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2024-04-19 12:40:10, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004757 3159 bp mRNA linear PRI 29-APR-2013
DEFINITION Homo sapiens aminoacyl tRNA synthetase complex-interacting
multifunctional protein 1 (AIMP1), transcript variant 1, mRNA.
ACCESSION NM_004757
VERSION NM_004757.3 GI:215490007
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3159)
AUTHORS Kwon,H.S., Park,M.C., Kim,D.G., Cho,K., Park,Y.W., Han,J.M. and
Kim,S.
TITLE Identification of CD23 as a functional receptor for the
proinflammatory cytokine AIMP1/p43
JOURNAL J. Cell. Sci. 125 (PT 19), 4620-4629 (2012)
PUBMED 22767513
REMARK GeneRIF: Downregulation of CD23 attenuated AIMP1-induced TNF-alpha
secretion and AIMP1 binding.
REFERENCE 2 (bases 1 to 3159)
AUTHORS Schwarz,M.A., Thornton,J., Xu,H., Awasthi,N. and Schwarz,R.E.
TITLE Cell proliferation and migration are modulated by
Cdk-1-phosphorylated endothelial-monocyte activating polypeptide II
JOURNAL PLoS ONE 7 (3), E33101 (2012)
PUBMED 22412987
REMARK GeneRIF: EMAP II has specific intracellular effects, and that this
intracellular function appears to antagonize its extracellular
anti-angiogenic effects during fetal development and pulmonary
disease progression.
REFERENCE 3 (bases 1 to 3159)
AUTHORS Clauss,M., Voswinckel,R., Rajashekhar,G., Sigua,N.L.,
Fehrenbach,H., Rush,N.I., Schweitzer,K.S., Yildirim,A.O.,
Kamocki,K., Fisher,A.J., Gu,Y., Safadi,B., Nikam,S., Hubbard,W.C.,
Tuder,R.M., Twigg,H.L. III, Presson,R.G., Sethi,S. and Petrache,I.
TITLE Lung endothelial monocyte-activating protein 2 is a mediator of
cigarette smoke-induced emphysema in mice
JOURNAL J. Clin. Invest. 121 (6), 2470-2479 (2011)
PUBMED 21576822
REMARK GeneRIF: EMAPII is elevated in the BALF of active smokers and
patients with COPD. Expression was increased in COPD lungs and
emphysema.
Erratum:[J Clin Invest. 2012 Jul 2;122(7):2703]
REFERENCE 4 (bases 1 to 3159)
AUTHORS Kim,S.S., Hur,S.Y., Kim,Y.R., Yoo,N.J. and Lee,S.H.
TITLE Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA
synthetase complex, is downregulated in gastric and colorectal
cancer
JOURNAL Tumori 97 (3), 380-385 (2011)
PUBMED 21789020
REMARK GeneRIF: Decreased expression of AIMP1 in gastric and colorectal
cancer tissues suggests that down-regulation of this protein may be
related to inactivation of the tumor suppressor functions of AIMP
proteins and might play a role in the development of GC and CRC.
REFERENCE 5 (bases 1 to 3159)
AUTHORS Youssef,M.M., Heng,Y.M., Powe,D.G., Edgson,J., Ellis,I.O. and
Murray,C.
TITLE Hypoxia-induced EMAP-II transcription in colorectal cancer
JOURNAL Egypt J Immunol 17 (2), 121-129 (2010)
PUBMED 23082492
REMARK GeneRIF: EMAP-II transcripts are upregulated in tumour cells in
hypoxic conditions.
REFERENCE 6 (bases 1 to 3159)
AUTHORS Kao,J., Houck,K., Fan,Y., Haehnel,I., Libutti,S.K., Kayton,M.L.,
Grikscheit,T., Chabot,J., Nowygrod,R., Greenberg,S. et al.
TITLE Characterization of a novel tumor-derived cytokine.
Endothelial-monocyte activating polypeptide II
JOURNAL J. Biol. Chem. 269 (40), 25106-25119 (1994)
PUBMED 7929199
REFERENCE 7 (bases 1 to 3159)
AUTHORS Lamour,V., Quevillon,S., Diriong,S., N'Guyen,V.C., Lipinski,M. and
Mirande,M.
