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2024-03-30 00:52:04, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004770               3597 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens potassium voltage-gated channel, Shab-related
            subfamily, member 2 (KCNB2), mRNA.
ACCESSION   NM_004770
VERSION     NM_004770.2  GI:27436973
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3597)
  AUTHORS   Hristov,K.L., Chen,M., Afeli,S.A., Cheng,Q., Rovner,E.S. and
            Petkov,G.V.
  TITLE     Expression and function of K(V)2-containing channels in human
            urinary bladder smooth muscle
  JOURNAL   Am. J. Physiol., Cell Physiol. 302 (11), C1599-C1608 (2012)
   PUBMED   22422395
  REMARK    GeneRIF: stromatoxin-1 -sensitive KV2-containing channels are
            expressed in detrusor smooth muscle (DSM); they control DSM
            excitability, intracellular Ca2+ levels, and myogenic and
            nerve-evoked contractions
REFERENCE   2  (bases 1 to 3597)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet. 8 (3), E1002559 (2012)
   PUBMED   22412388
REFERENCE   3  (bases 1 to 3597)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur. J. Hum. Genet. 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   4  (bases 1 to 3597)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum. Mol. Genet. 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   5  (bases 1 to 3597)
  AUTHORS   Nyholt,D.R., LaForge,K.S., Kallela,M., Alakurtti,K., Anttila,V.,
            Farkkila,M., Hamalainen,E., Kaprio,J., Kaunisto,M.A., Heath,A.C.,
            Montgomery,G.W., Gobel,H., Todt,U., Ferrari,M.D., Launer,L.J.,
            Frants,R.R., Terwindt,G.M., de Vries,B., Verschuren,W.M., Brand,J.,
            Freilinger,T., Pfaffenrath,V., Straube,A., Ballinger,D.G., Zhan,Y.,
            Daly,M.J., Cox,D.R., Dichgans,M., van den Maagdenberg,A.M.,
            Kubisch,C., Martin,N.G., Wessman,M., Peltonen,L. and Palotie,A.
  TITLE     A high-density association screen of 155 ion transport genes for
            involvement with common migraine
  JOURNAL   Hum. Mol. Genet. 17 (21), 3318-3331 (2008)
   PUBMED   18676988
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 3597)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 3597)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol. Rev. 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   8  (bases 1 to 3597)
  AUTHORS   Yan,L., Figueroa,D.J., Austin,C.P., Liu,Y., Bugianesi,R.M.,
            Slaughter,R.S., Kaczorowski,G.J. and Kohler,M.G.
  TITLE     Expression of voltage-gated potassium channels in human and rhesus
            pancreatic islets
  JOURNAL   Diabetes 53 (3), 597-607 (2004)
   PUBMED   14988243
REFERENCE   9  (bases 1 to 3597)
  AUTHORS   Schmalz,F., Kinsella,J., Koh,S.D., Vogalis,F., Schneider,A.,
            Flynn,E.R., Kenyon,J.L. and Horowitz,B.
  TITLE     Molecular identification of a component of delayed rectifier
            current in gastrointestinal smooth muscles
  JOURNAL   Am. J. Physiol. 274 (5 PT 1), G901-G911 (1998)
   PUBMED   9612272
REFERENCE   10 (bases 1 to 3597)
  AUTHORS   Hugnot,J.P., Salinas,M., Lesage,F., Guillemare,E., de Weille,J.,
            Heurteaux,C., Mattei,M.G. and Lazdunski,M.
  TITLE     Kv8.1, a new neuronal potassium channel subunit with specific
            inhibitory properties towards Shab and Shaw channels
  JOURNAL   EMBO J. 15 (13), 3322-3331 (1996)
   PUBMED   8670833
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF338730.1.
