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2024-04-25 05:48:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_004040 2384 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens ras homolog family member B (RHOB), mRNA.
ACCESSION NM_004040
VERSION NM_004040.2 GI:42716309
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2384)
AUTHORS Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L,
Gorlova OY, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P,
Garcia de la Pena P, Oreiro N, Roman-Ivorra JA, Castillo MJ,
Gonzalez-Gay MA, Saez-Comet L, Castellvi I, Schuerwegh AJ, Voskuyl
AE, Hoffmann-Vold AM, Hesselstrand R, Nordin A, Lunardi C, Scorza
R, van Laar JM, Shiels PG, Herrick A, Worthington J, Fonseca C,
Denton C, Tan FK, Arnett FC, Assassi S, Koeleman BP, Mayes MD,
Radstake TR and Martin J.
CONSRTM Spanish Scleroderma Group
TITLE Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic
sclerosis risk factors in a large independent replication study
JOURNAL Ann. Rheum. Dis. 72 (4), 602-607 (2013)
PUBMED 22896740
REMARK GeneRIF: The variants in the RHOB gene were not associated with
systemic sclerosis or any of its subsets.
REFERENCE 2 (bases 1 to 2384)
AUTHORS Kazerounian,S., Gerald,D., Huang,M., Chin,Y.R., Udayakumar,D.,
Zheng,N., O'Donnell,R.K., Perruzzi,C., Mangiante,L., Pourat,J.,
Phung,T.L., Bravo-Nuevo,A., Shechter,S., McNamara,S.,
Duhadaway,J.B., Kocher,O.N., Brown,L.F., Toker,A., Prendergast,G.C.
and Benjamin,L.E.
TITLE RhoB differentially controls Akt function in tumor cells and
stromal endothelial cells during breast tumorigenesis
JOURNAL Cancer Res. 73 (1), 50-61 (2013)
PUBMED 23135917
REMARK GeneRIF: In cancer cells in vitro or in vivo, RhoB functions as a
tumor suppressor that restricts EGF receptor (EGFR) cell surface
occupancy as well as Akt signaling
REFERENCE 3 (bases 1 to 2384)
AUTHORS Casteel,D.E., Turner,S., Schwappacher,R., Rangaswami,H., Su-Yuo,J.,
Zhuang,S., Boss,G.R. and Pilz,R.B.
TITLE Rho isoform-specific interaction with IQGAP1 promotes breast cancer
cell proliferation and migration
JOURNAL J. Biol. Chem. 287 (45), 38367-38378 (2012)
PUBMED 22992742
REMARK GeneRIF: Data show that the IQ-motif-containing GTPase-activating
protein IQGAP1 interacts directly with GTP-bound, prenylated RhoA
and RhoC, but not with RhoB.
REFERENCE 4 (bases 1 to 2384)
AUTHORS Vega,F.M., Colomba,A., Reymond,N., Thomas,M. and Ridley,A.J.
TITLE RhoB regulates cell migration through altered focal adhesion
dynamics
JOURNAL Open Biol 2 (5), 120076 (2012)
PUBMED 22724071
REMARK GeneRIF: RhoB contributes to directional cell migration by
regulating beta1 integrin surface levels and activity, thereby
stabilizing lamellipodial protrusions.
REFERENCE 5 (bases 1 to 2384)
AUTHORS Sloan,C.M., Quinn,C.V., Peters,J.P., Farley,J., Goetzinger,C.,
Wernli,M., DeMali,K.A. and Ellerbroek,S.M.
TITLE Divergence of Rho residue 43 impacts GEF activity
JOURNAL Small GTPases 3 (1), 15-22 (2012)
PUBMED 22673745
REMARK GeneRIF: Substitution of Val 43 with an Ile in RhoB negatively
affected nucleotide exchange in vitro.
REFERENCE 6 (bases 1 to 2384)
AUTHORS Robertson,D., Paterson,H.F., Adamson,P., Hall,A. and Monaghan,P.
TITLE Ultrastructural localization of ras-related proteins using
epitope-tagged plasmids
JOURNAL J. Histochem. Cytochem. 43 (5), 471-480 (1995)
PUBMED 7537292
REFERENCE 7 (bases 1 to 2384)
AUTHORS Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
TITLE Post-translational modifications of p21rho proteins
JOURNAL J. Biol. Chem. 267 (28), 20033-20038 (1992)
PUBMED 1400319
REFERENCE 8 (bases 1 to 2384)
AUTHORS Cannizzaro,L.A., Madaule,P., Hecht,F., Axel,R., Croce,C.M. and
Huebner,K.
TITLE Chromosome localization of human ARH genes, a ras-related gene
family
JOURNAL Genomics 6 (2), 197-203 (1990)
PUBMED 2407642
REFERENCE 9 (bases 1 to 2384)
AUTHORS Chardin,P., Madaule,P. and Tavitian,A.
