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2019-03-25 14:30:37, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004525              15735 bp    mRNA    linear   PRI 31-MAY-2013
DEFINITION  Homo sapiens low density lipoprotein receptor-related protein 2
            (LRP2), mRNA.
ACCESSION   NM_004525
VERSION     NM_004525.2  GI:126012572
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15735)
  AUTHORS   Dagil,R., O'Shea,C., Nykjaer,A., Bonvin,A.M. and Kragelund,B.B.
  TITLE     Gentamicin binds to the megalin receptor as a competitive inhibitor
            using the common ligand binding motif of complement type repeats:
            insight from the nmr structure of the 10th complement type repeat
            domain alone and in complex with gentamicin
  JOURNAL   J. Biol. Chem. 288 (6), 4424-4435 (2013)
   PUBMED   23275343
  REMARK    GeneRIF: Using NMR titration data in HADDOCK, we have generated a
            three-dimensional model describing the complex between megalin and
            gentamicin.
REFERENCE   2  (bases 1 to 15735)
  AUTHORS   Hamajima,N., Naito,M., Okada,R., Kawai,S., Yin,G., Morita,E.,
            Higashibata,T., Tamura,T., Nakagawa,H., Matsuo,H., Mori,A. and
            Wakai,K.
  TITLE     Significant interaction between LRP2 rs2544390 in intron 1 and
            alcohol drinking for serum uric acid levels among a Japanese
            population
  JOURNAL   Gene 503 (1), 131-136 (2012)
   PUBMED   22565184
  REMARK    GeneRIF: This study confirmed that LRP2 rs2544390 C/T at intron 1
            was associated with serum uric acid levels among Japanese males
            with SLC22A12 258WW, SLC2A9 rs11722228C allele, ABCG2 126QQ and
            141Q allele.
REFERENCE   3  (bases 1 to 15735)
  AUTHORS   Schreiber,A., Theilig,F., Schweda,F. and Hocherl,K.
  TITLE     Acute endotoxemia in mice induces downregulation of megalin and
            cubilin in the kidney
  JOURNAL   Kidney Int. 82 (1), 53-59 (2012)
   PUBMED   22437417
  REMARK    GeneRIF: Expression of megalin and cubilin is decreased during
            experimental endotoxemia, which may contribute to an increase in
            urine levels of albumin during acute renal failure.
REFERENCE   4  (bases 1 to 15735)
  AUTHORS   Ionita-Laza,I., Makarov,V. and Buxbaum,J.D.
  CONSRTM   ARRA Autism Sequencing Consortium
  TITLE     Scan-statistic approach identifies clusters of rare disease
            variants in LRP2, a gene linked and associated with autism spectrum
            disorders, in three datasets
  JOURNAL   Am. J. Hum. Genet. 90 (6), 1002-1013 (2012)
   PUBMED   22578327
  REMARK    GeneRIF: analysis of rare disease variants in LRP2, a gene linked
            and associated with autism spectrum disorders
REFERENCE   5  (bases 1 to 15735)
  AUTHORS   Wang,C., Hu,Y.M., He,J.W., Gu,J.M., Zhang,H., Hu,W.W., Yue,H.,
            Gao,G., Xiao,W.J., Yu,J.B., Ke,Y.H., Hu,Y.Q., Li,M., Liu,Y.J.,
            Fu,W.Z., Ren,Y. and Zhang,Z.L.
  TITLE     Association between low density lipoprotein receptor-related
            protein 2 gene polymorphisms and bone mineral density variation in
            Chinese population
  JOURNAL   PLoS ONE 6 (12), E28874 (2011)
   PUBMED   22174918
  REMARK    GeneRIF: A total of 330 Chinese female-offspring nuclear families
            with 1088 individuals and 400 Chinese male-offspring nuclear
            families with 1215 individuals were genotyped at six tag single
            nucleotide polymorphisms of the LRP2 gene.
REFERENCE   6  (bases 1 to 15735)
  AUTHORS   Farquhar,M.G.
  TITLE     The unfolding story of megalin (gp330): now recognized as a drug
            receptor
  JOURNAL   J. Clin. Invest. 96 (3), 1184 (1995)
   PUBMED   7657789
  REMARK    Review article
REFERENCE   7  (bases 1 to 15735)
  AUTHORS   Farquhar,M.G., Saito,A., Kerjaschki,D. and Orlando,R.A.
  TITLE     The Heymann nephritis antigenic complex: megalin (gp330) and RAP
  JOURNAL   J. Am. Soc. Nephrol. 6 (1), 35-47 (1995)
   PUBMED   7579068
  REMARK    Review article
REFERENCE   8  (bases 1 to 15735)
  AUTHORS   Orlando,R.A. and Farquhar,M.G.
  TITLE     Functional domains of the receptor-associated protein (RAP)
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (8), 3161-3165 (1994)
   PUBMED   7512726
REFERENCE   9  (bases 1 to 15735)
  AUTHORS   Christensen,E.I., Gliemann,J. and Moestrup,S.K.
  TITLE     Renal tubule gp330 is a calcium binding receptor for endocytic
            uptake of protein
  JOURNAL   J. Histochem. Cytochem. 40 (10), 1481-1490 (1992)
   PUBMED   1382088
REFERENCE   10 (bases 1 to 15735)
  AUTHORS   Raychowdhury,R., Niles,J.L., McCluskey,R.T. and Smith,J.A.
  TITLE     Autoimmune target in Heymann nephritis is a glycoprotein with
            homology to the LDL receptor
  JOURNAL   Science 244 (4909), 1163-1165 (1989)
   PUBMED   2786251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA401915.1, U33837.1,
            DA339827.1, AY265358.1, DA200673.1, CD673312.1, AC007556.3 and
            AY265357.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Feb 21, 2007 this sequence version replaced gi:6806918.