TITLE Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme
as a case of horizontal gene transfer
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (18), 8670-8674 (1994)
PUBMED 8078941
REFERENCE 8 (bases 1 to 3159)
AUTHORS Shiba,K., Suzuki,N., Shigesada,K., Namba,Y., Schimmel,P. and
Noda,T.
TITLE Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence
of the anticodon-binding domain and acquisition of a new structural
unit
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (16), 7435-7439 (1994)
PUBMED 8052601
REFERENCE 9 (bases 1 to 3159)
AUTHORS Kao,J., Fan,Y.G., Haehnel,I., Brett,J., Greenberg,S., Clauss,M.,
Kayton,M., Houck,K., Kisiel,W., Seljelid,R. et al.
TITLE A peptide derived from the amino terminus of
endothelial-monocyte-activating polypeptide II modulates
mononuclear and polymorphonuclear leukocyte functions, defines an
apparently novel cellular interaction site, and induces an acute
inflammatory response
JOURNAL J. Biol. Chem. 269 (13), 9774-9782 (1994)
PUBMED 7545917
REFERENCE 10 (bases 1 to 3159)
AUTHORS Kao,J., Ryan,J., Brett,G., Chen,J., Shen,H., Fan,Y.G., Godman,G.,
Familletti,P.C., Wang,F., Pan,Y.C. et al.
TITLE Endothelial monocyte-activating polypeptide II. A novel
tumor-derived polypeptide that activates host-response mechanisms
JOURNAL J. Biol. Chem. 267 (28), 20239-20247 (1992)
PUBMED 1400342
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK095951.1, DA211424.1,
BG941396.1, BC014051.2, BM314663.1 and BQ447202.1.
On Dec 3, 2008 this sequence version replaced gi:45006985.
Summary: The protein encoded by this gene is a cytokine that is
specifically induced by apoptosis, and it is involved in the
control of angiogenesis, inflammation, and wound healing. The
release of this cytokine renders the tumor-associated vasculature
sensitive to tumor necrosis factor. The precursor protein is
identical to the p43 subunit, which is associated with the
multi-tRNA synthetase complex, and it modulates aminoacylation
activity of tRNA synthetase in normal cells. This protein is also
involved in the stimulation of inflammatory responses after
proteolytic cleavage in tumor cells. Multiple transcript variants
encoding different isoforms have been found for this gene. A
pseudogene has been identified on chromosome 20. [provided by
RefSeq, Dec 2008].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the shorter isoform (a). Both variants 1 and
2 encode the same isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK095951.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-15 AK095951.1 1-15
16-540 DA211424.1 1-525 c
541-547 BG941396.1 1-7 c
548-1712 AK095951.1 548-1712
1713-2336 BC014051.2 1118-1741
2337-2658 BM314663.1 252-573
2659-3159 BQ447202.1 1-501 c
FEATURES Location/Qualifiers
source 1..3159
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q24"
gene 1..3159
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="aminoacyl tRNA synthetase complex-interacting
multifunctional protein 1"
/db_xref="GeneID:9255"
/db_xref="HGNC:10648"
/db_xref="MIM:603605"
exon 1..649
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 16
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:6856408"
variation 89
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:72660532"
variation 118
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149570845"
variation 206
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:193127149"
variation 267
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369944338"
variation 269..270
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="a"
/db_xref="dbSNP:149260576"
variation 275
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:183983932"
variation 276
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188526371"
variation 474
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:192139022"
variation 478
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:147248863"
variation 543
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:6814166"
variation 580
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:184350978"
variation 602
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:114717819"
variation 604
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376227763"
variation 621
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:188723134"
misc_feature 633..635
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="upstream in-frame stop codon"
variation 636
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:72878559"
exon 650..783
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 669
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376462029"
CDS 675..1613
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="isoform a precursor is encoded by transcript
variant 1; small inducible cytokine subfamily E, member 1
(endothelial monocyte-activating); endothelial
monocyte-activating polypeptide 2; endothelial-monocyte
activating polypeptide II; multisynthetase complex
auxiliary component p43; ARS-interacting multifunctional
protein 1; aminoacyl tRNA synthase complex-interacting
