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2024-04-19 13:27:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004226 5324 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens serine/threonine kinase 17b (STK17B), mRNA.
ACCESSION NM_004226
VERSION NM_004226.3 GI:217416412
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5324)
AUTHORS Ye,P., Zhao,L. and Gonda,T.J.
TITLE The MYB oncogene can suppress apoptosis in acute myeloid leukemia
cells by transcriptional repression of DRAK2 expression
JOURNAL Leuk. Res. 37 (5), 595-601 (2013)
PUBMED 23398943
REMARK GeneRIF: ChIP assays showed that in U937 cells MYB binds to a
conserved element upstream of the DRAK2 transcription start site.
REFERENCE 2 (bases 1 to 5324)
AUTHORS Yang,K.M., Kim,W., Bae,E., Gim,J., Weist,B.M., Jung,Y., Hyun,J.S.,
Hernandez,J.B., Leem,S.H., Park,T., Jeong,J., Walsh,C.M. and
Kim,S.J.
TITLE DRAK2 participates in a negative feedback loop to control
TGF-beta/Smads signaling by binding to type I TGF-beta receptor
JOURNAL Cell Rep 2 (5), 1286-1299 (2012)
PUBMED 23122956
REMARK GeneRIF: DRAK2 protein directly binds to the type I TGF-beta
receptor and Knockdown of DRAK2 suppresses the tumorigenic ability
of breast cancer cells.
REFERENCE 3 (bases 1 to 5324)
AUTHORS Newton,R.H., Leverrier,S., Srikanth,S., Gwack,Y., Cahalan,M.D. and
Walsh,C.M.
TITLE Protein kinase D orchestrates the activation of DRAK2 in response
to TCR-induced Ca2+ influx and mitochondrial reactive oxygen
generation
JOURNAL J. Immunol. 186 (2), 940-950 (2011)
PUBMED 21148796
REMARK GeneRIF: DRAK2 and protein kinase D form a novel signaling module
that controls calcium homeostasis following T cell activation.
REFERENCE 4 (bases 1 to 5324)
AUTHORS Landa,I., Ruiz-Llorente,S., Montero-Conde,C., Inglada-Perez,L.,
Schiavi,F., Leskela,S., Pita,G., Milne,R., Maravall,J., Ramos,I.,
Andia,V., Rodriguez-Poyo,P., Jara-Albarran,A., Meoro,A., del
Peso,C., Arribas,L., Iglesias,P., Caballero,J., Serrano,J.,
Pico,A., Pomares,F., Gimenez,G., Lopez-Mondejar,P., Castello,R.,
Merante-Boschin,I., Pelizzo,M.R., Mauricio,D., Opocher,G.,
Rodriguez-Antona,C., Gonzalez-Neira,A., Matias-Guiu,X.,
Santisteban,P. and Robledo,M.
TITLE The variant rs1867277 in FOXE1 gene confers thyroid cancer
susceptibility through the recruitment of USF1/USF2 transcription
factors
JOURNAL PLoS Genet. 5 (9), E1000637 (2009)
PUBMED 19730683
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 5324)
AUTHORS Doherty,G.A., Byrne,S.M., Austin,S.C., Scully,G.M., Sadlier,D.M.,
Neilan,T.G., Kay,E.W., Murray,F.E. and Fitzgerald,D.J.
TITLE Regulation of the apoptosis-inducing kinase DRAK2 by
cyclooxygenase-2 in colorectal cancer
JOURNAL Br. J. Cancer 101 (3), 483-491 (2009)
PUBMED 19638987
REMARK GeneRIF: Regulation of the apoptosis-inducing kinase DRAK2 by
cyclooxygenase-2 in colorectal cancer.
REFERENCE 6 (bases 1 to 5324)
AUTHORS Gatzka,M., Newton,R.H. and Walsh,C.M.
TITLE Altered thymic selection and increased autoimmunity caused by
ectopic expression of DRAK2 during T cell development
JOURNAL J. Immunol. 183 (1), 285-297 (2009)
PUBMED 19542440
REMARK GeneRIF: Strong suppression of T cell receptor signals during
thymic selection caused by ectopic DRAK2 expression in a DRAK2
transgenic mouse model of autoimmune encephalomyelitis alters the
responsiveness of peripheral T cells.
REFERENCE 7 (bases 1 to 5324)
AUTHORS Friedrich,M.L., Cui,M., Hernandez,J.B., Weist,B.M., Andersen,H.M.,
Zhang,X., Huang,L. and Walsh,C.M.