            
            Summary: The protein encoded by this gene, low density
            lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand
            endocytic receptor that is expressed in many different tissues but
            primarily in absorptive epithilial tissues such as the kidney. This
            glycoprotein has a large amino-terminal extracellular domain, a
            single transmembrane domain, and a short carboxy-terminal
            cytoplasmic tail. The extracellular ligand-binding-domains bind
            diverse macromolecules including albumin, apolipoproteins B and E,
            and lipoprotein lipase. The LRP2 protein is critical for the
            reuptake of numerous ligands, including lipoproteins, sterols,
            vitamin-binding proteins, and hormones. This protein also has a
            role in cell-signaling; extracellular ligands include parathyroid
            horomones and the morphogen sonic hedgehog while cytosolic ligands
            include MAP kinase scaffold proteins and JNK interacting proteins.
            Recycling of this membrane receptor is regulated by phosphorylation
            of its cytoplasmic domain. Mutations in this gene cause
            Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal
            syndrome (FOAR).[provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U33837.1, AY265358.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               DA401915.1         75-183
            110-460             U33837.1           1-351
            461-714             DA339827.1         339-592
            715-2237            AY265358.1         566-2088
            2238-2588           DA200673.1         91-441
            2589-3281           U33837.1           2480-3172
            3282-3422           CD673312.1         403-543
            3423-3872           U33837.1           3314-3763
            3873-3880           AC007556.3         150972-150979       c
            3881-10715          AY265358.1         3732-10566
            10716-12492         AY265357.1         10570-12346
            12493-14306         U33837.1           12384-14197
            14307-15735         AC007556.3         35125-36553         c
FEATURES             Location/Qualifiers
     source          1..15735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..15735
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="low density lipoprotein receptor-related protein 2"
                     /db_xref="GeneID:4036"
                     /db_xref="HGNC:6694"
                     /db_xref="MIM:600073"
     exon            1..292
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    49..51
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="upstream in-frame stop codon"
     CDS             214..14181
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="megalin; glycoprotein 330; low-density lipoprotein
                     receptor-related protein 2; calcium sensor protein;
                     Heymann nephritis antigen homolog; LRP-2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     2 precursor"
                     /protein_id="NP_004516.2"
                     /db_xref="GI:126012573"
                     /db_xref="CCDS:CCDS2232.1"
                     /db_xref="GeneID:4036"
                     /db_xref="HGNC:6694"
                     /db_xref="MIM:600073"
                     /translation="
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV
"
     sig_peptide     214..288
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     289..14178
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /product="low-density lipoprotein receptor-related protein
                     2"
     misc_feature    295..399
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(310..312,334..336,367..372)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(346..348,355..357,367..369,385..390)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    376..390
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    535..639
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(550..552,574..576,607..612)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(586..588,595..597,607..609,625..630)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    616..630
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    658..750
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(661..663,685..687,718..723)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(697..699,706..708,718..720,736..741)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    727..741
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    760..864
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(775..777,799..801,832..837)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(811..813,820..822,832..834,850..855)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    841..855
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    877..981
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(892..894,916..918,949..954)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(928..930,937..939,949..951,967..972)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    958..972
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    1009..1113
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(1024..1026,1051..1053,1084..1089)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(1063..1065,1072..1074,1084..1086,1102..1107)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    1093..1107
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    1456..1584
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    1519..1647
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 1"
     misc_feature    1594..1716
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    1648..1776
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 2"
     misc_feature    1720..1857
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    1777..1917
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 3"
     misc_feature    1864..1986
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    1918..2049
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 4"
     misc_feature    2050..2172
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 5"
     misc_feature    2470..2598
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 6"
     misc_feature    2539..2667
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    2599..2724
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 7"
     misc_feature    2725..2856
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 8"
     misc_feature    2725..2850
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:200965"
     misc_feature    2803..2925
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    2857..2988
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 9"
     misc_feature    3289..3393
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(3304..3306,3328..3330,3361..3366)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(3340..3342,3349..3351,3361..3363,3379..3384)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    3370..3384
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    3412..3516
