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2024-04-26 15:21:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004619 3988 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens TNF receptor-associated factor 5 (TRAF5), transcript
variant 1, mRNA.
ACCESSION NM_004619
VERSION NM_004619.3 GI:77404345
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3988)
AUTHORS Shen,J., Qiao,Y.Q., Ran,Z.H. and Wang,T.R.
TITLE Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory
bowel disease
JOURNAL Int J Med Sci 10 (2), 156-163 (2013)
PUBMED 23329887
REMARK GeneRIF: TRAF3 and TRAF5 are overexpressed in inflammatory bowel
disease
REFERENCE 2 (bases 1 to 3988)
AUTHORS Tao,T., Cheng,C., Ji,Y., Xu,G., Zhang,J., Zhang,L. and Shen,A.
TITLE Numbl inhibits glioma cell migration and invasion by suppressing
TRAF5-mediated NF-kappaB activation
JOURNAL Mol. Biol. Cell 23 (14), 2635-2644 (2012)
PUBMED 22593207
REMARK GeneRIF: Numbl interacted with tumor necrosis factor
receptor-associated factor 5, which signals upstream and is
required for the activation of NF-kappaB, and committed it to
proteasomal degradation by promoting K48-linked polyubiquitination
of TRAF5
REFERENCE 3 (bases 1 to 3988)
AUTHORS Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
Middeldorp,J.M. and de Sanjose,S.
TITLE Single nucleotide polymorphisms of matrix metalloproteinase 9
(MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
in chronic lymphocytic leukemia: results from the European
case-control study EpiLymph
JOURNAL Haematologica 96 (2), 323-327 (2011)
PUBMED 21048031
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
REFERENCE 4 (bases 1 to 3988)
AUTHORS Lee,K.M., Baris,D., Zhang,Y., Hosgood,H.D. III, Menashe,I.,
Yeager,M., Zahm,S.H., Wang,S.S., Purdue,M.P., Chanock,S., Zheng,T.,
Rothman,N. and Lan,Q.
TITLE Common single nucleotide polymorphisms in immunoregulatory genes
and multiple myeloma risk among women in Connecticut
JOURNAL Am. J. Hematol. 85 (8), 560-563 (2010)
PUBMED 20568250
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 3988)
AUTHORS Mosbruger,T.L., Duggal,P., Goedert,J.J., Kirk,G.D., Hoots,W.K.,
Tobler,L.H., Busch,M., Peters,M.G., Rosen,H.R., Thomas,D.L. and
Thio,C.L.
TITLE Large-scale candidate gene analysis of spontaneous clearance of
hepatitis C virus
JOURNAL J. Infect. Dis. 201 (9), 1371-1380 (2010)
PUBMED 20331378
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 3988)
AUTHORS Hsu,H., Solovyev,I., Colombero,A., Elliott,R., Kelley,M. and
Boyle,W.J.
TITLE ATAR, a novel tumor necrosis factor receptor family member, signals
through TRAF2 and TRAF5
JOURNAL J. Biol. Chem. 272 (21), 13471-13474 (1997)
PUBMED 9153189
REFERENCE 7 (bases 1 to 3988)
AUTHORS Tang,X.X., Pleasure,D.E. and Ikegaki,N.
TITLE cDNA cloning, chromosomal localization, and expression pattern of
EPLG8, a new member of the EPLG gene family encoding ligands of
EPH-related protein-tyrosine kinase receptors
JOURNAL Genomics 41 (1), 17-24 (1997)
PUBMED 9126477
REFERENCE 8 (bases 1 to 3988)
AUTHORS Aizawa,S., Nakano,H., Ishida,T., Horie,R., Nagai,M., Ito,K.,
Yagita,H., Okumura,K., Inoue,J. and Watanabe,T.
