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2024-04-27 07:14:32, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004073 2369 bp mRNA linear PRI 05-MAY-2013
DEFINITION Homo sapiens polo-like kinase 3 (PLK3), mRNA.
ACCESSION NM_004073
VERSION NM_004073.2 GI:41872373
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2369)
AUTHORS Salvi,M., Trashi,E., Cozza,G., Franchin,C., Arrigoni,G. and
Pinna,L.A.
TITLE Investigation on PLK2 and PLK3 substrate recognition
JOURNAL Biochim. Biophys. Acta 1824 (12), 1366-1373 (2012)
PUBMED 22828320
REMARK GeneRIF: have identified and validated as in vitro PLK2 and PLK3
substrates HSP90, GRP-94, beta-tubulin, calumenin, and 14-3-3
epsilon
REFERENCE 2 (bases 1 to 2369)
AUTHORS Hintermair,C., Heidemann,M., Koch,F., Descostes,N., Gut,M., Gut,I.,
Fenouil,R., Ferrier,P., Flatley,A., Kremmer,E., Chapman,R.D.,
Andrau,J.C. and Eick,D.
TITLE Threonine-4 of mammalian RNA polymerase II CTD is targeted by
Polo-like kinase 3 and required for transcriptional elongation
JOURNAL EMBO J. 31 (12), 2784-2797 (2012)
PUBMED 22549466
REMARK GeneRIF: Here, the authors report phosphorylation of Thr4 by
Polo-like kinase 3 in mammalian cells.
REFERENCE 3 (bases 1 to 2369)
AUTHORS Wang,J., Beauchemin,M. and Bertrand,R.
TITLE Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle
progression and checkpoints
JOURNAL Cell. Signal. 23 (12), 2030-2038 (2011)
PUBMED 21840391
REMARK GeneRIF: Bcl-xL phosphorylation at Ser49 by polo-like kinase 3
during cell cycle progression and checkpoints
REFERENCE 4 (bases 1 to 2369)
AUTHORS Wang,L., Payton,R., Dai,W. and Lu,L.
TITLE Hyperosmotic stress-induced ATF-2 activation through Polo-like
kinase 3 in human corneal epithelial cells
JOURNAL J. Biol. Chem. 286 (3), 1951-1958 (2011)
PUBMED 21098032
REMARK GeneRIF: hyperosmotic stress can activate the Plk3 signaling
pathway that subsequently regulates the AP-1 complex by directly
phosphorylating ATF-2 independent from the effects of JNK and p38
activation.
REFERENCE 5 (bases 1 to 2369)
AUTHORS Naik,M.U. and Naik,U.P.
TITLE Calcium- and integrin-binding protein 1 regulates microtubule
organization and centrosome segregation through polo like kinase 3
during cell cycle progression
JOURNAL Int. J. Biochem. Cell Biol. 43 (1), 120-129 (2011)
PUBMED 20951827
REMARK GeneRIF: Calcium- and integrin-binding protein 1 regulates
microtubule organization and centrosome segregation through polo
like kinase 3 during cell cycle progression.
REFERENCE 6 (bases 1 to 2369)
AUTHORS Ouyang,B., Li,W., Pan,H., Meadows,J., Hoffmann,I. and Dai,W.
TITLE The physical association and phosphorylation of Cdc25C protein
phosphatase by Prk
JOURNAL Oncogene 18 (44), 6029-6036 (1999)
PUBMED 10557092
REFERENCE 7 (bases 1 to 2369)
AUTHORS Kauselmann,G., Weiler,M., Wulff,P., Jessberger,S., Konietzko,U.,
Scafidi,J., Staubli,U., Bereiter-Hahn,J., Strebhardt,K. and Kuhl,D.
TITLE The polo-like protein kinases Fnk and Snk associate with a Ca(2+)-
and integrin-binding protein and are regulated dynamically with
synaptic plasticity
JOURNAL EMBO J. 18 (20), 5528-5539 (1999)
PUBMED 10523297
REFERENCE 8 (bases 1 to 2369)
AUTHORS Ouyang,B., Pan,H., Lu,L., Li,J., Stambrook,P., Li,B. and Dai,W.
TITLE Human Prk is a conserved protein serine/threonine kinase involved
in regulating M phase functions
JOURNAL J. Biol. Chem. 272 (45), 28646-28651 (1997)
PUBMED 9353331
REFERENCE 9 (bases 1 to 2369)
AUTHORS Peng,C.Y., Graves,P.R., Thoma,R.S., Wu,Z., Shaw,A.S. and
Piwnica-Worms,H.