TITLE Coding sequence of human rho cDNAs clone 6 and clone 9
JOURNAL Nucleic Acids Res. 16 (6), 2717 (1988)
PUBMED 3283705
REFERENCE 10 (bases 1 to 2384)
AUTHORS Madaule,P. and Axel,R.
TITLE A novel ras-related gene family
JOURNAL Cell 41 (1), 31-40 (1985)
PUBMED 3888408
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK124398.1 and BM669284.1.
On Feb 20, 2004 this sequence version replaced gi:4757763.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript is intronless :: BC066954.1, AK124398.1 [ECO:0000345]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2099 AK124398.1 1-2099
2100-2366 AK124398.1 2101-2367
2367-2384 BM669284.1 1-18 c
FEATURES Location/Qualifiers
source 1..2384
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p24"
gene 1..2384
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="ras homolog family member B"
/db_xref="GeneID:388"
/db_xref="HGNC:668"
/db_xref="HPRD:01321"
/db_xref="MIM:165370"
exon 1..2367
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/inference="alignment:Splign:1.39.8"
variation 12
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:187592043"
variation 26
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:376654937"
variation 34
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:142159875"
variation 36
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:369192394"
variation 38
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:146047620"
variation 50
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:190672342"
variation 99..100
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:11541347"
variation 126
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:182910766"
variation 128
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:11541349"
variation 138
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:11541348"
variation 199
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:112161123"
variation 209
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:372979673"
misc_feature 318..320
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="upstream in-frame stop codon"
variation 379
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:202053864"
variation 381
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:200862679"
variation 383
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:368950198"
CDS 393..983
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="oncogene RHO H6; rho-related GTP-binding protein
RhoB; Aplysia RAS-related homolog 6; h6; rho cDNA clone 6;
ras homolog gene family, member B"
/codon_start=1
/product="rho-related GTP-binding protein RhoB precursor"
/protein_id="NP_004031.1"
/db_xref="GI:4757764"
/db_xref="CCDS:CCDS1699.1"
/db_xref="GeneID:388"
/db_xref="HGNC:668"
/db_xref="HPRD:01321"
/db_xref="MIM:165370"
/translation="
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL
"
mat_peptide 393..971
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/product="Rho-related GTP-binding protein RhoB"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P62745.1)"
misc_feature 402..935
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="GTPase SAR1 and related small G proteins [General
function prediction only]; Region: COG1100"
/db_xref="CDD:224025"
misc_feature 405..929
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="Ras homology family A (RhoA)-like includes RhoA,
RhoB and RhoC; Region: RhoA_like; cd01870"
/db_xref="CDD:206662"
misc_feature order(405..407,492..494,501..506,513..515,519..521,
525..527,552..554,564..569,573..581,588..590,594..596,
606..608)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="GEF (guanine nucleotide exchange factor)
interaction site [polypeptide binding]; other site"
/db_xref="CDD:206662"
misc_feature 426..449
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="G1 box; other site"
/db_xref="CDD:206662"
misc_feature order(435..452,492..497,501..503,567..572,744..746,
750..752,873..878)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206662"
misc_feature order(459..461,465..479,516..521,525..533,546..554,
879..884,894..899,906..908)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="PKN/PRK1 effector interaction site; other site"
/db_xref="CDD:206662"
misc_feature order(492..494,498..500,504..509,579..590,597..599,
606..608,672..674)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="GAP (GTPase-activating protein) interaction site
[polypeptide binding]; other site"
/db_xref="CDD:206662"
misc_feature 492..518
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P62745.1);
Region: Effector region (Potential)"
misc_feature 492..518
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="Switch I region; other site"
/db_xref="CDD:206662"
misc_feature order(501..506,573..575,588..590,594..599,603..608,
615..617,705..710,714..716)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="GDI (guanine nucleotide dissociation inhibitor)
interaction site [polypeptide binding]; other site"
/db_xref="CDD:206662"
misc_feature 501..503
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="G2 box; other site"
/db_xref="CDD:206662"
misc_feature order(507..509,585..599,606..608,681..683,693..695,
705..707)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="Mdia effector interaction site; other site"
/db_xref="CDD:206662"
misc_feature order(507..512,585..590,594..599,606..608)
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="Rho kinase (ROCK) effector interaction site
[polypeptide binding]; other site"
/db_xref="CDD:206662"
misc_feature 567..578
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="G3 box; other site"
/db_xref="CDD:206662"
misc_feature 576..629
