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2024-04-27 06:55:09, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004330 2533 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 2
(BNIP2), mRNA.
ACCESSION NM_004330
VERSION NM_004330.2 GI:168480079
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2533)
AUTHORS Park,G., Jeong,J.W. and Kim,J.E.
TITLE SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic
cells
JOURNAL FEBS Lett. 585 (1), 219-224 (2011)
PUBMED 21130087
REMARK GeneRIF: Data imply that SIRT1 may mediate MPP(+)-induced
cytotoxicity, possibly through the regulation of BNIP2.
REFERENCE 2 (bases 1 to 2533)
AUTHORS Scott,G.B., Bowles,P.A., Wilson,E.B., Meade,J.L., Low,B.C.,
Davison,A., Blair,G.E. and Cook,G.P.
TITLE Identification of the BCL2/adenovirus E1B-19K protein-interacting
protein 2 (BNIP-2) as a granzyme B target during human natural
killer cell-mediated killing
JOURNAL Biochem. J. 431 (3), 423-431 (2010)
PUBMED 20704564
REMARK GeneRIF: Inhibition of BNIP-2 expression did not affect the
susceptibility to NK cell-mediated killing.
REFERENCE 3 (bases 1 to 2533)
AUTHORS Kelly,J.L., Novak,A.J., Fredericksen,Z.S., Liebow,M., Ansell,S.M.,
Dogan,A., Wang,A.H., Witzig,T.E., Call,T.G., Kay,N.E.,
Habermann,T.M., Slager,S.L. and Cerhan,J.R.
TITLE Germline variation in apoptosis pathway genes and risk of
non-Hodgkin's lymphoma
JOURNAL Cancer Epidemiol. Biomarkers Prev. 19 (11), 2847-2858 (2010)
PUBMED 20855536
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2533)
AUTHORS Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
Honda,M. and Tokunaga,K.
TITLE An approach based on a genome-wide association study reveals
candidate loci for narcolepsy
JOURNAL Hum. Genet. 128 (4), 433-441 (2010)
PUBMED 20677014
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 2533)
AUTHORS Valencia,C.A., Cotten,S.W. and Liu,R.
TITLE Cleavage of BNIP-2 and BNIP-XL by caspases
JOURNAL Biochem. Biophys. Res. Commun. 364 (3), 495-501 (2007)
PUBMED 17961507
REMARK GeneRIF: Our results suggest that the caspase-mediated cleavage of
BNIP-2 and BNIP-XL could result in the release of the BCH domain or
smaller fragments that are crucial for their proapoptotic
activities.
REFERENCE 6 (bases 1 to 2533)
AUTHORS Low,B.C., Seow,K.T. and Guy,G.R.
TITLE The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its
homophilic association and heterophilic interaction with Cdc42GAP
JOURNAL J. Biol. Chem. 275 (48), 37742-37751 (2000)
PUBMED 10954711
REFERENCE 7 (bases 1 to 2533)
AUTHORS Low,B.C., Seow,K.T. and Guy,G.R.
TITLE Evidence for a novel Cdc42GAP domain at the carboxyl terminus of
BNIP-2
JOURNAL J. Biol. Chem. 275 (19), 14415-14422 (2000)
PUBMED 10799524
REFERENCE 8 (bases 1 to 2533)
AUTHORS Low,B.C., Lim,Y.P., Lim,J., Wong,E.S. and Guy,G.R.
TITLE Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by
fibroblast growth factor receptor-1 prevents its binding to
Cdc42GAP and Cdc42
JOURNAL J. Biol. Chem. 274 (46), 33123-33130 (1999)
PUBMED 10551883
REFERENCE 9 (bases 1 to 2533)
AUTHORS Ohi,N., Tokunaga,A., Tsunoda,H., Nakano,K., Haraguchi,K., Oda,K.,
Motoyama,N. and Nakajima,T.
TITLE A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis
induced by Nip3 by forming a heterodimer through the C-terminal
hydrophobic region
JOURNAL Cell Death Differ. 6 (4), 314-325 (1999)
PUBMED 10381623
REFERENCE 10 (bases 1 to 2533)
AUTHORS Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
TITLE Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
of cellular proteins
JOURNAL Cell 79 (2), 341-351 (1994)
PUBMED 7954800
REMARK Erratum:[Cell. 1994 Dec 16;79(6):1121. PMID: 8001138]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC425485.1, BC002461.2 and
BX378770.2.
This sequence is a reference standard in the RefSeqGene project.
On Feb 22, 2008 this sequence version replaced gi:4757855.
Summary: This gene is a member of the BCL2/adenovirus E1B 19
kd-interacting protein (BNIP) family. It interacts with the E1B 19
kDa protein, which protects cells from virally-induced cell death.
The encoded protein also interacts with E1B 19 kDa-like sequences
of BCL2, another apoptotic protector. [provided by RefSeq, Mar
2011].
Sequence Note: The translation start codon selected for this RefSeq
is conserved in human and Rhesus macaque. A possible downstream
start codon, which shows better cross-species conservation, would
shorten the protein by 121 aa. The shorter protein is described in
the literature, including PMID:7954800. No experimental evidence
exists to show which start codon is used in vivo.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC002461.2, U15173.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-124 DC425485.1 1-124
125-1927 BC002461.2 1-1803
1928-2487 BX378770.2 1-560 c
2488-2533 BC002461.2 2364-2409
FEATURES Location/Qualifiers
source 1..2533
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q22.2"
gene 1..2533
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/note="BCL2/adenovirus E1B 19kDa interacting protein 2"
/db_xref="GeneID:663"
/db_xref="HGNC:1083"
/db_xref="MIM:603292"
exon 1..309
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
CDS 4..1311
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/codon_start=1
/product="BCL2/adenovirus E1B 19 kDa protein-interacting
protein 2"
/protein_id="NP_004321.2"
/db_xref="GI:168480080"
/db_xref="CCDS:CCDS10174.2"
/db_xref="GeneID:663"
/db_xref="HGNC:1083"
/db_xref="MIM:603292"
/translation="
MLCGFQEDATPPPPPRPRRLHRRLPRPEEVGMLSLPPGLLTVSGSAAAADAVPLRPGDWAGVSTADRGERAPLGPAFCDLAVSPTSPAWRGEEDEGAKASSGDIGSLDYQEFVVDIESRLRMEGVELKEEWQDEDFPIPLPEDDSIEADILAITGPEDQPGSLEVNGNKVRKKLMAPDISLTLDPSDGSVLSDDLDESGEIDLDGLDTPSENSNEFEWEDDLPKPKTTEVIRKGSITEYTAAEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYYGDGLNAIVVFAVCFMPESSQPNYRYLMDNLFKYVIGTLELLVAENYMIVYLNGATTRRKMPSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAELAELVPMEYVGIPECIKQVDQELNGKQDEPKNEQ
"
misc_feature 505..855
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/note="Bcl2-/adenovirus E1B nineteen kDa-interacting
protein 2; Region: BNIP2; pfam12496"
/db_xref="CDD:204941"
misc_feature 805..1236
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/note="Sec14p-like lipid-binding domain. Found in
secretory proteins, such as S. cerevisiae
phosphatidylinositol transfer protein (Sec14p), and in
lipid regulated proteins such as RhoGAPs, RhoGEFs and
neurofibromin (NF1). SEC14 domain of Dbl is known to...;
Region: SEC14; cd00170"
/db_xref="CDD:29115"
misc_feature order(868..870,874..876,880..882,967..969,997..999,
1042..1044,1054..1056,1066..1068,1078..1080,1087..1089,
1096..1098,1102..1104,1123..1125,1144..1146,1180..1182)
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/note="phospholipid binding pocket [chemical binding];
other site"
/db_xref="CDD:29115"
misc_feature order(1081..1083,1177..1179)
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/note="salt bridge; other site"
/db_xref="CDD:29115"
variation 7
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:6151434"
variation 128
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087328"
variation 132
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087330"
variation 133
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3087329"
variation 161
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087331"
variation 170
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3087332"
exon 310..416
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
exon 417..484
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
variation 437
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:6151509"
exon 485..661
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
exon 662..838
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
exon 839..941
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
variation 873
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057058"
exon 942..1073
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
variation 967
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1135148"
exon 1074..1160
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
exon 1161..1259
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
exon 1260..2518
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/inference="alignment:Splign:1.39.8"
variation 1323
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:6151583"
