgtgcgtcagaatcatctgaggaactttgctaaaatacaaaaatctggcctaagtagctccagatctaccttcataaaggaatctgaccactcctggatttggtaatttccaagttctgaaaattttacttaggatttaataactattaacatctgtccctacataggttttctttcctacttatataccttatgttctcttcattctaaccttcatcagtaatagggaaatgttttaattttatttttttagttgaagggtaatgtaccaaaaaatatagttcagtgaattaaaatgaacacacatgtgcaaccatcaattcaggtcaagaaatagaagattgtagcacacaaaagcctactcagccattctcccagtcactacttccttccttacccctgggttatttttgaaatgacacttgatgtatttccctctgttgctgttatgagaacattgctacagccaagtgttgtgtttctgtgtgcataggttgatacttaattatctccccactttttaataaacttttaatttggaaataattttagattgacagaaaagttgcaaagatagtgaggaaagttcctgtctactctttgctcagcttcccttaatgttaacattttatatagcaagatgcatttgtcaaagctaacaagttaacattggtacaatcactgttaattaaactgcacacaatattcagatttcaccacttttccactaatattctttcattgttctaggattcaattcaggagaccacatttcatctagccctcttttttaaaagtaaatacttttcagcacttacaggagttaactgagctggggcatcatggtgtatagacgccctgacactggtcatcttggaattcatttagtttgtcagtgggtgccctgacattctgtcacaacatcaatttgggaacatggcattatatttttatctttgaacttttttctttttggatgacatttgattaatgcgtcatcttggaacacattatcttttttcttggttatgtgatcaggaagattaatcagtttttcctgttcttggtataattcctgcttttcacatacctgtcccttacagttctctatatatacccttcccttattacacagagagaaatatctatctatactttttacacaaaatatacttcaaaagaaacaaaacagccacaattattaactttttaaataaatgagaatttaattatatcctaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9429 -> Molecular function: GO:0005215 [transporter activity] evidence: TAS
            GeneID:9429 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9429 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:9429 -> Molecular function: GO:0008559 [xenobiotic-transporting ATPase activity] evidence: TAS
            GeneID:9429 -> Molecular function: GO:0015232 [heme transporter activity] evidence: TAS
            GeneID:9429 -> Molecular function: GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] evidence: TAS
            GeneID:9429 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
            GeneID:9429 -> Biological process: GO:0006810 [transport] evidence: TAS
            GeneID:9429 -> Biological process: GO:0006855 [drug transmembrane transport] evidence: TAS
            GeneID:9429 -> Biological process: GO:0006879 [cellular iron ion homeostasis] evidence: TAS
            GeneID:9429 -> Biological process: GO:0015886 [heme transport] evidence: TAS
            GeneID:9429 -> Biological process: GO:0042493 [response to drug] evidence: TAS
            GeneID:9429 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:9429 -> Biological process: GO:0046415 [urate metabolic process] evidence: IMP
            GeneID:9429 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
            GeneID:9429 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:9429 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
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