GGRNA Home | Help | Advanced search

2019-03-23 03:23:49, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003856               2542 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript
            variant 2, mRNA.
ACCESSION   NM_003856
VERSION     NM_003856.2  GI:27894327
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Chen,L.Q., de Lemos,J.A., Das,S.R., Ayers,C.R. and Rohatgi,A.
  TITLE     Soluble ST2 is associated with all-cause and cardiovascular
            mortality in a population-based cohort: the Dallas Heart Study
  JOURNAL   Clin. Chem. 59 (3), 536-546 (2013)
   PUBMED   23220272
  REMARK    GeneRIF: Soluble ST2 is associated with all-cause and
            cardiovascular mortality in a population-based cohort.
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee
            JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K,
            Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z,
            Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN,
            Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A,
            Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De
            Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson
            LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas
            J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH,
            Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees
            CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W,
            Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M,
            Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber
            S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M,
            Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier
            RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V,
            Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD,
            Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and
            Cho JH.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Hirota,T., Takahashi,A., Kubo,M., Tsunoda,T., Tomita,K.,
            Sakashita,M., Yamada,T., Fujieda,S., Tanaka,S., Doi,S.,
            Miyatake,A., Enomoto,T., Nishiyama,C., Nakano,N., Maeda,K.,
            Okumura,K., Ogawa,H., Ikeda,S., Noguchi,E., Sakamoto,T., Hizawa,N.,
            Ebe,K., Saeki,H., Sasaki,T., Ebihara,T., Amagai,M., Takeuchi,S.,
            Furue,M., Nakamura,Y. and Tamari,M.
  TITLE     Genome-wide association study identifies eight new susceptibility
            loci for atopic dermatitis in the Japanese population
  JOURNAL   Nat. Genet. 44 (11), 1222-1226 (2012)
   PUBMED   23042114
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Salker,M.S., Nautiyal,J., Steel,J.H., Webster,Z., Sucurovic,S.,
            Nicou,M., Singh,Y., Lucas,E.S., Murakami,K., Chan,Y.W., James,S.,
            Abdallah,Y., Christian,M., Croy,B.A., Mulac-Jericevic,B., Quenby,S.
            and Brosens,J.J.
  TITLE     Disordered IL-33/ST2 activation in decidualizing stromal cells
            prolongs uterine receptivity in women with recurrent pregnancy loss
  JOURNAL   PLoS ONE 7 (12), E52252 (2012)
   PUBMED   23300625
  REMARK    GeneRIF: Il-33/ST2 activation in HESCS drives an autoinflammatory
            response that controls the temporal expression of receptivity genes
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Ramasamy A, Kuokkanen M, Vedantam S, Gajdos ZK, Couto Alves A, Lyon
            HN, Ferreira MA, Strachan DP, Zhao JH, Abramson MJ, Brown MA, Coin
            L, Dharmage SC, Duffy DL, Haahtela T, Heath AC, Janson C, Kahonen
            M, Khaw KT, Laitinen J, Le Souef P, Lehtimaki T, Madden PA, Marks
            GB, Martin NG, Matheson MC, Palmer CD, Palotie A, Pouta A,
            Robertson CF, Viikari J, Widen E, Wjst M, Jarvis DL, Montgomery GW,
            Thompson PJ, Wareham N, Eriksson J, Jousilahti P, Laitinen T,
            Pekkanen J, Raitakari OT, O'Connor GT, Salomaa V, Jarvelin MR and
            Hirschhorn JN.
  CONSRTM   Australian Asthma Genetics Consortium Collaborators
  TITLE     Genome-wide association studies of asthma in population-based
            cohorts confirm known and suggested loci and identify an additional
            association near HLA
  JOURNAL   PLoS ONE 7 (9), E44008 (2012)
   PUBMED   23028483
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Lohning,M., Stroehmann,A., Coyle,A.J., Grogan,J.L., Lin,S.,
            Gutierrez-Ramos,J.C., Levinson,D., Radbruch,A. and Kamradt,T.
  TITLE     T1/ST2 is preferentially expressed on murine Th2 cells, independent
            of interleukin 4, interleukin 5, and interleukin 10, and important
            for Th2 effector function
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (12), 6930-6935 (1998)
   PUBMED   9618516
REFERENCE   7  (bases 1 to 2542)
  AUTHORS   Kumar,S., Tzimas,M.N., Griswold,D.E. and Young,P.R.
