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2024-04-25 23:33:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004041 7539 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens arrestin, beta 1 (ARRB1), transcript variant 1, mRNA.
ACCESSION NM_004041
VERSION NM_004041.4 GI:320461703
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7539)
AUTHORS Li,J., Wei,B., Guo,A., Liu,C., Huang,S., Du,F., Fan,W., Bao,C. and
Pei,G.
TITLE Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis
with impaired TH17 cell differentiation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (18), 7395-7400 (2013)
PUBMED 23589893
REMARK GeneRIF: These findings indicate a critical role for beta-arrestin1
in the pathogenesis of collagen-induced arthritis and T(H)17 cell
differentiation.
REFERENCE 2 (bases 1 to 7539)
AUTHORS Pelzel,C., Begitt,A., Wenta,N. and Vinkemeier,U.
TITLE Evidence against a role for beta-arrestin1 in STAT1
dephosphorylation and the inhibition of interferon-gamma signaling
JOURNAL Mol. Cell 50 (1), 149-156 (2013)
PUBMED 23582260
REMARK GeneRIF: Data indicate that beta-arrestin1 is dispensable for STAT1
dephosphorylation and the termination of IFNgamma signaling.
REFERENCE 3 (bases 1 to 7539)
AUTHORS Ahn,K.H., Mahmoud,M.M., Shim,J.Y. and Kendall,D.A.
TITLE Distinct roles of beta-arrestin 1 and beta-arrestin 2 in
ORG27569-induced biased signaling and internalization of the
cannabinoid receptor 1 (CB1)
JOURNAL J. Biol. Chem. 288 (14), 9790-9800 (2013)
PUBMED 23449980
REMARK GeneRIF: analysis of roles of beta-arrestin 1 and beta-arrestin 2
in ORG27569-induced biased signaling and internalization of the
cannabinoid receptor 1
REFERENCE 4 (bases 1 to 7539)
AUTHORS Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
Johnson,J.A. and Boerwinkle,E.
TITLE Genome-wide association analyses suggest NELL1 influences adverse
metabolic response to HCTZ in African Americans
JOURNAL Pharmacogenomics J. (2013) In press
PUBMED 23400010
REMARK Publication Status: Available-Online prior to print
REFERENCE 5 (bases 1 to 7539)
AUTHORS Wang,L.G., Su,B.H. and Du,J.J.
TITLE Expression of beta-arrestin 1 in gastric cardiac adenocarcinoma and
its relation with progression
JOURNAL Asian Pac. J. Cancer Prev. 13 (11), 5671-5675 (2012)
PUBMED 23317236
REMARK GeneRIF: Overexpression of beta 1 arrestin in glandular epithelia
cells of mucinous adenocarcinoma is associated with gastric cardiac
adenocarcinoma.
REFERENCE 6 (bases 1 to 7539)
AUTHORS Goodman,O.B. Jr., Krupnick,J.G., Gurevich,V.V., Benovic,J.L. and
Keen,J.H.
TITLE Arrestin/clathrin interaction. Localization of the arrestin binding
locus to the clathrin terminal domain
JOURNAL J. Biol. Chem. 272 (23), 15017-15022 (1997)
PUBMED 9169477
REFERENCE 7 (bases 1 to 7539)
AUTHORS Iacovelli,L., Franchetti,R., Masini,M. and De Blasi,A.
TITLE GRK2 and beta-arrestin 1 as negative regulators of thyrotropin
receptor-stimulated response
JOURNAL Mol. Endocrinol. 10 (9), 1138-1146 (1996)
PUBMED 8885248
REFERENCE 8 (bases 1 to 7539)
AUTHORS Calabrese,G., Sallese,M., Stornaiuolo,A., Morizio,E., Palka,G. and
De Blasi,A.
TITLE Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome
11q13
JOURNAL Genomics 24 (1), 169-171 (1994)
PUBMED 7896272
REFERENCE 9 (bases 1 to 7539)
AUTHORS Parruti,G., Peracchia,F., Sallese,M., Ambrosini,G., Masini,M.,
Rotilio,D. and De Blasi,A.
