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2024-04-20 02:38:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004103 4193 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript
variant 2, mRNA.
ACCESSION NM_004103
VERSION NM_004103.4 GI:325651908
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4193)
AUTHORS Liu,R.F., Xu,X., Huang,J., Fei,Q.L., Chen,F., Li,Y.D. and Han,Z.G.
TITLE Down-regulation of miR-517a and miR-517c promotes proliferation of
hepatocellular carcinoma cells via targeting Pyk2
JOURNAL Cancer Lett. 329 (2), 164-173 (2013)
PUBMED 23142219
REMARK GeneRIF: Down-regulation of both miR-517a and miR-517c contribute
to hepatocellular carcinoma cells development through regulating
Pyk2.
REFERENCE 2 (bases 1 to 4193)
AUTHORS Yang,L., Liu,F., Xu,Z., Guo,N., Zheng,X. and Sun,C.
TITLE Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates
the chemotaxis and migration ability of squamous cell carcinoma of
the head and neck
JOURNAL Oncol. Rep. 28 (5), 1659-1664 (2012)
PUBMED 22923218
REMARK GeneRIF: findings showed that Pyk2 is overexpressed in squamous
cell carcinoma of the head and neck; data suggest that CCR7 via
Pyk2 and cofilin regulates the chemotaxis and migration ability of
metastatic squamous cell carcinoma of the head and neck cells
REFERENCE 3 (bases 1 to 4193)
AUTHORS Zhang,S.Y. and Qiu,X.S.
TITLE [Expression of SOCS3 and Pyk2 and their correlation in non-small
cell lung cancer]
JOURNAL Zhonghua Bing Li Xue Za Zhi 41 (10), 657-661 (2012)
PUBMED 23302305
REMARK GeneRIF: SOCS3 definitely plays roles in regulating Pyk2 signaling
and cell motility in A549 cells.
REFERENCE 4 (bases 1 to 4193)
AUTHORS Chapman,N.M., Yoder,A.N. and Houtman,J.C.
TITLE Non-catalytic functions of Pyk2 and Fyn regulate late stage
adhesion in human T cells
JOURNAL PLoS ONE 7 (12), E53011 (2012)
PUBMED 23300847
REMARK GeneRIF: the non-catalytic functions of the kinases Fyn and Pyk2
were required for late stage human T cell adhesion.
REFERENCE 5 (bases 1 to 4193)
AUTHORS Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
TITLE Genome-wide association scan of dental caries in the permanent
dentition
JOURNAL BMC Oral Health 12, 57 (2012)
PUBMED 23259602
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4193)
AUTHORS Avraham,S., London,R., Fu,Y., Ota,S., Hiregowdara,D., Li,J.,
Jiang,S., Pasztor,L.M., White,R.A., Groopman,J.E. et al.
TITLE Identification and characterization of a novel related adhesion
focal tyrosine kinase (RAFTK) from megakaryocytes and brain
JOURNAL J. Biol. Chem. 270 (46), 27742-27751 (1995)
PUBMED 7499242
REFERENCE 7 (bases 1 to 4193)
AUTHORS Sasaki,H., Nagura,K., Ishino,M., Tobioka,H., Kotani,K. and
Sasaki,T.
TITLE Cloning and characterization of cell adhesion kinase beta, a novel
protein-tyrosine kinase of the focal adhesion kinase subfamily
JOURNAL J. Biol. Chem. 270 (36), 21206-21219 (1995)
PUBMED 7673154
REFERENCE 8 (bases 1 to 4193)
AUTHORS Lev,S., Moreno,H., Martinez,R., Canoll,P., Peles,E.,
Musacchio,J.M., Plowman,G.D., Rudy,B. and Schlessinger,J.
TITLE Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation
of ion channel and MAP kinase functions
JOURNAL Nature 376 (6543), 737-745 (1995)
PUBMED 7544443
REFERENCE 9 (bases 1 to 4193)
AUTHORS Calalb,M.B., Polte,T.R. and Hanks,S.K.