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="Switch II region; other site"
/db_xref="CDD:206662"
misc_feature 741..752
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="G4 box; other site"
/db_xref="CDD:206662"
misc_feature 870..878
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/note="G5 box; other site"
/db_xref="CDD:206662"
misc_feature 957..959
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/experiment="experimental evidence, no additional details
recorded"
/note="palmitoylation site; modified site"
/citation=[7]
misc_feature 966..968
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/experiment="experimental evidence, no additional details
recorded"
/note="palmitoylation site; modified site"
/citation=[7]
misc_feature 969..971
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/experiment="experimental evidence, no additional details
recorded"
/note="Cysteine methyl ester; propagated from
UniProtKB/Swiss-Prot (P62745.1); methylation site"
misc_feature 969..971
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/experiment="experimental evidence, no additional details
recorded"
/note="prenylation site; modified site"
/citation=[7]
/db_xref="HPRD:03612"
misc_feature 969..971
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/experiment="experimental evidence, no additional details
recorded"
/note="prenylation site; modified site"
/citation=[7]
/db_xref="HPRD:00607"
variation 401
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:145485033"
variation 407
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:7043"
variation 453
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:140880883"
variation 491
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:145127070"
variation 494
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:201715144"
variation 500
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:376971291"
variation 503
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:140649204"
variation 504
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:11541350"
variation 530
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:371439659"
variation 578
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:201522561"
variation 592
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="g"
/replace="t"
/db_xref="dbSNP:201421541"
variation 596
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:61754182"
variation 597
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:62639992"
variation 626
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:200628855"
variation 692
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:147203679"
variation 752
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:142222635"
variation 770
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="g"
/replace="t"
/db_xref="dbSNP:137856773"
variation 773
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:199604392"
variation 811
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="g"
/replace="t"
/db_xref="dbSNP:376095527"
variation 844
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="g"
/replace="t"
/db_xref="dbSNP:140945749"
STS 845..966
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/standard_name="RH66820"
/db_xref="UniSTS:29414"
variation 857
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:143264692"
variation 890
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:148970048"
variation 938
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062149"
variation 980
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:373654925"
variation 1026
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062192"
variation 1166
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:182696067"
variation 1265
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="g"
/replace="t"
/db_xref="dbSNP:62121967"
variation 1290
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:112622561"
variation 1377
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062292"
variation 1416
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:187327344"
variation 1526
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="t"
/db_xref="dbSNP:192230103"
variation 1572
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:78953415"
variation 1592
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="g"
/db_xref="dbSNP:183777378"
variation 1681
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:115786444"
variation 1781
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:189132194"
variation 1893
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:192183115"
variation 1959
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:145967445"
variation 1990
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:79242034"
variation 1999
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:139892391"
variation 2011
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="g"
/db_xref="dbSNP:373830882"
variation 2099..2101
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="t"
/db_xref="dbSNP:34358430"
variation 2102..2103
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="t"
/replace="tt"
/db_xref="dbSNP:66460556"
variation 2104..2105
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="t"
/replace="tttt"
/db_xref="dbSNP:67442764"
variation 2111
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:79591078"
variation 2113
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:62121968"
variation 2127
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:77112597"
variation 2154
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:184500234"
STS 2158..2286
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/standard_name="RH44304"
/db_xref="UniSTS:4340"