TITLE Modulation of DRAK2 autophosphorylation by antigen receptor
signaling in primary lymphocytes
JOURNAL J. Biol. Chem. 282 (7), 4573-4584 (2007)
PUBMED 17182616
REMARK GeneRIF: DRAK2 kinase activity is regulated in a calcium-dependent
manner and that Ser(12) phosphorylation is necessary for optimal
suppression of T cell activation by this kinase
REFERENCE 8 (bases 1 to 5324)
AUTHORS Matsumoto,M., Miyake,Y., Nagita,M., Inoue,H., Shitakubo,D.,
Takemoto,K., Ohtsuka,C., Murakami,H., Nakamura,N. and Kanazawa,H.
TITLE A serine/threonine kinase which causes apoptosis-like cell death
interacts with a calcineurin B-like protein capable of binding
Na(+)/H(+) exchanger
JOURNAL J. Biochem. 130 (2), 217-225 (2001)
PUBMED 11481038
REFERENCE 9 (bases 1 to 5324)
AUTHORS Sanjo,H., Kawai,T. and Akira,S.
TITLE DRAKs, novel serine/threonine kinases related to death-associated
protein kinase that trigger apoptosis
JOURNAL J. Biol. Chem. 273 (44), 29066-29071 (1998)
PUBMED 9786912
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC114760.3 and BM994696.1.
On Dec 13, 2008 this sequence version replaced gi:31543661.
Sequence Note: The RefSeq transcript and protein were derived from
transcript and genomic sequence to make the sequence consistent
with the reference genome assembly. The extent of this RefSeq
transcript is supported by transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC016040.1, AB011421.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-37 AC114760.3 111212-111248 c
38-280 AC114760.3 110969-111211 c
281-446 AC114760.3 102898-103063 c
447-659 AC114760.3 96075-96287 c
660-804 AC114760.3 85547-85691 c
805-931 AC114760.3 83196-83322 c
932-980 AC114760.3 80885-80933 c
981-1160 AC114760.3 79256-79435 c
1161-1946 AC114760.3 76580-77365 c
1947-5057 AC114760.3 73469-76579 c
5058-5324 BM994696.1 1-267 c
FEATURES Location/Qualifiers
source 1..5324
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q32.3"
gene 1..5324
/gene="STK17B"
/gene_synonym="DRAK2"
/note="serine/threonine kinase 17b"
/db_xref="GeneID:9262"
/db_xref="HGNC:11396"
/db_xref="HPRD:05289"
/db_xref="MIM:604727"
exon 1..280
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
variation 195
/gene="STK17B"
/gene_synonym="DRAK2"
/replace="c"
/replace="t"
/db_xref="dbSNP:56228509"
exon 281..446
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
misc_feature 292..294
/gene="STK17B"
/gene_synonym="DRAK2"
/note="upstream in-frame stop codon"
CDS 325..1443
/gene="STK17B"
/gene_synonym="DRAK2"
/EC_number="2.7.11.1"
/note="death-associated protein kinase-related 2; DAP
kinase-related apoptosis-inducing protein kinase 2"
/codon_start=1
/product="serine/threonine-protein kinase 17B"
/protein_id="NP_004217.1"
/db_xref="GI:4758194"
/db_xref="CCDS:CCDS2315.1"
/db_xref="GeneID:9262"
/db_xref="HGNC:11396"
/db_xref="HPRD:05289"
/db_xref="MIM:604727"
/translation="
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
"
misc_feature 433..1203
/gene="STK17B"
/gene_synonym="DRAK2"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 439..1194
/gene="STK17B"
/gene_synonym="DRAK2"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(439..453,463..465,502..504,508..510,604..606,
652..663,673..675,679..681,796..798,802..804,808..813,
817..819,859..861,868..870,913..924)
/gene="STK17B"
/gene_synonym="DRAK2"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(439..453,463..465,502..504,508..510,604..606,
652..663,673..675,796..798,802..804,808..813,817..819,
859..861)
/gene="STK17B"
/gene_synonym="DRAK2"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(451..453,673..675,679..681,796..798,802..804,
808..810,868..870,913..924)
/gene="STK17B"
/gene_synonym="DRAK2"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(856..876,913..924)
/gene="STK17B"
/gene_synonym="DRAK2"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
exon 447..659
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