TITLE Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2
are involved in CD30-mediated NFkappaB activation
JOURNAL J. Biol. Chem. 272 (4), 2042-2045 (1997)
PUBMED 8999898
REFERENCE 9 (bases 1 to 3988)
AUTHORS Ishida,T.K., Tojo,T., Aoki,T., Kobayashi,N., Ohishi,T.,
Watanabe,T., Yamamoto,T. and Inoue,J.
TITLE TRAF5, a novel tumor necrosis factor receptor-associated factor
family protein, mediates CD40 signaling
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 93 (18), 9437-9442 (1996)
PUBMED 8790348
REFERENCE 10 (bases 1 to 3988)
AUTHORS Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
Yagita,H. and Okumura,K.
TITLE TRAF5, an activator of NF-kappaB and putative signal transducer for
the lymphotoxin-beta receptor
JOURNAL J. Biol. Chem. 271 (25), 14661-14664 (1996)
PUBMED 8663299
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB218840.1, AB000509.1,
U69108.1 and BU676629.1.
On Oct 8, 2005 this sequence version replaced gi:22027625.
Summary: The scaffold protein encoded by this gene is a member of
the tumor necrosis factor receptor-associated factor (TRAF) protein
family and contains a meprin and TRAF homology (MATH) domain, a
RING-type zinc finger, and two TRAF-type zinc fingers. TRAF
proteins are associated with, and mediate signal transduction from
members of the TNF receptor superfamily. This protein is one of the
components of a multiple protein complex which binds to tumor
necrosis factor (TNF) receptor cytoplasmic domains and mediates
TNF-induced activation. Alternate transcriptional splice variants
have been characterized. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longest
transcript. Variants 1, 2 and 3 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AB000509.1, CR536557.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-324 DB218840.1 78-401
325-2190 AB000509.1 319-2184
2191-2782 U69108.1 2072-2663
2783-3973 AB000509.1 2777-3967
3974-3988 BU676629.1 3-17 c
FEATURES Location/Qualifiers
source 1..3988
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32"
gene 1..3988
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TNF receptor-associated factor 5"
/db_xref="GeneID:7188"
/db_xref="HGNC:12035"
/db_xref="HPRD:03834"
/db_xref="MIM:602356"
exon 1..59
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
misc_feature 52..54
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="upstream in-frame stop codon"
exon 60..278
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
CDS 61..1734
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="RING finger protein 84"
/codon_start=1
/product="TNF receptor-associated factor 5"
/protein_id="NP_004610.1"
/db_xref="GI:11321603"
/db_xref="CCDS:CCDS1497.1"
/db_xref="GeneID:7188"
/db_xref="HGNC:12035"
/db_xref="HPRD:03834"
/db_xref="MIM:602356"
/translation="
MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
"
misc_feature 181..309
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 190..303
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(193..195,202..204,238..240,244..246,253..255,
262..264,292..294,301..303)
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 442..609
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 607..783
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 835..1080
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="Biogenesis of lysosome-related organelles complex-1
subunit 2; Region: BLOC1_2; pfam10046"
/db_xref="CDD:163611"
misc_feature 1093..1731
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00463.2);
Region: Interaction with EIF2AK2/PKR"
misc_feature 1270..1710
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="Tumor Necrosis Factor Receptor (TNFR)-Associated
Factor (TRAF) family, TRAF5 subfamily, TRAF domain,
C-terminal MATH subdomain; TRAF molecules serve as adapter
proteins that link TNFRs and downstream kinase cascades
resulting in the activation of...; Region: MATH_TRAF5;
cd03780"
/db_xref="CDD:58111"
misc_feature order(1279..1281,1285..1287,1369..1374,1465..1467,
1474..1476,1525..1527)
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:58111"
misc_feature order(1393..1395,1399..1401,1444..1446,1558..1560,
1609..1620)
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/note="TNFR binding site; other site"
/db_xref="CDD:58111"
variation 96
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:370825088"
variation 104
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:192648296"
variation 106
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:200654269"
variation 107
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:377497907"
variation 118
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:148579195"
variation 132
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:370299075"
variation 151
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374226783"
variation 155
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:199814704"
variation 165
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:368844464"
variation 172
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:368567277"
variation 173
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201400842"
variation 190
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:141533849"
variation 191
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:372772119"