            On Dec 31, 2002 this sequence version replaced gi:4758621.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. Four sequence-related
            potassium channel genes - shaker, shaw, shab, and shal - have been
            identified in Drosophila, and each has been shown to have human
            homolog(s). This gene encodes a member of the potassium channel,
            voltage-gated, shab-related subfamily. This member is a delayed
            rectifier potassium channel. The gene is expressed in
            gastrointestinal smooth muscle cells. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF338730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.2"
     gene            1..3597
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="potassium voltage-gated channel, Shab-related
                     subfamily, member 2"
                     /db_xref="GeneID:9312"
                     /db_xref="HGNC:6232"
                     /db_xref="HPRD:09666"
                     /db_xref="MIM:607738"
     exon            1..495
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="alignment:Splign:1.39.8"
     variation       52
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111466296"
     variation       169
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369340105"
     variation       238
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41265254"
     variation       315
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7845090"
     variation       378
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139609234"
     variation       436
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377213863"
     exon            496..1167
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    553..555
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="upstream in-frame stop codon"
     variation       564
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201897595"
     CDS             589..3324
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="delayed rectifier potassium channel protein;
                     potassium channel Kv2.2; voltage-gated potassium channel
                     subunit Kv2.2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily B
                     member 2"
                     /protein_id="NP_004761.2"
                     /db_xref="GI:27436974"
                     /db_xref="CCDS:CCDS6209.1"
                     /db_xref="GeneID:9312"
                     /db_xref="HGNC:6232"
                     /db_xref="HPRD:09666"
                     /db_xref="MIM:607738"
                     /translation="
MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM
"
     misc_feature    697..996
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="K+ channel tetramerisation domain; Region: K_tetra;
                     pfam02214"
                     /db_xref="CDD:202161"
     misc_feature    1159..1224
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     transmembrane region"
     misc_feature    1285..1347
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     transmembrane region"
     misc_feature    1294..1797
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="Ion transport protein; Region: Ion_trans;
                     pfam00520"
                     /db_xref="CDD:201279"
     misc_feature    <1306..1641
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="Polycystin cation channel; Region: PKD_channel;
                     pfam08016"
                     /db_xref="CDD:203839"
     misc_feature    1378..1440
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     transmembrane region"
     misc_feature    1483..1548
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     transmembrane region"
     misc_feature    1591..1653
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     transmembrane region"
     misc_feature    1609..1800
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="Ion channel; Region: Ion_trans_2; pfam07885"
                     /db_xref="CDD:203792"
     misc_feature    1729..1746
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     Region: Selectivity filter (By similarity)"
     misc_feature    1774..1836
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q92953.2);
                     transmembrane region"
     misc_feature    1999..2868
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /note="Kv2 voltage-gated K+ channel; Region: Kv2channel;
                     pfam03521"
                     /db_xref="CDD:112344"
     variation       605
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373744483"
     variation       631
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375433681"
     variation       638
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375896990"
     variation       711
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190037930"
     variation       744
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:34259157"
     variation       756
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150014572"
     variation       759
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41272419"
     variation       798
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372787931"
     variation       829
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:368956189"
     variation       835
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143538924"
     variation       842
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373152926"
     variation       882
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377766303"
     variation       940
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371078506"
     variation       942
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146530934"
     variation       1032
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375213947"
     variation       1123
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141103704"
     exon            1168..3582
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /inference="alignment:Splign:1.39.8"
     variation       1194
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370787718"
     variation       1251
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374088764"
     variation       1277..1278
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:373275350"
     variation       1277
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:80234000"