variation 2230..2232
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="ttg"
/db_xref="dbSNP:71820361"
variation 2231..2233
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="tgt"
/db_xref="dbSNP:56774510"
variation 2234
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="gtt"
/db_xref="dbSNP:111311975"
variation 2241..2242
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace=""
/replace="t"
/db_xref="dbSNP:71795177"
variation 2319
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="c"
/replace="t"
/db_xref="dbSNP:143778278"
variation 2355
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:144805732"
variation 2361
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:3180120"
variation 2363
/gene="RHOB"
/gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
/replace="a"
/replace="c"
/db_xref="dbSNP:3180121"
ORIGIN
atctgccaccgcagtctggttggagctgttgtcttgtatgctcagcgaggcccggagagacccgggagagagctaggccgagtccaccgcccgagtctgctgcccgagcccgcgttacgcacaaagccgccgatccccggcctggggtgagcagagcgaccaccgcccgggagcagcgcggcgagacgcacggtgcgccctatgcccccgcgcccccaccgcccccgccgcggcagccgaagcgcagcgagagaacgcgccaccgcggggcccgggtgcagctagcgaccctctcgccacctgcgcgcagcccgaggtgagcagtgagcggcgagcgggagggcagcgaggcgttcgcgggccccctcctgctgcccgggcccggcccgctcatggcggccatccgcaagaagctggtggtggtgggcgacggcgcgtgtggcaagacgtgcctgctgatcgtgttcagtaaggacgagttccccgaggtgtacgtgcccaccgtcttcgagaactatgtggccgacattgaggtggacggcaagcaggtggagctggcgctgtgggacacggcgggccaggaggactacgaccgcctgcggccgctctcctacccggacaccgacgtcattctcatgtgcttctcggtggacagcccggactcgctggagaacatccccgagaagtgggtccccgaggtgaagcacttctgtcccaatgtgcccatcatcctggtggccaacaaaaaagacctgcgcagcgacgagcatgtccgcacagagctggcccgcatgaagcaggaacccgtgcgcacggatgacggccgcgccatggccgtgcgcatccaagcctacgactacctcgagtgctctgccaagaccaaggaaggcgtgcgcgaggtcttcgagacggccacgcgcgccgcgctgcagaagcgctacggctcccagaacggctgcatcaactgctgcaaggtgctatgagggccgcgcccgtcgcgcctgcccctgccggcacggctccccctcctggaccagtcccccgcgagcccggagaaggggagacccgtgtcccacaaggaccccaccggcctgcctggcatctgtctgctgacgcctctggcttgcgccaggacttggcgtgggcaccgggcgcccccatcccagtgtctgtgtgcgtccagctgtgttgcacaggcctgggctccccactgagtgccaagggtcccctgagcatgcttttctgaagagccgggcctcagagtgtgtggctgtgtgtctgttcgactcccctcgccccattttcaccccacccccgcctctgatccccgggggcgagattggcgcgggagtgtggccgcgccccatcagatgttctcccttcaccagcgggagcttgatatcccttgtctgtaacatagaccccgggtactgcgggaggggagggctgctggggaggatggggggatgttatataaatatagatataattttattttcggagctaagatggtgttatttaagggtggtgatgggtgagcgctctggcccaggctgggccagactcccgcccaagcatgaacaggacttgaccatctttccaacccctggggaagacatttgcaactgacttggggaggacacagcttcagcacagcctctcctgcgggccagcccgctgcgaaccctccaccagctaccggagggaggagggaggatgcgctgtggggttgtttttgccataagcgaactttgtgcctgtcctagaagtgaaaattgttcagtccaagaaactgatgttatttgatttatttaaaggctaaaatttgtttttttattctttgcacaattgtttcattgtttgacacttaatgcactcgtcatttgcatacgacagtagcattctgaccacacttgtacgctgtaacctcatctacttctgatgtttttaaaaaatgacttttaacaaggagagggaaaagaaacccactaaattttgctttgtttccttgaagaatgtggcaacactgttttgtgattttatttgtgcaggtcatgcacacagttttgataaagggcagtaacaagtattggggcctattttttttttttccacaaggcattctctaaagctatgtgaaattttctctgcacctctgtacagagaatacacctgcccctgtatatccttttttcccctcccctccctcccagtggtacttctactaaattgttgtcttgttttttattttttaaataaactgacaaatgacaaaatggtgagcttatgatgtttacataaaagttctataagctgtgtatacagttttttatgtaaaatattaaaagactatgatgatgacatttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:388 -> Molecular function: GO:0003924 [GTPase activity] evidence: TAS
GeneID:388 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:388 -> Molecular function: GO:0005525 [GTP binding] evidence: TAS
GeneID:388 -> Molecular function: GO:0019003 [GDP binding] evidence: IEA
GeneID:388 -> Biological process: GO:0000910 [cytokinesis] evidence: IMP
GeneID:388 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:388 -> Biological process: GO:0006184 [GTP catabolic process] evidence: TAS
GeneID:388 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:388 -> Biological process: GO:0006927 [transformed cell apoptotic process] evidence: ISS
GeneID:388 -> Biological process: GO:0007155 [cell adhesion] evidence: ISS
GeneID:388 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
GeneID:388 -> Biological process: GO:0007266 [Rho protein signal transduction] evidence: TAS
GeneID:388 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:388 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:388 -> Biological process: GO:0008333 [endosome to lysosome transport] evidence: IDA
GeneID:388 -> Biological process: GO:0015031 [protein transport] evidence: IEA
GeneID:388 -> Biological process: GO:0030168 [platelet activation] evidence: TAS
GeneID:388 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP
GeneID:388 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: ISS
GeneID:388 -> Biological process: GO:0045786 [negative regulation of cell cycle] evidence: ISS
GeneID:388 -> Biological process: GO:0051056 [regulation of small GTPase mediated signal transduction] evidence: TAS
GeneID:388 -> Biological process: GO:0070301 [cellular response to hydrogen peroxide] evidence: IDA
GeneID:388 -> Biological process: GO:0071479 [cellular response to ionizing radiation] evidence: IDA
GeneID:388 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:388 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:388 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:388 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:388 -> Cellular component: GO:0010008 [endosome membrane] evidence: IDA
GeneID:388 -> Cellular component: GO:0031902 [late endosome membrane] evidence: IEA
GeneID:388 -> Cellular component: GO:0032154 [cleavage furrow] evidence: IDA
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@meso_cacase at
DBCLS
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