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2024-04-26 12:40:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004120 4148 bp mRNA linear PRI 04-JUL-2013
DEFINITION Homo sapiens guanylate binding protein 2, interferon-inducible
(GBP2), mRNA.
ACCESSION NM_004120
VERSION NM_004120.4 GI:520975408
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4148)
AUTHORS Lin X, Rice KL, Buzzai M, Hexner E, Costa FF, Kilpivaara O,
Mullally A, Soares MB, Ebert BL, Levine R and Licht JD.
TITLE miR-433 is aberrantly expressed in myeloproliferative neoplasms and
suppresses hematopoietic cell growth and differentiation
JOURNAL Leukemia 27 (2), 344-352 (2013)
PUBMED 22864358
REMARK GeneRIF: Downregulation of MIR-433 is associated with
myeloproliferative neoplasms.
REFERENCE 2 (bases 1 to 4148)
AUTHORS Christian SL, Zu D, Licursi M, Komatsu Y, Pongnopparat T, Codner DA
and Hirasawa K.
TITLE Suppression of IFN-induced transcription underlies IFN defects
generated by activated Ras/MEK in human cancer cells
JOURNAL PLoS ONE 7 (9), E44267 (2012)
PUBMED 22970192
REFERENCE 3 (bases 1 to 4148)
AUTHORS Abdullah N, Balakumari M and Sau AK.
TITLE Dimerization and its role in GMP formation by human guanylate
binding proteins
JOURNAL Biophys. J. 99 (7), 2235-2244 (2010)
PUBMED 20923658
REMARK GeneRIF: hGBP-1, hGBP-2 showed dimerization-related GTPase activity
for GMP formation.
Erratum:[Biophys J. 2011 Sep 21;101(6):1556]
REFERENCE 4 (bases 1 to 4148)
AUTHORS Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H,
Hibberd ML and Seielstad M.
TITLE New genetic associations detected in a host response study to
hepatitis B vaccine
JOURNAL Genes Immun. 11 (3), 232-238 (2010)
PUBMED 20237496
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 4148)
AUTHORS Britzen-Laurent N, Bauer M, Berton V, Fischer N, Syguda A,
Reipschlager S, Naschberger E, Herrmann C and Sturzl M.
TITLE Intracellular trafficking of guanylate-binding proteins is
regulated by heterodimerization in a hierarchical manner
JOURNAL PLoS ONE 5 (12), E14246 (2010)
PUBMED 21151871
REMARK GeneRIF: The in vivo localization of GBP-2 at cellular membranes is
regulated by isoprenylation and dimerization.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4148)
AUTHORS Guimaraes DP, Oliveira IM, de Moraes E, Paiva GR, Souza DM, Barnas
C, Olmedo DB, Pinto CE, Faria PA, De Moura Gallo CV, Small IA,
Ferreira CG and Hainaut P.
TITLE Interferon-inducible guanylate binding protein (GBP)-2: a novel
p53-regulated tumor marker in esophageal squamous cell carcinomas
JOURNAL Int. J. Cancer 124 (2), 272-279 (2009)
PUBMED 19003964
REMARK GeneRIF: GBP-2 is regulated by p53 and may have a role in
esophageal squamous cell carcinomas
REFERENCE 7 (bases 1 to 4148)
AUTHORS King JK, Yeh SH, Lin MW, Liu CJ, Lai MY, Kao JH, Chen DS and Chen
PJ.
TITLE Genetic polymorphisms in interferon pathway and response to
interferon treatment in hepatitis B patients: A pilot study
JOURNAL Hepatology 36 (6), 1416-1424 (2002)
PUBMED 12447867
REMARK GeneRIF: Observational study of gene-environment interaction. (HuGE
Navigator)
REFERENCE 8 (bases 1 to 4148)
AUTHORS Vestal DJ, Gorbacheva VY and Sen GC.
TITLE Different subcellular localizations for the related
interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for
different functions?
JOURNAL J. Interferon Cytokine Res. 20 (11), 991-1000 (2000)
PUBMED 11096456
REFERENCE 9 (bases 1 to 4148)
AUTHORS Neun R, Richter MF, Staeheli P and Schwemmle M.