TITLE Mitotic and G2 checkpoint control: regulation of 14-3-3 protein
binding by phosphorylation of Cdc25C on serine-216
JOURNAL Science 277 (5331), 1501-1505 (1997)
PUBMED 9278512
REFERENCE 10 (bases 1 to 2369)
AUTHORS Li,B., Ouyang,B., Pan,H., Reissmann,P.T., Slamon,D.J., Arceci,R.,
Lu,L. and Dai,W.
TITLE Prk, a cytokine-inducible human protein serine/threonine kinase
whose expression appears to be down-regulated in lung carcinomas
JOURNAL J. Biol. Chem. 271 (32), 19402-19408 (1996)
PUBMED 8702627
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AJ293866.1, BC013899.2, BC013960.2, AA421212.1 and BC004135.2.
On Feb 3, 2004 this sequence version replaced gi:4758015.
Summary: Cytokine-inducible kinase is a putative serine/threonine
kinase. CNK contains both a catalytic domain and a putative
regulatory domain. It may play a role in regulation of cell cycle
progression and tumorigenesis. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC013899.2, AJ293866.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-13 AJ293866.1 140-152
14-1570 BC013899.2 14-1570
1571-2353 BC013960.2 1436-2218
2354-2357 AA421212.1 1-4 c
2358-2369 BC004135.2 2223-2234
FEATURES Location/Qualifiers
source 1..2369
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p34.1"
gene 1..2369
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="polo-like kinase 3"
/db_xref="GeneID:1263"
/db_xref="HGNC:2154"
/db_xref="HPRD:04222"
/db_xref="MIM:602913"
exon 1..310
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
misc_feature 20..22
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="upstream in-frame stop codon"
CDS 101..2041
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/EC_number="2.7.11.21"
/note="proliferation-related kinase; cytokine-inducible
kinase; FGF-inducible kinase; PLK-3; cytokine-inducible
serine/threonine-protein kinase"
/codon_start=1
/product="serine/threonine-protein kinase PLK3"
/protein_id="NP_004064.2"
/db_xref="GI:41872374"
/db_xref="CCDS:CCDS515.1"
/db_xref="GeneID:1263"
/db_xref="HGNC:2154"
/db_xref="HPRD:04222"
/db_xref="MIM:602913"
/translation="
MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
"
misc_feature 281..1042
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature 284..1042
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(302..316,326..328,365..367,371..373,467..469,
515..526,536..538,542..544,653..655,659..661,665..670,
674..676,707..709,716..718,764..775)
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(302..316,326..328,365..367,371..373,467..469,
515..526,536..538,653..655,659..661,665..670,674..676,
707..709)
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(314..316,536..538,542..544,653..655,659..661,
665..667,716..718,764..775)
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(704..724,764..775)
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1508..1699
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="POLO box duplicated region; Region: POLO_box;
pfam00659"
/db_xref="CDD:144309"
misc_feature 1802..>1960
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/note="POLO box duplicated region; Region: POLO_box;
pfam00659"
/db_xref="CDD:144309"
variation 207
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="c"
/db_xref="dbSNP:112086768"
variation 232
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:372090200"
variation 271
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:377105150"
variation 282
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:17884581"
variation 296
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:369823567"
variation 301
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:374476487"
variation 304
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:17884316"
exon 311..418
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 329
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373295341"
variation 331
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:17882004"
variation 340
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:145203618"
variation 370
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:148986415"
variation 391
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:41311199"
exon 419..535
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 432
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:147999693"
variation 457
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:150499493"
variation 458
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:141583375"
variation 483
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:113255805"
exon 536..665
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 544
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="c"
/db_xref="dbSNP:140199593"
variation 560
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:144798633"
variation 587
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373341543"
variation 588
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:142872152"
variation 598
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:376275667"
variation 635
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:187943956"
variation 637
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:142337193"
variation 650
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:147843910"
variation 661
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:372956515"
exon 666..753
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 689
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:201696175"
variation 718
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:372124188"
variation 728
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:192834831"
variation 731
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:375166158"
variation 734
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:55786996"
exon 754..849
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 811
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:150340586"
variation 812
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:150751604"
variation 823
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:368536189"
variation 845
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:138624511"
