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2024-04-18 19:23:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004091 5201 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens E2F transcription factor 2 (E2F2), mRNA.
ACCESSION NM_004091
VERSION NM_004091.3 GI:315075284
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5201)
AUTHORS Wu,N., Xiao,L., Zhao,X., Zhao,J., Wang,J., Wang,F., Cao,S. and
Lin,X.
TITLE miR-125b regulates the proliferation of glioblastoma stem cells by
targeting E2F2
JOURNAL FEBS Lett. 586 (21), 3831-3839 (2012)
PUBMED 22999819
REMARK GeneRIF: miR-125b plays important roles in regulating the
proliferation of cancer stem cells by directly targeting E2F2.
REFERENCE 2 (bases 1 to 5201)
AUTHORS Lu,M., Liu,Z., Yu,H., Wang,L.E., Li,G., Sturgis,E.M., Johnson,D.G.
and Wei,Q.
TITLE Combined effects of E2F1 and E2F2 polymorphisms on risk and early
onset of squamous cell carcinoma of the head and neck
JOURNAL Mol. Carcinog. 51 (SUPPL 1), E132-E141 (2012)
PUBMED 22344756
REMARK GeneRIF: E2F1 and E2F2 genetic variants may jointly play important
roles in head and neck squamous cell carcinoma
REFERENCE 3 (bases 1 to 5201)
AUTHORS Vui-Kee,K., Mohd Dali,A.Z., Mohamed Rose,I., Ghazali,R., Jamal,R.
and Mokhtar,N.M.
TITLE Molecular markers associated with nonepithelial ovarian cancer in
formalin-fixed, paraffin-embedded specimens by genome wide
expression profiling
JOURNAL Kaohsiung J. Med. Sci. 28 (5), 243-250 (2012)
PUBMED 22531302
REMARK GeneRIF: Overexpression of E2F transcription factor 2 is associated
with nonepithelial ovarian cancer.
REFERENCE 4 (bases 1 to 5201)
AUTHORS Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
Middeldorp,J.M. and de Sanjose,S.
TITLE Single nucleotide polymorphisms of matrix metalloproteinase 9
(MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
in chronic lymphocytic leukemia: results from the European
case-control study EpiLymph
JOURNAL Haematologica 96 (2), 323-327 (2011)
PUBMED 21048031
REMARK GeneRIF: Observational study of gene-disease association and
gene-environment interaction. (HuGE Navigator)
REFERENCE 5 (bases 1 to 5201)
AUTHORS van der Watt,P.J., Ngarande,E. and Leaner,V.D.
TITLE Overexpression of Kpnbeta1 and Kpnalpha2 importin proteins in
cancer derives from deregulated E2F activity
JOURNAL PLoS ONE 6 (11), E27723 (2011)
PUBMED 22125623
REMARK GeneRIF: Findings suggest that the deregulated activity of E2F in
cancer cells causes increased activation of the Kpnbeta1 and
Kpnalpha2 promoters, leading to elevated levels of these proteins,
and ultimately impacting the cancer phenotype.
REFERENCE 6 (bases 1 to 5201)
AUTHORS Lin,S.Y., Black,A.R., Kostic,D., Pajovic,S., Hoover,C.N. and
Azizkhan,J.C.
TITLE Cell cycle-regulated association of E2F1 and Sp1 is related to
their functional interaction
JOURNAL Mol. Cell. Biol. 16 (4), 1668-1675 (1996)
PUBMED 8657142
REFERENCE 7 (bases 1 to 5201)
AUTHORS Karlseder,J., Rotheneder,H. and Wintersberger,E.
TITLE Interaction of Sp1 with the growth- and cell cycle-regulated
transcription factor E2F
JOURNAL Mol. Cell. Biol. 16 (4), 1659-1667 (1996)
PUBMED 8657141
REFERENCE 8 (bases 1 to 5201)
AUTHORS Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
TITLE In vivo association of E2F and DP family proteins
JOURNAL Mol. Cell. Biol. 15 (5), 2536-2546 (1995)
PUBMED 7739537
REFERENCE 9 (bases 1 to 5201)
AUTHORS Lees,J.A., Saito,M., Vidal,M., Valentine,M., Look,T., Harlow,E.,
Dyson,N. and Helin,K.
TITLE The retinoblastoma protein binds to a family of E2F transcription
factors
JOURNAL Mol. Cell. Biol. 13 (12), 7813-7825 (1993)
PUBMED 8246996
REFERENCE 10 (bases 1 to 5201)
AUTHORS Ivey-Hoyle,M., Conroy,R., Huber,H.E., Goodhart,P.J., Oliff,A. and
Heimbrook,D.C.