STS 1349..1490
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/standard_name="D15S1347"
/db_xref="UniSTS:70896"
variation 1474
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:6151584"
variation 1911
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:1057059"
variation 1928
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2306355"
STS 2034..2186
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/standard_name="D15S703E"
/db_xref="UniSTS:151610"
variation 2041
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1057061"
variation 2055
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:1057062"
variation 2209
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:6151585"
polyA_signal 2494..2499
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
polyA_site 2518
/gene="BNIP2"
/gene_synonym="BNIP-2; NIP2"
ORIGIN
gggatgctgtgtgggtttcaagaagacgccacgcctccgccgccgccacgcccccgccgcctccaccgccggctgccgcgcccggaggaggtcgggatgttatcacttccgccggggcttctcactgtgtccgggtcagctgctgccgccgacgccgtaccgctgcggccgggggattgggccggggtctccaccgccgaccgaggggagcgggctccgctcggccctgctttttgcgacctggccgtcagccccacgtcgccggcctggaggggcgaagaggacgagggggccaaggcttcctccggggacattggctccctggattatcaagagtttgtagttgacattgaatccaggctgaggatggaaggtgtggaacttaaagaagaatggcaagatgaagattttccgatacctttaccagaagatgatagtattgaagcagatatactagctataactggaccagaggaccagcctggctcactagaagttaatggaaataaagtgagaaagaaactaatggctccagacattagcctgacactggatcctagtgatggctctgtattgtcagatgatttggatgaaagtggggagattgacttagatggcttagacacaccgtcagagaatagtaatgagtttgagtgggaagatgatcttccaaaacccaagactactgaagtaattaggaaaggctcaattactgaatacacagcagcagaggaaaaagaagatggacgacgctggcgtatgttcaggattggagaacaggaccacagggttgatatgaaggcaattgaaccctataaaaaagttatcagccatgggggatattatggggatggattaaatgccattgttgtgtttgctgtctgtttcatgcctgaaagtagtcagcctaactatagatacctgatggacaatctttttaaatatgttattggcactttggagctattagtagcagaaaactacatgatagtttatttaaatggtgcaacaactcgaagaaaaatgcccagtctgggatggctcaggaaatgttatcagcaaattgatagaaggttacggaaaaatctaaaatccctaatcattgtacatccttcttggtttatcagaacacttctggctgttacaagaccatttattagctcgaaattcagccaaaaaattagatacgtgtttaatttggcagaactagcagaacttgtccccatggaatacgttggcataccagaatgcataaaacaagttgatcaagaacttaatggaaaacaagatgaaccgaaaaatgaacagtaagtttggcatctagtccaaacaagactgaagaatgtgctgatggagcagtgctgtttctgcattcataatgcatttattggcccatatttttatgtaacctgttacaaaatagacttgactttttcataatggacttttgtattatacaagggactgttcactgctgtactggtttgcaaatttcttgaatttagctctttaatagctaactgtattattatcgttttatattttatattgctaaatagagaaccacactttatataaagtagtttttgcatttgtttattgaatgatgcatcttcttcggtgaaatatttatatgcataaatggcaaaggaaagaaataatatatatttttatgtcattgagcaatattttttaatgtgtacctgtcttatggaagaaatatgcaggtatataagaccacgattttctaaagtgcatattagaatttttgtttttgtaaatggttaaatacatttcctgggtaacttaggaaattaagtttttcataaggcaacagatggttaaactgattgtcatgaatacccaaagatcatgtatataatcgaagtgtattagtaccatcccaaggtttttttctcatttaacatatttgtttcataattcagcaagtacagatgcaagcgcattgcacactttttcctttctaaacttaaagacaagtcaaaaagccattcttagaactagaggatttaagagggtaggaattagggtttgtatatatgtatatatgggacattttatcttctggcccaaagtcagaactttataaaaatcttgagtttgttcactaatgtgaaataagctatgtgtccagggtattgctcccctgagtgtatatgagtgctgagtagtattgcagagaatgtgatgagttattcactgtcacaactttttctatagaaaacaggggctgctttttaaactctcactatgggcactttaccaaaatacttccatatcaattatttgaactcggtagttgtttgacctagttagatgtggtgtttattcaagtttgtatgaaatcatgtttgacaatactgtaaattaggttaattttgtaagtcttagcatcatcatattgtgctgttttggataacacgtttgttacaagcatttaaactgtttcatttggtagtacctttacattgaaataaattgtgtttgtgcctccaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:663 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: TAS
GeneID:663 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS
GeneID:663 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:663 -> Biological process: GO:0006915 [apoptotic process] evidence: IPI
GeneID:663 -> Biological process: GO:0042692 [muscle cell differentiation] evidence: TAS
GeneID:663 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:663 -> Biological process: GO:0043547 [positive regulation of GTPase activity] evidence: TAS
GeneID:663 -> Biological process: GO:0051149 [positive regulation of muscle cell differentiation] evidence: TAS
GeneID:663 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
GeneID:663 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:663 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:663 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
GeneID:663 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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@meso_cacase at
DBCLS
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