variation 225
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:200989117"
variation 260
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:374448179"
exon 279..336
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 290
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:138541263"
variation 308
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:371824899"
variation 319
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:200231390"
variation 334
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201150771"
exon 337..438
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 354
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230778"
variation 392
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143951452"
variation 395
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:139835688"
variation 419
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:3946808"
exon 439..603
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 488
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:377704147"
variation 489
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:369624806"
variation 494
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143474206"
variation 504
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:34155984"
variation 508
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:183953361"
variation 509
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374099125"
variation 534
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:187481865"
variation 537
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:2230779"
variation 550
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:200980823"
variation 589
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:376733808"
exon 604..681
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 616
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:2271458"
variation 659
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:149809182"
exon 682..756
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 697
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:200289585"
variation 698
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:377012367"
variation 704
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370068812"
variation 741
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:145765066"
variation 747
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:79833851"
variation 751
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374585053"
variation 755
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:113925874"
exon 757..849
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 780
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:186895220"
variation 782
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:200691417"
variation 794
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:147658016"
variation 800
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370187802"
variation 812
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143383996"
variation 847
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:368184278"
exon 850..990
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 862
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:200398415"
variation 882
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:140547533"
variation 900
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:368057468"
variation 946
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:367768103"
variation 962
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:371288296"
variation 971
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:138593370"
variation 988
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:146187607"
variation 989
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:149548418"
exon 991..1159
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 1058
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:200530774"
variation 1099
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:369840198"
variation 1114
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:374270138"
variation 1132
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:2230780"
exon 1160..3978
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/inference="alignment:Splign:1.39.8"
variation 1162
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:147396608"
variation 1172
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:201823574"
variation 1175
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:377065340"
variation 1183
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:200020406"
variation 1193
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:192860244"
variation 1214
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:113770101"
variation 1233
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:369475274"
variation 1238
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:373368870"
variation 1251
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:183479167"
variation 1319
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:376419381"
variation 1322
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:78225734"
variation 1323
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370454821"
variation 1338
