2024-03-30 00:52:04, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004770 3597 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens potassium voltage-gated channel, Shab-related subfamily, member 2 (KCNB2), mRNA. ACCESSION NM_004770 VERSION NM_004770.2 GI:27436973 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3597) AUTHORS Hristov,K.L., Chen,M., Afeli,S.A., Cheng,Q., Rovner,E.S. and Petkov,G.V. TITLE Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle JOURNAL Am. J. Physiol., Cell Physiol. 302 (11), C1599-C1608 (2012) PUBMED 22422395 REMARK GeneRIF: stromatoxin-1 -sensitive KV2-containing channels are expressed in detrusor smooth muscle (DSM); they control DSM excitability, intracellular Ca2+ levels, and myogenic and nerve-evoked contractions REFERENCE 2 (bases 1 to 3597) AUTHORS Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A., Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G., Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y., Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R., Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K., McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A., Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M., Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and Peter,I. TITLE A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci JOURNAL PLoS Genet. 8 (3), E1002559 (2012) PUBMED 22412388 REFERENCE 3 (bases 1 to 3597) AUTHORS Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D., Gibson,G. and Goldstein,D.B. TITLE Common genetic variation and performance on standardized cognitive tests JOURNAL Eur. J. Hum. Genet. 18 (7), 815-820 (2010) PUBMED 20125193 REMARK Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820] REFERENCE 4 (bases 1 to 3597) AUTHORS Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y., Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M., Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C., Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M., Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J., George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A., Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M., Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R. TITLE Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis JOURNAL Hum. Mol. Genet. 18 (4), 767-778 (2009) PUBMED 19010793 REFERENCE 5 (bases 1 to 3597) AUTHORS Nyholt,D.R., LaForge,K.S., Kallela,M., Alakurtti,K., Anttila,V., Farkkila,M., Hamalainen,E., Kaprio,J., Kaunisto,M.A., Heath,A.C., Montgomery,G.W., Gobel,H., Todt,U., Ferrari,M.D., Launer,L.J., Frants,R.R., Terwindt,G.M., de Vries,B., Verschuren,W.M., Brand,J., Freilinger,T., Pfaffenrath,V., Straube,A., Ballinger,D.G., Zhan,Y., Daly,M.J., Cox,D.R., Dichgans,M., van den Maagdenberg,A.M., Kubisch,C., Martin,N.G., Wessman,M., Peltonen,L. and Palotie,A. TITLE A high-density association screen of 155 ion transport genes for involvement with common migraine JOURNAL Hum. Mol. Genet. 17 (21), 3318-3331 (2008) PUBMED 18676988 REMARK GeneRIF: Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) REFERENCE 6 (bases 1 to 3597) AUTHORS Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y., Jurisica,I. and Li,S.S. TITLE Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening JOURNAL Proteomics 7 (11), 1775-1785 (2007) PUBMED 17474147 REFERENCE 7 (bases 1 to 3597) AUTHORS Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D., Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W. and Wang,X. TITLE International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels JOURNAL Pharmacol. Rev. 57 (4), 473-508 (2005) PUBMED 16382104 REMARK Review article REFERENCE 8 (bases 1 to 3597) AUTHORS Yan,L., Figueroa,D.J., Austin,C.P., Liu,Y., Bugianesi,R.M., Slaughter,R.S., Kaczorowski,G.J. and Kohler,M.G. TITLE Expression of voltage-gated potassium channels in human and rhesus pancreatic islets JOURNAL Diabetes 53 (3), 597-607 (2004) PUBMED 14988243 REFERENCE 9 (bases 1 to 3597) AUTHORS Schmalz,F., Kinsella,J., Koh,S.D., Vogalis,F., Schneider,A., Flynn,E.R., Kenyon,J.L. and Horowitz,B. TITLE Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles JOURNAL Am. J. Physiol. 274 (5 PT 1), G901-G911 (1998) PUBMED 9612272 REFERENCE 10 (bases 1 to 3597) AUTHORS Hugnot,J.P., Salinas,M., Lesage,F., Guillemare,E., de Weille,J., Heurteaux,C., Mattei,M.G. and Lazdunski,M. TITLE Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels JOURNAL EMBO J. 15 (13), 3322-3331 (1996) PUBMED 8670833 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF338730.1. On Dec 31, 2002 this sequence version replaced gi:4758621. Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF338730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. FEATURES Location/Qualifiers source 1..3597 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="8" /map="8q13.2" gene 1..3597 /gene="KCNB2" /gene_synonym="KV2.2" /note="potassium voltage-gated channel, Shab-related subfamily, member 2" /db_xref="GeneID:9312" /db_xref="HGNC:6232" /db_xref="HPRD:09666" /db_xref="MIM:607738" exon 1..495 /gene="KCNB2" /gene_synonym="KV2.2" /inference="alignment:Splign:1.39.8" variation 52 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:111466296" variation 169 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:369340105" variation 238 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:41265254" variation 315 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:7845090" variation 378 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:139609234" variation 436 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:377213863" exon 496..1167 /gene="KCNB2" /gene_synonym="KV2.2" /inference="alignment:Splign:1.39.8" misc_feature 553..555 /gene="KCNB2" /gene_synonym="KV2.2" /note="upstream in-frame stop codon" variation 564 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:201897595" CDS 589..3324 /gene="KCNB2" /gene_synonym="KV2.2" /note="delayed rectifier potassium channel protein; potassium channel Kv2.2; voltage-gated potassium channel subunit Kv2.2" /codon_start=1 /product="potassium voltage-gated channel subfamily B member 2" /protein_id="NP_004761.2" /db_xref="GI:27436974" /db_xref="CCDS:CCDS6209.1" /db_xref="GeneID:9312" /db_xref="HGNC:6232" /db_xref="HPRD:09666" /db_xref="MIM:607738" /translation="
MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSDGRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGDTGYCPTRETSM
" misc_feature 697..996 /gene="KCNB2" /gene_synonym="KV2.2" /note="K+ channel tetramerisation domain; Region: K_tetra; pfam02214" /db_xref="CDD:202161" misc_feature 1159..1224 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); transmembrane region" misc_feature 1285..1347 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); transmembrane region" misc_feature 1294..1797 /gene="KCNB2" /gene_synonym="KV2.2" /note="Ion transport protein; Region: Ion_trans; pfam00520" /db_xref="CDD:201279" misc_feature <1306..1641 /gene="KCNB2" /gene_synonym="KV2.2" /note="Polycystin cation channel; Region: PKD_channel; pfam08016" /db_xref="CDD:203839" misc_feature 1378..1440 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); transmembrane region" misc_feature 1483..1548 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); transmembrane region" misc_feature 1591..1653 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); transmembrane region" misc_feature 1609..1800 /gene="KCNB2" /gene_synonym="KV2.2" /note="Ion channel; Region: Ion_trans_2; pfam07885" /db_xref="CDD:203792" misc_feature 1729..1746 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); Region: Selectivity filter (By similarity)" misc_feature 1774..1836 /gene="KCNB2" /gene_synonym="KV2.2" /inference="non-experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q92953.2); transmembrane region" misc_feature 1999..2868 /gene="KCNB2" /gene_synonym="KV2.2" /note="Kv2 voltage-gated K+ channel; Region: Kv2channel; pfam03521" /db_xref="CDD:112344" variation 605 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:373744483" variation 631 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:375433681" variation 638 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:375896990" variation 711 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:190037930" variation 744 /gene="KCNB2" /gene_synonym="KV2.2" /replace="g" /replace="t" /db_xref="dbSNP:34259157" variation 756 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:150014572" variation 759 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:41272419" variation 798 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:372787931" variation 829 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="t" /db_xref="dbSNP:368956189" variation 835 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:143538924" variation 842 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:373152926" variation 882 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:377766303" variation 940 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:371078506" variation 942 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:146530934" variation 1032 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:375213947" variation 1123 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:141103704" exon 1168..3582 /gene="KCNB2" /gene_synonym="KV2.2" /inference="alignment:Splign:1.39.8" variation 1194 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:370787718" variation 1251 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:374088764" variation 1277..1278 /gene="KCNB2" /gene_synonym="KV2.2" /replace="" /replace="c" /db_xref="dbSNP:373275350" variation 1277 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:80234000" variation 1279 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:367953569" variation 1448 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:142185006" variation 1451 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:151189961" variation 1473 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:371461377" variation 1498 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:200347487" variation 1500 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:373700542" variation 1530 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:145537672" variation 1575 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:140269443" variation 1591 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:368867147" variation 1647 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:372154473" variation 1781 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:376552017" variation 1797 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:150328423" variation 1851 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:369490973" variation 1866 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:375771803" variation 