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2024-04-19 20:55:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004402 3034 bp mRNA linear PRI 02-JUN-2013
DEFINITION Homo sapiens DNA fragmentation factor, 40kDa, beta polypeptide
(caspase-activated DNase) (DFFB), mRNA.
ACCESSION NM_004402
VERSION NM_004402.2 GI:51988888
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3034)
AUTHORS Iglesias-Guimarais,V., Gil-Guinon,E., Sanchez-Osuna,M.,
Casanelles,E., Garcia-Belinchon,M., Comella,J.X. and Yuste,V.J.
TITLE Chromatin collapse during caspase-dependent apoptotic cell death
requires DNA fragmentation factor, 40-kDa
subunit-/caspase-activated deoxyribonuclease-mediated 3'-OH
single-strand DNA breaks
JOURNAL J. Biol. Chem. 288 (13), 9200-9215 (2013)
PUBMED 23430749
REMARK GeneRIF: the highest order of chromatin compaction observed in the
later steps of caspase-dependent apoptosis relies on
DFF40/CAD-mediated DNA damage by generating 3'-OH ends in
single-strand rather than double-strand DNA nicks/breaks
REFERENCE 2 (bases 1 to 3034)
AUTHORS Errami,Y., Naura,A.S., Kim,H., Ju,J., Suzuki,Y., El-Bahrawy,A.H.,
Ghonim,M.A., Hemeida,R.A., Mansy,M.S., Zhang,J., Xu,M.,
Smulson,M.E., Brim,H. and Boulares,A.H.
TITLE Apoptotic DNA fragmentation may be a cooperative activity between
caspase-activated deoxyribonuclease and the poly(ADP-ribose)
polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized
endonuclease that translocates to the nucleus during apoptosis
JOURNAL J. Biol. Chem. 288 (5), 3460-3468 (2013)
PUBMED 23229555
REMARK GeneRIF: These results suggest a cooperative activity between CAD
and DNAS1L3 to accomplish internucleosomal DNA fragmentation .
REFERENCE 3 (bases 1 to 3034)
AUTHORS Jong,J.E., Jeong,K.W., Shin,H., Hwang,L.R., Lee,D. and Seo,T.
TITLE Human papillomavirus type 16 E6 protein inhibits DNA fragmentation
via interaction with DNA fragmentation factor 40
JOURNAL Cancer Lett. 324 (1), 109-117 (2012)
PUBMED 22609799
REMARK GeneRIF: Human papillomavirus type 16 E6 protein inhibits DNA
fragmentation via interaction with DNA fragmentation factor 40
REFERENCE 4 (bases 1 to 3034)
AUTHORS Iglesias-Guimarais,V., Gil-Guinon,E., Gabernet,G.,
Garcia-Belinchon,M., Sanchez-Osuna,M., Casanelles,E., Comella,J.X.
and Yuste,V.J.
TITLE Apoptotic DNA degradation into oligonucleosomal fragments, but not
apoptotic nuclear morphology, relies on a cytosolic pool of
DFF40/CAD endonuclease
JOURNAL J. Biol. Chem. 287 (10), 7766-7779 (2012)
PUBMED 22253444
REMARK GeneRIF: the cytosolic levels of DFF40/CAD are determinants in
achieving a complete apoptotic phenotype, including
oligonucleosomal DNA degradation.
REFERENCE 5 (bases 1 to 3034)
AUTHORS Dieker,J., Iglesias-Guimarais,V., Decossas,M., Stevenin,J., van der
Vlag,J., Yuste,V.J. and Muller,S.
TITLE Early apoptotic reorganization of spliceosomal proteins involves
caspases, CAD and rearrangement of NuMA
JOURNAL Traffic 13 (2), 257-272 (2012)
PUBMED 22023725
REMARK GeneRIF: During apoptotic rearrangement of interchromatin granule
clusters, the nuclear matrix (NuMa rearrangement) and chromatin are
closely associated. This process occurs in defined stages and
depends on the activity of protein phosphatases, caspases and CAD.
REFERENCE 6 (bases 1 to 3034)
AUTHORS Mukae,N., Enari,M., Sakahira,H., Fukuda,Y., Inazawa,J., Toh,H. and
Nagata,S.
TITLE Molecular cloning and characterization of human caspase-activated
DNase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (16), 9123-9128 (1998)
PUBMED 9689044
REFERENCE 7 (bases 1 to 3034)
AUTHORS Liu,X., Li,P., Widlak,P., Zou,H., Luo,X., Garrard,W.T. and Wang,X.
TITLE The 40-kDa subunit of DNA fragmentation factor induces DNA
fragmentation and chromatin condensation during apoptosis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (15), 8461-8466 (1998)
PUBMED 9671700
REFERENCE 8 (bases 1 to 3034)
AUTHORS Halenbeck,R., MacDonald,H., Roulston,A., Chen,T.T., Conroy,L. and
Williams,L.T.
