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2024-04-19 20:47:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004764 3591 bp mRNA linear PRI 26-MAY-2013
DEFINITION Homo sapiens piwi-like RNA-mediated gene silencing 1 (PIWIL1),
transcript variant 1, mRNA.
ACCESSION NM_004764
VERSION NM_004764.4 GI:300244499
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3591)
AUTHORS Liu,C., Qu,L., Dong,B., Xing,X., Ren,T., Zeng,Y., Jiang,B.,
Meng,L., Wu,J. and Shou,C.
TITLE Combined phenotype of 4 markers improves prognostic value of
patients with colon cancer
JOURNAL Am. J. Med. Sci. 343 (4), 295-302 (2012)
PUBMED 22261620
REMARK GeneRIF: A subgroup of more aggressive tumors can be identified by
evaluating Hiwi level in lymph node metastatic cancer.
REFERENCE 2 (bases 1 to 3591)
AUTHORS Wang,Y., Liu,Y., Shen,X., Zhang,X., Chen,X., Yang,C. and Gao,H.
TITLE The PIWI protein acts as a predictive marker for human gastric
cancer
JOURNAL Int J Clin Exp Pathol 5 (4), 315-325 (2012)
PUBMED 22670175
REMARK GeneRIF: Expression of PIWIL1 was an independent prognostic factor
in gastric cancer.
REFERENCE 3 (bases 1 to 3591)
AUTHORS Reeves,M.E., Baldwin,M.L., Aragon,R., Baldwin,S., Chen,S.T., Li,X.,
Mohan,S. and Amaar,Y.G.
TITLE RASSF1C modulates the expression of a stem cell renewal gene,
PIWIL1
JOURNAL BMC Res Notes 5, 239 (2012)
PUBMED 22591718
REMARK GeneRIF: Findings suggest the role of RASSF1C/PIWIL1 proteins in
initiation and progression of lung cancer.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3591)
AUTHORS Siddiqi,S., Terry,M. and Matushansky,I.
TITLE Hiwi mediated tumorigenesis is associated with DNA hypermethylation
JOURNAL PLoS ONE 7 (3), E33711 (2012)
PUBMED 22438986
REMARK GeneRIF: Hiwi-associated DNA hyper-methylation with subsequent
genetic and epigenetic changes favors a tumorigenic state
REFERENCE 5 (bases 1 to 3591)
AUTHORS Kowalczykiewic,D. and Wrzesinski,J.
TITLE [The role of piRNA and Piwi proteins in regulation of germline
development]
JOURNAL Postepy Biochem. 57 (3), 249-256 (2011)
PUBMED 22235650
REMARK GeneRIF: In this review, the current state of knowledge on the
structure, biogenesis and function of piRNA and their interactions
with Piwi proteins is presented.
Review article
REFERENCE 6 (bases 1 to 3591)
AUTHORS Tahbaz,N., Kolb,F.A., Zhang,H., Jaronczyk,K., Filipowicz,W. and
Hobman,T.C.
TITLE Characterization of the interactions between mammalian PAZ PIWI
domain proteins and Dicer
JOURNAL EMBO Rep. 5 (2), 189-194 (2004)
PUBMED 14749716
REFERENCE 7 (bases 1 to 3591)
AUTHORS Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
TITLE Identification of eight members of the Argonaute family in the
human genome small star, filled
JOURNAL Genomics 82 (3), 323-330 (2003)
PUBMED 12906857
REFERENCE 8 (bases 1 to 3591)
AUTHORS Qiao,D., Zeeman,A.M., Deng,W., Looijenga,L.H. and Lin,H.
TITLE Molecular characterization of hiwi, a human member of the piwi gene
family whose overexpression is correlated to seminomas
JOURNAL Oncogene 21 (25), 3988-3999 (2002)
PUBMED 12037681
REMARK GeneRIF: specifically expressed in both normal and malignant
spermatogenic cells in a maturation stage-dependent pattern, in
which it might function in germ cell proliferation
REFERENCE 9 (bases 1 to 3591)
AUTHORS Sharma,A.K., Nelson,M.C., Brandt,J.E., Wessman,M., Mahmud,N.,
Weller,K.P. and Hoffman,R.