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(3427..3429,3451..3453,3484..3489)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(3463..3465,3472..3474,3484..3486,3502..3507)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    3493..3507
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    3538..3642
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(3553..3555,3577..3579,3610..3615)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(3589..3591,3598..3600,3610..3612,3628..3633)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    3619..3633
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    3658..3762
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(3673..3675,3697..3699,3730..3735)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(3709..3711,3718..3720,3730..3732,3748..3753)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    3739..3753
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    3772..3879
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(3787..3789,3814..3816,3847..3852)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(3826..3828,3835..3837,3847..3849,3865..3870)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    3856..3870
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    3901..4005
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(3916..3918,3943..3945,3976..3981)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(3955..3957,3964..3966,3976..3978,3994..3999)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    3985..3999
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    4024..4128
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(4039..4041,4063..4065,4096..4101)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(4075..4077,4084..4086,4096..4098,4114..4119)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    4105..4119
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    4144..4245
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    4327..4392
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Complement Clr-like EGF-like; Region: cEGF;
                     pfam12662"
                     /db_xref="CDD:205000"
     misc_feature    4381..4500
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(4381..4383,4390..4392,4429..4431)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    4594..4713
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    4645..4773
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 10"
     misc_feature    4714..4842
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    4774..4902
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 11"
     misc_feature    4846..4980
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    4909..5040
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 12"
     misc_feature    4984..5109
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    5041..5175
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 13"
     misc_feature    5176..5298
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 14"
     misc_feature    <5452..6288
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG3391"
                     /db_xref="CDD:33198"
     misc_feature    5581..5709
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 15"
     misc_feature    5710..5859
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 16"
     misc_feature    5860..6003
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 17"
     misc_feature    5860..5997
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:200965"
     misc_feature    5944..6072
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    6004..6126
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 18"
     misc_feature    6127..6252
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 19"
     misc_feature    6487..>7077
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Uncharacterized conserved protein [Function
                     unknown]; Region: COG3391"
                     /db_xref="CDD:33198"
     misc_feature    6532..6681
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 20"
     misc_feature    6622..6756
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    6682..6816
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 21"
     misc_feature    6757..6888
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    6817..6948
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 22"
     misc_feature    6892..7014
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    6949..7080
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 23"
     misc_feature    7081..7206
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 24"
     misc_feature    7504..7644
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 25"
     misc_feature    7588..7713
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    7645..7767
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 26"
     misc_feature    7711..7839
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    7768..7899
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 27"
     misc_feature    7846..7968
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    7900..8022
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 28"
     misc_feature    8023..8151
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 29"
     misc_feature    8434..8538
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(8449..8451,8473..8475,8506..8511)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(8485..8487,8494..8496,8506..8508,8524..8529)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    8515..8529
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    8563..8664
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(8569..8571,8593..8595,8626..8631)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(8605..8607,8614..8616,8626..8628,8650..8655)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(8635..8640,8647..8655)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    8803..8898
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(8818..8820,8842..8844,8875..8880)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(8854..8856,8863..8865,8875..8877,8893..8898)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    8884..8898
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    8929..9027
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(8944..8946,8968..8970,9001..9006)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(8980..8982,8989..8991,9001..9003,9019..9024)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    9010..9024
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    9055..9177
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(9070..9072,9109..9111,9142..9147)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(9121..9123,9130..9132,9142..9144,9160..9165)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    9151..9165
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    9190..9294
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(9205..9207,9229..9231,9262..9267)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(9241..9243,9250..9252,9262..9264,9280..9285)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    9271..9285
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    <9337..9405