  TITLE     Expression of ST2, an interleukin-1 receptor homologue, is induced
            by proinflammatory stimuli
  JOURNAL   Biochem. Biophys. Res. Commun. 235 (3), 474-478 (1997)
   PUBMED   9207179
REFERENCE   8  (bases 1 to 2542)
  AUTHORS   Yanagisawa,K., Naito,Y., Kuroiwa,K., Arai,T., Furukawa,Y.,
            Tomizuka,H., Miura,Y., Kasahara,T., Tetsuka,T. and Tominaga,S.
  TITLE     The expression of ST2 gene in helper T cells and the binding of ST2
            protein to myeloma-derived RPMI8226 cells
  JOURNAL   J. Biochem. 121 (1), 95-103 (1997)
   PUBMED   9058198
REFERENCE   9  (bases 1 to 2542)
  AUTHORS   Gayle,M.A., Slack,J.L., Bonnert,T.P., Renshaw,B.R., Sonoda,G.,
            Taguchi,T., Testa,J.R., Dower,S.K. and Sims,J.E.
  TITLE     Cloning of a putative ligand for the T1/ST2 receptor
  JOURNAL   J. Biol. Chem. 271 (10), 5784-5789 (1996)
   PUBMED   8621446
REFERENCE   10 (bases 1 to 2542)
  AUTHORS   Tominaga,S., Yokota,T., Yanagisawa,K., Tsukamoto,T., Takagi,T. and
            Tetsuka,T.
  TITLE     Nucleotide sequence of a complementary DNA for human ST2
  JOURNAL   Biochim. Biophys. Acta 1171 (2), 215-218 (1992)
   PUBMED   1482686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030975.1.
            On Jan 24, 2003 this sequence version replaced gi:4507244.
            
            Summary: The protein encoded by this gene is a member of the
            interleukin 1 receptor family. Studies of the similar gene in mouse
            suggested that this receptor can be induced by proinflammatory
            stimuli, and may be involved in the function of helper T cells.
            This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1
            receptor, type II (IL1R2) and interleukin 1 receptor-like 2
            (IL1RL2) form a cytokine receptor gene cluster in a region mapped
            to chromosome 2q12. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' and 3' UTR,
            compared to variant 1. The resulting isoform (2) has a distinct and
            shorter C-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030975.1, AK291578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2542
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="interleukin 1 receptor-like 1"
                     /db_xref="GeneID:9173"
                     /db_xref="HGNC:5998"
                     /db_xref="MIM:601203"
     exon            1..81
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1..79
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="Region: the 5' UTR different from variant 1"
     variation       11
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:7571371"
     variation       61
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185771771"
     exon            82..291
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       159
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13431828"
     variation       160
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77378267"
     variation       169
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370403265"
     misc_feature    216..218
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="upstream in-frame stop codon"
     variation       219
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372016897"
     CDS             231..1217
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; homolog of mouse growth stimulation-expressed;
                     interleukin 1 receptor-related protein; interleukin-1
                     receptor-like 1"
                     /codon_start=1
                     /product="interleukin-1 receptor-like 1 isoform 2
                     precursor"
                     /protein_id="NP_003847.2"
                     /db_xref="GI:27894328"
                     /db_xref="CCDS:CCDS2058.1"
                     /db_xref="GeneID:9173"
                     /db_xref="HGNC:5998"
                     /db_xref="MIM:601203"
                     /translation="
MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPSKECF
"
     sig_peptide     231..284
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
     misc_feature    276..542
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="First immunoglobulin (Ig)-like domain of
                     interleukin-1 receptor (IL1R) and similar proteins;
                     Region: Ig1_IL1R_like; cd05756"
                     /db_xref="CDD:143233"
     misc_feature    order(282..284,288..305)
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="antagonist binding site; other site"
                     /db_xref="CDD:143233"
     mat_peptide     285..1214
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /product="interleukin-1 receptor-like 1 isoform 2"
     misc_feature    582..842
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="Second immunoglobulin (Ig)-like domain of
                     interleukin-1 receptor (IL1R) and similar proteins;
                     Region: Ig2_IL1R_like; cd05757"
                     /db_xref="CDD:143234"
     misc_feature    order(582..587,591..602,618..620,633..635,639..641,
                     723..725,837..839)
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="antagonist binding site; other site"
                     /db_xref="CDD:143234"
     variation       249
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142516188"
     variation       250
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201837678"
     variation       257
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115399106"
     variation       269
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200098412"
     variation       283
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376279073"
     exon            292..502
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       335
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144435600"
     variation       339
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146539272"
     variation       365
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190188722"
     variation       366
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182781591"
     variation       369
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201523855"
     variation       374
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147316935"
     variation       403
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140931129"
     variation       408
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146872465"
     variation       414
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375754947"
     variation       420
