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2024-04-25 21:57:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003821 2588 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens receptor-interacting serine-threonine kinase 2
(RIPK2), mRNA.
ACCESSION NM_003821
VERSION NM_003821.5 GI:93141034
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2588)
AUTHORS Cai,X., Du,J., Liu,Y., Xia,W., Liu,J., Zou,M., Wang,Y., Wang,M.,
Su,H. and Xu,D.
TITLE Identification and characterization of receptor-interacting protein
2 as a TNFR-associated factor 3 binding partner
JOURNAL Gene 517 (2), 205-211 (2013)
PUBMED 23333941
REMARK GeneRIF: In an attempt to explore TRAF3 binding partners that may
be involved in TRAF3-regulated signaling, a yeast two-hybrid screen
of a human spleen cDNA library was undertaken. RIP2 was identified
as a TRAF3 binding partner.
REFERENCE 2 (bases 1 to 2588)
AUTHORS Ver Heul,A.M., Fowler,C.A., Ramaswamy,S. and Piper,R.C.
TITLE Ubiquitin regulates caspase recruitment domain-mediated signaling
by nucleotide-binding oligomerization domain-containing proteins
NOD1 and NOD2
JOURNAL J. Biol. Chem. 288 (10), 6890-6902 (2013)
PUBMED 23300079
REMARK GeneRIF: Data suggest that ubiquitin (Ub) binding provides a
negative feedback loop upon NOD1 and NOD2 (nucleotide-binding
oligomerization domain-containing proteins)-dependent activation of
receptor-interacting protein kinase 2 (RIP2).
REFERENCE 3 (bases 1 to 2588)
AUTHORS Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
Vermeire,S., Barrett,J.C. and Cho,J.H.
CONSRTM International IBD Genetics Consortium (IIBDGC)
TITLE Host-microbe interactions have shaped the genetic architecture of
inflammatory bowel disease
JOURNAL Nature 491 (7422), 119-124 (2012)
PUBMED 23128233
REFERENCE 4 (bases 1 to 2588)
AUTHORS Wu,S., Kanda,T., Nakamoto,S., Imazeki,F. and Yokosuka,O.
TITLE Knockdown of receptor-interacting serine/threonine protein kinase-2
(RIPK2) affects EMT-associated gene expression in human hepatoma
cells
JOURNAL Anticancer Res. 32 (9), 3775-3783 (2012)
PUBMED 22993319
REMARK GeneRIF: RIPK2 might play an important role in hepatic cell
migration. These findings could shed new light on carcinogenesis
and on liver regeneration.
REFERENCE 5 (bases 1 to 2588)
AUTHORS Taxman,D.J., Lei,Y., Zhang,S., Holley-Guthrie,E., Offenbacher,S.
and Ting,J.P.
TITLE ASC-dependent RIP2 kinase regulates reduced PGE2 production in
chronic periodontitis
JOURNAL J. Dent. Res. 91 (9), 877-882 (2012)
PUBMED 22828789
REMARK GeneRIF: regulates reduced prostaglandin E2 production in chronic
periodontitis
REFERENCE 6 (bases 1 to 2588)
AUTHORS Inohara,N., Koseki,T., del Peso,L., Hu,Y., Yee,C., Chen,S.,
Carrio,R., Merino,J., Liu,D., Ni,J. and Nunez,G.
TITLE Nod1, an Apaf-1-like activator of caspase-9 and nuclear
factor-kappaB
JOURNAL J. Biol. Chem. 274 (21), 14560-14567 (1999)
PUBMED 10329646
REFERENCE 7 (bases 1 to 2588)
AUTHORS Bertin,J., Nir,W.J., Fischer,C.M., Tayber,O.V., Errada,P.R.,
Grant,J.R., Keilty,J.J., Gosselin,M.L., Robison,K.E., Wong,G.H.,
Glucksmann,M.A. and DiStefano,P.S.
TITLE Human CARD4 protein is a novel CED-4/Apaf-1 cell death family
member that activates NF-kappaB
JOURNAL J. Biol. Chem. 274 (19), 12955-12958 (1999)
PUBMED 10224040
REFERENCE 8 (bases 1 to 2588)
AUTHORS Thome,M., Hofmann,K., Burns,K., Martinon,F., Bodmer,J.L.,
Mattmann,C. and Tschopp,J.
TITLE Identification of CARDIAK, a RIP-like kinase that associates with
caspase-1
JOURNAL Curr. Biol. 8 (15), 885-888 (1998)
PUBMED 9705938
REFERENCE 9 (bases 1 to 2588)
AUTHORS McCarthy,J.V., Ni,J. and Dixit,V.M.