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(9346..9348,9379..9384)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(9358..9360,9367..9369,9379..9381,9397..9402)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    9388..9402
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    9436..9540
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(9451..9453,9475..9477,9508..9513)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(9487..9489,9496..9498,9508..9510,9526..9531)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    9517..9531
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    9607..9678
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Complement Clr-like EGF-like; Region: cEGF;
                     pfam12662"
                     /db_xref="CDD:205000"
     misc_feature    9667..9786
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Calcium-binding EGF domain; Region: EGF_CA;
                     pfam07645"
                     /db_xref="CDD:148962"
     misc_feature    9868..9993
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    9928..10056
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 30"
     misc_feature    9997..10125
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    10057..10185
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 31"
     misc_feature    10210..10341
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 32"
     misc_feature    10210..10335
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:200965"
     misc_feature    10285..10410
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    10342..10467
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 33"
     misc_feature    10411..10536
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    10468..10593
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 34"
     misc_feature    10747..10848
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(10762..10764,10789..10791,10822..10827)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(10801..10803,10810..10812,10822..10824,10840..10845)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    10831..10845
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    10870..10968
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(10885..10887,10909..10911,10942..10947)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(10921..10923,10930..10932,10942..10944,10960..10965)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    10951..10965
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    10993..>11055
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein receptor domain class A;
                     Region: LDLa; smart00192"
                     /db_xref="CDD:197566"
     misc_feature    11116..11211
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(11131..11133,11155..11157,11188..11193)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(11167..11169,11176..11178,11188..11190,11206..11211)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    11197..11211
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    11257..11355
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(11263..11265,11290..11292,11323..11328)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(11302..11304,11311..11313,11323..11325,11341..11346)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    11332..11346
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    11368..11475
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(11386..11388,11410..11412,11443..11448)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(11422..11424,11431..11433,11443..11445,11461..11466)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    11452..11466
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    11488..11592
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(11503..11505,11527..11529,11560..11565)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(11539..11541,11548..11550,11560..11562,11578..11583)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    11569..11583
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    11605..11709
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; Region:
                     LDLa; cd00112"
                     /db_xref="CDD:29012"
     misc_feature    order(11620..11622,11644..11646,11677..11682)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="putative binding surface; other site"
                     /db_xref="CDD:29012"
     misc_feature    order(11656..11658,11665..11667,11677..11679,11695..11700)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="calcium-binding site [ion binding]; other site"
                     /db_xref="CDD:29012"
     misc_feature    11686..11700
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="D-X-S-D-E motif; other site"
                     /db_xref="CDD:29012"
     misc_feature    12232..12324
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; Region: EGF_CA; cd00054"
                     /db_xref="CDD:28936"
     misc_feature    order(12232..12234,12241..12243,12280..12282)
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Ca2+ binding site [ion binding]; other site"
                     /db_xref="CDD:28936"
     misc_feature    12634..12741
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    12673..12801
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 35"
     misc_feature    12802..12933
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 36"
     misc_feature    12802..12927
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein receptor repeat class B;
                     Region: Ldl_recept_b; pfam00058"
                     /db_xref="CDD:200965"
     misc_feature    12877..13005
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     Region: LY; smart00135"
                     /db_xref="CDD:197533"
     misc_feature    12937..13062
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: LDL-receptor class B 37"
     misc_feature    13483..13551
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     transmembrane region"
     misc_feature    13570..13599
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: SH3-binding (Potential)"
     misc_feature    13774..13791
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: Endocytosis signal (Potential)"
     misc_feature    13978..14019
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: Interaction with DAB2"
     misc_feature    13990..14007
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: NPXY motif"
     misc_feature    14005..14016
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: SH2-binding (Potential)"
     misc_feature    14044..14079
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P98164.3);
                     Region: SH3-binding (Potential)"
     exon            293..400
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            401..523
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       461
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2229263"
     variation       512
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35642533"
     exon            524..640
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       604
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34592807"
     variation       615
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34104660"