TITLE CPAN, a human nuclease regulated by the caspase-sensitive inhibitor
DFF45
JOURNAL Curr. Biol. 8 (9), 537-540 (1998)
PUBMED 9560346
REFERENCE 9 (bases 1 to 3034)
AUTHORS Enari,M., Sakahira,H., Yokoyama,H., Okawa,K., Iwamatsu,A. and
Nagata,S.
TITLE A caspase-activated DNase that degrades DNA during apoptosis, and
its inhibitor ICAD
JOURNAL Nature 391 (6662), 43-50 (1998)
PUBMED 9422506
REMARK Erratum:[Nature 1998 May 28;393(6683):396]
REFERENCE 10 (bases 1 to 3034)
AUTHORS Liu,X., Zou,H., Slaughter,C. and Wang,X.
TITLE DFF, a heterodimeric protein that functions downstream of caspase-3
to trigger DNA fragmentation during apoptosis
JOURNAL Cell 89 (2), 175-184 (1997)
PUBMED 9108473
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC048797.1, AF039210.1 and
BC032827.1.
On Sep 13, 2004 this sequence version replaced gi:4758149.
Summary: Apoptosis is a cell death process that removes toxic
and/or useless cells during mammalian development. The apoptotic
process is accompanied by shrinkage and fragmentation of the cells
and nuclei and degradation of the chromosomal DNA into nucleosomal
units. DNA fragmentation factor (DFF) is a heterodimeric protein of
40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for
caspase-3 and triggers DNA fragmentation during apoptosis. DFF
becomes activated when DFFA is cleaved by caspase-3. The cleaved
fragments of DFFA dissociate from DFFB, the active component of
DFF. DFFB has been found to trigger both DNA fragmentation and
chromatin condensation during apoptosis. Alternatively spliced
transcript variants encoding distinct isoforms have been found for
this gene but the biological validity of these variants has not
been determined. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC048797.1, AF064019.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025089 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-853 BC048797.1 1-853
854-909 AF039210.1 531-586
910-1276 BC048797.1 910-1276
1277-3034 BC032827.1 1240-2997
FEATURES Location/Qualifiers
source 1..3034
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.3"
gene 1..3034
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/note="DNA fragmentation factor, 40kDa, beta polypeptide
(caspase-activated DNase)"
/db_xref="GeneID:1677"
/db_xref="HGNC:2773"
/db_xref="HPRD:03532"
/db_xref="MIM:601883"
exon 1..437
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 114
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:370303839"
misc_feature 174..176
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/note="upstream in-frame stop codon"
variation 226
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:370500366"
variation 283
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:376118176"
variation 286
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:34891610"
variation 294
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:12723005"
CDS 324..1340
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/note="caspase-activated nuclease; caspase-activated
deoxyribonuclease; caspase-activated DNase; DNA
fragmentation factor 40 kDa subunit"
/codon_start=1
/product="DNA fragmentation factor subunit beta"
/protein_id="NP_004393.1"
/db_xref="GI:4758150"
/db_xref="CCDS:CCDS52.1"
/db_xref="GeneID:1677"
/db_xref="HGNC:2773"
/db_xref="HPRD:03532"
/db_xref="MIM:601883"
/translation="
MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTEDYFPSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQRLLADLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSYPSTVGAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHSINPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLNCDPSRIYKPQTRLKRKQPVRKRQ
"
misc_feature 333..563
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/note="CIDE_N domain of CAD nuclease. The CIDE_N (cell
death-inducing DFF45-like effector, N-terminal) domain is
found at the N-terminus of CAD nuclease (caspase-activated
DNase/DNA fragmentation factor, DFF40) and its inhibitor,
ICAD(DFF45). These proteins are...; Region: CIDE_N_CAD;
cd06535"
/db_xref="CDD:119368"
misc_feature order(348..350,375..380,384..389,417..419,429..431)
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/note="CAD/ICAD heterodimer interaction site [polypeptide
binding]; other site"
/db_xref="CDD:119368"
misc_feature 615..1292
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/note="DNA fragmentation factor 40 kDa; Region: DFF40;
pfam09230"
/db_xref="CDD:150043"
exon 438..564
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 450
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:370680894"
variation 470
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:200326674"
variation 490
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:201900322"
variation 493
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="t"
/db_xref="dbSNP:150699255"
variation 504
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:139312649"
variation 537
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:147517965"
variation 542
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:143919670"
variation 556
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:367946340"
exon 565..753
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 582
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:375484294"
variation 584
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:368962997"
variation 603
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:372200331"
variation 621
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="t"
/db_xref="dbSNP:375297483"
variation 632
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:368953379"
variation 660
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:201987832"
variation 698
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:371235013"
variation 713
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:367884441"
variation 714
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:145965678"
variation 719