TITLE RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
JOURNAL J. Biol. Chem. 273 (27), 16968-16975 (1998)
PUBMED 9642260
REFERENCE 10 (bases 1 to 2588)
AUTHORS Inohara,N., del Peso,L., Koseki,T., Chen,S. and Nunez,G.
TITLE RICK, a novel protein kinase containing a caspase recruitment
domain, interacts with CLARP and regulates CD95-mediated apoptosis
JOURNAL J. Biol. Chem. 273 (20), 12296-12300 (1998)
PUBMED 9575181
REMARK Erratum:[J Biol Chem 1998 Jul 17;273(29):18675]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA040898.1, AY358814.1 and
AI824070.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 21, 2006 this sequence version replaced gi:40255024.
Summary: This gene encodes a member of the receptor-interacting
protein (RIP) family of serine/threonine protein kinases. The
encoded protein contains a C-terminal caspase activation and
recruitment domain (CARD), and is a component of signaling
complexes in both the innate and adaptive immune pathways. It is a
potent activator of NF-kappaB and inducer of apoptosis in response
to various stimuli. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY358814.1, AF027706.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-63 DA040898.1 1-63
64-2055 AY358814.1 1-1992
2056-2588 AI824070.1 1-533 c
FEATURES Location/Qualifiers
source 1..2588
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q21"
gene 1..2588
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="receptor-interacting serine-threonine kinase 2"
/db_xref="GeneID:8767"
/db_xref="HGNC:10020"
/db_xref="HPRD:04585"
/db_xref="MIM:603455"
exon 1..487
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 10
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:368068329"
variation 18
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199560220"
variation 37
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200731888"
variation 38
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:201500893"
variation 41
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199963938"
variation 51
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200464715"
variation 53
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201597341"
variation 58
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:115517126"
variation 67
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201169920"
variation 85
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:438243"
variation 100
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:202202705"
variation 104
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199801441"
variation 117
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201143747"
variation 144
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:202098541"
variation 156
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200267950"
variation 167
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200990169"
variation 168
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140020615"
variation 188
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200631105"
variation 198
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201523911"
variation 228
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199580324"
variation 237
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200192187"
variation 240
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371224967"
variation 260
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201245184"
variation 263
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73291433"
variation 267
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200627257"
variation 270
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201965208"
variation 271
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199566219"
variation 281
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200931262"
variation 297
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201755113"
misc_feature 300..302
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="upstream in-frame stop codon"
CDS 315..1937
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/EC_number="2.7.11.1"
/EC_number="2.7.10.2"
/note="receptor-interacting protein (RIP)-like interacting
caspase-like apoptosis regulatory protein (CLARP) kinase;
CARD-containing interleukin-1 beta-converting enzyme
(ICE)-associated kinase; growth-inhibiting gene 30;
CARD-carrying kinase; RIP-2; receptor-interacting protein
2; CARD-containing IL-1 beta ICE-kinase; tyrosine-protein
kinase RIPK2"
/codon_start=1
/product="receptor-interacting serine/threonine-protein
kinase 2"
/protein_id="NP_003812.1"
/db_xref="GI:4506537"
/db_xref="CCDS:CCDS6247.1"
/db_xref="GeneID:8767"
/db_xref="HGNC:10020"
/db_xref="HPRD:04585"
/db_xref="MIM:603455"
/translation="
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
"
misc_feature 375..1175
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="Protein kinase domain; Region: Pkinase; pfam00069"
/db_xref="CDD:200973"
misc_feature 378..1187
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(384..398,408..410,447..449,453..455,549..551,
597..608,618..620,624..626,750..752,756..758,762..767,
771..773,804..806,813..815,846..857)
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(384..398,408..410,447..449,453..455,549..551,
597..608,618..620,750..752,756..758,762..767,771..773,
804..806)
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(396..398,618..620,624..626,750..752,756..758,
762..764,813..815,846..857)
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(801..821,846..857)
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 816..818
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
misc_feature 840..842
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O43353.2); phosphorylation site"
misc_feature 840..842
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1401..1403
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
misc_feature 1491..1493
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
misc_feature 1626..1886
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/note="Caspase activation and recruitment domain of
Receptor Interacting Protein 2; Region: CARD_RIP2_CARD3;
cd08786"
/db_xref="CDD:176764"
misc_feature 1734..1736
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine, by autocatalysis; propagated from
UniProtKB/Swiss-Prot (O43353.2); phosphorylation site"
misc_feature 1893..1895
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
misc_feature 1899..1901
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
misc_feature 1905..1907
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
misc_feature 1929..1931
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O43353.2); phosphorylation site"