TITLE Molecular analysis of human beta-arrestin-1: cloning, tissue
distribution, and regulation of expression. Identification of two
isoforms generated by alternative splicing
JOURNAL J. Biol. Chem. 268 (13), 9753-9761 (1993)
PUBMED 8486659
REFERENCE 10 (bases 1 to 7539)
AUTHORS Lohse,M.J., Benovic,J.L., Codina,J., Caron,M.G. and Lefkowitz,R.J.
TITLE beta-Arrestin: a protein that regulates beta-adrenergic receptor
function
JOURNAL Science 248 (4962), 1547-1550 (1990)
PUBMED 2163110
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CR735690.1, BC003636.2,
AP001972.4, AK293758.1, DA358665.1, AL157484.1 and BM681392.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 29, 2011 this sequence version replaced gi:58219795.
Summary: Members of arrestin/beta-arrestin protein family are
thought to participate in agonist-mediated desensitization of
G-protein-coupled receptors and cause specific dampening of
cellular responses to stimuli such as hormones, neurotransmitters,
or sensory signals. Arrestin beta 1 is a cytosolic protein and acts
as a cofactor in the beta-adrenergic receptor kinase (BARK)
mediated desensitization of beta-adrenergic receptors. Besides the
central nervous system, it is expressed at high levels in
peripheral blood leukocytes, and thus the BARK/beta-arrestin system
is believed to play a major role in regulating receptor-mediated
immune functions. Alternatively spliced transcripts encoding
different isoforms of arrestin beta 1 have been described.
[provided by RefSeq, Jan 2011].
Transcript Variant: This variant (1) represents the longer
transcript variant and encodes the longer isoform (A).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC003636.2, AK289718.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-147 CR735690.1 38-184
148-2095 BC003636.2 1-1948
2096-3489 AP001972.4 167564-168957 c
3490-5032 AK293758.1 18-1560
5033-5177 DA358665.1 35-179
5178-6460 AL157484.1 1-1283
6461-6462 AP001972.4 164591-164592 c
6463-7515 AL157484.1 1284-2336
7516-7539 BM681392.1 1-24 c
FEATURES Location/Qualifiers
source 1..7539
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q13"
gene 1..7539
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/note="arrestin, beta 1"
/db_xref="GeneID:408"
/db_xref="HGNC:711"
/db_xref="HPRD:00146"
/db_xref="MIM:107940"
exon 1..244
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 93
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35382855"
variation 140
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:34386985"
CDS 225..1481
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/note="isoform A is encoded by transcript variant 1;
arrestin 2"
/codon_start=1
/product="beta-arrestin-1 isoform A"
/protein_id="NP_004032.2"
/db_xref="GI:10880136"
/db_xref="CCDS:CCDS44684.1"
/db_xref="GeneID:408"
/db_xref="HGNC:711"
/db_xref="HPRD:00146"
/db_xref="MIM:107940"
/translation="
MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR
"
misc_feature 225..713
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49407.2);
Region: Interaction with SRC (By similarity)"
misc_feature 276..746
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/note="Arrestin (or S-antigen), N-terminal domain; Region:
Arrestin_N; pfam00339"
/db_xref="CDD:201166"
misc_feature 357..482
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49407.2);
Region: Interaction with CHRM2 (By similarity)"
misc_feature 801..1280
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/note="Arrestin (or S-antigen), C-terminal domain; Region:
Arrestin_C; smart01017"
/db_xref="CDD:198085"
misc_feature 1176..1478
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49407.2);
Region: Interaction with TRAF6"
misc_feature 1377..1409
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P49407.2);
Region: [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif"
misc_feature 1458..1460
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by GRK5; propagated from