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:147675295"
variation 1363
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:201191929"
variation 1370
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:145871946"
variation 1377
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:369820230"
variation 1379
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:372814574"
variation 1380
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:200264560"
variation 1512
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201629340"
variation 1513
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143776579"
variation 1524
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:142045639"
variation 1571
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:377398420"
variation 1614
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:145342244"
variation 1645
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:201555136"
variation 1665
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:147801247"
variation 1666
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:149314484"
variation 1683
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:139643718"
variation 1704
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:147270768"
variation 1709
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:78164002"
variation 1717
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:191471582"
variation 1743
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:371227861"
variation 1778
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:183601818"
variation 1917
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:188266749"
variation 2191
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:1046690"
variation 2290
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:75241000"
variation 2318
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:75076283"
variation 2344
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:146769184"
variation 2457
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:372987588"
variation 2488
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:147929313"
variation 2517
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:71640009"
variation 2538
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:79012864"
variation 2584
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:150478547"
variation 2599
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:111307232"
variation 2642
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:370926928"
variation 2655
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:149568330"
variation 2767
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:202021817"
STS 2868..2956
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2910
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:143220164"
variation 2913
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:192988383"
variation 2953
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:138874475"
variation 3008
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:184674809"
variation 3034
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:377712073"
variation 3036
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:141997541"
variation 3056
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="c"
/db_xref="dbSNP:58510761"
variation 3082
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:190349032"
variation 3096
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:368281988"
variation 3160..3161
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace=""
/replace="ca"
/db_xref="dbSNP:372838455"
variation 3212
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:12143280"
variation 3232
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:181563780"
variation 3326
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="t"
/db_xref="dbSNP:146257194"
variation 3362
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:74137663"
variation 3403..3404
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace=""
/replace="c"
/db_xref="dbSNP:35232266"
variation 3451..3453
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace=""
/replace="ata"
/db_xref="dbSNP:376828636"
variation 3453
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:139298194"
variation 3541
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:186323245"
variation 3599
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:79204495"
variation 3621
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:370923000"
variation 3642
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="a"
/replace="g"
/db_xref="dbSNP:189164345"
STS 3732..3889
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/standard_name="SHGC-76306"
/db_xref="UniSTS:35516"
variation 3764
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:181868298"
polyA_site 3821
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
variation 3884
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="g"
/db_xref="dbSNP:74137664"
variation 3889
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="g"
/replace="t"
/db_xref="dbSNP:6690648"
variation 3967
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
/replace="c"
/replace="t"
/db_xref="dbSNP:141801188"
polyA_site 3973
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