TITLE Human CD34(+) stem cells express the hiwi gene, a human homologue
of the Drosophila gene piwi
JOURNAL Blood 97 (2), 426-434 (2001)
PUBMED 11154219
REFERENCE 10 (bases 1 to 3591)
AUTHORS Cox,D.N., Chao,A., Baker,J., Chang,L., Qiao,D. and Lin,H.
TITLE A novel class of evolutionarily conserved genes defined by piwi are
essential for stem cell self-renewal
JOURNAL Genes Dev. 12 (23), 3715-3727 (1998)
PUBMED 9851978
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB072454.1, BC028581.2,
AF104260.2 and DB527532.1.
On Jul 8, 2010 this sequence version replaced gi:66346724.
Summary: This gene encodes a member of the PIWI subfamily of
Argonaute proteins, evolutionarily conserved proteins containing
both PAZ and Piwi motifs that play important roles in stem cell
self-renewal, RNA silencing, and translational regulation in
diverse organisms. The encoded protein may play a role as an
intrinsic regulator of the self-renewal capacity of germline and
hematopoietic stem cells. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2010].
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC028581.2, AF387507.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-140 DB072454.1 1-140
141-203 DB072454.1 142-204
204-1743 BC028581.2 1-1540
1744-3029 AF104260.2 1529-2814
3030-3582 BC028581.2 2827-3379
3583-3591 DB527532.1 441-449
FEATURES Location/Qualifiers
source 1..3591
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.33"
gene 1..3591
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="piwi-like RNA-mediated gene silencing 1"
/db_xref="GeneID:9271"
/db_xref="HGNC:9007"
/db_xref="MIM:605571"
exon 1..259
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 14
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:79528159"
variation 36
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:139297271"
variation 39
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:35997018"
variation 90
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:111848437"
variation 91
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:371656010"
variation 112
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:182955466"
variation 127
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:369086320"
variation 212
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:147087823"
exon 260..349
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
misc_feature 263..265
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="upstream in-frame stop codon"
variation 263
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:369705077"
CDS 272..2857
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="isoform 1 is encoded by transcript variant 1; piwi
homolog; piwi-like protein 1"
/codon_start=1
/product="piwi-like protein 1 isoform 1"
/protein_id="NP_004755.2"
/db_xref="GI:66346725"
/db_xref="CCDS:CCDS9268.1"
/db_xref="GeneID:9271"
/db_xref="HGNC:9007"
/db_xref="MIM:605571"
/translation="
MTGRARARARGRARGQETAQLVGSTASQQPGYIQPRPQPPPAEGELFGRGRQRGTAGGTAKSQGLQISAGFQELSLAERGGRRRDFHDLGVNTRQNLDHVKESKTGSSGIIVRLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALLFQHEDLIGKCHAFDGTILFLPKRLQQKVTEVFSKTRNGEDVRITITLTNELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPNDPIDIPSHRLVIWPGFTTSILQYENSIMLCTDVSHKVLRSETVLDFMFNFYHQTEEHKFQEQVSKELIGLVVLTKYNNKTYRVDDIDWDQNPKSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGLTDKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKNDNVQRELRDWGLSFDSNLLSFSGRILQTEKIHQGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAANSLIQNLFKVTPAMGMQMRKAIMIEVDDRTEAYLRVLQQKVTADTQIVVCLLSSNRKDKYDAIKKYLCTDCPTPSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDIPLKLVMIVGIDCYHDMTAGRRSIAGFVASINEGMTRWFSRCIFQDRGQELVDGLKVCLQAALRAWNSCNEYMPSRIIVYRDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVVKKRVNTRFFAQSGGRLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDNSGLKPDHIQRLTYKLCHIYYNWPGVIRVPAPCQYAHKLAFLVGQSIHREPNLSLSNRLYYL
"
misc_feature 1097..1450
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="PAZ domain, Piwi_like subfamily. In multi-cellular
organisms, the Piwi protein appears to be essential for
the maintenance of germline stem cells. In the Drosophila
male germline, Piwi was shown to be involved in the
silencing of retrotransposons in the...; Region:
PAZ_piwi_like; cd02845"
/db_xref="CDD:30330"
misc_feature 1217..1225
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96J94.1);
Region: Required for binding 2'-O-methylated 3'-end of
piRNAs"
misc_feature order(1232..1234,1271..1273,1295..1297,1307..1309,
1361..1363,1409..1411,1415..1417)
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="nucleic acid-binding interface [nucleotide
binding]; other site"
/db_xref="CDD:30330"
misc_feature 1412..1414
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/experiment="experimental evidence, no additional details
recorded"
/note="Required for binding 2'-O-methylated 3'-end of
piRNAs; propagated from UniProtKB/Swiss-Prot (Q96J94.1);
other site"
misc_feature 1472..2803
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="Piwi_piwi-like_Euk: PIWI domain, Piwi-like
subfamily found in eukaryotes. This domain is found in
Piwi and closely related proteins, where it is believed to
perform a crucial role in germline cells, via RNA
silencing. RNA silencing refers to a group of...; Region:
Piwi_piwi-like_Euk; cd04658"
/db_xref="CDD:72943"
misc_feature 1889..2302