UniProtKB/Swiss-Prot (P49407.2); phosphorylation site"
misc_feature 1458..1460
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1458..1460
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:03479"
misc_feature 1458..1460
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 245..275
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 276..336
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 337..381
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 375
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:76716725"
exon 382..578
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 579..638
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 639..706
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 676
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:74550237"
variation 677
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75644954"
exon 707..842
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 843..927
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 928..1000
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 935
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76164956"
exon 1001..1138
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 1048
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:78979036"
exon 1139..1222
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 1210
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="t"
/db_xref="dbSNP:1132996"
exon 1223..1246
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 1247..1317
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 1318..1369
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
exon 1370..7522
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/inference="alignment:Splign:1.39.8"
variation 1398
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:77159361"
variation 1415
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1053781"
variation 1455
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:78052828"
variation 1469
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:78680537"
variation 1478
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75039319"
variation 1486
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="g"
/replace="t"
/db_xref="dbSNP:79269900"
variation 1489
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75794606"
variation 1577
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1053782"
STS 1610..1874
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="WI-21016"
/db_xref="UniSTS:68132"
polyA_site 2189
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
variation 3074
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35316816"
STS 3133..3260
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="WI-16137"
/db_xref="UniSTS:49577"
polyA_site 3264
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
variation 3441
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34598900"
variation 3556
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="c"
/db_xref="dbSNP:34601759"
variation 3698
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35329661"
variation 3731
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34824695"
STS 3911..4044
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="G31124"
/db_xref="UniSTS:13259"
STS 3953..4229
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="WI-20596"
/db_xref="UniSTS:13414"
variation 4244
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3893000"
STS 4950..5056
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="A009B14"
/db_xref="UniSTS:13309"
STS 4950..5056
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="G32376"
/db_xref="UniSTS:116965"
variation 5517
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376025219"
STS 6304..6375
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="STS-M78804"
/db_xref="UniSTS:11013"
variation 6941
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/replace="a"
/replace="g"
/db_xref="dbSNP:41429652"
STS 7350..7499