exon 850..1048
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 855
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:146191329"
variation 870
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:141585036"
variation 885
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139356641"
variation 901
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:144278029"
variation 903
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:372956892"
variation 909
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:374873402"
variation 947
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:17880471"
variation 952
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:144588011"
variation 962
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:183635555"
variation 971
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="c"
/db_xref="dbSNP:188046735"
variation 976
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:141393412"
variation 977
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200670234"
variation 996
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200000453"
variation 1004
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:151022853"
variation 1048
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:113071704"
exon 1049..1172
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1049
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:376266847"
variation 1060
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:201126945"
variation 1061
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:370347467"
variation 1065
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:11549456"
variation 1066
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:150150298"
variation 1073
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:140300759"
variation 1084
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:137889208"
variation 1085
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:199844223"
variation 1106
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="c"
/db_xref="dbSNP:112574988"
variation 1114
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:143812663"
variation 1146
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:375317245"
variation 1151
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200867561"
variation 1172
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:141933667"
exon 1173..1264
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1198
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:140777179"
variation 1207
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:149513425"
variation 1208
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:147444562"
variation 1219
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:149994530"
variation 1229
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:202193367"
variation 1234
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:17886354"
variation 1249
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:17884531"
variation 1258
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:145350752"
exon 1265..1358
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1331
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:375003454"
variation 1335
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:61789947"
variation 1347
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:369476256"
exon 1359..1442
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1368
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="t"
/db_xref="dbSNP:1804641"
variation 1372
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:367763271"
variation 1400
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:140688332"
exon 1443..1605
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1443
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:138312429"
variation 1456
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:11211036"
variation 1457
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:201492855"
variation 1463
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:202241709"
variation 1522
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:374959640"
variation 1523
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:201237567"
variation 1543
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:369110613"
variation 1547
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:17884653"
variation 1549
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:143263520"
variation 1550
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:200234281"
variation 1551
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:143522847"
variation 1570
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:150620830"
variation 1571
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:17855444"
variation 1593
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:17880829"
variation 1594
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:376386776"
exon 1606..1735
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1651
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373034569"
variation 1661
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:143496031"
variation 1667
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139294226"
variation 1696
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:200960803"
variation 1706
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:377380771"
exon 1736..1849
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1740
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:189573421"
variation 1760
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:61732496"
variation 1817
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:373854860"
variation 1837
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:199603205"
exon 1850..2358
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/inference="alignment:Splign:1.39.8"
variation 1883
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:369647110"
variation 1903
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:141071544"
variation 1929
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:55654497"
variation 1938
