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2024-04-24 20:05:03, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003841 1512 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens tumor necrosis factor receptor superfamily, member
10c, decoy without an intracellular domain (TNFRSF10C), mRNA.
ACCESSION NM_003841
VERSION NM_003841.3 GI:301898781
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1512)
AUTHORS Vaitkiene,P., Skiriute,D., Skauminas,K. and Tamasauskas,A.
TITLE GATA4 and DcR1 methylation in glioblastomas
JOURNAL Diagn Pathol 8, 7 (2013)
PUBMED 23320456
REMARK GeneRIF: GATA4 and DcR1 promoter hypermethylation is tumor specific
event in glioblastoma but they promoter methylation cannot be
considered as a prognostic marker of glioblastoma survival.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1512)
AUTHORS Braga Lda,C., Alvares da Silva Ramos,A.P., Traiman,P., Silva,L.M.
and Lopes da Silva-Filho,A.
TITLE TRAIL-R3-related apoptosis: epigenetic and expression analyses in
women with ovarian neoplasia
JOURNAL Gynecol. Oncol. 126 (2), 268-273 (2012)
PUBMED 22555108
REMARK GeneRIF: Primary EOC is associated to a lower TRAIL-R3 expression.
REFERENCE 3 (bases 1 to 1512)
AUTHORS Chamuleau,M.E., Ossenkoppele,G.J., van Rhenen,A., van Dreunen,L.,
Jirka,S.M., Zevenbergen,A., Schuurhuis,G.J. and van de
Loosdrecht,A.A.
TITLE High TRAIL-R3 expression on leukemic blasts is associated with poor
outcome and induces apoptosis-resistance which can be overcome by
targeting TRAIL-R2
JOURNAL Leuk. Res. 35 (6), 741-749 (2011)
PUBMED 21281967
REMARK GeneRIF: Data show that about 20% of AML patients highly expressed
decoy receptor TRAIL-R3, which was strongly correlated to a
shortened overall survival.
REFERENCE 4 (bases 1 to 1512)
AUTHORS Bisgin,A., Terzioglu,E., Aydin,C., Yoldas,B., Yazisiz,V., Balci,N.,
Bagci,H., Gorczynski,R.M., Akdis,C.A. and Sanlioglu,S.
TITLE TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2
expression on CD8+ T cells correlate with the disease severity in
patients with rheumatoid arthritis
JOURNAL BMC Musculoskelet Disord 11, 192 (2010)
PUBMED 20799941
REMARK GeneRIF: Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on
CD4-positive T cells, are positively correlated with patients' DAS
scores.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1512)
AUTHORS Zhang,Z. and Henzel,W.J.
TITLE Signal peptide prediction based on analysis of experimentally
verified cleavage sites
JOURNAL Protein Sci. 13 (10), 2819-2824 (2004)
PUBMED 15340161
REFERENCE 6 (bases 1 to 1512)
AUTHORS Ruiz de Almodovar,C., Lopez-Rivas,A., Redondo,J.M. and Rodriguez,A.
TITLE Transcription initiation sites and promoter structure of the human
TRAIL-R3 gene
JOURNAL FEBS Lett. 531 (2), 304-308 (2002)
PUBMED 12417331
REMARK GeneRIF: analysis of the transcription initiation sites and
promoter structure of the TRAIL-R3 gene
REFERENCE 7 (bases 1 to 1512)
AUTHORS MacFarlane,M., Ahmad,M., Srinivasula,S.M., Fernandes-Alnemri,T.,
Cohen,G.M. and Alnemri,E.S.
TITLE Identification and molecular cloning of two novel receptors for the
cytotoxic ligand TRAIL
JOURNAL J. Biol. Chem. 272 (41), 25417-25420 (1997)
PUBMED 9325248
REFERENCE 8 (bases 1 to 1512)
AUTHORS Degli-Esposti,M.A., Smolak,P.J., Walczak,H., Waugh,J., Huang,C.P.,
DuBose,R.F., Goodwin,R.G. and Smith,C.A.
TITLE Cloning and characterization of TRAIL-R3, a novel member of the
emerging TRAIL receptor family
JOURNAL J. Exp. Med. 186 (7), 1165-1170 (1997)
PUBMED 9314565
REFERENCE 9 (bases 1 to 1512)
AUTHORS Sheridan,J.P., Marsters,S.A., Pitti,R.M., Gurney,A., Skubatch,M.,
Baldwin,D., Ramakrishnan,L., Gray,C.L., Baker,K., Wood,W.I.,
Goddard,A.D., Godowski,P. and Ashkenazi,A.