TITLE Tyrosine phosphorylation of focal adhesion kinase at sites in the
catalytic domain regulates kinase activity: a role for Src family
kinases
JOURNAL Mol. Cell. Biol. 15 (2), 954-963 (1995)
PUBMED 7529876
REFERENCE 10 (bases 1 to 4193)
AUTHORS Coffer,P.J. and Woodgett,J.R.
TITLE Molecular cloning and characterisation of a novel putative
protein-serine kinase related to the cAMP-dependent and protein
kinase C families
JOURNAL Eur. J. Biochem. 201 (2), 475-481 (1991)
PUBMED 1718748
REMARK Erratum:[Eur J Biochem. 1992 May 1;205(3):1217. PMID: 1533586]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC036651.2, U43522.1, U33284.1,
AL120380.1, AF311103.5 and AW130888.1.
On Mar 10, 2011 this sequence version replaced gi:27886583.
Summary: This gene encodes a cytoplasmic protein tyrosine kinase
which is involved in calcium-induced regulation of ion channels and
activation of the map kinase signaling pathway. The encoded protein
may represent an important signaling intermediate between
neuropeptide-activated receptors or neurotransmitters that increase
calcium flux and the downstream signals that regulate neuronal
activity. The encoded protein undergoes rapid tyrosine
phosphorylation and activation in response to increases in the
intracellular calcium concentration, nicotinic acetylcholine
receptor activation, membrane depolarization, or protein kinase C
activation. This protein has been shown to bind CRK-associated
substrate, nephrocystin, GTPase regulator associated with FAK, and
the SH2 domain of GRB2. The encoded protein is a member of the FAK
subfamily of protein tyrosine kinases but lacks significant
sequence similarity to kinases from other subfamilies. Four
transcript variants encoding two different isoforms have been found
for this gene. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1, 2, and 3 all encode isoform a.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U43522.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-11 BC036651.2 396-406
12-320 U43522.1 2-310
321-582 BC036651.2 876-1137
583-2880 U33284.1 437-2734
2881-3274 AL120380.1 113-506
3275-4134 AF311103.5 68384-69243
4135-4193 AW130888.1 1-59 c
FEATURES Location/Qualifiers
source 1..4193
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p21.1"
gene 1..4193
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="protein tyrosine kinase 2 beta"
/db_xref="GeneID:2185"
/db_xref="HGNC:9612"
/db_xref="HPRD:03131"
/db_xref="MIM:601212"
exon 1..98
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 40
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:148985953"
variation 46
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:143804951"
exon 99..216
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 117
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140031457"
exon 217..457
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 223
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:370164260"
variation 231
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:375407456"
variation 232
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1128433"
misc_feature 236..238
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="upstream in-frame stop codon"
CDS 254..3283
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/EC_number="2.7.10.2"
/note="isoform a is encoded by transcript variant 2;
protein kinase B; cell adhesion kinase beta; related
adhesion focal tyrosine kinase; calcium-dependent tyrosine
kinase; protein-tyrosine kinase 2-beta; proline-rich
tyrosine kinase 2; focal adhesion kinase 2; FADK 2;
CAK-beta; calcium-regulated non-receptor proline-rich
tyrosine kinase; PTK2B protein tyrosine kinase 2 beta"
/codon_start=1
/product="protein-tyrosine kinase 2-beta isoform a"
/protein_id="NP_004094.3"
/db_xref="GI:27886584"
/db_xref="CCDS:CCDS6057.1"
/db_xref="GeneID:2185"
/db_xref="HGNC:9612"
/db_xref="HPRD:03131"
/db_xref="MIM:601212"
/translation="
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
"
misc_feature 374..1015
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="Band 4.1 homologues; Region: B41; smart00295"
/db_xref="CDD:197635"
misc_feature 686..1015
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="FERM central domain; Region: FERM_M; pfam00373"
/db_xref="CDD:201187"
misc_feature 1334..1336
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14289.2); phosphorylation site"
misc_feature 1376..1378
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14289.2); phosphorylation site"
misc_feature 1376..1378
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03131"
misc_feature 1448..1450
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14289.2); phosphorylation site"
misc_feature 1457..1459
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:02513"
misc_feature 1457..1459
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 1457..1459
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03131"
misc_feature 1505..2314
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="Catalytic domain of the Protein Tyrosine Kinase,
Focal Adhesion Kinase; Region: PTKc_FAK; cd05056"
/db_xref="CDD:133187"
misc_feature order(1544..1546,1550..1558,1568..1570,1616..1618,
1622..1624,1673..1675,1760..1762,1766..1768,1778..1780,
1898..1900,1910..1915,1919..1921,1952..1954,2003..2017,
2042..2044,2144..2146)
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="active site"
/db_xref="CDD:133187"
misc_feature order(1544..1546,1550..1558,1568..1570,1616..1618,
1622..1624,1673..1675,1760..1762,1766..1768,1778..1780)
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:133187"
misc_feature 1595..2290
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="Tyrosine kinase, catalytic domain; Region: TyrKc;