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
/standard_name="WI-15243"
/db_xref="UniSTS:19841"
polyA_signal 7483..7488
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
polyA_site 7522
/gene="ARRB1"
/gene_synonym="ARB1; ARR1"
ORIGIN
acaccccgcgcggttccacgcccctggccgcggcccgggcgctgcgctgctcgacgcggcgggcggcgggcggggaccgggggcgggggcggcggcggcggccgggagagcggaggaggcggagcagggagccgggagcgggctggcccgcgctcctcctgctggctggggattttccagcctgggcgctgacgccgcggacctccctgcgaccgtcgcggaccatgggcgacaaagggacccgagtgttcaagaaggccagtccaaatggaaagctcaccgtctacctgggaaagcgggactttgtggaccacatcgacctcgtggaccctgtggatggtgtggtcctggtggatcctgagtatctcaaagagcggagagtctatgtgacgctgacctgcgccttccgctatggccgggaggacctggatgtcctgggcctgacctttcgcaaggacctgtttgtggccaacgtacagtcgttcccaccggcccccgaggacaagaagcccctgacgcggctgcaggaacgcctcatcaagaagctgggcgagcacgcttaccctttcacctttgagatccctccaaaccttccatgttctgtgacactgcagccggggcccgaagacacggggaaggcttgcggtgtggactatgaagtcaaagccttctgcgcggagaatttggaggagaagatccacaagcggaattctgtgcgtctggtcatccggaaggttcagtatgccccagagaggcctggcccccagcccacagccgagaccaccaggcagttcctcatgtcggacaagcccttgcacctagaagcctctctggataaggagatctattaccatggagaacccatcagcgtcaacgtccacgtcaccaacaacaccaacaagacggtgaagaagatcaagatctcagtgcgccagtatgcagacatctgccttttcaacacagctcagtacaagtgccctgttgccatggaagaggctgatgacactgtggcacccagctcgacgttctgcaaggtctacacactgacccccttcctagccaataaccgagagaagcggggcctcgccttggacgggaagctcaagcacgaagacacgaacttggcctctagcaccctgttgagggaaggtgccaaccgtgagatcctggggatcattgtttcctacaaagtgaaagtgaagctggtggtgtctcggggcggcctgttgggagatcttgcatccagcgacgtggccgtggaactgcccttcaccctaatgcaccccaagcccaaagaggaacccccgcatcgggaagttccagagaacgagacgccagtagataccaatctcatagaacttgacacaaatgatgacgacattgtatttgaggactttgctcgccagagactgaaaggcatgaaggatgacaaggaggaagaggaggatggtaccggctctccacagctcaacaacagatagacgggccggccctgcctccacgtggctccggctccactctcgtgcactcggatgcttactcgtcttcttcctgttctggtttcttttcccctttgttcttccagtttctaccagggggccccgtgggcttccagatcacggtgatgaacctctggcctcaggattggccccacatcaccacgccaacaggaccacagcgcactggctccaccccatctctgccatctccactcccctccttttcatgctgtctcccagaaaagctgccagggctctggccttggaattggacttgagatggggagcagacaggggaggatggggaatgtgggacacggtgtggtgggcatgagggcttggaggggtggggatgagggctcaagacacgagagaagatgtccacggtcccaggtggttaacaaagttctggcagctaaaagatgaccgcgttgaaggccacctccttctggctgggaggggcagaactgtggacagattctcaatgcctttttgaagttctgacccaccaaagaccttctgccttcaccctcctccccacctgatgtccctctgtgtctgatagtgatgttggtgaaagttcgtagaccccaggagtagagaaaagcaactggactgactttcttaccagcagttacctagactgaggcaagctgtgtggactcacccaagtatatttcagtactgtcaggctgtgacatcttagctaccttgtatttcaagtgcatggccctgtctagagatatgcacagagagaaaagcagagggagggagggagggggtcttcagcaagcaccagcccccagcagagtgagctgaagctcctgaggagggttcccgaaggggggcgctcagagatgggggcagggggcggggagaggagagtctgccttatgtcccttccttgtggacttcacatggtcatgcaggaagtgaggatgggtgtccagcgggggccgaggccactagtatcctcctgcttccccctgccattctccagggctggactgaccctatggactgggagagagtgcctgaggccaccatgccacagtcaaagggggtcctatctcagaaggtggcagcatccactgagatatcctcacccgaagggaaggaggctgctgggtagcaaataagccccttcttttcttggtgagttgatgacctccaatagctcccagtgtcatgggtacccagtacgcattagctggtgttgggttgattgagacctggggcagttcctggggcaagaagccagatgggagatgagatagaaagtgttaggagttatcctctttgcctggcctttgagaataacttactgtgtgactttgggcaagttccttccccactctgggcctcagtttctcacttgggaaagcaaggagtttgaccagatgatcacaatgggccttcctagctctggccaccaagaatttgtgaacattagagctcctggtctggtgggtagagccagagctgctgactggtctctctgcctccagaggggatttattggacctcagaggtggcagggccctatggagcaccaactgccctcaaccccaccctgtgcccaagactgggaagggattgatgtcaggctgtggccataggtagcatgagttgcccaaggagggacagagcatatctttgctgaggcttggctgaggggcttatgatagggcttgcagtacctcacagccccctgtgggcacagacaccctgaggtttacccaggcaaatatattgattagcaggacaagggctctctcctcagtttctgctcccttccatctctctcccatacttgtctgaaaagggagacaaaaaatcttatacaagtggcatctcaatcctttccagtccagcacctcctggggcaggcagtgtgacttatttcctgtggtgaaatcacctgtttcacaagcctggcagcgcgacttctgagtctcatgaccactcaacccaagggacccctccccagaccagaaccaagtcagctgggggctgtcgtactaccctgtccagtcttgagggcctagttgcaggtcccccaggcatccagcccctcctagagcttgctgggcaggctgcacctcatctgggcaggcgcagagctgatgaaatgctggagcaatgcatggcaaacatatgccctccagtgtcttctgaaacctttggggctgacacaagatcctttagtgtttgggatgacctctttcctgcagacttcttcccctatccctaactcatgcatggaaaacgtttgtcaggctggtttcccgagcctcctgcacctcaacatcacgctcacccttttgggtttagcccagtgttatttagcaaatttctccagctgcagggaaggatcagagcactatcttttttttttttttttctcctggagccaggactgcacaaggcaatggccaaatttagttgaattcagcctaccatcctttgctgatgactcagctctatgccaagtactggagccacagagatgggtcagtcccagcccctgtcctcaggaagcccatggtcagggaaacgttgtagggataagtaatagagggcagttgccttcagggctcctggtggctgctggtccctatggtgccttgatgtgaattagaagacggtgccctttccaggtggattcagacctacactagaacgcacagctttgggagtgacacacaggttggattttagcaccccttgccccttggccagaggtgccctgctgcacggccatacgctgcagcctcgagggacacacaggccaaagtgtttccttcagcctcttcctggagaggaagccgcaggtcatgtttccaagcttctggtcaactccaggcaccacctcccagcccccaaacatggccgagccagtgcttctctgcagggcccctttcctttctggagtcagcctgcccaggtgataccttgaagtgaaactaggggtgggggagcctcactaggccccaggcaccatcccacagtactggcggtttctctgccaagtgtttggggcctgcactggccaagccatccgtcactgggactttgcagtgtgccctgtgggtggcgtgtggacaccggtccgggcaggaaggaaaagcatgccccggtgaaaacccaccgagcagagagccagcgggacctcctcagcattccacccaggggaagagttcagtccccatgaagataaggactgagttatttggctgcacctctcctcagcctcaaagctcagacctgctagagtgggttcacctggctgttggttctgtgggagagttcctgacaagctggttcctacatggtgcagtgaaaggaactctgtcctggaagtccccaatgccgcctctcagtcctgcctgtcaccaaccacctggggggcttgggcaagctactcaacctctggggctcaatttccctaactgtaaaatgggattgtaatcccttccctgcctgacgcaggaattgttatgaggcccagatgagatgaaagtcagcggtcagggctctgtaagttgaaaatggctggatgtgtgtggccctgccactgcagggatggcccaaggtcacacagaaagtttgctgcaggaggagccctccccaccagtcttcatcgcttgccctgcttctcacttaggcagatgtcaaccagaatgagatacagccaatttggctttgatgacccagctgagagggaaatttagatacaattcaggaatatcatgcccaaaaatagtggtcccagcaaccaggacacagagggaagacctggatattgtcagtgattggtggagggggacatcttggaccctcctaggcctggtgtcacatctcccatctctcagaccccacagaggccaaggggccttggctctgacccaggttaaagagagccaccagcccccaggctcagggagctgaaaccacccatccgcagaaatctaagggcaaggagaaatagaaattgtctgttccttcccttcaaagtgtaaggcctcttccaggagcaactggagccaccacagcttctcagtgacattgggagggcttcgggcccaggaaaaacccaagccttttgtcctgagagccgagccacagcggatgcagtggcgtcagcatcccagagcggcagcttctctcctgcctgtcactggggactggttgctctccacccatccaggaggaaggggttaggtcccagtcttacactcttatagggtctcatggacataggcctatgcctgttctgatatctataattttttaaactcaaaaggaccaaaacactcctgaaccctcatctatacggcctgcactgggcttggtgtttcctcctggcccaggcagctccatctcttctgccattcctcctggacgaaagtggcaggaccccacctctaccacttccccacagggtcactgcacagcggcttcaaagacacgccctgttgaaggggaaacatcctccccccatcacactccaactcgtcaccccaaaagggaagtcaaagcacaggtccgtggggcctatggtttgtagacactgacacagtggttttcaaaccaggtgctgcggaacccctgatattccacagagctttgtcaggggatgctaaagtgggaagatgggagtggaggcaaaggataggtttccagccctcctcccatttccgccgccaccagaataactctgcttttatctgtcttgcctactgagatttcattttcaagctttctttgaagaagaacttcaaaccaccatctcgaggtttgatcttagaccagccagcacaggttctattcttgctgttcatgttggaatggctccagcgttccagtacaaagtgtctttgtgttggaacttgggtcacagacccaggcacaagcatttatacacacacacacacacacacacacacacacacacacacacgtacatagttgatggtttttctagccaacccaccctgaagctctggccaaggtttgatttggacagggacctggtgctcagtggggatgggtcgtgaccctgatattggcccatgaagcatggggagctctggagcaaggaaacaggctcaatcccccactgaggacttgtgtctgcacccctatctggcaccccactttcctggcctaggcccaagggacacagcaggagaagcagtgtgataggagagaggctagggttaaattcatctttacacagcgccggatggatggaaatcttggctcacataaaagacagactcagggaggattttatgacaaaagtccctcctttgagggcaggattcccccaggaatcctggacactttagtgagaactggaccagcccttggcacaaaaccctgcctgccctgtcccccactcccaccccccagggaattctaggtgaaaatgtgaagctcagggcacagcaagcgcatgacacgggtgtattacattcggtccgagtgtgtccttagtttccctgtgtgcaaaatggggctagtccaggctcttcccacctcactgggacaattgcaagggtcataggagaggtgggtatgataggtggtcatatgaggtggtgagtatgagaggtgggtgcctcacaaactcggggtatggtcctgacctgcatggcagatgagcagagcacttgggaacgagcataggaagtgccatcttcccgggcatctctgctcagtgttaaggtctagccacagacactgtgggacctgcctcttcctatggaatgggggcctgcatgggttgtgtcctggggcaggagtgagggatggctgggaagaatctccaggtctgtggcccttgtgttgagtgattattttgtgacactctcattcctggaccacctgccaggtttatctgttatacctgtggcattcttattatgtcagacaagttattatagttcattcaactctaacaaatgaacaaaagaacaataaataggaggccattaaaggtcttttgtggcagaggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:408 -> Molecular function: GO:0004402 [histone acetyltransferase activity] evidence: IDA