1906 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:146080562" variation 1926 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:141965461" variation 1994 /gene="KCNB2" /gene_synonym="KV2.2" /replace="g" /replace="t" /db_xref="dbSNP:201676119" variation 2002 /gene="KCNB2" /gene_synonym="KV2.2" /replace="g" /replace="t" /db_xref="dbSNP:200516745" variation 2008 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:140088625" variation 2024..2025 /gene="KCNB2" /gene_synonym="KV2.2" /replace="" /replace="a" /db_xref="dbSNP:35414494" variation 2047 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:145767327" variation 2052 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:201431676" variation 2061 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:139383097" variation 2071 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:369194598" variation 2143 /gene="KCNB2" /gene_synonym="KV2.2" /replace="g" /replace="t" /db_xref="dbSNP:149424569" variation 2167 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:373435847" variation 2170 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="t" /db_xref="dbSNP:377338435" variation 2177 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:370109644" STS 2215..3020 /gene="KCNB2" /gene_synonym="KV2.2" /standard_name="KCNB2_V171" /db_xref="UniSTS:277410" variation 2229 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:200324895" variation 2254 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:144823279" variation 2327 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:373322976" variation 2330 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:148143740" variation 2349 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:141923254" variation 2355 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:377469016" variation 2361 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:146092769" variation 2408 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:370883521" variation 2409 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:201660881" variation 2422 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:140075333" variation 2454 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:143631623" variation 2456 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:370327292" variation 2463 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:146297405" variation 2464 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:139648032" variation 2494 /gene="KCNB2" /gene_synonym="KV2.2" /replace="g" /replace="t" /db_xref="dbSNP:373737384" variation 2505 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:200472384" variation 2508 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:372843947" variation 2524 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:199723904" variation 2541 /gene="KCNB2" /gene_synonym="KV2.2" /replace="" /replace="t" /db_xref="dbSNP:34289080" variation 2558 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:16938507" variation 2622 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:374713448" variation 2631 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:368768775" variation 2651 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:148879809" variation 2654 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:142592831" variation 2724 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:200773056" variation 2754 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:114148959" variation 2758 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:199530102" variation 2766 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:142525254" STS 2804..2934 /gene="KCNB2" /gene_synonym="KV2.2" /standard_name="RH71254" /db_xref="UniSTS:64526" variation 2833 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:143326877" variation 2850 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:200944661" variation 2868 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:115151346" variation 2939 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:369082497" variation 2965 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:138679918" variation 2985 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:199942722" variation 3009 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:140054176" variation 3021 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:150484780" variation 3063 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:138301209" variation 3065 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:202152751" variation 3075 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:373007065" variation 3086 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:375999807" variation 3139 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:149626685" variation 3144 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:145103530" variation 3155 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:138896608" variation 3156 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:118058550" variation 3172 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="t" /db_xref="dbSNP:370061449" variation 3173 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:200745790" variation 3180 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:146324637" variation 3201 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:11782118" variation 3220 