smart00219"
/db_xref="CDD:197581"
misc_feature order(1898..1900,1910..1912,2003..2017,2042..2044,
2144..2146)
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:133187"
misc_feature 1949..2023
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:133187"
misc_feature 1988..1990
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:02513"
misc_feature 1988..1990
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC, LYN and LCK; propagated
from UniProtKB/Swiss-Prot (Q14289.2); phosphorylation
site"
misc_feature 1988..1990
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03131"
misc_feature 1991..1993
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:02513"
misc_feature 1991..1993
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC, LYN and LCK; propagated
from UniProtKB/Swiss-Prot (Q14289.2); phosphorylation
site"
misc_feature 1991..1993
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03131"
misc_feature 2417..2419
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2537..2539
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14289.2); phosphorylation site"
misc_feature 2546..2548
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2585..2587
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03131"
misc_feature 2654..3280
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14289.2);
Region: Interaction with TGFB1I1 (By similarity)"
misc_feature 2708..2710
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2753..2755
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2768..2770
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14289.2); phosphorylation site"
misc_feature 2777..2779
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2798..2800
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2849..2851
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q14289.2); phosphorylation site"
misc_feature 2855..3280
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14289.2);
Region: Focal adhesion targeting (FAT)"
misc_feature 2861..3277
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/note="Focal adhesion targeting region; Region: Focal_AT;
pfam03623"
/db_xref="CDD:146323"
misc_feature 2894..2896
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by SRC; propagated from
UniProtKB/Swiss-Prot (Q14289.2); phosphorylation site"
misc_feature 2894..2896
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03131"
misc_feature 2969..2971
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/experiment="experimental evidence, no additional details
recorded"
/note="dephosphorylation site; modified site"
/db_xref="HPRD:01470"
variation 280
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1045510"
variation 282
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:111853465"
variation 298
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1045511"
variation 303
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:145156050"
variation 305
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:372930124"
variation 306
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200828678"
variation 325
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:138987198"
variation 364
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:142121795"
variation 365
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:144750616"
variation 390
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:368361431"
variation 399
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200987347"
variation 415
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1045512"
variation 434
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="t"
/db_xref="dbSNP:141851888"
variation 447
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:150796343"
variation 452
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:150603215"
variation 454
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:201752959"
variation 456
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:139777503"
exon 458..636
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 475
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:374033379"
variation 484
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:144837322"
variation 485
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:376146343"
variation 506
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:369608545"
variation 507
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:147218792"
variation 522
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:202215628"
variation 523
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375995220"
variation 551
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:140538134"
variation 567
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:371046279"
variation 574
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:375569512"
variation 582
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:149715605"
variation 583
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1030526"
variation 599
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:200325494"
variation 631
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200979526"
exon 637..724
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 698
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:148416337"
variation 703
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:367952743"
variation 717
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:192474266"
exon 725..804
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 729
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:373105458"
variation 752
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:375270527"
variation 785
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:112665817"
variation 787