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:140438463"
variation 740
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:139836683"
variation 743
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:371766008"
exon 754..833
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 765
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:371788433"
variation 797
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:373643674"
variation 817
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:201973418"
exon 834..1004
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 848
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:149142635"
variation 854
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:1141070"
variation 862
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:374203059"
variation 893
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:147533456"
variation 910
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:12738235"
variation 964
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:374397595"
exon 1005..1105
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 1017
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:374758045"
variation 1030
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:150541762"
variation 1056
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:146190593"
variation 1088
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="c"
/db_xref="dbSNP:368137137"
exon 1106..3028
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/inference="alignment:Splign:1.39.8"
variation 1127
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:200948914"
variation 1135
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:376971900"
variation 1153
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:12564400"
variation 1158
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="c"
/db_xref="dbSNP:181330365"
variation 1184
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:185984222"
variation 1212
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:59649948"
variation 1224
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:370054401"
variation 1229
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:367900103"
variation 1253
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:144923358"
variation 1277
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:3205087"
variation 1307
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:77942390"
variation 1311
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:200643246"
variation 1326
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:372527287"
variation 1327
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:199858021"
variation 1332
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:201390089"
variation 1333
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:368975039"
variation 1343
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:201777970"
variation 1347
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:375303772"
variation 1365
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:200852893"
variation 1381
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:371236966"
variation 1417
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:190758342"
variation 1455
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:181886097"
variation 1515
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:7555538"
variation 1524
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:41301969"
variation 1547
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:149045294"
variation 1560
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:143154829"
variation 1587
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:146888429"
variation 1607
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:140704651"
STS 1612..2254
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/standard_name="GDB:314949"
/db_xref="UniSTS:156503"
STS 1618..1753
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/standard_name="D17S610"
/db_xref="UniSTS:46230"
variation 1639
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:373339973"
STS 1656..2447
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
STS 1709..2466
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/standard_name="D5S2354"
/db_xref="UniSTS:473392"
STS 1736..2220
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/standard_name="L17705"
/db_xref="UniSTS:66091"
variation 1870
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:145869288"
variation 1871
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:138425140"
variation 2007
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:113527121"
variation 2065
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="c"
/db_xref="dbSNP:76726236"
variation 2081
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="c"
/db_xref="dbSNP:187389050"
variation 2123
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:141020982"
variation 2138
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:150219235"
variation 2176
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:45603135"
variation 2190
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:112256614"
variation 2191
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:138800314"
variation 2255
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:369469080"
variation 2282
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:10909817"
variation 2351
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:191010288"
variation 2355
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="t"
/db_xref="dbSNP:45463695"
STS 2396..2466
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/standard_name="D5S2354"
/db_xref="UniSTS:473392"
variation 2417
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:371191643"
variation 2469
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:182350316"
variation 2493
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="g"