GeneID:408 -> Molecular function: GO:0004857 [enzyme inhibitor activity] evidence: TAS
GeneID:408 -> Molecular function: GO:0005096 [GTPase activator activity] evidence: IMP
GeneID:408 -> Molecular function: GO:0005159 [insulin-like growth factor receptor binding] evidence: IPI
GeneID:408 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:408 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
GeneID:408 -> Molecular function: GO:0031434 [mitogen-activated protein kinase kinase binding] evidence: IEA
GeneID:408 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:408 -> Molecular function: GO:0031701 [angiotensin receptor binding] evidence: IPI
GeneID:408 -> Molecular function: GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] evidence: IEA
GeneID:408 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IMP
GeneID:408 -> Biological process: GO:0002031 [G-protein coupled receptor internalization] evidence: IMP
GeneID:408 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IMP
GeneID:408 -> Biological process: GO:0006892 [post-Golgi vesicle-mediated transport] evidence: TAS
GeneID:408 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS
GeneID:408 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:408 -> Biological process: GO:0007602 [phototransduction] evidence: IEA
GeneID:408 -> Biological process: GO:0015031 [protein transport] evidence: IEA
GeneID:408 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
GeneID:408 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IMP
GeneID:408 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:408 -> Biological process: GO:0031397 [negative regulation of protein ubiquitination] evidence: IDA
GeneID:408 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:408 -> Biological process: GO:0032092 [positive regulation of protein binding] evidence: IEA
GeneID:408 -> Biological process: GO:0032715 [negative regulation of interleukin-6 production] evidence: IDA
GeneID:408 -> Biological process: GO:0032717 [negative regulation of interleukin-8 production] evidence: IDA
GeneID:408 -> Biological process: GO:0033138 [positive regulation of peptidyl-serine phosphorylation] evidence: IEA
GeneID:408 -> Biological process: GO:0035025 [positive regulation of Rho protein signal transduction] evidence: IMP
GeneID:408 -> Biological process: GO:0035066 [positive regulation of histone acetylation] evidence: IMP
GeneID:408 -> Biological process: GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] evidence: IEA
GeneID:408 -> Biological process: GO:0043149 [stress fiber assembly] evidence: IMP
GeneID:408 -> Biological process: GO:0043161 [proteasomal ubiquitin-dependent protein catabolic process] evidence: IMP
GeneID:408 -> Biological process: GO:0043547 [positive regulation of GTPase activity] evidence: IMP
GeneID:408 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:408 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IDA
GeneID:408 -> Biological process: GO:0090240 [positive regulation of histone H4 acetylation] evidence: IMP
GeneID:408 -> Cellular component: GO:0000139 [Golgi membrane] evidence: TAS
GeneID:408 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:408 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:408 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:408 -> Cellular component: GO:0005765 [lysosomal membrane] evidence: TAS
GeneID:408 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:408 -> Cellular component: GO:0005834 [heterotrimeric G-protein complex] evidence: TAS
GeneID:408 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:408 -> Cellular component: GO:0005905 [coated pit] evidence: IEA
GeneID:408 -> Cellular component: GO:0030659 [cytoplasmic vesicle membrane] evidence: TAS
GeneID:408 -> Cellular component: GO:0031143 [pseudopodium] evidence: IEA
GeneID:408 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: IDA
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