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202037442"
     variation       463
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1041973"
     variation       468
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200028993"
     variation       469
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34210856"
     variation       487
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145568700"
     variation       490
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369779260"
     exon            503..677
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       529
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141061248"
     variation       536
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148229923"
     variation       543
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200221077"
     variation       545
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111382791"
     variation       552
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199800154"
     variation       597
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371207219"
     variation       599
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140675864"
     variation       614
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376294785"
     variation       629
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:149494752"
     variation       637
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143378674"
     variation       658
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367674419"
     variation       660
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141010284"
     variation       677
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200484415"
     exon            678..840
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       688
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114797672"
     variation       713
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142878092"
     variation       716
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189627011"
     variation       755
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200131845"
     variation       756
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34225180"
     variation       767
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368736748"
     variation       769
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141101455"
     variation       796
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148867750"
     variation       806
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112336397"
     variation       814
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201973706"
     variation       817
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200831341"
     variation       821
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368468978"
     variation       826
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368053458"
     variation       831
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137964169"
     variation       832
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143458919"
     variation       833
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201621624"
     variation       834
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201365371"
     exon            841..912
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       873
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75320001"
     variation       876
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111970215"
     variation       880
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:188504053"
     variation       882
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373122141"
     exon            913..1054
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       921
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75779188"
     variation       974
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150894779"
     variation       975
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146105446"
     variation       977
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372957266"
     variation       982
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140073514"
     exon            1055..2508
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /inference="alignment:Splign:1.39.8"
     variation       1088
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199635856"
     variation       1103
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35298562"
     variation       1116
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146406137"
     variation       1120
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140301260"
     variation       1121
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373664545"
     variation       1134
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150347157"
     variation       1159
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368714053"
     STS             1161..1325
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /standard_name="RH68200"
                     /db_xref="UniSTS:79528"
     variation       1175
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372391703"
     variation       1190
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202062299"
     misc_feature    1201..2542
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /note="Region: 3' region different from variant 1"
     STS             1266..1426
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /standard_name="D2S2552"
                     /db_xref="UniSTS:58525"
     variation       1266
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375803902"
     variation       1267
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191129267"
     variation       1301
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139756621"
     variation       1332
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12905"
     variation       1446
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144457031"
     variation       1534
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184372967"
     variation       1535
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3771175"
     variation       1584
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114464599"
     variation       1606
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3821204"
     variation       1641
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146609476"
     variation       1711
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:192786331"
     variation       1728