TITLE GTPase properties of the interferon-induced human guanylate-binding
protein 2
JOURNAL FEBS Lett. 390 (1), 69-72 (1996)
PUBMED 8706832
REFERENCE 10 (bases 1 to 4148)
AUTHORS Cheng YS, Patterson CE and Staeheli P.
TITLE Interferon-induced guanylate-binding proteins lack an N(T)KXD
consensus motif and bind GMP in addition to GDP and GTP
JOURNAL Mol. Cell. Biol. 11 (9), 4717-4725 (1991)
PUBMED 1715024
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB274428.1, BC073163.1,
BC022272.1, AI400402.1, AI445567.1, AI085798.1, AC104459.2,
DB229415.1 and BM993865.1.
On Jul 4, 2013 this sequence version replaced gi:38327557.
Summary: This gene belongs to the guanine-binding protein (GBP)
family, which includes interferon-induced proteins that can bind to
guanine nucleotides (GMP, GDP and GTP). The encoded protein is a
GTPase which hydrolyzes GTP, predominantly to GDP. The protein may
play a role as a marker of squamous cell carcinomas. [provided by
RefSeq, Jul 2013].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC073163.1, AK226018.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-63 DB274428.1 1-63
64-1242 BC073163.1 1-1179
1243-1464 BC022272.1 1198-1419
1465-2195 BC073163.1 1402-2132
2196-2638 AI400402.1 24-466 c
2639-3048 AI445567.1 1-410 c
3049-3113 AI085798.1 12-76 c
3114-3204 AC104459.2 32081-32171 c
3205-3746 DB229415.1 2-543
3747-4148 BM993865.1 1-402 c
FEATURES Location/Qualifiers
source 1..4148
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p22.2"
gene 1..4148
/gene="GBP2"
/note="guanylate binding protein 2, interferon-inducible"
/db_xref="GeneID:2634"
/db_xref="HGNC:4183"
/db_xref="MIM:600412"
exon 1..297
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
misc_feature 279..281
/gene="GBP2"
/note="upstream in-frame stop codon"
exon 298..504
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
CDS 315..2090
/gene="GBP2"
/note="GTP-binding protein 2; guanine nucleotide-binding
protein 2"
/codon_start=1
/product="interferon-induced guanylate-binding protein 2"
/protein_id="NP_004111.2"
/db_xref="GI:38327558"
/db_xref="CCDS:CCDS719.1"
/db_xref="GeneID:2634"
/db_xref="HGNC:4183"
/db_xref="MIM:600412"
/translation="
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
"
mat_peptide 315..2078
/gene="GBP2"
/product="Interferon-induced guanylate-binding protein 2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P32456.3)"
misc_feature 315..1241
/gene="GBP2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P32456.3);
Region: GTPase domain (Globular) (By similarity)"
misc_feature 408..1133
/gene="GBP2"
/note="Guanylate-binding protein (GBP) family (N-terminal
domain); Region: GBP; cd01851"
/db_xref="CDD:206650"
misc_feature 447..470
/gene="GBP2"
/note="G1 box; other site"
/db_xref="CDD:206650"
misc_feature order(453..473,513..521,534..539,612..614,855..860,
1029..1031)
/gene="GBP2"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206650"
misc_feature order(504..521,534..557)
/gene="GBP2"
/note="Switch I region; other site"
/db_xref="CDD:206650"
misc_feature 537..539
/gene="GBP2"
/note="G2 box; other site"
/db_xref="CDD:206650"
misc_feature 603..614
/gene="GBP2"
/note="G3 box; other site"
/db_xref="CDD:206650"
misc_feature order(609..623,654..674,681..689)
/gene="GBP2"
/note="Switch II region; other site"
/db_xref="CDD:206650"
misc_feature 855..866
/gene="GBP2"
/note="G4 box; other site"
/db_xref="CDD:206650"
misc_feature 1023..1031
/gene="GBP2"
/note="G5 box; other site"
/db_xref="CDD:206650"
misc_feature 1158..2048
/gene="GBP2"
/note="Guanylate-binding protein, C-terminal domain;
Region: GBP_C; pfam02841"
/db_xref="CDD:202427"
exon 505..632
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 633..742
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 743..939
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 940..1182
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 1183..1463
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 1464..1676
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 1677..1779
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 1780..1973
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
exon 1974..4133
/gene="GBP2"
/inference="alignment:Splign:1.39.8"
STS 1974..2171
/gene="GBP2"
/standard_name="SHGC-75111"
/db_xref="UniSTS:41845"
STS 2080..2802
/gene="GBP2"
/standard_name="GBP2_2313"
/db_xref="UniSTS:280691"
STS 2124..2231
/gene="GBP2"
/standard_name="WI-9135"
/db_xref="UniSTS:33149"
polyA_signal 2178..2183
/gene="GBP2"
polyA_site 2198
/gene="GBP2"
/note="The 3' most polyA site has not been determined.