multifunctional protein 1; multisynthase complex auxiliary
component p43"
/codon_start=1
/product="aminoacyl tRNA synthase complex-interacting
multifunctional protein 1 isoform a precursor"
/protein_id="NP_004748.2"
/db_xref="GI:45006986"
/db_xref="CCDS:CCDS3674.1"
/db_xref="GeneID:9255"
/db_xref="HGNC:10648"
/db_xref="MIM:603605"
/translation="
MANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK
"
misc_feature 690..812
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12904.2);
Region: Required for fibroblast proliferation"
misc_feature 834..1256
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12904.2);
Region: Interaction with HSP90B1 (By similarity)"
misc_feature 975..1016
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12904.2);
Region: Required for endothelial cell death"
misc_feature 1014..1250
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12904.2);
Region: Required for endothelial cell migration"
mat_peptide 1113..1610
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/product="aminoacyl tRNA synthase complex-interacting
multifunctional protein 1 isoform a"
misc_feature 1122..1430
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="tRNA-binding-domain-containing EMAP2-like proteins.
This family contains a diverse fraction of tRNA binding
proteins, including Caenorhabditis elegans methionyl-tRNA
synthetase (CeMetRS), human tyrosyl- tRNA synthetase
(hTyrRS), Saccharomyces cerevisiae...; Region:
tRNA_bind_EMAP-II_like; cd02799"
/db_xref="CDD:48401"
misc_feature 1146..1166
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="cytokine-active heptapeptide; other site"
/db_xref="CDD:48401"
misc_feature order(1191..1193,1230..1232,1308..1310,1320..1322,
1341..1343,1350..1352)
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/note="putative tRNA-binding site [nucleotide binding];
other site"
/db_xref="CDD:48401"
variation 698
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11544777"
variation 743
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:369984537"
variation 745
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:369840696"
exon 784..897
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 786
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377086510"
variation 819
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373122636"
exon 898..1065
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 909
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:1134648"
variation 917
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142036705"
variation 927
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:377235344"
variation 935
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:181917989"
variation 938
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369233911"
variation 940
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202131629"
variation 943
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:36110860"
variation 949
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:202168884"
variation 957
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377566711"
variation 966..967
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="ca"
/db_xref="dbSNP:387906865"
variation 983
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:151123024"
variation 984
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:113844295"
variation 986
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201162461"
variation 997
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:184999759"
variation 1015
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375592576"
variation 1023
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2230255"
variation 1031
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146841053"
variation 1033
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367813302"
variation 1037
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:143898497"
variation 1057
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371028279"
exon 1066..1277
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 1066
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372933784"
variation 1075
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:144311249"
variation 1094
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374629021"
variation 1101
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185378147"
variation 1135
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:202139899"
variation 1143
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145221722"
variation 1152
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:367982035"
variation 1158
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200374617"
variation 1165
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149144042"
variation 1190
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199812889"
variation 1192
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143219988"
variation 1218
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148281523"
variation 1225