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:373156197" variation 3252 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:370511237" variation 3272 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:372736949" variation 3279 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:377151381" variation 3284 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:370294553" variation 3313 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:200182849" variation 3337 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:374333209" variation 3351 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:369154174" variation 3448 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="c" /db_xref="dbSNP:143136293" variation 3463 /gene="KCNB2" /gene_synonym="KV2.2" /replace="a" /replace="g" /db_xref="dbSNP:181020654" variation 3474 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="t" /db_xref="dbSNP:185096014" variation 3522 /gene="KCNB2" /gene_synonym="KV2.2" /replace="c" /replace="g" /db_xref="dbSNP:189562693" polyA_signal 3556..3561 /gene="KCNB2" /gene_synonym="KV2.2" polyA_site 3582 /gene="KCNB2" /gene_synonym="KV2.2" ORIGIN
cgccgccgctgcgcctcgggcagccccagcgagcggcaactcccgggctggcgcggctcgctttctggctccttccgcgcggcgagctcagccccgctcgatttttcctcttctgttccagccctctcttgtctgggtggctgtggcggcggcagggggatggggaccccgtgtggggaaggggttgaagatcgatgaagattattgttcttttaaaggatgccttagcttcctcccgccgcctttcctctgagccttcctactagagaccgtgaaccagagtcagggatgtaaagacagggggaaagcacgccgggagctccagccagccggggagaccctcctctctgtggaggggagggggatttccagcgacaggtcattggcgaaggggatcgtcgcggggagaggctccccggagggagcggggaatcccacagccctttgtggtgcccgagcccgtgccgcctgctgagcggggtctgtgggagctagctttgtcagtggaaatgcctgccccagagggatattgcttcagttgacctcattttttaaggaccctggctctgcggctttgtccagttcaaaatggcagaaaaggctcccccgggcttaaacaggaagacttcaaggtcgacactttcccttcctccagagcctgtggacattatccggagcaaaacatgctccaggagagttaagatcaatgtggggggcctcaaccacgaagtcctgtggagaacgctggacaggctgcccaggacgcgcctggggaagcttcgagactgcaacacacacgagagcctcctggaagtgtgcgacgactataatctgaacgagaacgagtatttctttgatcggcatccaggagccttcacttccattttaaatttctaccggaccgggaaactccatatgatggaagaaatgtgtgcactttcgtttggccaagaacttgattactgggggattgatgagatctacttggagtcctgctgccaggccagatatcatcaaaaaaaagaacaaatgaacgaagaactgaggcgagaggcagagactatgcgagagcgagaaggagaagagtttgataatacctgctgccctgataaaaggaagaaactgtgggacttgctggagaaacctaactcatcagtggctgcaaagatcctggccatcgtgtctatcctgttcattgtgctttccaccattgctttgtctctcaatacgctgccggagctgcaggaaacggacgaatttggacaactcaatgacaaccgccaattagcacacgtggaggctgtgtgtattgcatggtttaccatggagtaccttttgcgattcttatcctcaccaaataaatggaagttcttcaaaggcccactgaatgtcattgatttgctggccatcttgccgtactatgtcaccatttttctgacggagtccaacaagagcgtgctgcagttccaaaacgtgaggcgcgtggtccagatcttccgaatcatgcgcatcctcaggatcctgaaactcgccaggcattcgacaggcctgcagtctctgggtttcacccttaggcggagttacaatgaattgggcttgttgatattgtttctggccatggggataatgatattttccagcctggtattttttgctgagaaggatgaagatgctaccaagttcaccagtatccctgcatcattttggtgggccaccatcaccatgaccactgttggctatggtgacatttaccctaaaacattactagggaaaattgtgggaggtctgtgctgtattgctggggttctggttattgcccttcctatcccaattattgtgaacaatttttctgagttttacaaggagcagaaacgccaagagaaagcaattaaaaggagggaggctcttgagcgggccaaaaggaacggaagcatcgtttctatgaacttaaaagatgccttcgctcgaagtatggaactgatagatgtggctgttgagaaggccggagagtccgccaacacaaaggactccgccgacgataatcacctgtcgccaagccggtggaagtgggccaggaaggctctgtcggaaacaagctccaacaagtctttcgagaataagtaccaggaggttagccaaaaagactcccacgagcagctgaacaacacgtcttcctccagcccacagcatctgagtgcccagaaactggagatgctatacaatgaaatcaccaagacacagcctcattctcacccaaacccagactgccaagaaaagcctgagaggccatctgcatatgaagaagagattgaaatggaagaagtggtgtgtccacaggagcagctggccgtggcacagaccgaggtcattgtggacatgaagagcacctccagcatcgacagcttcaccagctgtgccaccgacttcacagagacagagagatcgccgctgccgccgccctccgcctctcacttgcagatgaagttcccaaccgacctcccagggacagaagagcaccaaagagctaggggccccccgtttctaactctatccagagagaaaggacctgctgccagggatggcacgctggagtatgccccagttgacataactgtgaacctcgatgccagtggctcccagtgtgggctacatagtcctttgcagtctgacaatgccaccgacagtcctaagagctctctaaaaggcagcaacccactaaagtccagatccctcaaagtgaactttaaggaaaatagaggcagtgcaccacagaccccgcccagcacagccaggccactgccagtcaccacagctgacttttcgctcactaccccgcagcacatcagtaccatcctcttagaagaaaccccctcccagggagacagacccttgctgggcactgaggtttcagcgccttgtcagggaccttccaaagggctgtcccccaggtttcccaagcagaaactgttccctttctcttcaagagagaggaggagcttcactgaaatagatactggtgacgacgaagacttcttagagctcccaggggcaagggaggagaagcaggtggactccagcccaaattgctttgcagataagcctagtgatgggagagaccctttaagagaagagggcagtgtgggctcttcctccccgcaggacacaggtcacaactgtaggcaagacatttaccatgctgtgagtgaagtcaaaaaggacagtagtcaagaagggtgcaagatggaaaatcacttgtttgccccagaaattcattccaacccaggagacacaggttattgtcccacacgtgaaaccagcatgtgactagttacaaaagcaataaattgaaacaaaacaaaacaaaacaaaacttgtttcttaaaaatgcggttaataatgcctgtgaactaaaaaaatgggaagccctccccaaaaaaagtgcataaaatgttatttttgcatggcatgaacagtttagcttaagtactgtttaaataatgagtcaagactgcattttgtaacaaaccaacaaaaatgactgaagaacagtgaacaaataaaaagagctctattaggaaccaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:9312 -> Molecular function: GO:0005251 [delayed rectifier potassium channel activity] evidence: TAS GeneID:9312 -> Biological process: GO:0006813 [potassium ion transport] evidence: TAS GeneID:9312 -> Biological process: GO:0006940 [regulation of smooth muscle contraction] evidence: TAS GeneID:9312 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS GeneID:9312 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA GeneID:9312 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS GeneID:9312 -> Cellular component: GO:0008076 [voltage-gated potassium channel complex] evidence: IEA
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