This is an internal polyA site"
STS 2980..3329
/gene="GBP2"
/standard_name="G62972"
/db_xref="UniSTS:140097"
ORIGIN
ccttttatggtgaatgagtcactgctttagttgatactttgtttcatattagtgcatttctttgcagaggttacctctttttcttgtctctcgtcaggtctctgacattgacagagcctggacgttggaggaagccccaggacgttggaggggtaaagtaaaagtccacagttaccgtgagagaaaaaagagggagaaagcagtgcagccaaactcggaagaaaagagaggaggaaaaggactcgactttcacattggaacaaccttctttccagtgctaaaggatctctgatctggggaacaacaccctggacatggctccagagatcaacttgccgggcccaatgagcctcattgataacactaaagggcagctggtggtgaatccagaagctctgaagatcctatctgcaattacgcagcctgtggtggtggtggcgattgtgggcctctatcgcacaggcaaatcctacctgatgaacaagctggctgggaagaaaaacggcttctctctaggctccacagtgaagtctcacaccaagggaatctggatgtggtgtgtgcctcatcccaagaagccagaacacaccctagttctgctcgacactgagggcctgggagatatagagaagggtgacaatgagaatgactcctggatctttgccttggccatcctcctgagcagcaccttcgtgtacaatagcatgggaaccatcaaccagcaggccatggaccaacttcactatgtgacagagctgacagatcgaatcaaggcaaactcctcacctggtaacaattctgtagacgactcagctgactttgtgagcttttttccagcatttgtgtggactctcagagatttcaccctggaactggaagtagatggagaacccatcactgctgatgactacttggagctttcgctaaagctaagaaaaggtactgataagaaaagtaaaagctttaatgatcctcggttgtgcatccgaaagttcttccccaagaggaagtgcttcgtcttcgattggcccgctcctaagaagtaccttgctcacctagagcagctaaaggaggaagagctgaaccctgatttcatagaacaagttgcagaattttgttcctacatcctcagccattccaatgtcaagactctttcaggtggcattccagtcaatgggcctcgtctagagagcctggtgctgacctacgtcaatgccatcagcagtggggatctaccctgcatggagaacgcagtcctggccttggcccagatagagaactcagccgcagtggaaaaggctattgcccactatgaacagcagatgggccagaaggtgcagctgcccacggaaaccctccaggagctgctggacctgcacagggacagtgagagagaggccattgaagtcttcatgaagaactctttcaaggatgtggaccaaatgttccagaggaaattaggggcccagttggaagcaaggcgagatgacttttgtaagcagaattccaaagcatcatcagattgttgcatggctttacttcaggatatatttggccctttagaagaagatgtcaagcagggaacattttctaaaccaggaggttaccgtctctttactcagaagctgcaggagctgaagaataagtactaccaggtgccaaggaaggggatacaggccaaagaggtgctgaaaaaatatttggagtccaaggaggatgtggctgatgcacttctacagactgatcagtcactctcagaaaaggaaaaagcgattgaagtggaacgtataaaggctgaatctgcagaagctgcaaagaaaatgttggaggaaatacaaaagaagaatgaggagatgatggaacagaaagagaagagttatcaggaacatgtgaaacaattgactgagaagatggagagggacagggcccagttaatggcagagcaagagaagaccctcgctcttaaacttcaggaacaggaacgccttctcaaggagggattcgagaatgagagcaagagacttcaaaaagacatatgggatatccagatgagaagcaaatcattggagccaatatgtaacatactctaaaagtccaaggagcaaaatttgcctgtccagctccctctccccaagaaacaacatgaatgagcaacttcagagtgtcaaacaactgccattaaacttaactcaaaatcatgatgcatgcatttttgttgaaccataaagtttgcaaagtaaaggttaagtatgaggtcaatgttttacctacagagcaattcaactcatgcttatttatagtactaacttttaatatgatctttaactaaatcctatatttgaaatcatacacaaggactcaagagagatattgtgtaactaggatgcattttccaatgagatatcttgcagtttctgttctgggtagatttttttctctcatatgcaccacccttactgtatattcagtcctatactcttattcagggatttaactatggtcgtagcatagggctgaagtgttgtgaatatgatgaaaatgtgatgagaccaaacaaaccatggggcacagtagagcatcactcctgccaagtggtctttgtatggcatgctggctgcaaataaaggagatctgggacacttaactaggcttttaaagtacagacagtgcacagttctcatttgggtggaggctgcatgatctgtgggcactagcagagaaagtggttgcctctgtgcagaatgcatttatgagtagaggctccaccttctctgtccatgtaaaccctctaggtaattactgccccattcccaggccacctagatctctcttctctagtctcccttagtcttttctctttcctgaagtttagaaaataacttctacaatcacagaaaggaaagctttaactcaaactcaaattactttccattcttctgaggaccaggactataatcctataaagcctaaaacttgactgcatttttctctctgctcctctgctatgacattatatcctcaaagctactcagggtaaatgacttactaaaaaaaaaaaaatgacagattgaaaaatcaagaataattcattaatacaaaacattatcctactacaattgtttcaggatgtgtattattcagagttcttcatggcaaataacaatctgctcagcaatttaagtaaaaagtaatttactttttaataccattaggttgcacaccgatgctccagaattgtgagggagccatactctacagctattccaccgaggataatactaccattgtaaaggcatctcacgggaaaacaacacagctaccatgaaccagcaccatgatctctggatgaaatgctggaagcttctgcagtgtcagctatgagtaaatggatgccaccaccttcacattttcagtaaacaaatactcccctaccccatgaaaagttgcatctttgagctgctcacatctccagctaagcctcacaaaagtcaatctgcagggaagaatctaaatcatatgcctacccatgggaaagtctgagaattagagtatttttgtcttctacttttggaggaagaaactaataacgtgggaaattttcctgtatgtttagtcaaccagtttttccatgcagatgtatggagataaatcttatagtaggaataacctaagacttgagttagtatttttgtgtacatcagatacaacactcttctcatcttttttgtcattatttttcaatgttgttttaatctttccactgttgtttcatgtcatgcactttgttaatattctttaagttattcttagtttttaacaatgatacttaagaaagacttaataggactatagaataggtactccctattccccaaccctgggaacacaatttaacatattagttcatttgtatttaagatctatcttgtttatgcctcagtttagttattgctcttacctttcaaacagttagtattttgtatctagttctgtgaaagcaaaaagcaactttattctttcttacaattccccttttacttaatcggaacatttctttcctgtttgttcattagtcactctcagataaatgaatagtctctttttctaaaaaaaaaaataacatttgacctaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2634 -> Molecular function: GO:0003924 [GTPase activity] evidence: IEA
GeneID:2634 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
GeneID:2634 -> Biological process: GO:0006955 [immune response] evidence: TAS
GeneID:2634 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: TAS
GeneID:2634 -> Biological process: GO:0060333 [interferon-gamma-mediated signaling pathway] evidence: TAS
GeneID:2634 -> Biological process: GO:0060337 [type I interferon-mediated signaling pathway] evidence: TAS
GeneID:2634 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IEA
GeneID:2634 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:2634 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
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