variation 546
/gene="STK17B"
/gene_synonym="DRAK2"
/replace="a"
/replace="g"
/db_xref="dbSNP:10931726"
exon 660..804
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
exon 805..931
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
exon 932..980
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
exon 981..1160
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
variation 1065
/gene="STK17B"
/gene_synonym="DRAK2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1054537"
exon 1161..5307
/gene="STK17B"
/gene_synonym="DRAK2"
/inference="alignment:Splign:1.39.8"
STS 1178..1825
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="STK17B_8918"
/db_xref="UniSTS:467919"
STS 1426..1559
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="RH65509"
/db_xref="UniSTS:30839"
STS 2625..2808
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="RH16437"
/db_xref="UniSTS:57325"
STS 2719..2845
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="SGC34048"
/db_xref="UniSTS:42835"
STS 3162..3299
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="D16S325"
/db_xref="UniSTS:147089"
STS 3190..3292
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="D8S2282"
/db_xref="UniSTS:473910"
STS 3191..3372
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="D10S2448"
/db_xref="UniSTS:474444"
STS 3198..3286
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 3268..3372
/gene="STK17B"
/gene_synonym="DRAK2"
/standard_name="D11S3114"
/db_xref="UniSTS:152207"
ORIGIN
gaacggcgatgccccagacgcggctgcagttttcaaaccgcgactgcaagcttcggtagtcctctccgctgctgtcgccaggagtcacttcacgagaagccaggtcacaaccgtcggcccttgtctggaaaagtaaaagtggatcctgccacgttcggagctccctggcgcctcgcccggctggagctagagaactcgtcctgtggcggcccccggcgtggggcgggacagcggccccctggagggggcagtcccgggagaacctgcggcggccggagcggtaaaaataagtgactaaagaagcagacctgggaatcacctaacatgtcgaggaggagatttgattgccgaagtatttcaggcctactaactacaactcctcaaattccaataaaaatggaaaactttaataatttctatatacttacatctaaagagctagggagaggaaaatttgctgtggttagacaatgtatatcaaaatctactggccaagaatatgctgcaaaatttctaaaaaagagaagaagaggacaggattgtcgagcagaaattttacacgagattgctgtgcttgaattggcaaagtcttgtccccgtgttattaatcttcatgaggtctatgaaaatacaagtgaaatcattttgatattggaatatgctgcaggtggagaaattttcagcctgtgtttacctgagttggctgaaatggtttctgaaaatgatgttatcagactcattaaacaaatacttgaaggagtttattatctacatcagaataacattgtacaccttgatttaaagccacagaatatattactgagcagcatataccctctcggggacattaaaatagtagattttggaatgtctcgaaaaatagggcatgcgtgtgaacttcgggaaatcatgggaacaccagaatatttagctccagaaatcctgaactatgatcccattaccacagcaacagatatgtggaatattggtataatagcatatatgttgttaactcacacatcaccatttgtgggagaagataatcaagaaacatacctcaatatttctcaagttaatgtagattattcggaagaaactttttcatcagtttcacagctggccacagactttattcagagccttttagtaaaaaatccagagaaaagaccaacagcagagatatgcctttctcattcttggctacagcagtgggactttgaaaacttgtttcaccctgaagaaacttccagttcctctcaaactcaggatcattctgtaaggtcctctgaagacaagacttctaaatcctcctgtaatggaacctgtggtgatagagaagacaaagagaatatcccagaggatagcagcatggtttccaaaagatttcgtttcgatgactcattacccaatccccatgaacttgtttcagatttgctctgttagcacttttttctttgactcatttggactgaatttgaaattttatatccactccagtgagattatgatttgtagcttcatatatgacatgtttatattgtaaatgcacttttccatggaataatttagggaagtgttttaatgttaaattactagttgctagcatgttatgatttcatatcctgagatagctctgcagataagaaaatatttaaatatatgacaaaaagtaaaattgtacatgtgagtttacatgttaatgaaataattcaacttcaaatgaacttaccagaatgttttgcatatcaacaaaaaaagtggcttgagttttattatagttggtgtaaactgaacacagtgaagacattggaatttaataggttctctctctaaggtgactcttataccatgcctctatcaacataatttgtttaggaaagcagtatgaagtttaagccaaaataatttctactttatagatgctcaagagacattttacaattgaaaatgtctttcaattacaaatattttgaaacttcgtaagattttcattctctgtggtctgttatatgagagagatcctttaactagagcaaagagggagttagaaacctgatcagggatattctttacaagttggagcagaggaaagagtagcatgccttcgtattttaacgcaaatgtctttttcctcctcccaacctacttgagatctgataaggtctggaagatggagatatttggtatgcaagtgtagagttttttaatcctccagaatttctagagtagaagatacttaggtatagttaaatattctgtatttttagtcaaacatatttattaattgaatatagaagaaaatgttgacacactcagacagcttactgaattttagatgtcttctgcatcttagaatacaagccagtcattcagagttctaaaagtatgcataaaaaattacagcaccggtaggtctattaacacagtgcccgagtcagcggtagcaagactgatgtgatcataaaacatgacatcaggctcgtctgaagttcttgtgtgaaattcctagtgagtgaggaggctcagcttaaagccatctgcagagtggcccctcattgtggtcttttgctgggaccaatgcaagagactagggagagcaaaatgtttgcttatggctagagactatatccagccctaatgatggggaaagttagtccttttcgggtaatcttttatgaattttcacctgatgaccgttatattggtctgttatcatgttacgataactgtgatctcatgaccatgttgctgtatcagaagaaatagtttgacaaatggtaacaacaacctgatgttccccctttagacctttaacttctcaaaattttggtaagtttccaaattctttaataataacttaaaactttttgaataactatcaggtcactttatttgaccacatggtgaattcctttaatgtcttcagcatttgttaaggaaaagttttctctacttgtgtgtgtatgtgtgcacatgtgtgtatgtacaggtgtatgtatatatctatagatagatacaatacattctttagacacttttcaagattctttgctgtggtatattgtgctcaactcaggtgccaaaggagctttttttttttttttttttttttgagatggagttttgctctgtctctcaggctggagtgcagtggcatgatctcagctcacggcaacctctgcctcccgggttcaagcaattctcctgtctcagcctcctgagtagttgggattacaggcgcatgccaccgtgcccagctaatttttgtatttttagtagagacggggtttcaccatgttggccaggctggtcacaaactcctgacttcaagtgatccacccgcctcggcctcccaaagtgctgggattacaggcgtgagccactgcgcccccgcccaggagctcttttcttatgacatataaattatgacatttatattctttatatgactttatgttctcttcttatgacatttaaattctttaagtagtttgttggtccaataaactagacgttgtataatctaaattgagcccttgtatatctaaaactgatgagttgtttctaaattgttgattgtccatttacttgcctttggtattaagataatgcaagtaaagtttagtaagtcattggataatgaaatgattatgtttctgaagaccatattatatttttaatttttagaggaatcatgccatcccccaaaaaatcaagaaatatttgaattttaaattataagttcatttgttaaaagacatttttacaaatgtctgaaaatcttaaaatactttacatctacctttaagtagtagaatacagagctgtaaatttccatgccttttttcctgatattaagttttatagtaaaaaagcaactagtgattgcacaaagaatataaaaatccactctttttacaaaggtgtgaatttaaataacgttattgattggaatatgaaaatagaccaatcatttaagagctttttagcaaatgattcaattcttactctttttctcccaagattgaaaagcataatgtatttctctaaagtaggaatctagagagcccctgtgagtggacaaatgtcagtaacacttgaacacatgagaagataagtgttatgttgtgataatttaaagttaaatttgctttttgggtaggatccctaaatagatgggatttttaaatagatgatatatagatgacaattgcaattgtcattttaattattttccctacagtaaagaacctagctctgagcagtgaaattgtaatggcactttaaaggaagtaagccgttaactgttctctagtggagcgatctccaactgttttggcactagggacgggttttgtggaagaaaatttttccacaggactgggggtttagggggatggtttcaggatgattcaagtacattacatttatcattagattctcataaggagcatgcaacctagatctcttgcacgtgtggttcacagcaggattcgagctcctttgagaatctaatgccatggctgatctaacaggaaactgagctcaggcagtaatgcttggcaccgccccccaccttctatgcagcccggtcgtggcctggggactggggacccctgctctagtcagtaataaggtacttgtgccagaatataaatcaacacattgcttcctttatcaaagaagtcttgttatttaaaaaaagtcaactgagccagtatgattagtgatgtaattgattttcattctggcacaagcctctttcattctggacagctcacaaatagttaatggaccatgctttgaatagccttcctctaagcaacatttataaatactgatattttagaactgtttacatttcttctgtttatttttgaattttcagtttgatatcttgtccttattcattgttgtataaacaactgtactttaatttcaagtagtattaaaagtatttcacttcagtttggggggattattatcaatttataattttataaaagtattttaaagaataattgtaaattttccataaattacaacttcctgccatattttattaaataataatcttgcttaaggcatatagacagacattattatgagtattccagtaaaaaaaatctacatcaacttgaccattctggctaaaaattaaaaagcacttttttatatctgtggttgtcatttgtttcaaagcatttctaaatttattgttcttaaaagtatgtctgcatgttctagcctttgacctaggtcatctatgaaccctctttgtgtctaataaacatatctgtaaaggcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:9262 -> Molecular function: GO:0004672 [protein kinase activity] evidence: ISS
GeneID:9262 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:9262 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:9262 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:9262 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:9262 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IMP
GeneID:9262 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: IDA
GeneID:9262 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: ISS
GeneID:9262 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:9262 -> Cellular component: GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] evidence: IEA
GeneID:9262 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:9262 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_004217 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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