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2024-03-29 18:51:10, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_004475               2659 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens flotillin 2 (FLOT2), mRNA.
ACCESSION   NM_004475
VERSION     NM_004475.2  GI:94538361
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2659)
  AUTHORS   Baumann,T., Affentranger,S. and Niggli,V.
  TITLE     Evidence for chemokine-mediated coalescence of preformed flotillin
            hetero-oligomers in human T-cells
  JOURNAL   J. Biol. Chem. 287 (47), 39664-39672 (2012)
   PUBMED   23012365
  REMARK    GeneRIF: results support predominant formation of flotillin-1 and
            -2 hetero-oligomers in resting and chemokine-stimulated human
            T-cells which may importantly contribute to structuring of the
            uropod.
REFERENCE   2  (bases 1 to 2659)
  AUTHORS   Solis,G.P., Schrock,Y., Hulsbusch,N., Wiechers,M., Plattner,H. and
            Stuermer,C.A.
  TITLE     Reggies/flotillins regulate E-cadherin-mediated cell contact
            formation by affecting EGFR trafficking
  JOURNAL   Mol. Biol. Cell 23 (10), 1812-1825 (2012)
   PUBMED   22438585
  REMARK    GeneRIF: by promoting EGFR internalization, reggie-1 restricts EGFR
            signaling involved in E-cadherin macropinocytosis and recycling and
            regulate adherens junction formation
REFERENCE   3  (bases 1 to 2659)
  AUTHORS   Li,Y., Martin,B.R., Cravatt,B.F. and Hofmann,S.L.
  TITLE     DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on
            induction of neuronal differentiation in cultured cells
  JOURNAL   J. Biol. Chem. 287 (1), 523-530 (2012)
   PUBMED   22081607
  REMARK    GeneRIF: potentially relevant protein substrates of DHHC5
REFERENCE   4  (bases 1 to 2659)
  AUTHORS   Cornfine,S., Himmel,M., Kopp,P., El Azzouzi,K., Wiesner,C.,
            Kruger,M., Rudel,T. and Linder,S.
  TITLE     The kinesin KIF9 and reggie/flotillin proteins regulate matrix
            degradation by macrophage podosomes
  JOURNAL   Mol. Biol. Cell 22 (2), 202-215 (2011)
   PUBMED   21119006
  REMARK    GeneRIF: Reggie-1 (flotillin-2) dynamically colocalizes with KIF9
            in living cells
REFERENCE   5  (bases 1 to 2659)
  AUTHORS   Ge,L., Qi,W., Wang,L.J., Miao,H.H., Qu,Y.X., Li,B.L. and Song,B.L.
  TITLE     Flotillins play an essential role in Niemann-Pick C1-like
            1-mediated cholesterol uptake
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (2), 551-556 (2011)
   PUBMED   21187433
  REMARK    GeneRIF: flotillins have a role in NPC1L1-mediated cholesterol
            uptake and NPC1L1-flotillins-postive cholesterol-enriched membrane
            microdomains are involved in the mechanism for efficient
            cholesterol absorption
REFERENCE   6  (bases 1 to 2659)
  AUTHORS   Salzer,U. and Prohaska,R.
  TITLE     Stomatin, flotillin-1, and flotillin-2 are major integral proteins
            of erythrocyte lipid rafts
  JOURNAL   Blood 97 (4), 1141-1143 (2001)
   PUBMED   11159550
REFERENCE   7  (bases 1 to 2659)
  AUTHORS   Hazarika,P., Dham,N., Patel,P., Cho,M., Weidner,D., Goldsmith,L.
            and Duvic,M.
  TITLE     Flotillin 2 is distinct from epidermal surface antigen (ESA) and is
            associated with filopodia formation
  JOURNAL   J. Cell. Biochem. 75 (1), 147-159 (1999)
   PUBMED   10462713
REFERENCE   8  (bases 1 to 2659)
  AUTHORS   Volonte,D., Galbiati,F., Li,S., Nishiyama,K., Okamoto,T. and
            Lisanti,M.P.
  TITLE     Flotillins/cavatellins are differentially expressed in cells and
            tissues and form a hetero-oligomeric complex with caveolins in
            vivo. Characterization and epitope-mapping of a novel flotillin-1
            monoclonal antibody probe
  JOURNAL   J. Biol. Chem. 274 (18), 12702-12709 (1999)
   PUBMED   10212252
REFERENCE   9  (bases 1 to 2659)
  AUTHORS   Schroeder,W.T., Stewart-Galetka,S., Mandavilli,S., Parry,D.A.,
            Goldsmith,L. and Duvic,M.
