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2024-04-27 04:59:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004526 3504 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens minichromosome maintenance complex component 2 (MCM2),
transcript variant 1, mRNA.
ACCESSION NM_004526
VERSION NM_004526.3 GI:409971406
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3504)
AUTHORS Toubaji,A., Sutcliffe,S., Chaux,A., Lecksell,K., Hicks,J., De
Marzo,A.M., Platz,E.A. and Netto,G.J.
TITLE Immunohistochemical expression of minichromosome maintenance
complex protein 2 predicts biochemical recurrence in prostate
cancer: a tissue microarray and digital imaging analysis-based
study of 428 cases
JOURNAL Hum. Pathol. 43 (11), 1852-1865 (2012)
PUBMED 22554381
REMARK GeneRIF: Immunohistochemical expression of minichromosome
maintenance complex protein 2 predicts biochemical recurrence in
prostate cancer.
REFERENCE 2 (bases 1 to 3504)
AUTHORS Kang,Y.H., Galal,W.C., Farina,A., Tappin,I. and Hurwitz,J.
TITLE Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its
action with DNA polymerase epsilon in rolling circle DNA synthesis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (16), 6042-6047 (2012)
PUBMED 22474384
REMARK GeneRIF: Data show that using a 200-nt primed circular DNA
substrate, the combined action of DNA polymerase epsilon and the
Cdc45/Mcm2-7/GINS (CMG complex) leads to the formation of products
>10 kb in length.
REFERENCE 3 (bases 1 to 3504)
AUTHORS Conesa-Zamora,P., Trujillo-Santos,J., Orantes-Casado,F.J.,
Ortiz-Reina,S., Torres-Moreno,D. and Perez-Guillermo,M.
TITLE Analysis of performance characteristics of five cell cycle-related
immunohistochemical markers and human papillomavirus genotyping in
the diagnosis of cervical squamous cell carcinoma precursor lesions
JOURNAL Anal. Quant. Cytol. Histol. 34 (1), 49-55 (2012)
PUBMED 22590819
REMARK GeneRIF: ProEx C showed the best specificity; p16 displayed the
highest sensitivity and area under receiver operating
characteristic curve for squamous intraepithelial lesions
diagnosis.
REFERENCE 4 (bases 1 to 3504)
AUTHORS Suzuki,S., Kurata,M., Abe,S., Miyazawa,R., Murayama,T., Hidaka,M.,
Yamamoto,K. and Kitagawa,M.
TITLE Overexpression of MCM2 in myelodysplastic syndromes: association
with bone marrow cell apoptosis and peripheral cytopenia
JOURNAL Exp. Mol. Pathol. 92 (1), 160-166 (2012)
PUBMED 22115939
REMARK GeneRIF: The up-regulated expression of MCM2 is associated with
frequent apoptosis in myelodysplastic syndromes (MDS) and may have
an important role in the pathogenesis of MDS.
REFERENCE 5 (bases 1 to 3504)
AUTHORS Guler,N., Comunoglu,N. and Cabbar,F.
TITLE Ki-67 and MCM-2 in dental follicle and odontogenic cysts: the
effects of inflammation on proliferative markers
JOURNAL ScientificWorldJournal 2012, 946060 (2012)
PUBMED 22778705
REMARK GeneRIF: The results of this study indicated that the higher MCM-2
expressions in RC than the KCOT might be related to the
inflammation and this protein might be more sensitive to
inflammation.
REFERENCE 6 (bases 1 to 3504)
AUTHORS Ishimi,Y., Ichinose,S., Omori,A., Sato,K. and Kimura,H.
TITLE Binding of human minichromosome maintenance proteins with histone
H3
JOURNAL J. Biol. Chem. 271 (39), 24115-24122 (1996)
PUBMED 8798650
REFERENCE 7 (bases 1 to 3504)
AUTHORS Nakatsuru,S., Sudo,K. and Nakamura,Y.