     variation       1279
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367953569"
     variation       1448
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142185006"
     variation       1451
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151189961"
     variation       1473
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371461377"
     variation       1498
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200347487"
     variation       1500
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373700542"
     variation       1530
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145537672"
     variation       1575
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140269443"
     variation       1591
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368867147"
     variation       1647
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372154473"
     variation       1781
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376552017"
     variation       1797
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150328423"
     variation       1851
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369490973"
     variation       1866
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375771803"
     variation       1906
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146080562"
     variation       1926
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141965461"
     variation       1994
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201676119"
     variation       2002
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200516745"
     variation       2008
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140088625"
     variation       2024..2025
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35414494"
     variation       2047
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145767327"
     variation       2052
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201431676"
     variation       2061
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139383097"
     variation       2071
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369194598"
     variation       2143
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149424569"
     variation       2167
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373435847"
     variation       2170
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377338435"
     variation       2177
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370109644"
     STS             2215..3020
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /standard_name="KCNB2_V171"
                     /db_xref="UniSTS:277410"
     variation       2229
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200324895"
     variation       2254
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144823279"
     variation       2327
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373322976"
     variation       2330
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148143740"
     variation       2349
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141923254"
     variation       2355
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377469016"
     variation       2361
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146092769"
     variation       2408
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370883521"
     variation       2409
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201660881"
     variation       2422
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140075333"
     variation       2454
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143631623"
     variation       2456
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370327292"
     variation       2463
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146297405"
     variation       2464
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139648032"
     variation       2494
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373737384"
     variation       2505
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200472384"
     variation       2508
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372843947"
     variation       2524
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199723904"
     variation       2541
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34289080"
     variation       2558
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16938507"
     variation       2622
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374713448"
     variation       2631
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368768775"
     variation       2651
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148879809"
     variation       2654
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142592831"
     variation       2724
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200773056"
     variation       2754
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114148959"
     variation       2758
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199530102"
     variation       2766
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:142525254"
     STS             2804..2934
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /standard_name="RH71254"
                     /db_xref="UniSTS:64526"
     variation       2833
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143326877"
     variation       2850
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200944661"
     variation       2868
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115151346"
     variation       2939
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369082497"
     variation       2965
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138679918"
     variation       2985
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199942722"
     variation       3009
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140054176"
     variation       3021
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150484780"
     variation       3063
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138301209"
     variation       3065
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202152751"
     variation       3075
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373007065"
     variation       3086