  TITLE     Cloning and characterization of a novel epidermal cell surface
            antigen (ESA)
  JOURNAL   J. Biol. Chem. 269 (31), 19983-19991 (1994)
   PUBMED   8051082
REFERENCE   10 (bases 1 to 2659)
  AUTHORS   Schroeder,W.T., Siciliano,M.J., Stewart-Galetka,S.L. and Duvic,M.
  TITLE     The human gene for an epidermal surface antigen (M17S1) is located
            at 17q11-12
  JOURNAL   Genomics 11 (2), 481-482 (1991)
   PUBMED   1769667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA390100.1, BC003683.1,
            BC017292.1 and M60922.1.
            On May 4, 2006 this sequence version replaced gi:4758393.
            
            Summary: Caveolae are small domains on the inner cell membrane
            involved in vesicular trafficking and signal transduction. This
            gene encodes a caveolae-associated, integral membrane protein,
            which is thought to function in neuronal signaling. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                CA390100.1         1-88
            89-1104             BC003683.1         1-1016
            1105-1535           BC017292.1         927-1357
            1536-2631           M60922.1           1392-2487
            2632-2659           BC017292.1         2454-2481
FEATURES             Location/Qualifiers
     source          1..2659
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11-q12"
     gene            1..2659
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="flotillin 2"
                     /db_xref="GeneID:2319"
                     /db_xref="HGNC:3758"
                     /db_xref="MIM:131560"
     exon            1..172
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    40..42
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="upstream in-frame stop codon"
     CDS             124..1410
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="Flotillin 2 (epidermal surface antigen 1); membrane
                     component, chromosome 17, surface marker 1 (35kD protein
                     identified by monoclonal antibody ECS-1); membrane
                     component chromosome 17 surface marker 1"
                     /codon_start=1
                     /product="flotillin-2"
                     /protein_id="NP_004466.2"
                     /db_xref="GI:94538362"
                     /db_xref="CCDS:CCDS11245.2"
                     /db_xref="GeneID:2319"
                     /db_xref="HGNC:3758"
                     /db_xref="MIM:131560"
                     /translation="
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
"
     misc_feature    139..1374
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="Uncharacterized protein conserved in bacteria
                     [Function unknown]; Region: COG2268"
                     /db_xref="CDD:32449"
     misc_feature    253..636
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="Band_7_flotillin: a subgroup of the band 7 domain
                     of flotillin (reggie) like proteins. This subgroup
                     contains proteins similar to stomatin, prohibitin,
                     flotillin, HlfK/C and podicin.  These two proteins are
                     lipid raft-associated.  Individual proteins of...; Region:
                     Band_7_flotillin; cd03399"
                     /db_xref="CDD:48211"
     misc_feature    <985..1173
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /note="The band 7 domain of flotillin (reggie) like
                     proteins. This group contains proteins similar to
                     stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many
                     of these band 7 domain-containing proteins are lipid
                     raft-associated.  Individual proteins of this...; Region:
                     Band_7; cl02525"
                     /db_xref="CDD:207629"
     exon            173..254
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            255..345
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            346..469
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            470..588
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            589..702
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            703..822
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            823..1037
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            1038..1221
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            1222..1371
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     exon            1372..2632
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /inference="alignment:Splign:1.39.8"
     variation       1418
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1060244"
     variation       1536
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060247"
     STS             1722..2623