TITLE Isolation and mapping of a human gene (MCM2) encoding a product
homologous to yeast proteins involved in DNA replication
JOURNAL Cytogenet. Cell Genet. 68 (3-4), 226-230 (1995)
PUBMED 7842741
REFERENCE 8 (bases 1 to 3504)
AUTHORS Todorov,I.T., Pepperkok,R., Philipova,R.N., Kearsey,S.E.,
Ansorge,W. and Werner,D.
TITLE A human nuclear protein with sequence homology to a family of early
S phase proteins is required for entry into S phase and for cell
division
JOURNAL J. Cell. Sci. 107 (PT 1), 253-265 (1994)
PUBMED 8175912
REFERENCE 9 (bases 1 to 3504)
AUTHORS Mincheva,A., Todorov,I., Werner,D., Fink,T.M. and Lichter,P.
TITLE The human gene for nuclear protein BM28 (CDCL1), a new member of
the early S-phase family of proteins, maps to chromosome band 3q21
JOURNAL Cytogenet. Cell Genet. 65 (4), 276-277 (1994)
PUBMED 8258304
REFERENCE 10 (bases 1 to 3504)
AUTHORS Todorov,I.T., Lavigne,J., Sakr,F., Kaneva,R., Foisy,S. and
Bibor-Hardy,V.
TITLE Nuclear matrix protein mitotin messenger RNA is expressed at
constant levels during the cell cycle
JOURNAL Biochem. Biophys. Res. Commun. 177 (1), 395-400 (1991)
PUBMED 1710453
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB100427.1 and BC007938.2.
On Oct 24, 2012 this sequence version replaced gi:33356546.
Summary: The protein encoded by this gene is one of the highly
conserved mini-chromosome maintenance proteins (MCM) that are
involved in the initiation of eukaryotic genome replication. The
hexameric protein complex formed by MCM proteins is a key component
of the pre-replication complex (pre_RC) and may be involved in the
formation of replication forks and in the recruitment of other DNA
replication related proteins. This protein forms a complex with
MCM4, 6, and 7, and has been shown to regulate the helicase
activity of the complex. This protein is phosphorylated, and thus
regulated by, protein kinases CDC2 and CDC7. Multiple alternatively
spliced transcript variants have been found, but the full-length
nature of some variants has not been defined. [provided by RefSeq,
Oct 2012].
Transcript Variant: This variant (1) encodes a functional protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC014272.2, D21063.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-92 DB100427.1 1-92
93-3504 BC007938.2 1-3412
FEATURES Location/Qualifiers
source 1..3504
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q21"
gene 1..3504
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="minichromosome maintenance complex component 2"
/db_xref="GeneID:4171"
/db_xref="HGNC:6944"
/db_xref="HPRD:00303"
/db_xref="MIM:116945"
exon 1..116
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 29..30
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace=""
/replace="c"
/db_xref="dbSNP:34940832"
variation 46
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:146365324"
misc_feature 48..50
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="upstream in-frame stop codon"
variation 53
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:368605937"
variation 73
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:373148451"
variation 79
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:375179722"
variation 82
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:369455363"
CDS 111..2825
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/EC_number="3.6.4.12"
/note="cyclin-like 1; minichromosome maintenance deficient
2 (mitotin); cell devision cycle-like 1; nuclear protein
BM28; minichromosome maintenance protein 2 homolog; MCM2
minichromosome maintenance deficient 2, mitotin"
/codon_start=1
/product="DNA replication licensing factor MCM2"
/protein_id="NP_004517.2"
/db_xref="GI:33356547"
/db_xref="CCDS:CCDS3043.1"
/db_xref="GeneID:4171"
/db_xref="HGNC:6944"
/db_xref="HPRD:00303"
/db_xref="MIM:116945"
/translation="
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF
"
misc_feature 114..881
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49736.4);
Region: Interaction with KAT7 (By similarity)"
misc_feature 114..116
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (P49736.4); acetylation site"
misc_feature 147..149
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49736.4); phosphorylation site"
misc_feature 147..149
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 183..185
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 186..188
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49736.4); phosphorylation site"
misc_feature 186..188
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 186..188
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 189..191
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49736.4); phosphorylation site"
misc_feature 189..191
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 189..191
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 213..215
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 225..227
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P49736.4); phosphorylation site"
misc_feature 225..227
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 228..230
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDC7; propagated from
UniProtKB/Swiss-Prot (P49736.4); phosphorylation site"
misc_feature 228..230
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 231..233
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49736.4); phosphorylation site"
misc_feature 231..233
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 231..233
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 267..269
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CDC7; propagated from
UniProtKB/Swiss-Prot (P49736.4); phosphorylation site"
misc_feature 267..269
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 285..287
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P49736.4); phosphorylation site"