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375999807"
     variation       3139
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149626685"
     variation       3144
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145103530"
     variation       3155
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138896608"
     variation       3156
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:118058550"
     variation       3172
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370061449"
     variation       3173
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200745790"
     variation       3180
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146324637"
     variation       3201
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11782118"
     variation       3220
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373156197"
     variation       3252
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370511237"
     variation       3272
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372736949"
     variation       3279
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377151381"
     variation       3284
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370294553"
     variation       3313
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200182849"
     variation       3337
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374333209"
     variation       3351
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369154174"
     variation       3448
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143136293"
     variation       3463
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181020654"
     variation       3474
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185096014"
     variation       3522
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189562693"
     polyA_signal    3556..3561
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
     polyA_site      3582
                     /gene="KCNB2"
                     /gene_synonym="KV2.2"
ORIGIN      
cgccgccgctgcgcctcgggcagccccagcgagcggcaactcccgggctggcgcggctcgctttctggctccttccgcgcggcgagctcagccccgctcgatttttcctcttctgttccagccctctcttgtctgggtggctgtggcggcggcagggggatggggaccccgtgtggggaaggggttgaagatcgatgaagattattgttcttttaaaggatgccttagcttcctcccgccgcctttcctctgagccttcctactagagaccgtgaaccagagtcagggatgtaaagacagggggaaagcacgccgggagctccagccagccggggagaccctcctctctgtggaggggagggggatttccagcgacaggtcattggcgaaggggatcgtcgcggggagaggctccccggagggagcggggaatcccacagccctttgtggtgcccgagcccgtgccgcctgctgagcggggtctgtgggagctagctttgtcagtggaaatgcctgccccagagggatattgcttcagttgacctcattttttaaggaccctggctctgcggctttgtccagttcaaaatggcagaaaaggctcccccgggcttaaacaggaagacttcaaggtcgacactttcccttcctccagagcctgtggacattatccggagcaaaacatgctccaggagagttaagatcaatgtggggggcctcaaccacgaagtcctgtggagaacgctggacaggctgcccaggacgcgcctggggaagcttcgagactgcaacacacacgagagcctcctggaagtgtgcgacgactataatctgaacgagaacgagtatttctttgatcggcatccaggagccttcacttccattttaaatttctaccggaccgggaaactccatatgatggaagaaatgtgtgcactttcgtttggccaagaacttgattactgggggattgatgagatctacttggagtcctgctgccaggccagatatcatcaaaaaaaagaacaaatgaacgaagaactgaggcgagaggcagagactatgcgagagcgagaaggagaagagtttgataatacctgctgccctgataaaaggaagaaactgtgggacttgctggagaaacctaactcatcagtggctgcaaagatcctggccatcgtgtctatcctgttcattgtgctttccaccattgctttgtctctcaatacgctgccggagctgcaggaaacggacgaatttggacaactcaatgacaaccgccaattagcacacgtggaggctgtgtgtattgcatggtttaccatggagtaccttttgcgattcttatcctcaccaaataaatggaagttcttcaaaggcccactgaatgtcattgatttgctggccatcttgccgtactatgtcaccatttttctgacggagtccaacaagagcgtgctgcagttccaaaacgtgaggcgcgtggtccagatcttccgaatcatgcgcatcctcaggatcctgaaactcgccaggcattcgacaggcctgcagtctctgggtttcacccttaggcggagttacaatgaattgggcttgttgatattgtttctggccatggggataatgatattttccagcctggtattttttgctgagaaggatgaagatgctaccaagttcaccagtatccctgcatcattttggtgggccaccatcaccatgaccactgttggctatggtgacatttaccctaaaacattactagggaaaattgtgggaggtctgtgctgtattgctggggttctggttattgcccttcctatcccaattattgtgaacaatttttctgagttttacaaggagcagaaacgccaagagaaagcaattaaaaggagggaggctcttgagcgggccaaaaggaacggaagcatcgtttctatgaacttaaaagatgccttcgctcgaagtatggaactgatagatgtggctgttgagaaggccggagagtccgccaacacaaaggactccgccgacgataatcacctgtcgccaagccggtggaagtgggccaggaaggctctgtcggaaacaagctccaacaagtctttcgagaataagtaccaggaggttagccaaaaagactcccacgagcagctgaacaacacgtcttcctccagcccacagcatctgagtgcccagaaactggagatgctatacaatgaaatcaccaagacacagcctcattctcacccaaacccagactgccaagaaaagcctgagaggccatctgcatatgaagaagagattgaaatggaagaagtggtgtgtccacaggagcagctggccgtggcacagaccgaggtcattgtggacatgaagagcacctccagcatcgacagcttcaccagctgtgccaccgacttcacagagacagagagatcgccgctgccgccgccctccgcctctcacttgcagatgaagttcccaaccgacctcccagggacagaagagcaccaaagagctaggggccccccgtttctaactctatccagagagaaaggacctgctgccagggatggcacgctggagtatgccccagttgacataactgtgaacctcgatgccagtggctcccagtgtgggctacatagtcctttgcagtctgacaatgccaccgacagtcctaagagctctctaaaaggcagcaacccactaaagtccagatccctcaaagtgaactttaaggaaaatagaggcagtgcaccacagaccccgcccagcacagccaggccactgccagtcaccacagctgacttttcgctcactaccccgcagcacatcagtaccatcctcttagaagaaaccccctcccagggagacagacccttgctgggcactgaggtttcagcgccttgtcagggaccttccaaagggctgtcccccaggtttcccaagcagaaactgttccctttctcttcaagagagaggaggagcttcactgaaatagatactggtgacgacgaagacttcttagagctcccaggggcaagggaggagaagcaggtggactccagcccaaattgctttgcagataagcctagtgatgggagagaccctttaagagaagagggcagtgtgggctcttcctccccgcaggacacaggtcacaactgtaggcaagacatttaccatgctgtgagtgaagtcaaaaaggacagtagtcaagaagggtgcaagatggaaaatcacttgtttgccccagaaattcattccaacccaggagacacaggttattgtcccacacgtgaaaccagcatgtgactagttacaaaagcaataaattgaaacaaaacaaaacaaaacaaaacttgtttcttaaaaatgcggttaataatgcctgtgaactaaaaaaatgggaagccctccccaaaaaaagtgcataaaatgttatttttgcatggcatgaacagtttagcttaagtactgtttaaataatgagtcaagactgcattttgtaacaaaccaacaaaaatgactgaagaacagtgaacaaataaaaagagctctattaggaaccaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9312 -> Molecular function: GO:0005251 [delayed rectifier potassium channel activity] evidence: TAS
            GeneID:9312 -> Biological process: GO:0006813 [potassium ion transport] evidence: TAS
            GeneID:9312 -> Biological process: GO:0006940 [regulation of smooth muscle contraction] evidence: TAS
            GeneID:9312 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
            GeneID:9312 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA
            GeneID:9312 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:9312 -> Cellular component: GO:0008076 [voltage-gated potassium channel complex] evidence: IEA

by @meso_cacase at DBCLS
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