TITLE Control of TRAIL-induced apoptosis by a family of signaling and
decoy receptors
JOURNAL Science 277 (5327), 818-821 (1997)
PUBMED 9242611
REFERENCE 10 (bases 1 to 1512)
AUTHORS Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
TITLE An antagonist decoy receptor and a death domain-containing receptor
for TRAIL
JOURNAL Science 277 (5327), 815-818 (1997)
PUBMED 9242610
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC380668.1, AF012536.1 and
AF014794.1.
This sequence is a reference standard in the RefSeqGene project.
On Jul 30, 2010 this sequence version replaced gi:22547120.
Summary: The protein encoded by this gene is a member of the
TNF-receptor superfamily. This receptor contains an extracellular
TRAIL-binding domain and a transmembrane domain, but no cytoplasmic
death domain. This receptor is not capable of inducing apoptosis,
and is thought to function as an antagonistic receptor that
protects cells from TRAIL-induced apoptosis. This gene was found to
be a p53-regulated DNA damage-inducible gene. The expression of
this gene was detected in many normal tissues but not in most
cancer cell lines, which may explain the specific sensitivity of
cancer cells to the apoptosis-inducing activity of TRAIL. [provided
by RefSeq, Jul 2008].
CCDS Note: This CCDS representation uses a downstream AUG start
codon. This start codon has a strong Kozak signal and is restricted
to human. An upstream start codon, which has a weak Kozak signal
and is conserved in some other primates, is also present. The use
of the upstream start codon would result in a protein that is 40 aa
longer at the N-terminus. However, this would eliminate a signal
peptide that is predicted for the shorter but not the longer
N-terminus. PMID:9242611 shows experimental evidence for cleavage
of a signal peptide following aa 25 from the downstream start, and
this is also confirmed in PMID:15340161. Therefore, the downstream
start codon is represented for this CCDS.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF033854.1, AF016267.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-116 DC380668.1 1-116
117-1229 AF012536.1 1-1113
1230-1512 AF014794.1 1071-1353
FEATURES Location/Qualifiers
source 1..1512
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p22-p21"
gene 1..1512
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="tumor necrosis factor receptor superfamily, member
10c, decoy without an intracellular domain"
/db_xref="GeneID:8794"
/db_xref="HGNC:11906"
/db_xref="HPRD:04681"
/db_xref="MIM:603613"
exon 1..368
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/inference="alignment:Splign:1.39.8"
variation 66
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:73546638"
misc_feature 106
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="alternative transcription start site;
PMID:12417331"
misc_feature 133
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="alternative transcription start site;
PMID:12417331"
misc_feature 140
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="alternative transcription start site;
PMID:12417331"
misc_feature 150
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="alternative transcription start site;
PMID:12417331"
misc_feature 154
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="alternative transcription start site;
PMID:12417331"
misc_feature 180..182
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="upstream in-frame stop codon"
variation 227
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:41308122"
variation 242
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:139576559"
variation 247
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="g"
/replace="t"
/db_xref="dbSNP:41308124"
variation 268
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:376315455"
variation 270
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="g"
/replace="t"
/db_xref="dbSNP:200834372"
variation 305
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:375556643"
CDS 309..1088
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="decoy receptor 1; lymphocyte inhibitor of TRAIL;
antagonist decoy receptor for TRAIL/Apo-2L; cytotoxic
TRAIL receptor-3; decoy TRAIL receptor without death
domain; TNF-related apoptosis-inducing ligand receptor 3"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 10C precursor"
/protein_id="NP_003832.2"
/db_xref="GI:22547121"
/db_xref="CCDS:CCDS6037.1"
/db_xref="GeneID:8794"
/db_xref="HGNC:11906"
/db_xref="HPRD:04681"
/db_xref="MIM:603613"
/translation="
MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV
"
sig_peptide 309..377
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 378..1085
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/product="tumor necrosis factor receptor superfamily
member 10C"
misc_feature 429..695
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cd00185"
/db_xref="CDD:29147"
misc_feature order(429..431,459..461,471..473,477..479,501..503,
510..512,543..545)
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(459..488,498..512,612..620)
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature order(531..533,564..566,591..593,657..659,681..683)
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(540..545,561..569)
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 639..755
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="Tumor necrosis factor receptor / nerve growth
factor receptor repeats; Region: TNFR; smart00208"
/db_xref="CDD:128504"
misc_feature order(657..659,681..695)
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/note="90's loop TNF binding site; other site"
/db_xref="CDD:29147"
variation 328
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:10107826"
variation 329..330
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="cc"
/replace="tt"
/db_xref="dbSNP:374790272"
variation 329
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:10107827"
variation 332
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:376883302"
variation 334
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:191930177"
variation 351
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="g"
/replace="t"
/db_xref="dbSNP:147367612"
exon 369..474
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/inference="alignment:Splign:1.39.8"
variation 376
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:371065044"
variation 443
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:372665548"
exon 475..588
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/inference="alignment:Splign:1.39.8"
variation 480
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="g"