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:11991368"
variation 804
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:55781835"
exon 805..867
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 830
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:140796597"
variation 856
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:145177380"
exon 868..922
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 892
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375640807"
variation 913
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:201588000"
exon 923..1063
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 972
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:188634353"
variation 973
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:141577958"
variation 994
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140672253"
variation 1025
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:150448766"
variation 1031
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:201457448"
variation 1044
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:61738530"
exon 1064..1138
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1084
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:201163206"
variation 1085
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:199835327"
variation 1102
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:149578035"
variation 1113
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:369828516"
variation 1138
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:372782567"
exon 1139..1240
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1153
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200116993"
variation 1154
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200025953"
variation 1160
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:367987503"
variation 1189
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:143285330"
variation 1230
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:139089526"
variation 1239
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:142980389"
exon 1241..1358
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1263
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:367810356"
variation 1300
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:372119534"
variation 1311
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:374576859"
variation 1328
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:56175011"
exon 1359..1398
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1370
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:370030419"
exon 1399..1445
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1402
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:140576421"
variation 1413
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:199551006"
variation 1416
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:148998768"
variation 1422
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="t"
/db_xref="dbSNP:201276254"
exon 1446..1496
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1470
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:201712625"
variation 1474
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:374442178"
variation 1485
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:150760494"
variation 1489
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:139140589"
variation 1492
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:55853846"
variation 1494
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:41276291"
exon 1497..1594
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1510
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:372161863"
variation 1523
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:149530445"
variation 1525
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139830819"
variation 1538
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:201274282"
variation 1539
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:144179520"
variation 1594
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:7005936"
exon 1595..1679
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1619
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:374032290"
variation 1627
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:55718452"
variation 1640
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:199794154"
variation 1652
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:148995232"
variation 1671
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:191072490"
variation 1676
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:375881525"
exon 1680..1780
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1696
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373082114"
variation 1697
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:199752331"
variation 1753
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:112296188"
variation 1769
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:369129837"
exon 1781..1896
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1801
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:373779845"
variation 1817
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:111770927"
variation 1832
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:116574797"
variation 1852
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:369029128"
variation 1883
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:112334653"
variation 1884
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:151100763"
variation 1888
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375279180"
variation 1889
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:141042486"