variation 341
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2293809"
variation 344
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200872639"
variation 346
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:11558818"
variation 350
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201625891"
variation 353
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:145668778"
variation 360
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138256567"
variation 364
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202204060"
variation 372
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200206389"
variation 378
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201325791"
variation 395
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:142758819"
variation 419
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200258974"
variation 425
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201130149"
variation 442
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199587269"
variation 444
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200399465"
variation 449
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201453980"
variation 476
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:372244188"
exon 488..641
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 510
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202051711"
variation 515
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201933732"
variation 557
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:372948601"
variation 558
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:199801531"
variation 614
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200736854"
variation 624
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:200818100"
exon 642..797
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 645
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200012651"
variation 682
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200964555"
variation 683
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:143616808"
variation 698
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202151044"
exon 798..955
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 812
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148055988"
variation 829
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141768697"
variation 850
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:202080836"
variation 867
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:147448769"
variation 887
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200485473"
variation 897
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201424642"
variation 926
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:56257721"
variation 935
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200839340"
variation 936
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201397208"
variation 953
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140457229"
exon 956..1005
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 984
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201490684"
exon 1006..1167
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 1015
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201631696"
variation 1089
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373852693"
variation 1090
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230801"
variation 1092
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375657882"
variation 1095
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202156416"
variation 1102
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2230802"
variation 1104
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368538168"
variation 1116
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35004667"
variation 1130
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:185951821"
variation 1148
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202013403"
variation 1157
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200162747"
exon 1168..1253
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 1195
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374514969"
variation 1213
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:113501262"
variation 1224
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:199715424"
variation 1239
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200899275"
variation 1253
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:35395048"
exon 1254..1343
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 1273
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201291360"
variation 1316
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201740409"
variation 1323
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199850869"
variation 1327
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201164963"
variation 1340
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:202109387"
variation 1341..1342
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace=""
/replace="g"
/db_xref="dbSNP:72249238"
exon 1344..1437
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 1351
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200625019"
variation 1385
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201478995"
variation 1397
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:199570893"
variation 1402
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200826927"
variation 1427
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace=""
/replace="t"
/db_xref="dbSNP:72297818"
variation 1433
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371304420"
exon 1438..1599
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 1440
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201124230"
variation 1443
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201993178"
variation 1447
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:145012807"
variation 1461
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:368231600"
variation 1465
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:200241122"
variation 1511
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:144876128"
variation 1514
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:1052720"
variation 1532
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202213761"
variation 1545
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:148803672"
variation 1546
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201134480"
variation 1559
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:56109184"
variation 1584
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200397135"