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /standard_name="FLOT2__6735"
                     /db_xref="UniSTS:471437"
     variation       1741
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11547605"
     variation       1869
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10205"
     STS             1876..2102
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /standard_name="D17S963"
                     /db_xref="UniSTS:148646"
     STS             2345..2493
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /standard_name="RH17712"
                     /db_xref="UniSTS:85003"
     variation       2360
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:14117"
     variation       2365
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060288"
     variation       2461
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:9617"
     variation       2473
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11547606"
     variation       2559
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060340"
     variation       2564
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060343"
     variation       2604
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060351"
     polyA_signal    2611..2616
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
     polyA_site      2632
                     /gene="FLOT2"
                     /gene_synonym="ECS-1; ECS1; ESA; ESA1; M17S1"
ORIGIN      
ggcgagcgagcgggcggccggccgctgggggtggcgggataggctgggcgcggccggcgctgcagacccgctgctgttgtccgggtctgtgcggtcccgagggccctccgtgccgccggcgccatgggcaattgccacacggtggggcccaacgaggcgctggtggtttcagggggctgttgtggttccgactataaacagtacgtgtttggcggctgggcctgggcctggtggtgtatctccgacactcagaggatttccctagagattatgacgttgcagccccgctgcgaggacgtagagacggccgagggggtagctttaactgtgacgggtgtcgcccaggtgaagatcatgacggagaaggaactcctggccgtggcttgtgagcagtttctgggtaagaatgtgcaggacatcaaaaacgtcgtcctgcagaccctggagggacatctgcgctccatcctcgggaccctgacagtggagcagatttatcaggaccgggaccagtttgccaagctggtgcgggaggtggcagcccctgatgttggccgcatgggcattgagatcctcagcttcaccatcaaggacgtgtatgacaaagtggactatctgagctccctgggcaagacgcagactgccgtggtgcagagagatgctgacattggcgtggccgaggctgaacgggacgcaggcatccgggaagctgagtgcaagaaggagatgctggatgtgaagttcatggcagacaccaagattgctgactctaagcgagccttcgagctgcaaaagtcagccttcagtgaggaggttaacatcaagacagctgaggcccagttggcctatgagctgcagggggcccgtgaacagcagaagatccggcaggaagagattgagattgaggttgtgcagcgcaagaaacagattgccgtggaggcacaggagatcctgcgtacggacaaggagctcatcgctacagtgcgccggcctgccgaggccgaggcccaccgcatccagcagattgccgagggtgaaaaggtgaagcaggtcctcttggcacaggcagaggctgagaagatccgcaaaatcggggaggcggaagcggcagtcatcgaggcgatgggcaaggcagaggctgagcggatgaagctcaaggcagaagcctaccagaaatacggggatgcagccaagatggccttggtgctagaggccctgccccagattgctgccaaaatcgctgccccacttaccaaggtcgatgagattgtggtcctcagtggagacaacagtaaggtcacatcagaagtgaaccgactgctggccgagctgcctgcctctgtgcatgccctcacaggcgtggacctgtctaagatacccctgatcaagaaggccactggtgtgcaggtgtgaggctcctgcaggcccactctcttcagcagccacccggccctccctccagcacccgttttaatcccacagaacaacgggaacgttactgactctggtgccttatctcgaagggaccagaagtgctgcgtgttcaggccatctctggctgtcttcctgtctctcctgtctgtccacctcctcctcttcctctcctttaccccactttcactgccactttcatcaggtttgtgtctcatctccctgcgtgtcttttcctttgtctgtctttttctttcccccatgcacatcatgtagattaagctgaagatgtttattacaatcactctctgtggggggtggccctgctgctcctcagaatcctggtgccttgaagttctctgtgcatctgtccatcctccctatggccctggccagagctcagcatgggcaggggttctgggtaggacggtcactgtcctctctcctggactggtcttcccagccctaaaccctgccccaggaagcccacagcctcacctgctgctgcccctctaggtctgggcagccatgacctgcagggcccagagacactgtccttcccctcatccacccaaggccccagccagcgctcataccctgtcctttctccctgaccccaagggcacagaggcaaggcctcctgtctacagcagcttcctcagtttcctactgccttaggaggcccctgcttgtgctcagggaaggcctcttcatgggcatgttcctgctggggcggtgcggtttggtcccaactctgctaagttttctgagatgagggtctagccctgttggggacagaaaagtgtgtagaccttcttcctgctagggctgcactgtcctgggtgttgggcccttctggtggacaaggctgtgccaaccctgtacagaatcgagtgctgtagcctggccagaccccagagcccttgtgccatctttcttcctggccagagtgatggggttccagccatggggaagcaacccaatcctctgtctccttgctccaatggaggcagaagagcccaggacccaagcgtcttggcaggggtgctgtgaatgtccagtggtcccagctccccaccctggccctgccccagcctgtgtagctcttcctgcatgtggatgctgcatgtctggtctggggcttggatgttgcactgccccactgcctgtcccttctggtaaaataaagaactcttaatgcccaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2319 -> Molecular function: GO:0035255 [ionotropic glutamate receptor binding] evidence: IEA
            GeneID:2319 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:2319 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
            GeneID:2319 -> Cellular component: GO:0002080 [acrosomal membrane] evidence: IEA
            GeneID:2319 -> Cellular component: GO:0005768 [endosome] evidence: IDA
            GeneID:2319 -> Cellular component: GO:0005886 [plasma membrane] evidence: NAS
            GeneID:2319 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:2319 -> Cellular component: GO:0016600 [flotillin complex] evidence: IEA
            GeneID:2319 -> Cellular component: GO:0030139 [endocytic vesicle] evidence: IDA

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