exon 1897..1997
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1912
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:368168032"
variation 1953
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="t"
/db_xref="dbSNP:112211925"
variation 1959
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:200141263"
variation 1981
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:151293619"
exon 1998..2087
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 1998
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139127669"
variation 2004
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:141562215"
variation 2032
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:377608759"
variation 2072
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:181922180"
variation 2075
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:370995513"
exon 2088..2292
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2089
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:376666218"
variation 2153
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200282956"
variation 2159
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200235961"
variation 2209
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:147029499"
variation 2226
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:138935546"
variation 2258
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375221108"
variation 2264
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:369239201"
variation 2272
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:149334019"
variation 2275
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:372149978"
exon 2293..2401
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2296
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:374105065"
variation 2297
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:142897332"
variation 2300
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:191110858"
variation 2317
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:368617865"
variation 2335
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:372707177"
variation 2345
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:144604358"
variation 2346
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:35174236"
variation 2366
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="t"
/db_xref="dbSNP:200441000"
variation 2369
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:377363024"
exon 2402..2467
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2404
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:1128435"
variation 2423
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:368579457"
variation 2430
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:141726800"
variation 2431
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:144972819"
variation 2440
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139850323"
variation 2445
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="t"
/db_xref="dbSNP:112133314"
exon 2468..2593
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2478
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="g"
/replace="t"
/db_xref="dbSNP:143169594"
variation 2480
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:368243738"
variation 2513
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:146171096"
variation 2531
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:144910489"
variation 2541
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139028524"
variation 2562
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:150074089"
variation 2579
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:374410320"
variation 2582
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200652368"
variation 2592
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200782817"
exon 2594..2740
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2600
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:367803850"
variation 2611
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:199504084"
variation 2674
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:371375403"
variation 2676
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:55747955"
exon 2741..2776
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2747
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:145396684"
variation 2766
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:751019"
variation 2770
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375230281"
exon 2777..2801
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2801
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:41276293"
exon 2802..2848
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2832
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:370659369"
variation 2844
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:147909940"
exon 2849..2986
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2879
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:141604763"
variation 2881
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:1879184"
variation 2901
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:148098986"
variation 2922
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140923137"
variation 2923
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:376321919"
variation 2924
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200062537"
variation 2933
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:150385119"
variation 2935
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:138068144"
variation 2956
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:142584961"
variation 2962
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace=""
/replace="c"
/db_xref="dbSNP:67956828"