     exon            641..751
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            752..865
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       852
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229266"
     exon            866..982
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            983..1135
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       988
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34693334"
     exon            1136..1255
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            1256..1384
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            1385..1554
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            1555..1778
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            1779..1985
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            1986..2188
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            2189..2329
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       2219
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34291900"
     exon            2330..2533
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            2534..2726
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       2645
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:17848140"
     variation       2673
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2241190"
     exon            2727..2852
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            2853..2983
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       2939
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:36082715"
     exon            2984..3121
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       3052
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:80338746"
     exon            3122..3403
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       3147
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17848143"
     variation       3267
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2075249"
     exon            3404..3643
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       3462
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2302691"
     exon            3644..3763
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            3764..3880
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            3881..4258
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       4049
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:17848149"
     exon            4259..4507
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       4449
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:34915742"
     exon            4508..4719
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       4557
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35297090"
     exon            4720..4904
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            4905..5133
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       5088
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229267"
     exon            5134..5311
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            5312..5440
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       5313
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2302694"
     exon            5441..5607
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            5608..5751
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            5752..5861
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            5862..6039
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            6040..6253
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            6254..6493
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       6258
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34834388"
     variation       6319
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34041086"
     variation       6407
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2228168"
     variation       6480
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2228169"
     exon            6494..6682
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            6683..7603
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       6686
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:34052957"
     variation       6972
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35114151"
     variation       7023
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2228170"
     variation       7063
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35413340"
     variation       7167
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34223099"
     exon            7604..7769
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            7770..7928
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            7929..8218
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       8107
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17848169"
     variation       8131
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34026778"
     exon            8219..8422
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            8423..8665
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            8666..8791
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            8792..8911
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       8827
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2228171"
     exon            8912..9043
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            9044..9245
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            9246..9541
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       9495
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34813328"
     exon            9542..10058
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       9626
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35086590"
     variation       9826
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35734447"
     exon            10059..10211
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       10127
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3213760"
     exon            10212..10382
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            10383..10606
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            10607..10784
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       10716
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2229265"
     exon            10785..10981
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       10860
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17848184"
     exon            10982..11227
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       11107
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17848188"
     exon            11228..11356
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       11305
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34355135"
     exon            11357..11476
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            11477..11593
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            11594..11710
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            11711..11848