TITLE Cloning and characterization of E2F-2, a novel protein with the
biochemical properties of transcription factor E2F
JOURNAL Mol. Cell. Biol. 13 (12), 7802-7812 (1993)
PUBMED 8246995
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from L22846.1, AL021154.1 and
AF086395.1.
On Dec 15, 2010 this sequence version replaced gi:34485718.
Summary: The protein encoded by this gene is a member of the E2F
family of transcription factors. The E2F family plays a crucial
role in the control of cell cycle and action of tumor suppressor
proteins and is also a target of the transforming proteins of small
DNA tumor viruses. The E2F proteins contain several evolutionally
conserved domains found in most members of the family. These
domains include a DNA binding domain, a dimerization domain which
determines interaction with the differentiation regulated
transcription factor proteins (DP), a transactivation domain
enriched in acidic amino acids, and a tumor suppressor protein
association domain which is embedded within the transactivation
domain. This protein and another 2 members, E2F1 and E2F3, have an
additional cyclin binding domain. This protein binds specifically
to retinoblastoma protein pRB in a cell-cycle dependent manner, and
it exhibits overall 46% amino acid identity to E2F1. [provided by
RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: L22846.1, BC053676.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025089 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1765 L22846.1 2-1766
1766-4636 AL021154.1 56750-59620 c
4637-5201 AF086395.1 1-565
FEATURES Location/Qualifiers
source 1..5201
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36"
gene 1..5201
/gene="E2F2"
/gene_synonym="E2F-2"
/note="E2F transcription factor 2"
/db_xref="GeneID:1870"
/db_xref="HGNC:3114"
/db_xref="HPRD:02692"
/db_xref="MIM:600426"
exon 1..679
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
misc_feature 350..352
/gene="E2F2"
/gene_synonym="E2F-2"
/note="upstream in-frame stop codon"
CDS 428..1741
/gene="E2F2"
/gene_synonym="E2F-2"
/codon_start=1
/product="transcription factor E2F2"
/protein_id="NP_004082.1"
/db_xref="GI:4758226"
/db_xref="CCDS:CCDS236.1"
/db_xref="GeneID:1870"
/db_xref="HGNC:3114"
/db_xref="HPRD:02692"
/db_xref="MIM:600426"
/translation="
MLQGPRALASAAGQTPKVVPAMSPTELWPSGLSSPQLCPATATYYTPLYPQTAPPAAAPGTCLDATPHGPEGQVVRCLPAGRLPAKRKLDLEGIGRPVVPEFPTPKGKCIRVDGLPSPKTPKSPGEKTRYDTSLGLLTKKFIYLLSESEDGVLDLNWAAEVLDVQKRRIYDITNVLEGIQLIRKKAKNNIQWVGRGMFEDPTRPGKQQQLGQELKELMNTEQALDQLIQSCSLSFKHLTEDKANKRLAYVTYQDIRAVGNFKEQTVIAVKAPPQTRLEVPDRTEDNLQIYLKSTQGPIEVYLCPEEVQEPDSPSEEPLPSTSTLCPSPDSAQPSSSTDPSIMEPTASSVPAPAPTPQQAPPPPSLVPLEATDSLLELPHPLLQQTEDQFLSPTLACSSPLISFSPSLDQDDYLWGLEAGEGISDLFDSYDLGDLLIN
"
misc_feature 620..742
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14209.1);
Region: Cyclin A/CDK2 binding (Potential)"
misc_feature 812..1009
/gene="E2F2"
/gene_synonym="E2F-2"
/note="E2F/DP family winged-helix DNA-binding domain;
Region: E2F_TDP; pfam02319"
/db_xref="CDD:202203"
misc_feature 890..955
/gene="E2F2"
/gene_synonym="E2F-2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14209.1);
Region: Leucine-zipper"
misc_feature 905..1015
/gene="E2F2"
/gene_synonym="E2F-2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14209.1);
Region: DEF box"
misc_feature 1016..1294
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14209.1);
Region: Dimerization (Potential)"
misc_feature 1502..1738
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14209.1);
Region: Transactivation (Potential)"
misc_feature 1655..1708
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14209.1);
Region: Retinoblastoma protein binding (Potential)"
variation 658
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3218124"
variation 671
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3218125"
exon 680..785