misc_feature 285..287
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature <345..>566
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="Mini-chromosome maintenance protein 2; Region:
MCM2_N; pfam12619"
/db_xref="CDD:204981"
misc_feature 426..428
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 432..434
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATR; propagated from
UniProtKB/Swiss-Prot (P49736.4); phosphorylation site"
misc_feature 432..434
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 519..521
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 525..527
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49736.4); phosphorylation site"
misc_feature 525..527
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 525..527
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 756..758
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (P49736.4); acetylation site"
misc_feature 981..2519
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="minichromosome maintenance proteins; Region: MCM;
smart00350"
/db_xref="CDD:197672"
misc_feature 1251..1253
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P49736.4); phosphorylation site"
misc_feature 1662..2102
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="The AAA+ (ATPases Associated with a wide variety of
cellular Activities) superfamily represents an ancient
group of ATPases belonging to the ASCE (for additional
strand, catalytic E) division of the P-loop NTPase fold.
The ASCE division also includes ABC; Region: AAA; cd00009"
/db_xref="CDD:99707"
misc_feature 1677..1700
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="Walker A motif; other site"
/db_xref="CDD:99707"
misc_feature order(1680..1703,1869..1871,2001..2003)
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:99707"
misc_feature 1857..1874
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="Walker B motif; other site"
/db_xref="CDD:99707"
misc_feature 2073..2084
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49736.4);
Region: Arginine finger"
misc_feature 2076..2078
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/note="arginine finger; other site"
/db_xref="CDD:99707"
exon 117..346
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 125
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:148166817"
variation 152
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:376102107"
variation 163
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:185298481"
variation 207
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:144051770"
variation 208
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:142494006"
variation 236
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:140680894"
variation 240
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:375851208"
variation 310
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201221422"
variation 314
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:3087452"
STS 335..615
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/standard_name="RH25268"
/db_xref="UniSTS:91813"
exon 347..522
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 354
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:200588762"
variation 356
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:186022338"
variation 384
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:374471462"
variation 387
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:199660068"
variation 388
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:150844852"
variation 453
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:201721106"
variation 463
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:139163788"
variation 464
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:373434842"
variation 487
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:149927939"
variation 488
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:2257836"
variation 505
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201216288"
variation 508
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:34997321"
variation 513
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307314"
exon 523..783
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 527
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:377197527"
variation 533
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:145141037"
variation 540
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:139973267"
variation 546
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:200927653"
variation 547
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:190889381"
variation 556
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:35343063"
variation 565
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:200231306"
variation 568
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:368377044"
variation 584
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:369899498"
variation 590
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:2307312"
variation 593
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:372044409"
variation 606
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1048225"
variation 614
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:893293"
variation 623
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:62264117"
variation 684
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:199665704"
variation 686
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:140577001"
variation 689
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:150457733"
variation 703
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376214773"
variation 704
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:371840356"
variation 729
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:375722226"
variation 732
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201424836"
variation 761
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:138251000"
variation 768
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201262336"
exon 784..1003
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 790
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:370122469"
variation 797
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:373076757"
variation 834
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:201515306"
variation 836
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:371226878"
variation 865
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:144115876"
variation 866
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:146895950"
variation 869
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:35749886"
variation 905
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376345350"
variation 932
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:142980535"
variation 933
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:144753488"
variation 938
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:368230142"
variation 961
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:148533176"
variation 997
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:199968234"
exon 1004..1211
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 1044
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:141867973"
variation 1061
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:150564590"
variation 1112
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:376347464"
variation 1135
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:139899850"
variation 1184
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:143514266"
variation 1185
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201802595"
variation 1202
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:200752349"
exon 1212..1346
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 1244
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:112997630"
variation 1258
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:146752036"
variation 1267
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:139136642"
variation 1268
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:149877642"
variation 1275
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:377581276"
variation 1277
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:369427101"
variation 1285
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:144869999"
variation 1296
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:3087450"
variation 1307
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087449"
variation 1308
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:371462307"
variation 1340
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:202032909"
variation 1341
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:373695678"
exon 1347..1538
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 1349
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:187407254"
variation 1384
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:371208727"
variation 1386
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:369473650"
variation 1388
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:147725704"
variation 1392
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:201123662"
variation 1399
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:372110727"
variation 1428
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:372976124"
variation 1440
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:199539311"
variation 1481
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:142512970"
variation 1482
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376973485"
variation 1497
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="t"
/db_xref="dbSNP:190988564"
variation 1503
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:182603137"
variation 1514
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:140620010"
exon 1539..1632
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 1564
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:139336906"
variation 1595
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:375359892"
variation 1611
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:13087457"
variation 1620
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:150403449"
exon 1633..1883
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 1662
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:138119298"
variation 1663
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:149592386"
variation 1670
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:57045995"
variation 1700
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:377737717"
variation 1763
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:182677955"
variation 1766
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:138708920"
variation 1784
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376837416"
variation 1795
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:199793381"
variation 1820
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:373318008"
exon 1884..2010
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 1977
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:372340490"
variation 1985
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:377688408"
variation 1997
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:141735401"
variation 1998
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:138684820"
exon 2011..2123
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 2048
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:377306111"
variation 2055