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="g"
/db_xref="dbSNP:151278318"
variation 1941
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:139393415"
variation 1951
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:147096151"
variation 1952
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:17881786"
variation 1964
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:11549457"
STS 2038..2260
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/standard_name="SHGC-74733"
/db_xref="UniSTS:76999"
variation 2064
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:140530007"
variation 2073
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:372111343"
variation 2164
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:185367591"
variation 2182
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="a"
/replace="g"
/db_xref="dbSNP:369956135"
variation 2204
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:189778487"
variation 2209
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="c"
/replace="t"
/db_xref="dbSNP:17880703"
variation 2238
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/replace="g"
/replace="t"
/db_xref="dbSNP:1804640"
polyA_signal 2335..2340
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
polyA_site 2350
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 2353
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 2358
/gene="PLK3"
/gene_synonym="CNK; FNK; PRK"
ORIGIN
cctgggcgccagcgcagcgtagcaaatccaggcagcgccacgcgcggccggggccgggcggaaccgagaagccgggaccgcgctgcgacgcgccggccgcatggagcctgccgccggtttcctgtctccgcgccccttccagcgtgcggccgccgcgcccgctcccccggccgggcccgggccgcctccgagtgccttgcgcggacctgagctggagatgctggccgggctaccgacgtcagaccccgggcgcctcatcacggacccgcgcagcggccgcacctacctcaaaggccgcttgttgggcaaggggggcttcgcccgctgctacgaggccactgacacagagactggcagcgcctacgctgtcaaagtcatcccgcagagccgcgtcgccaagccgcatcagcgcgagaagatcctaaatgagattgagctgcaccgagacctgcagcaccgccacatcgtgcgtttttcgcaccactttgaggacgctgacaacatctacattttcttggagctctgcagccgaaagtccctggcccacatctggaaggcccggcacaccctgttggagccagaagtgcgctactacctgcggcagatcctttctggcctcaagtacttgcaccagcgcggcatcttgcaccgggacctcaagttgggaaattttttcatcactgagaacatggaactgaaggtgggggattttgggctggcagcccggttggagcctccggagcagaggaagaagaccatctgtggcacccccaactatgtggctccagaagtgctgctgagacagggccacggccctgaggcggatgtatggtcactgggctgtgtcatgtacacgctgctctgcgggagccctccctttgagacggctgacctgaaggagacgtaccgctgcatcaagcaggttcactacacgctgcctgccagcctctcactgcctgcccggcagctcctggccgccatccttcgggcctcaccccgagaccgcccctctattgaccagatcctgcgccatgacttctttaccaagggctacacccccgatcgactccctatcagcagctgcgtgacagtcccagacctgacaccccccaacccagctaggagtctgtttgccaaagttaccaagagcctctttggcagaaagaagaagagtaagaatcatgcccaggagagggatgaggtctccggtttggtgagcggcctcatgcgcacatccgttggccatcaggatgccaggccagaggctccagcagcttctggcccagcccctgtcagcctggtagagacagcacctgaagacagctcaccccgtgggacactggcaagcagtggagatggatttgaagaaggtctgactgtggccacagtagtggagtcagccctttgtgctctgagaaattgtatagccttcatgcccccagcggaacagaacccggcccccctggcccagccagagcctctggtgtgggtcagcaagtgggttgactactccaataagttcggctttgggtatcaactgtccagccgccgtgtggctgtgctcttcaacgatggcacacatatggccctgtcggccaacagaaagactgtgcactacaatcccaccagcacaaagcacttctccttctccgtgggtgctgtgccccgggccctgcagcctcagctgggtatcctgcggtacttcgcctcctacatggagcagcacctcatgaagggtggagatctgcccagtgtggaagaggtagaggtacctgctccgcccttgctgctgcagtgggtcaagacggatcaggctctcctcatgctgtttagtgatggcactgtccaggtgaacttctacggggaccacaccaagctgattctcagtggctgggagcccctccttgtgacttttgtggcccgaaatcgtagtgcttgtacttacctcgcttcccaccttcggcagctgggctgctctccagacctgcggcagcgactccgctatgctctgcgcctgctccgggaccgcagcccagcctaggacccaagccctgaggcctgaggcctgtgcctgtcaggctctggcccttgcctttgtggccttcccccttcctttggtgcctcactgggggctttgggccgaatcccccagggaatcagggaccagctttactggagttgggggcggcttgtcttcgctggctcctaccccatctccaagataagcctgagccttagctcccagctagggggcgttatttatggaccacttttatttattgtcagacacttatttattgggatgtgagccccaggggggcctcctcctaggataataaacaattttgcagaattggaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1263 -> Molecular function: GO:0002039 [p53 binding] evidence: IDA
GeneID:1263 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:1263 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1263 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1263 -> Biological process: GO:0000075 [cell cycle checkpoint] evidence: ISS
GeneID:1263 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: IMP
GeneID:1263 -> Biological process: GO:0000084 [S phase of mitotic cell cycle] evidence: IMP
GeneID:1263 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
GeneID:1263 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:1263 -> Biological process: GO:0000302 [response to reactive oxygen species] evidence: IDA
GeneID:1263 -> Biological process: GO:0000910 [cytokinesis] evidence: TAS
GeneID:1263 -> Biological process: GO:0006468 [protein phosphorylation] evidence: TAS
GeneID:1263 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:1263 -> Biological process: GO:0006970 [response to osmotic stress] evidence: IDA
GeneID:1263 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IDA
GeneID:1263 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
GeneID:1263 -> Biological process: GO:0007093 [mitotic cell cycle checkpoint] evidence: TAS
GeneID:1263 -> Biological process: GO:0007113 [endomitotic cell cycle] evidence: TAS
GeneID:1263 -> Biological process: GO:0009314 [response to radiation] evidence: IDA
GeneID:1263 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
GeneID:1263 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: ISS
GeneID:1263 -> Biological process: GO:0090166 [Golgi disassembly] evidence: IDA
GeneID:1263 -> Biological process: GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia] evidence: IDA
GeneID:1263 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:1263 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:1263 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:1263 -> Cellular component: GO:0005795 [Golgi stack] evidence: IDA
GeneID:1263 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:1263 -> Cellular component: GO:0030425 [dendrite] evidence: IEA
GeneID:1263 -> Cellular component: GO:0043025 [neuronal cell body] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_004064 -> EC 2.7.11.21
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.