variation 2963
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:373751030"
variation 2967
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace=""
/replace="g"
/db_xref="dbSNP:66538136"
variation 2971
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:145985190"
exon 2987..3067
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 2999
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="t"
/db_xref="dbSNP:138597669"
variation 3002
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace=""
/replace="c"
/db_xref="dbSNP:67688486"
variation 3022
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375077657"
variation 3034
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:368007448"
variation 3052
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:56046263"
variation 3059
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:146212589"
exon 3068..4165
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/inference="alignment:Splign:1.39.8"
variation 3076
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:148410575"
variation 3081
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:142503445"
variation 3093
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:369127469"
variation 3113
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:368912045"
variation 3115
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:150697356"
variation 3133
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1879182"
variation 3145
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373204049"
variation 3146
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:376904047"
variation 3157
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1879181"
variation 3161
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:56263944"
variation 3166
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:371598283"
variation 3182
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="c"
/db_xref="dbSNP:374175947"
variation 3186
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200679547"
variation 3193
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:55875819"
variation 3206
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:17853678"
variation 3211
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:141744444"
variation 3226
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:377662396"
variation 3229
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:145477508"
variation 3280
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:370726123"
variation 3284
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:201288691"
variation 3309
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200608411"
variation 3327
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:376386614"
variation 3333
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:370773139"
STS 3357..3517
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/standard_name="RH69058"
/db_xref="UniSTS:20264"
variation 3374
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:2271920"
variation 3417
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:138280120"
variation 3495
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:149603572"
variation 3501
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:187592518"
variation 3623
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:149554544"
variation 3629
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:142234209"
variation 3680
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace=""
/replace="c"
/db_xref="dbSNP:35217263"
variation 3863
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:191973179"
STS 3886..4093
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/standard_name="HSC25C022"
/db_xref="UniSTS:24321"
STS 3908..4080
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/standard_name="RH12429"
/db_xref="UniSTS:4805"
variation 3939
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:184815854"
variation 3943
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="g"
/db_xref="dbSNP:189817494"
variation 3972
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="a"
/replace="g"
/db_xref="dbSNP:371764700"
variation 4052
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1473234"
variation 4086
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062927"
variation 4122
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
/replace="c"
/replace="t"
/db_xref="dbSNP:1045551"
polyA_signal 4141..4146
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
polyA_site 4165
/gene="PTK2B"
/gene_synonym="CADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2;
RAFTK"
ORIGIN
gaataggactagcaacttcatagacggttgtgaagacaagctagacggcagatgaaagttcttggcacagagtgaacacttgataaactatatggcagccacagcctccggagccgttgcacacctacctgcccggccgacttacctgtacttgccgccgtcccggctcacctggcggtgcccgaggagtagtcgctggagtccgcgcctccctgggactgcaatgtgccgatcttagctgctgcctgagaggatgtctggggtgtccgagcccctgagtcgagtaaagttgggcacgttacgccggcctgaaggccctgcagagcccatggtggtggtaccagtagatgtggaaaaggaggacgtgcgtatcctcaaggtctgcttctatagcaacagcttcaatcctgggaaaaacttcaaactggtcaaatgcactgtccagacggagatccgggagatcatcacctccatcctgctgagcgggcggatcgggcccaacatccggttggctgagtgctatgggctgaggctgaagcacatgaagtccgatgagatccactggctgcacccacagatgacggtgggtgaggtgcaggacaagtatgagtgtctgcacgtggaagccgagtggaggtatgaccttcaaatccgctacttgccagaagacttcatggagagcctgaaggaggacaggaccacgctgctctatttttaccaacagctccggaacgactacatgcagcgctacgccagcaaggtcagcgagggcatggccctgcagctgggctgcctggagctcaggcggttcttcaaggatatgccccacaatgcacttgacaagaagtccaacttcgagctcctagaaaaggaagtggggctggacttgtttttcccaaagcagatgcaggagaacttaaagcccaaacagttccggaagatgatccagcagaccttccagcagtacgcctcgctcagggaggaggagtgcgtcatgaagttcttcaacactctcgccggcttcgccaacatcgaccaggagacctaccgctgtgaactcattcaaggatggaacattactgtggacctggtcattggccctaaagggatccgccagctgactagtcaggacgcaaagcccacctgcctggccgagttcaagcagatcaggtccatcaggtgcctcccgctggaggagggccaggcagtacttcagctgggcattgaaggtgccccccaggccttgtccatcaaaacctcatccctagcagaggctgagaacatggctgacctcatagacggctactgccggctgcagggtgagcaccaaggctctctcatcatccatcctaggaaagatggtgagaagcggaacagcctgccccagatccccatgctaaacctggaggcccggcggtcccacctctcagagagctgcagcatagagtcagacatctacgcagagattcccgacgaaaccctgcgaaggcccggaggtccacagtatggcattgcccgtgaagatgtggtcctgaatcgtattcttggggaaggcttttttggggaggtctatgaaggtgtctacacaaatcacaaaggggagaaaatcaatgtagctgtcaagacctgcaagaaagactgcactctggacaacaaggagaagttcatgagcgaggcagtgatcatgaagaacctcgaccacccgcacatcgtgaagctgatcggcatcattgaagaggagcccacctggatcatcatggaattgtatccctatggggagctgggccactacctggagcggaacaagaactccctgaaggtgctcaccctcgtgctgtactcactgcagatatgcaaagccatggcctacctggagagcatcaactgcgtgcacagggacattgctgtccggaacatcctggtggcctcccctgagtgtgtgaagctgggggactttggtctttcccggtacattgaggacgaggactattacaaagcctctgtgactcgtctccccatcaaatggatgtccccagagtccattaacttccgacgcttcacgacagccagtgacgtctggatgttcgccgtgtgcatgtgggagatcctgagctttgggaagcagcccttcttctggctggagaacaaggatgtcatcggggtgctggagaaaggagaccggctgcccaagcctgatctctgtccaccggtcctttataccctcatgacccgctgctgggactacgaccccagtgaccggccccgcttcaccgagctggtgtgcagcctcagtgacgtttatcagatggagaaggacattgccatggagcaagagaggaatgctcgctaccgaacccccaaaatcttggagcccacagccttccaggaacccccacccaagcccagccgacctaagtacagaccccctccgcaaaccaacctcctggctccaaagctgcagttccaggttcctgagggtctgtgtgccagctctcctacgctcaccagccctatggagtatccatctcccgttaactcactgcacaccccacctctccaccggcacaatgtcttcaaacgccacagcatgcgggaggaggacttcatccaacccagcagccgagaagaggcccagcagctgtgggaggctgaaaaggtcaaaatgcggcaaatcctggacaaacagcagaagcagatggtggaggactaccagtggctcaggcaggaggagaagtccctggaccccatggtttatatgaatgataagtccccattgacgccagagaaggaggtcggctacctggagttcacagggcccccacagaagcccccgaggctgggcgcacagtccatccagcccacagctaacctggaccggactgatgacctggtgtacctcaatgtcatggagctggtgcgggccgtgctggagctcaagaatgagctctgtcagctgccccccgagggctacgtggtggtggtgaagaatgtggggctgaccctgcggaagctcatcgggagcgtggatgatctcctgccttccttgccgtcatcttcacggacagagatcgagggcacccagaaactgctcaacaaagacctggcagagctcatcaacaagatgcggctggcacagcagaacgccgtgacctccctaagtgaggagtgcaagaggcagatgctgacggcttcacacaccctggctgtggacgccaagaacctgctcgacgctgtggaccaggccaaggttctggccaatctggcccacccacctgcagagtgacggagggtgggggccacctgcctgcgtcttccgcccctgcctgccatgtacctcccctgccttgctgttggtcatgtgggtcttccagggggaaggccaaggggagtcaccttcccttgccactttgcacgacgccctctccccacccctacccctggctgtactgctcaggctgcagctggacagaggggactctgggctatggacacagggtgacggtgacaaagatggctcagagggggactgctgctgcctggccactgctccctaagccagcctggtccatgcagggggctcctgggggtggggaggtgtcacatggtgcccctagctttatatatggacatggcaggccgatttgggaaccaagctattcctttcccttcctcttcggccctcagatgtcccttgatgcacagagaagctggggaggagctttgttttgggggtcaggcagccagtgagatgagggatgggcctggcattcttgtacagtgtatattgaaatttatttaatgtgagtttggtctggactgacagcatgtgccctcctgagggaggacctggggcacagtccaggaacaagctaattgggagtccaggcacaggatgctgtgttgtcaacaaaccaagcatcagggggaagaagcagagagatgcggccaagataggaccttgggccaaatccgctctcttcctgcccctctttctctttcttcctttactttcccttgcttttccctcttttcttactcctcctctttctctccccaacccccattctcatctgcacccttcttttctcatgtgtttgcataaacattcttttaacttctttctatttgacttgtggttgaattaaaattgtcccatttgctttgcaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2185 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
GeneID:2185 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IDA
GeneID:2185 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:2185 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:2185 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:2185 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
GeneID:2185 -> Molecular function: GO:0043423 [3-phosphoinositide-dependent protein kinase binding] evidence: IEA
GeneID:2185 -> Biological process: GO:0000165 [MAPK cascade] evidence: IEA
GeneID:2185 -> Biological process: GO:0001556 [oocyte maturation] evidence: IEA
GeneID:2185 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:2185 -> Biological process: GO:0001954 [positive regulation of cell-matrix adhesion] evidence: IMP
GeneID:2185 -> Biological process: GO:0002040 [sprouting angiogenesis] evidence: ISS
GeneID:2185 -> Biological process: GO:0002315 [marginal zone B cell differentiation] evidence: ISS
GeneID:2185 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS
GeneID:2185 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:2185 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:2185 -> Biological process: GO:0006950 [response to stress] evidence: TAS
GeneID:2185 -> Biological process: GO:0006970 [response to osmotic stress] evidence: IEA
GeneID:2185 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:2185 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: IMP
GeneID:2185 -> Biological process: GO:0007172 [signal complex assembly] evidence: IEA
GeneID:2185 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: IEA
GeneID:2185 -> Biological process: GO:0007204 [elevation of cytosolic calcium ion concentration] evidence: IEA
GeneID:2185 -> Biological process: GO:0007229 [integrin-mediated signaling pathway] evidence: IMP
GeneID:2185 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
GeneID:2185 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IMP
GeneID:2185 -> Biological process: GO:0008360 [regulation of cell shape] evidence: IMP
GeneID:2185 -> Biological process: GO:0009612 [response to mechanical stimulus] evidence: IEA
GeneID:2185 -> Biological process: GO:0009725 [response to hormone stimulus] evidence: IEA
GeneID:2185 -> Biological process: GO:0009749 [response to glucose stimulus] evidence: IEA
GeneID:2185 -> Biological process: GO:0010226 [response to lithium ion] evidence: IEA
GeneID:2185 -> Biological process: GO:0010595 [positive regulation of endothelial cell migration] evidence: IDA
GeneID:2185 -> Biological process: GO:0010752 [regulation of cGMP-mediated signaling] evidence: IEA