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:377424967"
variation 2064
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:201684888"
variation 2096
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:138093592"
variation 2108
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:111530425"
variation 2109
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:2307311"
exon 2124..2375
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 2131
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:142652347"
variation 2140
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:370006900"
variation 2160
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201200738"
variation 2166
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:11541852"
variation 2181
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:150514271"
variation 2203
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:139449344"
variation 2212
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:149699620"
variation 2223
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:147793264"
variation 2237
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:199907942"
variation 2244
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:142890769"
variation 2251
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:201217644"
variation 2289
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:2307313"
variation 2308
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:374686602"
variation 2309
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:144817363"
variation 2344
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376563084"
exon 2376..2558
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 2377
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:147917433"
variation 2384
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:149009392"
variation 2410
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:12482"
variation 2425
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:372194428"
variation 2446
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201828053"
variation 2474
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376569612"
variation 2478
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:369079696"
variation 2480
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:143447982"
variation 2489
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:200244254"
variation 2491
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:375684929"
variation 2499
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:376831247"
variation 2537
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:371014572"
variation 2538
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:140928153"
variation 2541
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:150230243"
variation 2545
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:185316647"
exon 2559..2714
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 2568
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:138865006"
variation 2584
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:374590880"
variation 2587
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201882833"
variation 2591
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:368722217"
variation 2597
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:373238083"
variation 2636
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:141996483"
variation 2645
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:146246663"
variation 2653
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:137990158"
variation 2666
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:190121900"
variation 2680
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:140905579"
variation 2683
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:144122212"
variation 2690
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="g"
/db_xref="dbSNP:377692299"
variation 2696
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201109342"
exon 2715..3488
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/inference="alignment:Splign:1.39.8"
variation 2788
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:368010365"
variation 2789
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:202207227"
variation 2792
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:6794323"
variation 2799
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:142055220"
variation 2810
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:376562317"
variation 2826
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:368340805"
variation 2845
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:368920498"
STS 2923..3247
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/standard_name="D3S3345"
/db_xref="UniSTS:67443"
STS 2946..3403
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/standard_name="GDB:568593"
/db_xref="UniSTS:157727"
variation 2970
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:201056689"
variation 2973
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="c"
/db_xref="dbSNP:116343860"
STS 3048..3299
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/standard_name="STS-X67334"
/db_xref="UniSTS:55752"
variation 3119
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:371969091"
variation 3141
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:138698648"
variation 3245
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="t"
/db_xref="dbSNP:141767294"
variation 3322
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:73861539"
variation 3338
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:188052534"
variation 3341
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:116989425"
variation 3346
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="a"