variation 1585
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201155764"
exon 1600..2585
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/inference="alignment:Splign:1.39.8"
variation 1603
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201741198"
variation 1614
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:199907869"
variation 1639
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200769968"
variation 1653
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201993993"
variation 1658
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199937839"
variation 1690
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:151303469"
variation 1722
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201181884"
variation 1743
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201967341"
variation 1766
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:200160003"
variation 1784
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:16900617"
variation 1795
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:367938611"
variation 1827
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201504169"
variation 1830
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201094757"
variation 1857
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201728754"
variation 1877
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200194636"
variation 1891
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201561176"
variation 1904
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:186397742"
variation 1908
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:202215265"
variation 1930
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:371815685"
variation 1962
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200466894"
variation 1966
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:201544199"
variation 1968
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:375229775"
variation 1971
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199573292"
variation 1975
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200835566"
polyA_site 1984
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
variation 2018
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201403469"
variation 2019
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:148928069"
polyA_site 2030
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
variation 2034
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200518169"
variation 2058
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201638848"
variation 2076
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200195273"
variation 2085
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:200799692"
variation 2093
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201970959"
polyA_site 2130
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
variation 2140
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145659908"
variation 2155
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200982255"
variation 2190
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201813591"
variation 2195
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:117440883"
variation 2196
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201188382"
variation 2245
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:201971248"
variation 2248
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200628189"
variation 2267
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201523744"
variation 2286
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:117941615"
variation 2288
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:16900627"
variation 2294
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201509311"
variation 2298
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:138298950"
variation 2317
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200793966"
variation 2355
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201550298"
variation 2356
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:199564321"
STS 2358..2520
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/standard_name="RH48506"
/db_xref="UniSTS:2139"
variation 2429
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="g"
/replace="t"
/db_xref="dbSNP:200930936"
variation 2459
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201760872"
variation 2461..2465
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace=""
/replace="aaaac"
/db_xref="dbSNP:139127134"
variation 2463..2467
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace=""
/replace="aacaa"
/db_xref="dbSNP:59258471"
variation 2463
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:199646435"
variation 2470
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200479145"
polyA_signal 2485..2490
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
variation 2492
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:201355110"
variation 2497
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="t"
/db_xref="dbSNP:200154668"
polyA_site 2505
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
variation 2540
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201173525"
variation 2549
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:201974867"
polyA_signal 2561..2566
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
polyA_site 2585
/gene="RIPK2"
/gene_synonym="CARD3; CARDIAK; CCK; GIG30; RICK; RIP2"
ORIGIN
gagctcgggcggccggagctggtcgctgcgcgcgccggggggagggccggggctgcgagagaggaagctctttcgcggcgctacggcgttggcaccagtctctagaaaagaagtcagctctggttcggagaagcagcggctggcgtgggccatccggggaatgggcgccctcgtgacctagtgttgcggggcaaaaagggtcttgccggcctcgctcgtgcaggggcgtatctgggcgcctgagcgcggcgtgggagccttgggagccgccgcagcagggggcacacccggaaccggcctgagcgcccgggaccatgaacggggaggccatctgcagcgccctgcccaccattccctaccacaaactcgccgacctgcgctacctgagccgcggcgcctctggcactgtgtcgtccgcccgccacgcagactggcgcgtccaggtggccgtgaagcacctgcacatccacactccgctgctcgacagtgaaagaaaggatgtcttaagagaagctgaaattttacacaaagctagatttagttacattcttccaattttgggaatttgcaatgagcctgaatttttgggaatagttactgaatacatgccaaatggatcattaaatgaactcctacataggaaaactgaatatcctgatgttgcttggccattgagatttcgcatcctgcatgaaattgcccttggtgtaaattacctgcacaatatgactcctcctttacttcatcatgacttgaagactcagaatatcttattggacaatgaatttcatgttaagattgcagattttggtttatcaaagtggcgcatgatgtccctctcacagtcacgaagtagcaaatctgcaccagaaggagggacaattatctatatgccacctgaaaactatgaacctggacaaaaatcaagggccagtatcaagcacgatatatatagctatgcagttatcacatgggaagtgttatccagaaaacagccttttgaagatgtcaccaatcctttgcagataatgtatagtgtgtcacaaggacatcgacctgttattaatgaagaaagtttgccatatgatatacctcaccgagcacgtatgatctctctaatagaaagtggatgggcacaaaatccagatgaaagaccatctttcttaaaatgtttaatagaacttgaaccagttttgagaacatttgaagagataacttttcttgaagctgttattcagctaaagaaaacaaagttacagagtgtttcaagtgccattcacctatgtgacaagaagaaaatggaattatctctgaacatacctgtaaatcatggtccacaagaggaatcatgtggatcctctcagctccatgaaaatagtggttctcctgaaacttcaaggtccctgccagctcctcaagacaatgattttttatctagaaaagctcaagactgttattttatgaagctgcatcactgtcctggaaatcacagttgggatagcaccatttctggatctcaaagggctgcattctgtgatcacaagaccactccatgctcttcagcaataataaatccactctcaactgcaggaaactcagaacgtctgcagcctggtatagcccagcagtggatccagagcaaaagggaagacattgtgaaccaaatgacagaagcctgccttaaccagtcgctagatgcccttctgtccagggacttgatcatgaaagaggactatgaacttgttagtaccaagcctacaaggacctcaaaagtcagacaattactagacactactgacatccaaggagaagaatttgccaaagttatagtacaaaaattgaaagataacaaacaaatgggtcttcagccttacccggaaatacttgtggtttctagatcaccatctttaaatttacttcaaaataaaagcatgtaagtgactgtttttcaagaagaaatgtgtttcataaaaggatatttatatctctgttgctttgactttttttatataaaatccgtgagtattaaagctttattgaaggttctttgggtaaatattagtctccctccatgacactgcagtattttttttaattaatacaagtaaaaagtttgaattttgctacatagttcaatttttatgtctcttttgttaacagaaaccacttttaaaggatagtaattattcttgtttataacagtgccttaaggtatgatgtatttctgatggaagccattttcacattcatgttcttcatggattatttgttacttgtctaagatgcaatttgattttatgaagtatataccctttacccaccagagacagtacagaatccctgccctaaaatcccaggcttaattgccctacaaagggttattaatttaaaactccattattaggattacattttaaagttttatttatgaattccctttaaaaatgatatttcaaaggtaaaacaatacaatataaagaaaaaaataaatatattaataccggcttcctgtccccatttttaacctcagccttccctactgtcaccaacaaccaagctaaataaagtcaacagcctgatgtgtaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8767 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:8767 -> Molecular function: GO:0004715 [non-membrane spanning protein tyrosine kinase activity] evidence: IEA
GeneID:8767 -> Molecular function: GO:0004871 [signal transducer activity] evidence: TAS
GeneID:8767 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8767 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:8767 -> Molecular function: GO:0030274 [LIM domain binding] evidence: IPI
GeneID:8767 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IDA
GeneID:8767 -> Molecular function: GO:0050700 [CARD domain binding] evidence: IDA
GeneID:8767 -> Molecular function: GO:0050700 [CARD domain binding] evidence: IPI
GeneID:8767 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
GeneID:8767 -> Biological process: GO:0001961 [positive regulation of cytokine-mediated signaling pathway] evidence: IEA
GeneID:8767 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0002250 [adaptive immune response] evidence: ISS
GeneID:8767 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0002827 [positive regulation of T-helper 1 type immune response] evidence: IEA
GeneID:8767 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:8767 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
GeneID:8767 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:8767 -> Biological process: GO:0007249 [I-kappaB kinase/NF-kappaB cascade] evidence: ISS
GeneID:8767 -> Biological process: GO:0007254 [JNK cascade] evidence: TAS
GeneID:8767 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: IMP
GeneID:8767 -> Biological process: GO:0031398 [positive regulation of protein ubiquitination] evidence: NAS
GeneID:8767 -> Biological process: GO:0031663 [lipopolysaccharide-mediated signaling pathway] evidence: IEA
GeneID:8767 -> Biological process: GO:0032722 [positive regulation of chemokine production] evidence: IEA
GeneID:8767 -> Biological process: GO:0032727 [positive regulation of interferon-alpha production] evidence: NAS
GeneID:8767 -> Biological process: GO:0032728 [positive regulation of interferon-beta production] evidence: NAS
GeneID:8767 -> Biological process: GO:0032729 [positive regulation of interferon-gamma production] evidence: IEA
GeneID:8767 -> Biological process: GO:0032735 [positive regulation of interleukin-12 production] evidence: NAS
GeneID:8767 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IEA
GeneID:8767 -> Biological process: GO:0032755 [positive regulation of interleukin-6 production] evidence: IEA
GeneID:8767 -> Biological process: GO:0032760 [positive regulation of tumor necrosis factor production] evidence: IEA
GeneID:8767 -> Biological process: GO:0033091 [positive regulation of immature T cell proliferation] evidence: IEA
GeneID:8767 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: IDA
GeneID:8767 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0042098 [T cell proliferation] evidence: IEA
GeneID:8767 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:8767 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
GeneID:8767 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IDA
GeneID:8767 -> Biological process: GO:0043330 [response to exogenous dsRNA] evidence: IEA
GeneID:8767 -> Biological process: GO:0045087 [innate immune response] evidence: ISS
GeneID:8767 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:8767 -> Biological process: GO:0045627 [positive regulation of T-helper 1 cell differentiation] evidence: IEA
GeneID:8767 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: NAS
GeneID:8767 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IEA
GeneID:8767 -> Biological process: GO:0046641 [positive regulation of alpha-beta T cell proliferation] evidence: IEA
GeneID:8767 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0050830 [defense response to Gram-positive bacterium] evidence: IEA
GeneID:8767 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: ISS
GeneID:8767 -> Biological process: GO:0050852 [T cell receptor signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: TAS
GeneID:8767 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
GeneID:8767 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IEA
GeneID:8767 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS
GeneID:8767 -> Biological process: GO:0070427 [nucleotide-binding oligomerization domain containing 1 signaling pathway] evidence: IEA
GeneID:8767 -> Biological process: GO:0070431 [nucleotide-binding oligomerization domain containing 2 signaling pathway] evidence: IEA
GeneID:8767 -> Biological process: GO:0070555 [response to interleukin-1] evidence: IEA
GeneID:8767 -> Biological process: GO:0070671 [response to interleukin-12] evidence: IEA
GeneID:8767 -> Biological process: GO:0070673 [response to interleukin-18] evidence: IEA
GeneID:8767 -> Biological process: GO:0071223 [cellular response to lipoteichoic acid] evidence: IEA
GeneID:8767 -> Biological process: GO:0071224 [cellular response to peptidoglycan] evidence: IEA
GeneID:8767 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:8767 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_003812 -> EC 2.7.10.2
NP_003812 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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