/db_xref="dbSNP:145921851"
variation 496
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:374294925"
variation 499
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:61756239"
variation 512
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:74480765"
variation 525
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:150502977"
variation 532
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:375695049"
variation 533
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:61736402"
variation 550
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:114291970"
variation 553
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:114358398"
variation 555
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:192946577"
variation 580
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:139657865"
variation 587
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:144392720"
exon 589..697
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/inference="alignment:Splign:1.39.8"
variation 601
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:367722416"
variation 619
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:201656774"
variation 650
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:371508678"
variation 658
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:146592155"
exon 698..1494
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/inference="alignment:Splign:1.39.8"
variation 716
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:181921509"
variation 728
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:369615757"
variation 734
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:373458956"
variation 775
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:376360379"
variation 797
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="g"
/replace="t"
/db_xref="dbSNP:35739295"
variation 814
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:200276762"
variation 822
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:76324416"
variation 824
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:113644198"
variation 853
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:61736404"
variation 855
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:372467352"
variation 859
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:61736405"
variation 860
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:41308126"
variation 869
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:11780493"
variation 904
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:12550828"
variation 914
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:151239314"
variation 935
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:140895906"
variation 949
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:61736406"
variation 959
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:11780526"
variation 994
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:9644063"
variation 1003
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:138041234"
variation 1004
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:149479140"
variation 1034
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:200178922"
variation 1043
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:370853616"
variation 1044
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:143879407"
variation 1098
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:370518771"
variation 1131
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:201593663"
variation 1209
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:139720010"
variation 1220
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:186114162"
variation 1275
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:190637563"
variation 1288
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="g"
/db_xref="dbSNP:117020629"
variation 1296
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="t"
/db_xref="dbSNP:182744474"
STS 1336..1463
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/standard_name="WI-11701"
/db_xref="UniSTS:70005"
variation 1440
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="c"
/db_xref="dbSNP:142617596"
variation 1444
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="c"
/replace="g"
/db_xref="dbSNP:375148091"
variation 1459
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
/replace="a"
/replace="g"
/db_xref="dbSNP:117325737"
polyA_site 1494
/gene="TNFRSF10C"
/gene_synonym="CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3;
TRAILR3; TRID"
ORIGIN
gaggccatgccccttttctgagtgcttggaagtgactgctgcaagtgacaagtgaccacgccttttcccccgcgggtataaattcagaggcgctgcgctccgattctggcagtgcagctgtgggaacctctccacgcgcacgaactcagccaacgatttctgatagatttttgggagtttgaccagagatgcaaggggtgaaggagcgcttcctaccgttagggaactctggggacagagcgccccggccgcctgatggccgaggcagggtgcgacccaggacccaggacggcgtcgggaaccataccatggcccggatccccaagaccctaaagttcgtcgtcgtcatcgtcgcggtcctgctgccagtcctagcttactctgccaccactgcccggcaggaggaagttccccagcagacagtggccccacagcaacagaggcacagcttcaagggggaggagtgtccagcaggatctcatagatcagaacatactggagcctgtaacccgtgcacagagggtgtggattacaccaacgcttccaacaatgaaccttcttgcttcccatgtacagtttgtaaatcagatcaaaaacataaaagttcctgcaccatgaccagagacacagtgtgtcagtgtaaagaaggcaccttccggaatgaaaactccccagagatgtgccggaagtgtagcaggtgccctagtggggaagtccaagtcagtaattgtacgtcctgggatgatatccagtgtgttgaagaatttggtgccaatgccactgtggaaaccccagctgctgaagagacaatgaacaccagcccggggactcctgccccagctgctgaagagacaatgaacaccagcccagggactcctgccccagctgctgaagagacaatgaccaccagcccggggactcctgccccagctgctgaagagacaatgaccaccagcccggggactcctgccccagctgctgaagagacaatgaccaccagcccggggactcctgcctcttctcattacctctcatgcaccatcgtagggatcatagttctaattgtgcttctgattgtgtttgtttgaaagacttcactgtggaagaaattccttccttacctgaaaggttcaggtaggcgctggctgagggcggggggcgctggacactctctgccctgcctccctctgctgtgttcccacagacagaaacgcctgcccctgccccaagtcctggtgtctccagcctggctctatcttcctccttgtgatcgtcccatccccacatcccgtgcaccccccaggaccctggtctcatcagtccctctcctggagctgggggtccacacatctcccagccaagtccaagagggcagggccagttcctcccatcttcaggcccagccaggcagggggcagtcggctcctcaactgggtgacaagggtgaggatgagaagtggtcacgggatttattcagccttggtcagagcagaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8794 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: TAS
GeneID:8794 -> Molecular function: GO:0045569 [TRAIL binding] evidence: IEA
GeneID:8794 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:8794 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:8794 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:8794 -> Cellular component: GO:0031225 [anchored to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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