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96J94.1);
Region: RNA-binding (By similarity)"
misc_feature order(1973..1975,1985..1987,2021..2032,2039..2041,
2069..2071,2078..2080,2090..2092,2102..2104)
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="5' RNA guide strand anchoring site; other site"
/db_xref="CDD:72943"
misc_feature order(2165..2167,2171..2173,2375..2377,2777..2779)
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/note="active site"
/db_xref="CDD:72943"
variation 289
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:142397870"
variation 314
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:150787742"
variation 331
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:374386771"
variation 338
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:139256282"
variation 341
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:74472943"
variation 342
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:200414750"
variation 349
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201104805"
exon 350..461
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 364
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:373242831"
variation 365
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:75876550"
variation 366
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:200930825"
variation 392
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="c"
/db_xref="dbSNP:370704151"
variation 417
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:146544413"
variation 422
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:144603967"
variation 426
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="c"
/db_xref="dbSNP:141316012"
variation 444
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:80000029"
variation 459
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:374078683"
exon 462..587
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 496
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:374469378"
variation 519
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:201447253"
variation 565
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:143665312"
exon 588..802
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 616
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:145821284"
variation 695
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:375349486"
variation 702
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:1496856"
variation 720
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:76993556"
variation 731
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:369491337"
variation 769
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:372419033"
variation 793
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:143819641"
exon 803..924
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 841
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:200760485"
variation 867
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:148178950"
exon 925..1005
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 959
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:369068461"
exon 1006..1203
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1076
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:142628217"
variation 1180
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:146939410"
variation 1199
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:186750683"
exon 1204..1315
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1263
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:201056133"
variation 1279
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200572269"
variation 1282
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:146680674"
variation 1293
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="g"
/db_xref="dbSNP:148826391"
variation 1306
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="g"
/db_xref="dbSNP:181529291"
exon 1316..1442
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1379
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:200413984"
variation 1380
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:369600464"
variation 1399
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:10848087"
exon 1443..1560
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1474
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:368086386"
variation 1492
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:185995248"
variation 1498
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:375915792"
variation 1526
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:35540071"
variation 1527
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:138419869"
exon 1561..1675
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1564
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:138596008"
variation 1589
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="g"
/db_xref="dbSNP:201685412"
variation 1674
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:149285666"
exon 1676..1863
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1678
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:144546887"
variation 1718
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="c"
/db_xref="dbSNP:148492556"
variation 1744
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:17856812"
variation 1773
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:112831011"
variation 1774