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141415581"
variation 1240
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113532028"
variation 1256
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146996325"
variation 1266
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138106524"
exon 1278..1446
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
variation 1288
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371607548"
variation 1310
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143586104"
variation 1316
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201441520"
variation 1353
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374893263"
variation 1367
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200239982"
variation 1381
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201023640"
variation 1439
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371633224"
exon 1447..3146
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/inference="alignment:Splign:1.39.8"
STS 1529..1609
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-67688"
/db_xref="UniSTS:53199"
variation 1537
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371587424"
variation 1556
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369128827"
variation 1557
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147167431"
variation 1583
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201514824"
variation 1584
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373047626"
variation 1608
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:138429424"
variation 1629
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="a"
/db_xref="dbSNP:368302512"
variation 1630
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185429433"
variation 1640
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:113120506"
variation 1641
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371096541"
variation 1642
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369486213"
variation 1713
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3805410"
STS 1752..2486
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SCYE1_2292"
/db_xref="UniSTS:280985"
variation 1794
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189803309"
variation 1795
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147386651"
variation 1797
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="t"
/db_xref="dbSNP:34498392"
variation 1801
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:139649385"
variation 1817
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3805411"
variation 1871
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:142599031"
variation 2041
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376349817"
variation 2051
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116122330"
STS 2113..2306
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-132391"
/db_xref="UniSTS:170814"
variation 2125
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:182065529"
STS 2159..2324
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-59700"
/db_xref="UniSTS:23723"
variation 2205
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11544778"
variation 2208
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111236636"
variation 2254
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:60786555"
STS 2281..2385
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="SHGC-24759"
/db_xref="UniSTS:31095"
variation 2298
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:186440569"
polyA_signal 2316..2321
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
variation 2319
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372503930"
polyA_site 2336
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
variation 2343..2344
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace=""
/replace="t"
/db_xref="dbSNP:11383965"
polyA_signal 2391..2396
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
polyA_site 2413
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
variation 2424
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190859723"
variation 2427
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139596725"
variation 2480
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34894323"
variation 2558
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:6828660"
variation 2682
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3109951"
STS 2736..2984
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/standard_name="G35299"
/db_xref="UniSTS:30122"
variation 2791
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:13534"
variation 2915
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="g"
/replace="t"
/db_xref="dbSNP:11544779"
variation 2932
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371865014"
variation 3036
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114810277"
variation 3103
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
/replace="a"
/replace="c"
/db_xref="dbSNP:76283285"
polyA_signal 3125..3130