/replace="g"
/db_xref="dbSNP:12298"
variation 3362
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="g"
/replace="t"
/db_xref="dbSNP:189683455"
variation 3401
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:17538767"
variation 3456
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
/replace="c"
/replace="t"
/db_xref="dbSNP:182305027"
polyA_signal 3466..3471
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
polyA_site 3488
/gene="MCM2"
/gene_synonym="BM28; CCNL1; cdc19; CDCL1; D3S3194;
MITOTIN"
ORIGIN
atgacgtcgcgttccgtagggctcttcccgggctttggtgggtcacgtgaaccacttttcgcgcgaaacctggttgttgctgtagtggcggagaggatcgtggtactgctatggcggaatcatcggaatccttcaccatggcatccagcccggcccagcgtcggcgaggcaatgatcctctcacctccagccctggccgaagctcccggcgtactgatgccctcacctccagccctggccgtgaccttccaccatttgaggatgagtccgaggggctcctaggcacagaggggcccctggaggaagaagaggatggagaggagctcattggagatggcatggaaagggactaccgcgccatcccagagctggacgcctatgaggccgagggactggctctggatgatgaggacgtagaggagctgacggccagtcagagggaggcagcagagcgggccatgcggcagcgtgaccgggaggctggccggggcctgggccgcatgcgccgtgggctcctgtatgacagcgatgaggaggacgaggagcgccctgcccgcaagcgccgccaggtggagcgggccacggaggacggcgaggaggacgaggagatgatcgagagcatcgagaacctggaggatctcaaaggccactctgtgcgcgagtgggtgagcatggcgggcccccggctggagatccaccaccgcttcaagaacttcctgcgcactcacgtcgacagccacggccacaacgtcttcaaggagcgcatcagcgacatgtgcaaagagaaccgtgagagcctggtggtgaactatgaggacttggcagccagggagcacgtgctggcctacttcctgcctgaggcaccggcggagctgctgcagatctttgatgaggctgccctggaggtggtactggccatgtaccccaagtacgaccgcatcaccaaccacatccatgtccgcatctcccacctgcctctggtggaggagctgcgctcgctgaggcagctgcatctgaaccagctgatccgcaccagtggggtggtgaccagctgcactggcgtcctgccccagctcagcatggtcaagtacaactgcaacaagtgcaatttcgtcctgggtcctttctgccagtcccagaaccaggaggtgaaaccaggctcctgtcctgagtgccagtcggccggcccctttgaggtcaacatggaggagaccatctatcagaactaccagcgtatccgaatccaggagagtccaggcaaagtggcggctggccggctgccccgctccaaggacgccattctcctcgcagatctggtggacagctgcaagccaggagacgagatagagctgactggcatctatcacaacaactatgatggctccctcaacactgccaatggcttccctgtctttgccactgtcatcctagccaaccacgtggccaagaaggacaacaaggttgctgtaggggaactgaccgatgaagatgtgaagatgatcactagcctctccaaggatcagcagatcggagagaagatctttgccagcattgctccttccatctatggtcatgaagacatcaagagaggcctggctctggccctgttcggaggggagcccaaaaacccaggtggcaagcacaaggtacgtggtgatatcaacgtgctcttgtgcggagaccctggcacagcgaagtcgcagtttctcaagtatattgagaaagtgtccagccgagccatcttcaccactggccagggggcgtcggctgtgggcctcacggcgtatgtccagcggcaccctgtcagcagggagtggaccttggaggctggggccctggttctggctgaccgaggagtgtgtctcattgatgaatttgacaagatgaatgaccaggacagaaccagcatccatgaggccatggagcaacagagcatctccatctcgaaggctggcatcgtcacctccctgcaggctcgctgcacggtcattgctgccgccaaccccataggagggcgctacgacccctcgctgactttctctgagaacgtggacctcacagagcccatcatctcacgctttgacatcctgtgtgtggtgagggacaccgtggacccagtccaggacgagatgctggcccgcttcgtggtgggcagccacgtcagacaccaccccagcaacaaggaggaggaggggctggccaatggcagcgctgctgagcccgccatgcccaacacgtatggcgtggagcccctgccccaggaggtcctgaagaagtacatcatctacgccaaggagagggtccacccgaagctcaaccagatggaccaggacaaggtggccaagatgtacagtgacctgaggaaagaatctatggcgacaggcagcatccccattacggtgcggcacatcgagtccatgatccgcatggcggaggcccacgcgcgcatccatctgcgggactatgtgatcgaagacgacgtcaacatggccatccgcgtgatgctggagagcttcatagacacacagaagttcagcgtcatgcgcagcatgcgcaagacttttgcccgctacctttcattccggcgtgacaacaatgagctgttgctcttcatactgaagcagttagtggcagagcaggtgacatatcagcgcaaccgctttggggcccagcaggacactattgaggtccctgagaaggacttggtggataaggctcgtcagatcaacatccacaacctctctgcattttatgacagtgagctcttcaggatgaacaagttcagccacgacctgaaaaggaaaatgatcctgcagcagttctgaggccctatgccatccataaggattccttgggattctggtttggggtggtcagtgccctctgtgctttatggacacaaaaccagagcacttgatgaactcggggtactagggtcagggcttatagcaggatgtctggctgcacctggcatgactgtttgtttctccaagcctgctttgtgcttctcacctttgggtgggatgccttgccagtgtgtcttacttggttgctgaacatcttgccacctccgagtgctttgtctccactcagtaccttggatcagagctgctgagttcaggatgcctgcgtgtggtttaggtgttagccttcttacatggatgtcaggagagctgctgccctcttggcgtgagttgcgtattcaggctgcttttgctgcctttggccagagagctggttgaagatgtttgtaatcgttttcagtctcctgcaggtttctgtgcccctgtggtggaagagggcacgacagtgccagcgcagcgttctgggctcctcagtcgcaggggtgggatgtgagtcatgcggattatccactcgccacagttatcagctgccattgctccctgtctgtttccccactctcttatttgtgcattcggtttggtttctgtagttttaatttttaataaagttgaataaaatataaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4171 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:4171 -> Molecular function: GO:0003678 [DNA helicase activity] evidence: IEA
GeneID:4171 -> Molecular function: GO:0003688 [DNA replication origin binding] evidence: IEA
GeneID:4171 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:4171 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4171 -> Molecular function: GO:0042393 [histone binding] evidence: IEA
GeneID:4171 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:4171 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
GeneID:4171 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:4171 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:4171 -> Biological process: GO:0006268 [DNA unwinding involved in DNA replication] evidence: IEA
GeneID:4171 -> Biological process: GO:0006270 [DNA replication initiation] evidence: IMP
GeneID:4171 -> Biological process: GO:0006271 [DNA strand elongation involved in DNA replication] evidence: TAS
GeneID:4171 -> Biological process: GO:0006334 [nucleosome assembly] evidence: IEA
GeneID:4171 -> Biological process: GO:0007049 [cell cycle] evidence: TAS
GeneID:4171 -> Biological process: GO:0071353 [cellular response to interleukin-4] evidence: IEA
GeneID:4171 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:4171 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:4171 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:4171 -> Cellular component: GO:0005664 [nuclear origin of replication recognition complex] evidence: IEA
GeneID:4171 -> Cellular component: GO:0042555 [MCM complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_004517 -> EC 3.6.4.12
by
@meso_cacase at
DBCLS
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