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:1106041"
variation 1802
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:373679672"
variation 1823
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:146066302"
variation 1824
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:367820124"
variation 1840
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:187863102"
variation 1851
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:1106042"
exon 1864..1936
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1885
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:34275838"
exon 1937..2137
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 1975
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:151261790"
variation 1992
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:145656437"
variation 1995
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:17852568"
variation 2050
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:138228908"
variation 2062
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="g"
/db_xref="dbSNP:145330850"
variation 2069
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:376637485"
variation 2122
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:368678399"
exon 2138..2241
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 2147
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:202172901"
variation 2156
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:201853462"
variation 2164
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:35377726"
variation 2176
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:183048707"
variation 2205
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:146897162"
variation 2241
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:199654827"
exon 2242..2312
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 2242
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:147567224"
variation 2253
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:377411680"
variation 2256
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="g"
/db_xref="dbSNP:371066715"
variation 2258
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:374602004"
variation 2289
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:141921798"
variation 2296
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:377358932"
exon 2313..2466
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 2314
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:200510720"
variation 2337
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:186261053"
variation 2365
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:372258497"
variation 2374
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:143082104"
variation 2380
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:374592795"
variation 2416
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:188915650"
variation 2447
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:199601525"
variation 2460
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:200703653"
exon 2467..2592
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 2474
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:372240124"
variation 2478
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:117506395"
variation 2488
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:375503700"
variation 2549
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:141199371"
variation 2560
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:372451593"
variation 2561
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:369868529"
exon 2593..2740
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
STS 2616..2807
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/standard_name="PIWIL1"
/db_xref="UniSTS:504221"
variation 2636
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:373256222"
variation 2674
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:150359032"
variation 2675
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:377093609"
variation 2723
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:370486312"
variation 2730
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:374930923"
variation 2735
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:376697933"
variation 2740
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:138000461"
exon 2741..3591
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/inference="alignment:Splign:1.39.8"
variation 2808
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="g"
/replace="t"
/db_xref="dbSNP:201574124"
variation 2825
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:372364939"
variation 2841
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:142677968"
variation 2842
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:377153706"
variation 2869
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:371432936"
variation 3030
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:10773771"
variation 3057
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="c"
/db_xref="dbSNP:111352260"
variation 3141
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:77617856"
variation 3153
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:201636250"
STS 3287..3419
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/standard_name="RH102272"
/db_xref="UniSTS:96606"
variation 3513