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368205427"
     variation       1810
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:13001714"
     variation       1812
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13007174"
     variation       1837
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:112204660"
     variation       1838
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113456083"
     variation       1858
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139845574"
     variation       1909
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:12712142"
     variation       1923
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116953957"
     variation       1926
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115600688"
     variation       1952
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:189187555"
     variation       1957
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114564028"
     variation       2042
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369264182"
     variation       2069
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113709807"
     variation       2117
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73004222"
     variation       2132
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181674853"
     variation       2144
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:13007819"
     variation       2149
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2160203"
     variation       2176
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114520889"
     variation       2183
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184750440"
     variation       2306
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149041524"
     variation       2397
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:189476163"
     variation       2406
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:58758331"
     variation       2430
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147861961"
     polyA_signal    2487..2492
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
     polyA_site      2508
                     /gene="IL1RL1"
                     /gene_synonym="DER4; FIT-1; IL33R; ST2; ST2L; ST2V; T1"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
gaggagggacctacaaagactggaaactattcttagctccgtcactgactccaagttcatcccctctgtctttcagtttggttgagatataggctactcttcccaactcagtcttgaagagtatcaccaactgcctcatgtgtggtgaccttcactgtcgtatgccagtgactcatctggagtaatctcaacaacgagttaccaatacttgctcttgattgataaacagaatggggttttggatcttagcaattctcacaattctcatgtattccacagcagcaaagtttagtaaacaatcatggggcctggaaaatgaggctttaattgtaagatgtcctagacaaggaaaacctagttacaccgtggattggtattactcacaaacaaacaaaagtattcccactcaggaaagaaatcgtgtgtttgcctcaggccaacttctgaagtttctaccagctgcagttgctgattctggtatttatacctgtattgtcagaagtcccacattcaataggactggatatgcgaatgtcaccatatataaaaaacaatcagattgcaatgttccagattatttgatgtattcaacagtatctggatcagaaaaaaattccaaaatttattgtcctaccattgacctctacaactggacagcacctcttgagtggtttaagaattgtcaggctcttcaaggatcaaggtacagggcgcacaagtcatttttggtcattgataatgtgatgactgaggacgcaggtgattacacctgtaaatttatacacaatgaaaatggagccaattatagtgtgacggcgaccaggtccttcacggtcaaggatgagcaaggcttttctctgtttccagtaatcggagcccctgcacaaaatgaaataaaggaagtggaaattggaaaaaacgcaaacctaacttgctctgcttgttttggaaaaggcactcagttcttggctgccgtcctgtggcagcttaatggaacaaaaattacagactttggtgaaccaagaattcaacaagaggaagggcaaaatcaaagtttcagcaatgggctggcttgtctagacatggttttaagaatagctgacgtgaaggaagaggatttattgctgcagtacgactgtctggccctgaatttgcatggcttgagaaggcacaccgtaagactaagtaggaaaaatccaagtaaggagtgtttctgagactttgatcacctgaactttctctagcaagtgtaagcagaatggagtgtggttccaagagatccatcaagacaatgggaatggcctgtgccataaaatgtgcttctcttcttcgggatgttgtttgctgtctgatctttgtagactgttcctgtttgctgggagcttctctgctgcttaaattgttcgtcctcccccactccctcctatcgttggtttgtctagaacactcagctgcttctttggtcatccttgttttctaactttatgaactccctctgtgtcactgtatgtgaaaggaaatgcaccaacaaccgtaaactgaacgtgttcttttgtgctcttttataacttgcattacatgttgtaagcatggtccgttctatacctttttctggtcataatgaacactcattttgttagcgagggtggtaaagtgaacaaaaaggggaagtatcaaactactgccatttcagtgagaaaatcctaggtgctactttataataagacatttgttaggccattcttgcattgatataaagaaatacctgagactgggtgatttatatgaaaagaggtttaattggctcacagttctgcaggctgtatgggaagcatggcggcatctgcttctggggacacctcaggagctttactcatggcagaaggcaaagcaaaggcaggcacttcacacagtaaaagcaggagcgagagagaggtgccacactgaaacagccagatctcatgagaagtcactcactattgcaaggacagcatcaaagagatggtgctaaaccattcatgatgaactcacccccatgatccaatcacctcccaccaggctccacctcgaatactggggattaccattcagcatgagatttgggcaggaacacagacccaaaccataccacacacattatcattgttaaactttgtaaagtatttaaggtacatggaacacacgggaagtctggtagctcagcccatttctttattgcatctgttattcaccatgtaattcaggtaccacgtattccagggagcctttcttggccctcagtttgcagtatacacactttccaagtactcttgtagcatcctgtttgtatcatagcactggtcacattgccttacctaaatctgtttgacagtctgctcaacacgactgcaagctccatgagggcagggacatcatctcttccatctttgggtccttagtgcaatacctggcagctagccagtgctcagctaaatatttgttgactgaataaatgaatgcacaaccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9173 -> Molecular function: GO:0002113 [interleukin-33 binding] evidence: IEA
            GeneID:9173 -> Molecular function: GO:0002114 [interleukin-33 receptor activity] evidence: IEA
            GeneID:9173 -> Molecular function: GO:0004896 [cytokine receptor activity] evidence: TAS
            GeneID:9173 -> Molecular function: GO:0004908 [interleukin-1 receptor activity] evidence: IEA
            GeneID:9173 -> Molecular function: GO:0005057 [receptor signaling protein activity] evidence: TAS
            GeneID:9173 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9173 -> Biological process: GO:0002826 [negative regulation of T-helper 1 type immune response] evidence: IEA
            GeneID:9173 -> Biological process: GO:0006955 [immune response] evidence: NAS
            GeneID:9173 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:9173 -> Biological process: GO:0032689 [negative regulation of interferon-gamma production] evidence: IEA
            GeneID:9173 -> Biological process: GO:0032754 [positive regulation of interleukin-5 production] evidence: IEA
            GeneID:9173 -> Biological process: GO:0043032 [positive regulation of macrophage activation] evidence: IEA
            GeneID:9173 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEA
            GeneID:9173 -> Biological process: GO:0050729 [positive regulation of inflammatory response] evidence: IEA
            GeneID:9173 -> Biological process: GO:0090197 [positive regulation of chemokine secretion] evidence: IEA
            GeneID:9173 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
            GeneID:9173 -> Cellular component: GO:0009897 [external side of plasma membrane] evidence: IEA
            GeneID:9173 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.