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
exon 786..1005
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
exon 1006..1164
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
variation 1040
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2229297"
exon 1165..1279
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
exon 1280..1472
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
exon 1473..5193
/gene="E2F2"
/gene_synonym="E2F-2"
/inference="alignment:Splign:1.39.8"
STS 1527..1669
/gene="E2F2"
/gene_synonym="E2F-2"
/standard_name="SHGC-74381"
/db_xref="UniSTS:34021"
STS 1624..1720
/gene="E2F2"
/gene_synonym="E2F-2"
/standard_name="GDB:636071"
/db_xref="UniSTS:158520"
variation 1883
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3218208"
variation 2061
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1057480"
variation 2156
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="a"
/replace="t"
/db_xref="dbSNP:3218209"
variation 2157
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="a"
/replace="t"
/db_xref="dbSNP:3218210"
variation 2319
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3218211"
variation 2680
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3795305"
STS 3328..3349
/gene="E2F2"
/gene_synonym="E2F-2"
/db_xref="UniSTS:98954"
variation 3627
/gene="E2F2"
/gene_synonym="E2F-2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3820028"
STS 4152..4322
/gene="E2F2"
/gene_synonym="E2F-2"
/standard_name="D1S1425"
/db_xref="UniSTS:149621"
polyA_signal 5173..5178
/gene="E2F2"
/gene_synonym="E2F-2"
polyA_site 5193
/gene="E2F2"
/gene_synonym="E2F-2"
ORIGIN
aggactagagagcgagccgcaaggaagtcggtgcagtcgagacccccctccccatcccagcgcatcgcgtctccgccgagcttgagggcacgccggggacccctccccagagccggccggaccccaggtgccgaggccttggggagcgcggggcgtcccgggtcgcggtgccctcgggacgagacagcccctggcagtgccaccaccgcagccgccgggcgatctccaagcggcgatctctaagcgctgctctctgctcggccgcgggccaggaggggagggtccggccttgccccgcaggcgtccattggcggcttcccccggcctccgcgccatgccgcgggccgtgtgaaaggcggcagcaccggaacccgcaggtgtccgcgggcgcgccaagcccttttgggtagggggcgccttactcgctatgctgcaagggccccgggccttggcttcggccgctgggcagaccccgaaggtggtgcccgcgatgagccccacagagctgtggccatccggcctcagcagcccccagctctgcccagctactgctacctactacacaccgctgtacccgcagacggcgcctcccgcagcggcgccaggcacctgcctcgacgccactccccacggacccgagggccaagttgtgcgatgcctgccggcaggccggctgccggccaaaaggaagctggatctggaggggattgggaggcccgtcgtccctgagttcccaacccccaaggggaagtgcatcagagtggatggcctccccagccccaaaacccccaaatcccccggggagaagactcggtatgacacttcgctggggctgctcaccaagaagttcatttacctcctgagcgagtcagaggatggggtcctggacctgaactgggccgctgaggtgctggacgtgcagaagcggcgcatctatgacatcaccaacgtgctggaaggcatccagctcatccgcaagaaggccaagaacaacatccagtgggtaggcaggggaatgtttgaagaccccaccagacctgggaagcagcaacagctggggcaggagctgaaggagctgatgaacacggagcaggccttggaccagctcatccagagctgctctctgagcttcaagcacctgactgaggacaaggccaacaagaggctggcctatgtgacttaccaggatatccgtgctgttggcaactttaaggagcagacagtgattgccgtcaaggcccctccgcagacgagactggaagtgcccgacaggactgaggacaacctgcagatatatctcaagagcacccaagggcccatcgaagtctacctgtgcccagaggaggtgcaggagccggacagtccttccgaggagcctctcccctctacctccaccctctgccccagccctgactctgcccagcccagcagcagcaccgaccctagcatcatggagcccacagcatcctcagtgccagcaccagcgccaaccccccagcaggccccaccgcctccatccctggtccccttggaggctactgacagcctgctggagctgccgcacccactcctgcagcagactgaggaccagttcctgtccccgaccctggcgtgcagctcccctctgatcagcttctccccatccttggaccaggacgactacctgtggggcttggaggcgggtgagggcatcagcgatctcttcgactcctacgaccttggggacctgttgattaattgagtggccctgcctgcccccagcagcctgcccccgactctacctcctcacagacaggctgacagcccctctgcctgcacagggacattggacactaggtgctgccctcagggcatggggtctcctcgcctttcctgccccagccggcagaagctgtgtggggagatatgaatggtacgggtgaggagtggataaggggtggtcctcaccttcctaatggaagctgggcctagggaggcccatccagtcttctgacttctgacctctcacaagaaggctgcaggtgaggtggccaagtccagggaaaggccctgctacctccttttgaggggtaattaggaccctcgacgtaccaagaagcacataatgcctttgtatttatttcaggttgagttgtttgtttgtcctccctgagttttagcagggaggttgttctagtttttagtgagacctctgcagacaggcccatcactgtccatgttccagggcaggtctgggtttccaagggaggggcccaggctacatccttggtttccccactgtggtgggggctgggactctgaggggctgtccagtctgctagaatgctaattgcacttaggcctcatggttctagtaaacggcagctgtgggcccttttgcctcttcccctgttcttggcctcacatctccagctgagctgccggtcttggcttcctggtcgcctctgtcccagagatggtcccagggagccatcctagggcaggtagcactgaggctcctgtggaaacaggagccacctgctcaggagacccctttcctgaggaagtccttacctctccccttgagatgtaaaaatggtccagcagagacaagctcccgtggaaaacagacaggagcatgggggcagctgtcatggctgtggcgggcacttttcctcagagtttctgccttgcgctggtccaggagccattttgcaccaaggacttggtaggcagaggcagccccactgtaaagaagggtcagattaaaacaaaaaactgccaaaagcatcccctctgccccccatgtggcactggcatcattctctgcttccctgggaggaattttttcaccatgttattgaaggggatggttcattaaggactccacccctcagagctcactcagaccccaaggacagaggtgactggggcttggtgacttgttcactccttttttcccaggtatactgaaggggtgacagagagaggtcttcatggcagaccaggccttcacagctaatggggagaggaactcatgttacctctgcaggcctggggtcctgagggggtcttttggcttcagcctgttcccccagaggcttgatcatcccacattgtcccttcagctcagctgctcttctcccccacccaccctgggatgtgggtgctctgggctgaaccaaggctatgacttctggagagaggctcaggggttggtctgagaggcctgccatccacccctcagggagctaggttttctcagaggctcagctggacagcactttttagaaaagtttgtagcattaagctggtttaaaatatgaagttggttttgttggatggctcctgagctgactgactgatgtctgaagtttgagacgagggattatttcagggtggggcccaatgtgatctaatgcccagctggggacaattgtgcctcatcatttgctcaaattcctgggcccccaagttagccccctcccaggagtggtcagcgggtcacagctgcccccactctataagcagggctaattgtgtaccctttgcagaaatgcttttggtctcctacccaaatactcacaagggtcttatcagacgcccgtcttaaagtccagcatgctcagggaccctgtgtaggatctcgtttgtggtgagtgggctgctctgaggtctccactgggctgccatttagccatgtgccatctctgaagtcagaggtgtttgactcccattccttgggctctggagctttccccaagaattacatcagagaaaaggaagaaggggcctgcaggacccattgggaatgagtttaatactgaagtctggaatgtaagctcatgccctagaggcctctccatatggctggtcaggggagctgccttcaggcttgtgccccgtgtgctcagcagctgcctctgtccccctctactgtccctttcacaccttgcctggccaaggggctagacctcccaggctaagcctcagattcagtgcaggacacaagctcatgcccccgtcttgccagtgacacttgaagcctcccgacttccacagagtgcttcaggacacattttgagtggtattttcttttctttttttcttctttttttttttttttgagatggagtctcgctctgttgcccaggctggagtgcagtggcctgatctcggctcactgcaacctctgcctcccaggttcaagcgattcttctgcctcagcctccagagtagctgggactatagacatgcaccaccacgcccggctaattttgtatttttggtcgagacggggttttgccatgttagtcaggctggtcttgaactcctgacctcaagtgatccaccacctcggcctcccaaagtgttgagatgacaggcacgagccaccaggcccagcctgagtggtattttctttagggaccaggtagactttaaaacgagggtaagagaaaagccagtgtctttctgaggtaaataatttctgccaggaaacttcccagccccaccagcagcccccctaaaaaaatcactcgtgtccccagggacttctaaagcttggggctccaggaaatcatccagtagagttggagattcagagatttcttgaagccagggacatgctcctaactcctttcccattaaaggtgttagaatagaccagagggtgtcccttttccacagtaatgggatcggctggtgtgccttcagggaggaagagggaggtggtcaagcttgaaaaactggctttaggatggttctgactttgttctccctccccaagtgttctcaacctccattctgcagtgttcagagttttagggaaagggtttgggtgccccagcatccaggtgttgtgtggcttagcgcatgtgaagtgaaaaccttctggggttgtttggaagcagctttctggttcttgtgattgtatcctgaggtcccagaaccctattctcccacgaggatcctcagtgaccatggtggccacacgcctggccagcctgctggctcctgggtgagctgaagaaccttgcctgtggcacttttcgagggtgagctggaaccgagagaacatggtccccgtgctgggactcatgcgggtcatttcctgccggcctggtttcgcctggtcgtgtctttatgagcaccatgtaagcctccttgtattgagataattgggcattaaacattaaactgcagctctgggcaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1870 -> Molecular function: GO:0001047 [core promoter binding] evidence: IDA
GeneID:1870 -> Molecular function: GO:0003677 [DNA binding] evidence: TAS
GeneID:1870 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:1870 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1870 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:1870 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:1870 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
GeneID:1870 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:1870 -> Biological process: GO:0051726 [regulation of cell cycle] evidence: IEA
GeneID:1870 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1870 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IEA
by
@meso_cacase at
DBCLS
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