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:142576649"
variation 3544
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="g"
/db_xref="dbSNP:374015145"
polyA_signal 3561..3566
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
variation 3584
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="c"
/replace="t"
/db_xref="dbSNP:188210436"
polyA_site 3587
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
variation 3588
/gene="PIWIL1"
/gene_synonym="HIWI; MIWI; PIWI"
/replace="a"
/replace="t"
/db_xref="dbSNP:375904521"
ORIGIN
ttactgggcgtatggcgtacagacacgaggccggcgcccgggaggcggtgttcatccgcccgggaaaagagcgcctgttgctcgctgcccgcgtgtccctggctctctcgggaacccagcgccgaaggcgaggtgggcgcgggccgaaggaggtcctgggaggtcggcggcgcggagggatctccgcgggagccgttggggctgttggcctcgggctgaggtgcaaggaccaggactagggcgagggcagcggtccaagaaatagaaaacaatgactgggagagcccgagccagagccagaggaagggcccgcggtcaggagacagcgcagctggtgggctccactgccagtcagcaacctggttatattcagcctaggcctcagccgccaccagcagagggggaattatttggccgtggacggcagagaggaacagcaggaggaacagccaagtcacaaggactccagatatctgctggatttcaggagttatcgttagcagagagaggaggtcgtcgtagagattttcatgatcttggtgtgaatacaaggcagaacctagaccatgttaaagaatcaaaaacaggttcttcaggcattatagtaaggttaagcactaaccatttccggctgacatcccgtccccagtgggccttatatcagtatcacattgactataacccactgatggaagccagaagactccgttcagctcttctttttcaacacgaagatctaattggaaagtgtcatgcttttgatggaacgatattatttttacctaaaagactacagcaaaaggttactgaagtttttagtaagacccggaatggagaggatgtgaggataacgatcactttaacaaatgaacttccacctacatcaccaacttgtttgcagttctataatattattttcaggaggcttttgaaaatcatgaatttgcaacaaattggacgaaattattataacccaaatgacccaattgatattccaagtcacaggttggtgatttggcctggcttcactacttccatccttcagtatgaaaacagcatcatgctctgcactgacgttagccataaagtccttcgaagtgagactgttttggatttcatgttcaacttttatcatcagacagaagaacataaatttcaagaacaagtttccaaagaactaataggtttagttgttcttaccaagtataacaataagacatacagagtggatgatattgactgggaccagaatcccaagagcacctttaagaaagccgacggctctgaagtcagcttcttagaatactacaggaagcaatacaaccaagagatcaccgacttgaagcagcctgtcttggtcagccagcccaagagaaggcggggccctggggggacactgccagggcctgccatgctcattcctgagctctgctatcttacaggtctaactgataaaatgcgtaatgattttaacgtgatgaaagacttagccgttcatacaagactaactccagagcaaaggcagcgtgaagtgggacgactcattgattacattcataaaaacgataatgttcaaagggagcttcgagactggggtttgagctttgattccaacttactgtccttctcaggaagaattttgcaaacagaaaagattcaccaaggtggaaaaacatttgattacaatccacaatttgcagattggtccaaagaaacaagaggtgcaccattaattagtgttaagccactagataactggctgttgatctatacgcgaagaaattatgaagcagccaattcattgatacaaaatctatttaaagttacaccagccatgggcatgcaaatgagaaaagcaataatgattgaagtggatgacagaactgaagcctacttaagagtcttacagcaaaaggtcacagcagacacccagatagttgtctgtctgttgtcaagtaatcggaaggacaaatacgatgctattaaaaaatacctgtgtacagattgccctaccccaagtcagtgtgtggtggcccgaaccttaggcaaacagcaaactgtcatggccattgctacaaagattgccctacagatgaactgcaagatgggaggagagctctggagggtggacatccccctgaagctcgtgatgatcgttggcatcgattgttaccatgacatgacagctgggcggaggtcaatcgcaggatttgttgccagcatcaatgaagggatgacccgctggttctcacgctgcatatttcaggatagaggacaggagctggtagatgggctcaaagtctgcctgcaagcggctctgagggcttggaatagctgcaatgagtacatgcccagccggatcatcgtgtaccgcgatggcgtaggagacggccagctgaaaacactggtgaactacgaagtgccacagtttttggattgtctaaaatccattggtagaggttacaaccctagactaacggtaattgtggtgaagaaaagagtgaacaccagattttttgctcagtctggaggaagacttcagaatccacttcctggaacagttattgatgtagaggttaccagaccagaatggtatgacttttttatcgtgagccaggctgtgagaagtggtagtgtttctcccacacattacaatgtcatctatgacaacagcggcctgaagccagaccacatacagcgcttgacctacaagctgtgccacatctattacaactggccaggtgtcattcgtgttcctgctccttgccagtacgcccacaagctggcttttcttgttggccagagtattcacagagagccaaatctgtcactgtcaaaccgcctttactacctctaacctgcagaagacgatgcagccgcttttctttttgaaatgactttgggatttttttaagcttttatttactttttttttaactgttatctttctggatgaaacttgggaaggggattaggagatctagcattttatttctagcattgctattcaccggcttccttattttatacgtaaaaattaagattttatattttatcttcttgtttctcatagatattttgtgagcatttttttgtttattttgaagaaatgtggataagatacttggtagtataaaacagactctctgagagtatttgaaatgtgtttggagatttacttaaacgtactttcaggagtgagcaagtcctacttataaacctatattaactttatttttgagatacctgttttgaatttaaaggagataagaggcgtaaagtaggatgctcactacaaccataggtggggtttcagctcatatcttaaagataaaaggtactattatataacctatacacaagatacaggagaaaatatgcttgatttttatttggcaggggggctaggttgtatgggagtaaaaaaaacattgaaaatttttaaattgtccaaagaaacattttaagactctttaacaaaaaaggccatgagtaaatctctatattaacattactatttattttgttttggaactgggacatgattctatttgttataaaataaaattgatgtgattgtcaccttatttg
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9271 -> Molecular function: GO:0003727 [single-stranded RNA binding] evidence: IEA
GeneID:9271 -> Molecular function: GO:0003729 [mRNA binding] evidence: ISS
GeneID:9271 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9271 -> Molecular function: GO:0034584 [piRNA binding] evidence: ISS
GeneID:9271 -> Biological process: GO:0006417 [regulation of translation] evidence: IEA
GeneID:9271 -> Biological process: GO:0007126 [meiosis] evidence: IEA
GeneID:9271 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:9271 -> Biological process: GO:0007286 [spermatid development] evidence: ISS
GeneID:9271 -> Biological process: GO:0031047 [gene silencing by RNA] evidence: ISS
GeneID:9271 -> Biological process: GO:0034587 [piRNA metabolic process] evidence: IEA
GeneID:9271 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:9271 -> Cellular component: GO:0005844 [polysome] evidence: IEA
GeneID:9271 -> Cellular component: GO:0005845 [mRNA cap binding complex] evidence: IEA
GeneID:9271 -> Cellular component: GO:0033391 [chromatoid body] evidence: ISS
GeneID:9271 -> Cellular component: GO:0043186 [P granule] evidence: ISS
by
@meso_cacase at
DBCLS
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