GeneID:2185 -> Biological process: GO:0010758 [regulation of macrophage chemotaxis] evidence: ISS
GeneID:2185 -> Biological process: GO:0010976 [positive regulation of neuron projection development] evidence: IMP
GeneID:2185 -> Biological process: GO:0014009 [glial cell proliferation] evidence: IEA
GeneID:2185 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:2185 -> Biological process: GO:0030155 [regulation of cell adhesion] evidence: IMP
GeneID:2185 -> Biological process: GO:0030307 [positive regulation of cell growth] evidence: IEA
GeneID:2185 -> Biological process: GO:0030335 [positive regulation of cell migration] evidence: IMP
GeneID:2185 -> Biological process: GO:0030502 [negative regulation of bone mineralization] evidence: ISS
GeneID:2185 -> Biological process: GO:0030826 [regulation of cGMP biosynthetic process] evidence: IEA
GeneID:2185 -> Biological process: GO:0030838 [positive regulation of actin filament polymerization] evidence: IMP
GeneID:2185 -> Biological process: GO:0031175 [neuron projection development] evidence: IEA
GeneID:2185 -> Biological process: GO:0032863 [activation of Rac GTPase activity] evidence: IEA
GeneID:2185 -> Biological process: GO:0032960 [regulation of inositol trisphosphate biosynthetic process] evidence: ISS
GeneID:2185 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IMP
GeneID:2185 -> Biological process: GO:0042220 [response to cocaine] evidence: IEA
GeneID:2185 -> Biological process: GO:0042493 [response to drug] evidence: IEA
GeneID:2185 -> Biological process: GO:0042542 [response to hydrogen peroxide] evidence: IEA
GeneID:2185 -> Biological process: GO:0042976 [activation of Janus kinase activity] evidence: IMP
GeneID:2185 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:2185 -> Biological process: GO:0043149 [stress fiber assembly] evidence: IEA
GeneID:2185 -> Biological process: GO:0043267 [negative regulation of potassium ion transport] evidence: IDA
GeneID:2185 -> Biological process: GO:0043507 [positive regulation of JUN kinase activity] evidence: IEA
GeneID:2185 -> Biological process: GO:0043534 [blood vessel endothelial cell migration] evidence: IEA
GeneID:2185 -> Biological process: GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] evidence: ISS
GeneID:2185 -> Biological process: GO:0045428 [regulation of nitric oxide biosynthetic process] evidence: IEA
GeneID:2185 -> Biological process: GO:0045453 [bone resorption] evidence: ISS
GeneID:2185 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
GeneID:2185 -> Biological process: GO:0045638 [negative regulation of myeloid cell differentiation] evidence: IMP
GeneID:2185 -> Biological process: GO:0045727 [positive regulation of translation] evidence: IEA
GeneID:2185 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IEA
GeneID:2185 -> Biological process: GO:0045860 [positive regulation of protein kinase activity] evidence: IMP
GeneID:2185 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IMP
GeneID:2185 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: TAS
GeneID:2185 -> Biological process: GO:0048010 [vascular endothelial growth factor receptor signaling pathway] evidence: IMP
GeneID:2185 -> Biological process: GO:0048041 [focal adhesion assembly] evidence: IEA
GeneID:2185 -> Biological process: GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] evidence: IDA
GeneID:2185 -> Biological process: GO:0050848 [regulation of calcium-mediated signaling] evidence: IEA
GeneID:2185 -> Biological process: GO:0051000 [positive regulation of nitric-oxide synthase activity] evidence: IEA
GeneID:2185 -> Biological process: GO:0051279 [regulation of release of sequestered calcium ion into cytosol] evidence: ISS
GeneID:2185 -> Biological process: GO:0051591 [response to cAMP] evidence: IEA
GeneID:2185 -> Biological process: GO:0051592 [response to calcium ion] evidence: IEA
GeneID:2185 -> Biological process: GO:0070098 [chemokine-mediated signaling pathway] evidence: ISS
GeneID:2185 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IMP
GeneID:2185 -> Biological process: GO:0071300 [cellular response to retinoic acid] evidence: IMP
GeneID:2185 -> Biological process: GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: IDA
GeneID:2185 -> Biological process: GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: IEA
GeneID:2185 -> Biological process: GO:2000114 [regulation of establishment of cell polarity] evidence: ISS
GeneID:2185 -> Biological process: GO:2000249 [regulation of actin cytoskeleton reorganization] evidence: ISS
GeneID:2185 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IEA
GeneID:2185 -> Biological process: GO:2000538 [positive regulation of B cell chemotaxis] evidence: ISS
GeneID:2185 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:2185 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:2185 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:2185 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:2185 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:2185 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA
GeneID:2185 -> Cellular component: GO:0005938 [cell cortex] evidence: IEA
GeneID:2185 -> Cellular component: GO:0014069 [postsynaptic density] evidence: IEA
GeneID:2185 -> Cellular component: GO:0030027 [lamellipodium] evidence: IDA
GeneID:2185 -> Cellular component: GO:0030424 [axon] evidence: IEA
GeneID:2185 -> Cellular component: GO:0030426 [growth cone] evidence: IEA
GeneID:2185 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA
GeneID:2185 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_004094 -> EC 2.7.10.2
by
@meso_cacase at
DBCLS
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