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       11814
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2229268"
     exon            11849..11971
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            11972..12100
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            12101..12232
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            12233..12364
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            12365..12508
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       12493
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2075252"
     exon            12509..12674
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       12633
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34663643"
     exon            12675..12803
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            12804..13024
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       12938
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35942532"
     exon            13025..13201
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            13202..13321
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            13322..13412
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       13326
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:990626"
     exon            13413..13480
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            13481..13601
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            13602..13731
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            13732..13833
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       13758
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34029982"
     exon            13834..13941
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            13942..14013
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     exon            14014..15735
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /inference="alignment:Splign:1.39.8"
     variation       14016
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34564141"
     STS             14023..14656
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /standard_name="LRP2_7816"
                     /db_xref="UniSTS:467751"
     STS             14331..14468
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /standard_name="WI-17537"
                     /db_xref="UniSTS:26882"
     polyA_signal    14477..14482
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
     polyA_site      14494
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
     variation       15246
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1019334"
     variation       15289
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace=""
                     /replace="gt"
                     /replace="tt"
                     /replace="ttt"
                     /db_xref="dbSNP:3083239"
     variation       15310..15311
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:3083240"
     STS             15483..15638
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /standard_name="A009P03"
                     /db_xref="UniSTS:2385"
     STS             15483..15638
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /standard_name="G32722"
                     /db_xref="UniSTS:117304"
     STS             15495..15703
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /standard_name="RH45139"
                     /db_xref="UniSTS:26027"
     variation       15581..15582
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
                     /replace=""
                     /replace="gatg"
                     /db_xref="dbSNP:3083261"
     polyA_signal    15714..15719
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
     polyA_site      15735
                     /gene="LRP2"
                     /gene_synonym="DBS; GP330"
ORIGIN      
ggtctaaagggctttatgcactgtctggagggtggggactggcgcgggtagaaaacgggatgcctcgggcgtgggggcaggcttttggccactaggagctggcggaggtgcagacctaaaggagcgttcgctagcagaggcgctgccggtgcggtgtgctacgcgcgcccacctcccggggaaggaacggcgaggccggggaccgtcgcggagatggatcgcgggccggcagcagtggcgtgcacgctgctcctggctctcgtcgcctgcctagcgccggccagtggccaagaatgtgacagtgcgcattttcgctgtggaagtgggcattgcatccctgcagactggaggtgtgatgggaccaaagactgttcagatgacgcggatgaaattggctgcgctgttgtgacctgccagcagggctatttcaagtgccagagtgagggacaatgcatccccaactcctgggtgtgtgaccaagatcaagactgtgatgatggctcagatgaacgtcaagattgctcacaaagtacatgctcaagtcatcagataacatgctccaatggtcagtgtatcccaagtgaatacaggtgcgaccacgtcagagactgccccgatggagctgatgagaatgactgccagtacccaacatgtgagcagcttacttgtgacaatggggcctgctataacaccagtcagaagtgtgattggaaagttgattgcagggactcctcagatgaaatcaactgcactgagatatgcttgcacaatgagttttcatgtggcaatggagagtgtatccctcgtgcttatgtctgtgaccatgacaatgattgccaagacggcagtgacgaacatgcttgcaactatccgacctgcggtggttaccagttcacttgccccagtggccgatgcatttatcaaaactgggtttgtgatggagaagatgactgtaaagataatggagatgaagatggatgtgaaagcggtcctcatgatgttcataaatgttccccaagagaatggtcttgcccagagtcgggacgatgcatctccatttataaagtttgtgatgggattttagattgcccaggaagagaagatgaaaacaacactagtaccggaaaatactgtagtatgactctgtgctctgccttgaactgccagtaccagtgccatgagacgccgtatggaggagcgtgtttttgtcccccaggttatatcatcaaccacaatgacagccgtacctgtgttgagtttgatgattgccagatatggggaatttgtgaccagaagtgtgaaagccgacctggccgtcacctgtgccactgtgaagaagggtatatcttggagcgtggacagtattgcaaagctaatgattcctttggcgaggcctccattatcttctccaatggtcgggatttgttaattggtgatattcatggaaggagcttccggatcctagtggagtctcagaatcgtggagtggccgtgggtgtggctttccactatcacctgcaaagagttttttggacagacaccgtgcaaaataaggttttttcagttgacattaatggtttaaatatccaagaggttctcaatgtttctgttgaaaccccagagaacctggctgtggactgggttaataataaaatctatctagtggaaaccaaggtcaaccgcatagatatggtaaatttggatggaagctatcgggttacccttataactgaaaacttggggcatcctagaggaattgccgtggacccaactgttggttatttatttttctcagattgggagagcctttctggggaacctaagctggaaagggcattcatggatggcagcaaccgtaaagacttggtgaaaacaaagctgggatggcctgctggggtaactctggatatgatatcgaagcgtgtttactgggttgactctcggtttgattacattgaaactgtaacttatgatggaattcaaaggaagactgtagttcatggaggctccctcattcctcatccctttggagtaagcttatttgaaggtcaggtgttctttacagattggacaaagatggccgtgctgaaggcaaacaagttcacagagaccaacccacaagtgtactaccaggcttccctgaggccctatggagtgactgtttaccattccctcagacagccctatgctaccaatccgtgtaaagataacaatgggggctgtgagcaggtctgtgtcctcagccacagaacagataatgatggtttgggtttccgttgcaagtgcacattcggcttccaactggatacagatgagcgccactgcattgctgttcagaatttcctcattttttcatcccaagttgctattcgtgggatcccgttcaccttgtctacccaggaagatgtcatggttccagtttcggggaatccttctttctttgtcgggattgattttgacgcccaggacagcactatctttttttcagatatgtcaaaacacatgatttttaagcaaaagattgatggcacaggaagagaaattctcgcagctaacagggtggaaaatgttgaaagtttggcttttgattggatttcaaagaatctctattggacagactctcattacaagagtatcagtgtcatgaggctagctgataaaacgagacgcacagtagttcagtatttaaataacccacggtcggtggtagttcatccttttgccgggtatctattcttcactgattggttccgtcctgctaaaattatgagagcatggagtgacggatctcacctcttgcctgtaataaacactactcttggatggcccaatggcttggccatcgattgggctgcttcacgattgtactgggtagatgcctattttgataaaattgagcacagcacctttgatggtttagacagaagaagactgggccatatagagcagatgacacatccgtttggacttgccatctttggagagcatttattttttactgactggagactgggtgccattattcgagtcaggaaagcagatggtggagaaatgacagttatccgaagtggcattgcttacatactgcatttgaaatcgtatgatgtcaacatccagactggttctaacgcctgtaatcaacccacgcatcctaacggtgactgcagccacttctgcttcccggtgccaaatttccagcgagtgtgtgggtgcccttatggaatgaggctggcttccaatcacttgacatgcgagggggacccaaccaatgaaccacccacagagcagtgtggcttattttccttcccctgtaaaaatggcagatgtgtgcccaattactatctctgtgatggagtcgatgattgtcatgataacagtgatgagcaactatgtggcacacttaataatacctgttcatcttcggcgttcacctgtggccatggggagtgcattcctgcacactggcgctgtgacaaacgcaacgactgtgtggatggcagtgatgagcacaactgccccacccacgcacctgcttcctgccttgacacccaatacacctgtgataatcaccagtgtatctcaaagaactgggtctgtgacacagacaatgattgtggggatggatctgatgaaaagaactgcaattcgacagagacatgccaacctagtcagtttaattgccccaatcatcgatgtattgacctatcgtttgtctgtgatggtgacaaggattgtgttgatggatctgatgaggttggttgtgtattaaactgtactgcttctcaattcaagtgtgccagtggggataaatgtattggcgtcacaaatcgttgtgatggtgtttttgattgcagtgacaactcggatgaagcaggctgtccaaccaggcctcctggtatgtgccactcagatgaatttcagtgccaagaagatggtatctgcatcccgaacttctgggaatgtgatgggcatccagactgcctctatggatctgatgagcacaatgcctgtgtccccaagacttgcccttcatcatatttccactgtgacaacggaaactgcatccacagggcatggctctgtgatcgggacaatgactgcggggatatgagtgatgagaaggactgccctactcagccctttcgctgtcctagttggcaatggcagtgtcttggccataacatctgtgtgaatctgagtgtagtgtgtgatggcatctttgactgccccaatgggacagatgagtccccactttgcaatgggaacagctgctcagatttcaatggtggttgtactcacgagtgtgttcaagagccctttggggctaaatgcctatgtccattgggattcttacttgccaatgattctaagacctgtgaagacatagatgaatgtgatattctaggctcttgtagccagcactgttacaatatgagaggttctttccggtgctcgtgtgatacaggctacatgttagaaagtgatgggaggacttgcaaagttacagcatctgagagtctgctgttacttgtggcaagtcagaacaaaattattgccgacagtgtcacctcccaggtccacaatatctattcattggtcgagaatggttcttacattgtagctgttgattttgattcaattagtggtcgtatcttttggtctgatgcaactcagggtaaaacctggagtgcgtttcaaaatggaacggacagaagagtggtatttgacagtagcatcatcttgactgaaactattgcaatagattgggtaggtcgtaatctttactggacagactatgctctggaaacaattgaagtctccaaaattgatgggagccacaggactgtgctgattagtaaaaacctaacaaatccaagaggactagcattagatcccagaatgaatgagcatctactgttctggtctgactggggccaccaccctcgcatcgagcgagccagcatggacggcagcatgcgcactgtcattgtccaggacaagatcttctggccctgcggcttaactattgactaccccaacagactgctctacttcatggactcctatcttgattacatggacttttgtgattataatggacaccatcggagacaggtgatagccagtgatttgattatacggcacccctatgccctaactctctttgaagactctgtgtactggactgaccgtgctactcgtcgggttatgcgagccaacaagtggcatggagggaaccagtcagttgtaatgtataatattcaatggccccttgggattgttgcggttcatccttcgaaacaaccaaattccgtgaatccatgtgccttttcccgctgcagccatctctgcctgctttcctcacaggggcctcatttttactcctgtgtttgtccttcaggatggagtctgtctcctgatctcctgaattgcttgagagatgatcaacctttcttaataactgtaaggcaacatataatttttggaatctcccttaatcctgaggtgaagagcaatgatgctatggtccccatagcagggatacagaatggtttagatgttgaatttgatgatgctgagcaatacatctattgggttgaaaatccaggtgaaattcacagagtgaagacagatggcaccaacaggacagtatttgcttctatatctatggtggggccttctatgaacctggccttagattggatttcaagaaacctttattctaccaatcctagaactcagtcaatcgaggttttgacactccacggagatatcagatacagaaaaacattgattgccaatgatgggacagctcttggagttggctttccaattggcataactgttgatcctgctcgtgggaagctgtactggtcagaccaaggaactgacagtggggttcctgccaagatcgccagtgctaacatggatggcacatctgtgaaaactctctttactgggaacctcgaacacctggagtgtgtcactcttgacatcgaagagcagaaactctactgggcagtcactggaagaggagtgattgaaagaggaaacgtggatggaacagatcgaatgatcctggtacaccagctttcccacccctggggaattgcagtccatgattctttcctttattatactgatgaacagtatgaggtcattgaaagagttgataaggccactggggccaacaaaatagtcttgagagataatgttccaaatctgaggggtcttcaagtttatcacagacgcaatgccgccgaatcctcaaatggctgtagcaacaacatgaatgcctgtcagcagatttgcctgcctgtaccaggaggattgttttcctgcgcctgtgccactggatttaaactcaatcctgataatcggtcctgctctccatataactctttcattgttgtttcaatgctgtctgcaatcagaggctttagcttggaattgtcagatcattcagaaaccatggtgccggtggcaggccaaggacgaaacgcactgcatgtggatgtggatgtgtcctctggctttatttattggtgtgattttagcagctcagtggcatctgataatgcgatccgtagaattaaaccagatggatcttctctgatgaacattgtgacacatggaataggagaaaatggagtccggggtattgcagtggattgggtagcaggaaatctttatttcaccaatgcctttgtttctgaaacactgatagaagttctgcggatcaatactacttaccgccgtgttcttcttaaagtcacagtggacatgcctaggcatattgttgtagatcccaagaacagatacctcttctgggctgactatgggcagagaccaaagattgagcgttctttccttgactgtaccaatcgaacagtgcttgtgtcagagggcattgtcacaccacggggcttggcagtggaccgaagtgatggctacgtttattgggttgatgattctttagatataattgcaaggattcgtatcaatggagagaactctgaagtgattcgttatggcagtcgttacccaactccttatggcatcactgtttttgaaaattctatcatatgggtagataggaatttgaaaaagatcttccaagccagcaaggaaccagagaacacagagccacccacagtgataagagacaatatcaactggctaagagatgtgaccatctttgacaagcaagtccagccccggtcaccagcagaggtcaacaacaacccttgcttggaaaacaatggtgggtgctctcatctctgctttgctctgcctggattgcacaccccaaaatgtgactgtgcctttgggaccctgcaaagtgatggcaagaattgtgccatttcaacagaaaatttcctcatctttgccttgtctaattccttgagaagcttacacttggaccctgaaaaccatagcccacctttccaaacaataaatgtggaaagaactgtcatgtctctagactatgacagtgtaagtgatagaatctacttcacacaaaatttagcctctggagttggacagatttcctatgccaccctgtcttcagggatccatactccaactgtcattgcttcaggtatagggactgctgatggcattgcctttgactggattactagaagaatttattacagtgactacctcaaccagatgattaattccatggctgaagatgggtctaaccgcactgtgatagcccgcgttccaaaaccaagagcaattgtgttagatccctgccaagggtacctgtactgggctgactgggatacacatgccaaaatcgagagagccacattgggaggaaacttccgcgtacccattgtgaacagcagtctggtcatgcccagtgggctgactctggactatgaagaggaccttctctactgggtggatgctagtctgcagaggattgaacgcagcactctgacgggcgtggatcgtgaagtcattgtcaatgcagccgttcatgcttttggcttgactctctatggccagtatatttactggactgacttgtacacacaaagaatttaccgagctaacaaatatgacgggtcaggtcagattgcaatgaccacaaatttgctctcccagcccaggggaatcaacactgttgtgaagaaccagaaacaacagtgtaacaatccttgtgaacagtttaatgggggctgcagccatatctgtgcaccaggtccaaatggtgccgagtgccagtgtccacatgagggcaactggtatttggccaacaacaggaagcactgcattgtggacaatggtgaacgatgtggtgcatcttccttcacctgctccaatgggcgctgcatctcggaagagtggaagtgtgataatgacaacgactgtggggatggcagtgatgagatggaaagtgtctgtgcacttcacacctgctcaccgacagccttcacctgtgccaatgggcgatgtgtccaatactcttaccgctgtgattactacaatgactgtggtgatggcagtgatgaggcagggtgcctgttcagggactgcaatgccaccacggagtttatgtgcaataacagaaggtgcatacctcgtgagtttatctgcaatggtgtagacaactgccatgataataacacttcagatgagaaaaattgccctgatcgcacttgccagtctggatacacaaaatgtcataattcaaatatttgtattcctcgcgtttatttgtgtgacggagacaatgactgtggagataacagtgatgaaaaccctacttattgcaccactcacacgtgcagcagcagtgagttccaatgcgcatctgggcgctgtattcctcaacattggtattgtgatcaagaaacagattgttttgatgcctctgatgaacctgcctcttgtggtcactctgagcgaacatgcctagctgatgagttcaagtgtgatggtgggaggtgcatcccaagcgaatggatctgtgacggtgataatgactgtggggatatgagtgacgaggataaaaggcaccagtgtcagaatcaaaactgctcggattccgagtttctctgtgtaaatgacagacctccggacaggaggtgcattccccagtcttgggtctgtgatggcgatgtggattgtactgacggctacgatgagaatcagaattgcaccaggagaacttgctctgaaaatgaattcacctgtggttacggactgtgtatcccaaagatattcaggtgtgaccggcacaatgactgtggtgactatagcgacgagaggggctgcttataccagacttgccaacagaatcagtttacctgtcagaacgggcgctgcattagtaaaaccttcgtctgtgatgaggataatgactgtggagacggatctgatgagctgatgcacctgtgccacaccccagaacccacgtgtccacctcacgagttcaagtgtgacaatgggcgctgcatcgagatgatgaaactctgcaaccacctagatgactgtttggacaacagcgatgagaaaggctgtggcattaatgaatgccatgacccttcaatcagtggctgcgatcacaactgcacagacaccttaaccagtttctattgttcctgtcgtcctggttacaagctcatgtctgacaagcggacttgtgttgatattgatgaatgcacagagatgccttttgtctgtagccagaagtgtgagaatgtaataggctcctacatctgtaagtgtgccccaggctacctccgagaaccagatggaaagacctgccggcaaaacagtaacatcgaaccctatctcatttttagcaaccgttactatttgagaaatttaactatagatggctatttttactccctcatcttggaaggactggacaatgttgtggcattagattttgaccgagtagagaagagattgtattggattgatacacagaggcaagtcattgagagaatgtttctgaataagacaaacaaggagacaatcataaaccacagactaccagctgcagaaagtctggctgtagactgggtttccagaaagctctactggttggatgcccgcctggatggcctctttgtctctgacctcaatggtggacaccgccgcatgctggcccagcactgtgtggatgccaacaacaccttctgctttgataatcccagaggacttgcccttcaccctcaatatgggtacctctactgggcagactggggtcaccgcgcatacattgggagagtaggcatggatggaaccaacaagtctgtgataatctccaccaagttagagtggcctaatggcatcaccattgattacaccaatgatctactctactgggcagatgcccacctgggttacatagagtactctgatttggagggccaccatcgacacacggtgtatgatggggcactgcctcaccctttcgctattaccatttttgaagacactatttattggacagattggaatacaaggacagtggaaaagggaaacaaatatgatggatcaaatagacagacactggtgaacacaacacacagaccatttgacatccatgtgtaccatccatataggcagcccattgtgagcaatccctgtggtaccaacaatggtggctgttctcatctctgcctcatcaagccaggaggaaaagggttcacttgcgagtgtccagatgacttccgcacccttcagctgagtggcagcacctactgcatgcccatgtgctccagcacccagttcctgtgcgctaacaatgaaaagtgcattcctatctggtggaaatgtgatggacagaaagactgctcagatggctctgatgaactggccctttgcccgcagcgcttctgccgactgggacagttccagtgcagtgacggcaactgcaccagcccgcagactttatgcaatgctcaccaaaattgccctgatgggtctgatgaagaccgtcttctttgtgagaatcaccactgtgactccaatgaatggcagtgcgccaacaaacgttgcatcccagaatcctggcagtgtgacacatttaacgactgtgaggataactcagatgaagacagttcccactgtgccagcaggacctgccggccgggccagtttcggtgtgctaatggccgctgcatcccgcaggcctggaagtgtgatgtggataatgattgtggagaccactcggatgagcccattgaagaatgcatgagctctgcccatctctgtgacaacttcacagaattcagctgcaaaacaaattaccgctgcatcccaaagtgggccgtgtgcaatggtgtagatgactgcagggacaacagtgatgagcaaggctgtgaggagaggacatgccatcctgtgggggatttccgctgtaaaaatcaccactgcatccctcttcgttggcagtgtgatgggcaaaatgactgtggagataactcagatgaggaaaactgtgctccccgggagtgcacagagagcgagtttcgatgtgtcaatcagcagtgcattccctcgcgatggatctgtgaccattacaacgactgtggggacaactcagatgaacgggactgtgagatgaggacctgccatcctgaatattttcagtgtacaagtggacattgtgtacacagtgaactgaaatgcgatggatccgctgactgtttggatgcgtctgatgaagctgattgtcccacacgctttcctgatggtgcatactgccaggctactatgttcgaatgcaaaaaccatgtttgtatcccgccatattggaaatgtgatggcgatgatgactgtggcgatggttcagatgaagaacttcacctgtgcttggatgttccctgtaattcaccaaaccgtttccggtgtgacaacaatcgctgcatttatagtcatgaggtgtgcaatggtgtggatgactgtggagatggaactgatgagacagaggagcactgtagaaaaccgacccctaaaccttgtacagaatatgaatataagtgtggcaatgggcattgcattccacatgacaatgtgtgtgatgatgccgatgactgtggtgactggtccgatgaactgggttgcaataaaggaaaagaaagaacatgtgctgaaaatatatgcgagcaaaattgtacccaattaaatgaaggaggatttatctgctcctgtacagctgggttcgaaaccaatgtttttgacagaacctcctgtctagatatcaatgaatgtgaacaatttgggacttgtccccagcactgcagaaataccaaaggaagttatgagtgtgtctgtgctgatggcttcacgtctatgagtgaccgccctggaaaacgatgtgcagctgagggtagctctcctttgttgctactgcctgacaatgtccgaattcgaaaatataatctctcatctgagaggttctcagagtatcttcaagatgaggaatatatccaagctgttgattatgattgggatcccaaggacataggcctcagtgttgtgtattacactgtgcgaggggagggctctaggtttggtgctatcaaacgtgcctacatccccaactttgaatccggccgcaataatcttgtgcaggaagttgacctgaaactgaaatacgtaatgcagccagatggaatagcagtggactgggttggaaggcatatttactggtcagatgtcaagaataaacgcattgaggtggctaaacttgatggaaggtacagaaagtggctgatttccactgacctggaccaaccagctgctattgctgtgaatcccaaactagggcttatgttctggactgactggggaaaggaacctaaaatcgagtctgcctggatgaatggagaggaccgcaacatcctggttttcgaggaccttggttggccaactggcctttctatcgattatttgaacaatgaccgaatctactggagtgacttcaaggaggacgttattgaaaccataaaatatgatgggactgataggagagtcattgcaaaggaagcaatgaacccttacagcctggacatctttgaagaccagttatactggatatctaaggaaaagggagaagtatggaaacaaaataaatttgggcaaggaaagaaagagaaaacgctggtagtgaacccttggctcactcaagttcgaatctttcatcaactcagatacaataagtcagtgcccaacctttgcaaacagatctgcagccacctctgccttctgagacctggaggatacagctgtgcctgtccccaaggctccagctttatagaggggagcaccactgagtgtgatgcagccatcgaactgcctatcaacctgccccccccatgcaggtgcatgcacggaggaaattgctattttgatgagactgacctccccaaatgcaagtgtcctagcggctacaccggaaaatattgtgaaatggcgttttcaaaaggcatctctccaggaacaaccgcagtagctgtgctgttgacaatcctcttgatcgtcgtaattggagctctggcaattgcaggattcttccactatagaaggaccggctcccttttgcctgctctgcccaagctgccaagcttaagcagtctcgtcaagccctctgaaaatgggaatggggtgaccttcagatcaggggcagatcttaacatggatattggagtgtctggttttggacctgagactgctattgacaggtcaatggcaatgagtgaagactttgtcatggaaatggggaagcagcccataatatttgaaaacccaatgtactcagccagagacagtgctgtcaaagtggttcagccaatccaggtgactgtatctgaaaatgtggataataagaattatggaagtcccataaacccttctgagatagttccagagacaaacccaacttcaccagctgctgatggaactcaggtgacaaaatggaatctcttcaaacgaaaatctaaacaaactaccaactttgaaaatccaatctatgcacagatggagaacgagcaaaaggaaagtgttgctgcgacaccacctccatcaccttcgctccctgctaagcctaagcctccttcgagaagagacccaactccaacctattctgcaacagaagacacttttaaagacaccgcaaatcttgttaaagaagactctgaagtatagctataccagctatttagggaataattagaaacacacttttgcacatatattttttacaaacagatgaaaaaagttaacattcagtactttatgaaaaaaatatatttttccctgtttgcctatagttggaggtatcctgtgtgtctttttttacttatgccgtctcatatttttacaaataattatcacaatgtactatatgtatatctttgcactgaagttgtctgaaggtaatactataaatatattgtatatttgtaaattttggaaagattatcctgttactgaatttgctaataaagatgtctgctgatttggttggtgatcattatagtaaatgatccaacaagaaaaggaattgactggggacctttagccgtgtctaaagaagaggcaccactcatatttcctataaaattatctaggaaaggaatccaggccccgctcttgggtccatttttacacattagcacttaattaatgttcaatattacatgtcaatttgattaatggctatgttgataggggccactatgtgttgtatagacatctggacttgactgtagactcctcagataatacagaaggtaggaaaagcaattcagtttggcccttctgtgtgttggcattgtctaaccagaactctctgtttcatgtgtgttctctcactagctgccaagacaacatttttatttgtgatgtctatgaggaaatcccatatcattaagtgccagtgtcctgcattgagtttgtggttaattaaatgagctcttctgctgatggaccctggagcaatttctcccctcacctgacattcaaggtggtcacctgccctagtagttggagctcagtagctgaatttctgaaaccaaatctgtgtcttcataaaataaggtgcaaaaaaaaaaaataccagttaagtaaagcctcaactgggtttttgtttctatgaaaatatcattataatcactatttatttcctaagttgaacctgaatagaaagggaaaccattcttattaagctttttattaggccctgtggctaaatgtgtacatttatattagaatgtactgtacagtccagatcttttctttaattcttattggttttttttttttttttttttttagagatggagtcttgctatattgccaaggctgatcttgaagtcctgggctcaagtgatcctcccacctcagcctcctgagtggttggggttacgggcgtgagccactgtgcctggcttccagctctcctcttaaatagtgggtatagtctgcacaacaggaaccatggcaggaatatacactttcccatagcaaatagcatacctgactctctgtgctaatattgcacatttgttaaacaatgaatgaatggatggatggatggatggatgaatgaatgaaacatatactactgattattttattccagagttctcaaaatatttgttgctgatattttgagtgctgactgtaattactttgattagataaacaactggaaataatgctgctgaaaaagttctaataaatgtgtattttatcaga
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4036 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
            GeneID:4036 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4036 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
            GeneID:4036 -> Biological process: GO:0001523 [retinoid metabolic process] evidence: TAS
            GeneID:4036 -> Biological process: GO:0006486 [protein glycosylation] evidence: TAS
            GeneID:4036 -> Biological process: GO:0006629 [lipid metabolic process] evidence: TAS
            GeneID:4036 -> Biological process: GO:0006897 [endocytosis] evidence: TAS
            GeneID:4036 -> Biological process: GO:0006898 [receptor-mediated endocytosis] evidence: IEA
            GeneID:4036 -> Biological process: GO:0007603 [phototransduction, visible light] evidence: TAS
            GeneID:4036 -> Biological process: GO:0008202 [steroid metabolic process] evidence: TAS
            GeneID:4036 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
            GeneID:4036 -> Biological process: GO:0030900 [forebrain development] evidence: IEA
            GeneID:4036 -> Biological process: GO:0042359 [vitamin D metabolic process] evidence: TAS
            GeneID:4036 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:4036 -> Cellular component: GO:0005764 [lysosome] evidence: TAS
            GeneID:4036 -> Cellular component: GO:0005768 [endosome] evidence: IEA
            GeneID:4036 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IEA
            GeneID:4036 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
            GeneID:4036 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:4036 -> Cellular component: GO:0005905 [coated pit] evidence: IEA
            GeneID:4036 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:4036 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: ISS
            GeneID:4036 -> Cellular component: GO:0030139 [endocytic vesicle] evidence: IEA
            GeneID:4036 -> Cellular component: GO:0031526 [brush border membrane] evidence: IEA

by @meso_cacase at DBCLS
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