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
polyA_site 3146
/gene="AIMP1"
/gene_synonym="EMAP2; EMAPII; HLD3; p43; SCYE1"
ORIGIN
agtgacagagcgattactaagcctacggttcccaaacgactcaggtgaacctgatttacaggaaaggcgggctgtagctagggatggagacagtacctatcagcaagcggctccacagctcggttctctatctattctgaagacatgcggggccactcactgctcctgatagtcctctacctcccacagaccccacccactacgacacggaaaactggattacccaaatacctgcctctgagtctggggacgcaggcaagcacaaagacaagggggatggagcttctacacagggccccagcgctgtcgctgtggctgctgctgccgctacggcttagtgcaccagacgctgcatttcaggtgctcctacaaaagaggccactcctggaacgccgggagctcagacgctgccctttgctcgcgagccaagtcagccaaggttaaccttcgcggaacccggcgaggagcgcaagcctggccttccccaaacacagatccgagcttttcaccctctaccctcccctcagcctggccttttcttccgccctcacagccaccgcgacccaacgctgaggaaagaccccgacttgtggtgtccttccccttgcccaaactggccacgaaaggacatatagcgagagagaaagaggattttctgccgtctcttggcaaaaatggcaaataatgatgctgttctgaagagactggagcagaagggtgcagaggcagatcaaatcattgaatatcttaagcagcaagtttctctacttaaggagaaagcaattttgcaggcaactttgagggaagagaagaaacttcgagttgaaaatgctaaactgaagaaagaaattgaagaactgaaacaagagctaattcaggcagaaattcaaaatggagtgaagcaaataccatttccatctggtactccactgcacgctaattctatggtttctgaaaatgtgatacagtctacagcagtaacaaccgtatcttctggtaccaaagaacagataaaaggaggaacaggagacgaaaagaaagcgaaagagaaaattgaaaagaaaggagagaagaaggagaaaaaacagcaatcaatagctggaagtgccgactctaagccaatagatgtttcccgtctggatcttcgaattggttgcatcataactgctagaaaacaccctgatgcagattctttgtatgtggaagaagtagatgtcggagaaatagccccaaggacagttgtcagtggcctggtgaatcatgttcctcttgaacagatgcaaaatcggatggtgattttactttgtaacctgaaacctgcaaagatgaggggagtattatctcaagcaatggtcatgtgtgctagttcaccagagaaaattgaaatcttggctcctccaaatgggtctgttcctggagacagaattacttttgatgctttcccaggagagcctgacaaggagctgaatcctaagaagaagatttgggagcagatccagcctgatcttcacactaatgatgagtgtgtggctacatacaaaggagttccctttgaggtgaaagggaagggagtatgtagggctcaaaccatgagcaacagtggaatcaaataaaatgcttccactaccaaaagacattagagaaaaccttaaaagtaataaagagaaatatatttgtcacttatacctaaaatatgagtggctcatttttgcattactctcttctagacttgactagtcatttacttggtatatattgttttcattgattggggaaacactagatttttacctcggtttttgatcatttataatggagagaggaagttgcctatgttttgtaataatttattttttagcaggaatattgattagcagcttttttttctttatacacatagataactaactagattaatgtttagtttcttatttgtaggcacaggatgcatgaaatttcaagctctgggattttttgtatattgtgtatctgtatcaaaaatatcctctccttttcaaaaatgacaggttggaaaatgtttgtcagacttattaactggtcatattataataatactgataatgaccaactgctcattctgaaagccaaacataaaagctaggagaagtggcatctgaacatttttgctttgctgccagagtaaccctgactaataatacaataacagcaatttttttaaaaaactgagatttcctactggcttgaagtttttctatttagcaaaataattagtaataagttttgactaggtctaaagaatgaacacattgtaaacagttgccacagtagtttctaataaattgatcataaaagcagctatcctttttttttttaattctagcttctttttaaagattatttgggtacctaataaaggataatttatatcttattacagactgatattttgctttttcatgtgtcatcatactgtcagtatattaaaagaaattacagcctaaaacttaacatataccatacatatatattaaggtgtcaaatagctattctcactcatcttacaaatattgtaagagcaataaaaattaattgaggaattataagcctacaggtcatcagccttgaggtgattactgatgatttgggcttacacacatgtcagcaagatagggagtgtggataggggagggctggtagctaacaaggggcctcacagagaaatattagtgactttaaccaggtttcagaatctgggccttacctttacaggttcaacaaaagaatggcatcaatagaggcagaagtatagacattgttttaaaaatacacacatgcacacacacacaaaacattttagcattatagctgtctgaatccttcaataagaaggagaggcacacacaaatacacacactcacacaaaactcaacaaccataaaacaaccctgcatgttataaaaggcagaattaaattttatttatttaaatccatggaactctggtaggccaggatatattatagtaccattatcaatgtgatattctgaaaatatgaactgagcgtcattaacaattgttggtacctaaacacaaaatgaatttcaaaagttactttgttctcaagatatgtcattcttttgggaataaatacttctggtgacaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9255 -> Molecular function: GO:0000049 [tRNA binding] evidence: IDA
GeneID:9255 -> Molecular function: GO:0005125 [cytokine activity] evidence: ISS
GeneID:9255 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:9255 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:9255 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:9255 -> Biological process: GO:0001937 [negative regulation of endothelial cell proliferation] evidence: IDA
GeneID:9255 -> Biological process: GO:0006006 [glucose metabolic process] evidence: IEA
GeneID:9255 -> Biological process: GO:0006418 [tRNA aminoacylation for protein translation] evidence: TAS
GeneID:9255 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:9255 -> Biological process: GO:0006935 [chemotaxis] evidence: TAS
GeneID:9255 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
GeneID:9255 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
GeneID:9255 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:9255 -> Biological process: GO:0007267 [cell-cell signaling] evidence: IDA
GeneID:9255 -> Biological process: GO:0009611 [response to wounding] evidence: TAS
GeneID:9255 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:9255 -> Biological process: GO:0050900 [leukocyte migration] evidence: IDA
GeneID:9255 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
GeneID:9255 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:9255 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
GeneID:9255 -> Cellular component: GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex] evidence: IDA
GeneID:9255 -> Cellular component: GO:0030133 [transport vesicle] evidence: IEA
by
@meso_cacase at
DBCLS
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