/replace="t"
/db_xref="dbSNP:11806014"
variation 2559
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:57612726"
variation 2567
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="t"
/db_xref="dbSNP:75813733"
variation 2578
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:142911080"
variation 2646
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:114196787"
variation 2696
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:187893180"
variation 2738
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:114676501"
variation 2739
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:374595988"
variation 2775
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:148456348"
variation 2792
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="g"
/db_xref="dbSNP:7537210"
variation 2806
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:11806049"
variation 2841
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:191031774"
variation 2842
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:182606831"
variation 2862
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:41301971"
variation 2863
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="a"
/replace="g"
/db_xref="dbSNP:10909818"
variation 2875
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:150546571"
variation 2930
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:187292905"
polyA_signal 3006..3011
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
variation 3008
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/replace="c"
/replace="t"
/db_xref="dbSNP:7551237"
polyA_site 3026
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 3028
/gene="DFFB"
/gene_synonym="CAD; CPAN; DFF-40; DFF2; DFF40"
ORIGIN
ccgctactctggccctcagggttgtgtagtttccggggccacggcacctgggcacaccaggtggcgtcgcgcctttgctttcctgagccttctgagtaaggtaatgtggtgtccgtggggcgacgcctgcgcacaagaccgcgtcgggcctcacttttcccaggccttctgggtaatgtagtttccgggatcggcacccggcctgtgccagcttgcagagctcaccaggtgcagacccctgcggccagggcgaggacggatctgagcagctgggcagcaggtgccaccgcctgtgggacccagagggcttgaggacatctgcaatgctccagaagcccaagagcgtgaagctgcgggccctgcgcagcccgaggaagttcggcgtggctggccggagctgccaggaggtgctgcgcaagggctgtctccgcttccagctccctgagcgcggttcccggctgtgcctgtacgaggatggcacggagctgacggaagattacttccccagtgttcccgacaacgccgagctggtgctgctcaccttgggccaggcctggcagggctatgtgagcgacatcaggcgcttcctcagtgcatttcacgagccacaggtggggctcatccaggccgcccagcagctgctgtgtgatgagcaggccccacagaggcagaggctgctggctgacctcctgcacaacgtcagccagaacatcgcggccgagacccgggctgaggacccgccgtggtttgaaggcttggagtcccgatttcagagcaagtctggctatctgagatacagctgtgagagccggatccggagttacctgagggaggtgagctcctacccctccacggtgggtgcggaggctcaggaggaattcctgcgggtcctcggctccatgtgccagaggctccggtccatgcagtacaatggcagctacttcgacagaggagccaagggcggcagccgcctctgcacaccggaaggctggttctcctgccagggtccctttgacatggacagctgcttatcaagacactccatcaacccctacagtaacagggagagcaggatcctcttcagcacctggaacctggatcacataatagaaaagaaacgcaccatcattcctacactggtggaagcaattaaggaacaagatggaagagaagtggactgggagtatttttatggcctgctttttacctcagagaacctaaaactagtgcacattgtctgccataagaaaaccacccacaagctcaactgtgacccaagcagaatctacaaaccccagacaaggttgaagcggaagcagcctgtgcggaaacgccagtgacacgtacacaccacgtcctggtctttgtttgaggcctgacgtgggcatcattttaacaggtgccttttttgtttttttgtttttcgtttttttggtcactccagtagctcctggaaaaaaccttaaaaaatgtttcctccaaatctgatttcattacatttctgaattgttggggttttttttgttgttttgttttgttttgtagatggagtttcacttttgttgcccaggctggagtgtagtggcgcgatctcggctcagcctcccgagtagctgggattacaggcatgtgccaccacgcccggctaatgtttgtatttttagtagagacggggtttcaccatgttggtcaggctggtctcaaactcctgacctcaggtgatccgcccacctcagcctcccaaagtgctgggatgacaggtgtgagccactgcgcccagcctgaatcatttcttataccttctgacagcccaacttccagaggacagctctggggtactcgttggatgtctgtgagtacctggtcatacgggtcagtagggataagaattgtctctgggctgaggaattcttctgttctctggtttcaccagcgttgggtttgctcatgtaatgtggtcaccatactcaaatggtgtcatggctgaagttggccaccttgcttgagggacaagttgtttatgtatcagctctctgctgggtctccctttccatggcaaatgggcagctccatcctcttgactcttctaaatgcccaaaagaggtgtcatgctttgggggtacgatgtttatactccgtaaagaacatacaaggacattcactgctgatttttttttttgtttgtttgagacagggtctcactctgtcgctcaggctggagtgcagtgatgcaatcttggctcactgcaacctccgcctctcaggttcaagtggttctcctgcctcagcctcccaagtagctgggattacaggcacctaccaccagggccagctaatttttgtatgtttagtagaaacggggtttcaccatgttggccaggctgttctcgaactcctgacctcaggtgatctgcccgcctcggtctcccaaagtgctgggattacaggcatgagccactgcacctgacctgctgaattgtttataatggcaagaaataggaaaccccccaatgtctgttgaacagctatcacgttgaaccacgtgaaactgctgttttctaggccaaaaatggtgagcgatcatttatttcatgattcaacctgatacatttacatagtgcaaaactgtgtcacagtttcaggcttttatgaggaaagcgtttctgtgtagaaactggaagctgttcagggcatcggcagctgaaccctgctccgttggtcagcgttactatcatctcggatcatatggagctcatgtcagccgtgtgggtggcgggtgcacagagacggtctggaaggaaacacgcggatctgaacagcagtaatcctgggggatacgggggttgggctagattacagagggctcattttctacgtcatgtattttatgatacttgaattttttgaaatgggcatttattttataacatgttaaaatgtactttttaaattaagtcattttgtaatatttgaatttttacatttgttgtacaatcaggaaaagcaataaagatttttcaaaaatagaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1677 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:1677 -> Molecular function: GO:0004516 [nicotinate phosphoribosyltransferase activity] evidence: IEA
GeneID:1677 -> Molecular function: GO:0004536 [deoxyribonuclease activity] evidence: IEA
GeneID:1677 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:1677 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: IDA
GeneID:1677 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: TAS
GeneID:1677 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:1677 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:1677 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:1677 -> Biological process: GO:0030263 [apoptotic chromosome condensation] evidence: IDA
GeneID:1677 -> Biological process: GO:0035556 [intracellular signal transduction] evidence: TAS
GeneID:1677 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IDA
GeneID:1677 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:1677 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1677 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
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