polyA_site 3978
/gene="TRAF5"
/gene_synonym="MGC:39780; RNF84"
ORIGIN
agacgcacgtgagggaaatcagatgactggacttgtagatactaacggttctgaagcggaatggcttattcagaagagcataaaggtatgccctgtggtttcatccgccagaattccggcaactccatttccttggactttgagcccagtatagagtaccagtttgtggagcggttggaagagcgctacaaatgtgccttctgccactcggtgcttcacaacccccaccagacaggatgtgggcaccgcttctgccagcactgcatcctgtccctgagagaattaaacacagtgccaatctgccctgtagataaagaggtcatcaaatctcaggaggtttttaaagacaattgttgcaaaagagaagtcctcaacttatatgtatattgcagcaatgctcctggatgtaatgccaaggttattctgggccggtaccaggatcaccttcagcagtgcttatttcaacctgtgcagtgttctaatgagaagtgccgggagccagtcctacggaaagacctgaaagagcatttgagtgcatcctgtcagtttcgaaaggaaaaatgcctttattgcaaaaaggatgtggtagtcatcaatctacagaatcatgaggaaaacttgtgtcctgaatacccagtattttgtcccaacaattgtgcgaagattattctaaaaactgaggtagatgaacacctggctgtatgtcctgaagctgagcaagactgtccttttaagcactatggctgtgctgtaacggataaacggaggaacctgcagcaacatgagcattcagccttacgggagcacatgcgtttggttttagaaaagaatgtccaattagaagaacagatttctgacttacacaagagcctagaacagaaagaaagtaaaatccagcagctagcagaaactataaagaaacttgaaaaggagttcaagcagtttgcacagttgtttggcaaaaatggaagcttcctcccaaacatccaggtttttgccagtcacattgacaagtcagcttggctagaagctcaagtgcatcaattattacaaatggttaaccagcaacaaaataaatttgacctgagacctttgatggaagcagttgatacagtgaaacagaaaattaccctgctagaaaacaatgatcaaagattagccgttttagaagaggaaactaacaaacatgatacccacattaatattcataaagcacagctgagtaaaaatgaagagcgatttaaactgctggagggtacttgctataatggaaagctcatttggaaggtgacagattacaagatgaagaagagagaggcggtggatgggcacacagtgtccatcttcagccagtccttctacaccagccgctgtggctaccggctctgtgctagagcatacctgaatggggatgggtcagggagggggtcacacctgtccctatactttgtggtcatgcgaggagagtttgactcactgttgcagtggccattcaggcagagggtgaccctgatgcttctggaccagagtggcaaaaagaacattatggagaccttcaaacctgaccccaatagcagcagctttaaaagacctgatggggagatgaacattgcatctggctgtccccgctttgtggctcattctgttttggagaatgccaagaacgcctacattaaagatgacactctgttcttgaaagtggccgtggacttaactgacctggaggatctctagtcactgttatggggtgataagaggacttcttggggccagaactgtggaggagagcacatttgattatcatattgacctggatttagactcaaagcacatttgtatttgcctttttccttaacgtttgaagtcagtttaaaacttctgaagtgctgtctttttacattttactctgtcccagtttgaaacttaaaactcttagaatattctcttattatttatatttttatatttcttgaaagatggtaagtttcttgaagtttttggggcgtttctcttttactggtgcttagcgcagtgtctcgggcactctaaatattgagtgttatggaggacacagaggtagcagaatcccagttgaaaatgttttgatattttattgtttggcctattgattctagacctggccttaagtctgcaaaagccatctttataaggtaggctgttccagttaagtagtgggtgatgtagttacaaagataatatgctcagtttggacctttttttcagttaaatgctaaatatatgaaaattactatacctctaagtattttcatgaaattcaccagcagtttgcaagcacagttttgcaaggctgcataagaactggtgaatggggtaagcattttcattcttcctgctgaagtaaagcagaaagtactgcatagtatatgagatatagccagctagctaaagttcagattttgttaggttcaaccctatgaaaaaaactattttcataggtcaaaaatggtaaaaaattagcagtttcataagattcaaccaaataaatatatatatacacacacacatacatatacacctatatatgtgtgtatacaaacagttcgaatgtattttggtgacagtaataaatcaatgtgaggatggatagaatttagtatatgatagagaaaatgtcataaatggataaaaggaatttacaacttgaggagaaaacctttacaatttcctatgggtgtcagaagtactctcagcgaaaactgatggctaaaacagtatctactattctctgataactttttttttgagacagagtttcattgtcacccaggctggagtacagtggcatgatctcagctcactgcaaactctgcctcccgaattcaagtgattctcctgcctcagcctcctgagtagctgggattacaggcgcccgtcaccacacccaggtaatttttgtatttttagtagagacggagttttgccatgttggccaagctgatctcaaactcctgacctcaagtgatctgcccgcctcggcctcccaaagtgctgagattacaggcatgacccaccgcgtcaagcctctgacaactattgaatttgtaagctgctatgcaaatgggcatttatataaacttgtgatgtttcttgtcagaattctgagtactctgtgaagaacagaaatgatcatattcttatgcatctatctgtatgggtctgaaggtgtatatacaaactgagatgagtccttatgactcttgataagcctgagtttaacaacaacaaaaatgccaagttgtcctgagcccttctgcgttgttatgccacttccctactgctcatatgcacgctggctcccctgggcacgcaaggatgagtatgggccatgggcccctgtagagctgcttacctggtgatgaccatgcaccttacaatttctgaacagttaaccctatagaagcatgctttatatgagtgtcttctgggaagaggaaccttcttaatctcttctgtgggattttcaaaatgctaaagactcacactgcagcaatcatcccagatgattaaattcaaagaaataggttcacaacaggaatatactgaagaactagagtgtcactgctggtgaactgtggcacggttgctcaacacatcacctcggacaaattcaggaagcatttctttagcccacaagtccagacccaggtgctctgtatgtttgtttttaatattcatcatatccaagttcactctgtcttcctgagcagtggaagatcatattgctgtaacttcttttaagtagttgatgtggaaaacattttaaagtgaatttgtcaaaatgctggttttgtgttttatccaacttttgtgcatatatataaagtatgtcatggcatggtttgcttaggagttcagagttccttcatcatcgaaatagtgattaagtgatcccagaacaaggaatactagagtaaaaagcacctctttttcacaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7188 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IEA
GeneID:7188 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:7188 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7188 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7188 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:7188 -> Molecular function: GO:0031996 [thioesterase binding] evidence: IPI
GeneID:7188 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7188 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7188 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:7188 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IEA
GeneID:7188 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:7188 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IMP
GeneID:7188 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IMP
GeneID:7188 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:7188 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:7188 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: ISS
GeneID:7188 -> Cellular component: GO:0035631 [CD40 receptor complex] evidence: ISS
by
@meso_cacase at
DBCLS
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