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2024-04-24 01:19:46, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003810 1953 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens tumor necrosis factor (ligand) superfamily, member 10
(TNFSF10), transcript variant 1, mRNA.
ACCESSION NM_003810
VERSION NM_003810.3 GI:300193030
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1953)
AUTHORS Stagg,H.W., Bowen,K.A., Sawant,D.A., Rodriguez,M., Tharakan,B. and
Childs,E.W.
TITLE Tumor necrosis factor-related apoptosis-inducing ligand promotes
microvascular endothelial cell hyperpermeability through
phosphatidylinositol 3-kinase pathway
JOURNAL Am. J. Surg. 205 (4), 419-425 (2013)
PUBMED 23375756
REMARK GeneRIF: TRAIL-induced microvascular hyperpermeability is
phosphatidylinositol 3-kinase (PI3K)-dependent and may be mediated
by caspase-3 cleavage of the endothelial adherens junctional
complex.
REFERENCE 2 (bases 1 to 1953)
AUTHORS Zhang,N., Wang,X., Huo,Q., Li,X., Wang,H., Schneider,P., Hu,G. and
Yang,Q.
TITLE The oncogene metadherin modulates the apoptotic pathway based on
the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis
Factor-related Apoptosis-inducing Ligand) in breast cancer
JOURNAL J. Biol. Chem. 288 (13), 9396-9407 (2013)
PUBMED 23408429
REMARK GeneRIF: oncogene metadherin modulates the apoptotic pathway based
on the tumor necrosis factor superfamily member TRAIL (Tumor
Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer
REFERENCE 3 (bases 1 to 1953)
AUTHORS Levidou,G., Thymara,I., Saetta,A.A., Papanastasiou,P.,
Pavlopoulos,P., Sakellariou,S., Fragkou,P., Patsouris,E. and
Korkolopoulou,P.
TITLE TRAIL and osteoprotegerin (OPG) expression in bladder urothelial
carcinoma: correlation with clinicopathological parameters and
prognosis
JOURNAL Pathology 45 (2), 138-144 (2013)
PUBMED 23277172
REMARK GeneRIF: OPG and TRAIL are frequently expressed and coexpressed in
bladder urothelial carcinomas, supporting the involvement of OPG in
the resistance to TRAIL-driven apoptosis.
REFERENCE 4 (bases 1 to 1953)
AUTHORS Spes,A., Sobotic,B., Turk,V. and Turk,B.
TITLE Cysteine cathepsins are not critical for TRAIL- and CD95-induced
apoptosis in several human cancer cell lines
JOURNAL Biol. Chem. 393 (12), 1417-1431 (2012)
PUBMED 23667901
REMARK GeneRIF: Data indicate that cysteine cathepsins are not required
for the TRAIL- and CD95-mediated apoptosis in various human cancer
cell lines.
REFERENCE 5 (bases 1 to 1953)
AUTHORS Grunert,M., Gottschalk,K., Kapahnke,J., Gundisch,S., Kieser,A. and
Jeremias,I.
TITLE The adaptor protein FADD and the initiator caspase-8 mediate
activation of NF-kappaB by TRAIL
JOURNAL Cell Death Dis 3, E414 (2012)
PUBMED 23096115
REMARK GeneRIF: FADD and the initiator caspase-8 mediate activation of
NF-kappaB by TRAIL.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1953)
AUTHORS Pan,G., Ni,J., Wei,Y.F., Yu,G., Gentz,R. and Dixit,V.M.
TITLE An antagonist decoy receptor and a death domain-containing receptor
for TRAIL
JOURNAL Science 277 (5327), 815-818 (1997)
PUBMED 9242610
REFERENCE 7 (bases 1 to 1953)
AUTHORS Pan,G., O'Rourke,K., Chinnaiyan,A.M., Gentz,R., Ebner,R., Ni,J. and
Dixit,V.M.
TITLE The receptor for the cytotoxic ligand TRAIL
JOURNAL Science 276 (5309), 111-113 (1997)
PUBMED 9082980
REFERENCE 8 (bases 1 to 1953)
AUTHORS Marsters,S.A., Pitti,R.M., Donahue,C.J., Ruppert,S., Bauer,K.D. and
Ashkenazi,A.
TITLE Activation of apoptosis by Apo-2 ligand is independent of FADD but
blocked by CrmA
JOURNAL Curr. Biol. 6 (6), 750-752 (1996)
PUBMED 8793301
REFERENCE 9 (bases 1 to 1953)
AUTHORS Pitti,R.M., Marsters,S.A., Ruppert,S., Donahue,C.J., Moore,A. and
Ashkenazi,A.
TITLE Induction of apoptosis by Apo-2 ligand, a new member of the tumor
necrosis factor cytokine family
JOURNAL J. Biol. Chem. 271 (22), 12687-12690 (1996)
PUBMED 8663110
REFERENCE 10 (bases 1 to 1953)
AUTHORS Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
al.
TITLE Identification and characterization of a new member of the TNF
family that induces apoptosis
JOURNAL Immunity 3 (6), 673-682 (1995)
PUBMED 8777713
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA969653.1, AC007919.18 and
AC016938.24.
On Jul 7, 2010 this sequence version replaced gi:23510439.
Summary: The protein encoded by this gene is a cytokine that
belongs to the tumor necrosis factor (TNF) ligand family. This
protein preferentially induces apoptosis in transformed and tumor
cells, but does not appear to kill normal cells although it is
expressed at a significant level in most normal tissues. This
protein binds to several members of TNF receptor superfamily
including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,
TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity
of this protein may be modulated by binding to the decoy receptors
TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot
induce apoptosis. The binding of this protein to its receptors has
been shown to trigger the activation of MAPK8/JNK, caspase 8, and
caspase 3. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Jul 2010].
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BG534448.1, U37518.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-60 DA969653.1 1-60
61-255 AC007919.18 4049-4243 c
256-393 AC016938.24 35112-35249 c
394-436 AC016938.24 31868-31910 c
437-541 AC016938.24 29468-29572 c
542-1748 AC016938.24 25964-27170 c
1749-1953 AC016938.24 25759-25963 c
FEATURES Location/Qualifiers
source 1..1953
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q26"
gene 1..1953
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/note="tumor necrosis factor (ligand) superfamily, member
10"
/db_xref="GeneID:8743"
/db_xref="HGNC:11925"
/db_xref="HPRD:04670"
/db_xref="MIM:603598"
exon 1..255
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/inference="alignment:Splign:1.39.8"
misc_feature 49..51
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/note="upstream in-frame stop codon"
CDS 124..969
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/note="isoform 1 is encoded by transcript variant 1; Apo-2
ligand; TNF-related apoptosis inducing ligand TRAIL; tumor
necrosis factor (ligand) family, member 10; tumor necrosis
factor apoptosis-inducing ligand splice variant delta;
chemokine tumor necrosis factor ligand superfamily member
10"
/codon_start=1
/product="tumor necrosis factor ligand superfamily member
10 isoform 1"
/protein_id="NP_003801.1"
/db_xref="GI:4507593"
/db_xref="CCDS:CCDS3219.1"
/db_xref="GeneID:8743"
/db_xref="HGNC:11925"
/db_xref="HPRD:04670"
/db_xref="MIM:603598"
/translation="
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
"
misc_feature 175..237
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P50591.1);
transmembrane region"
misc_feature 424..426
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 427..429
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 487..957
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/note="Tumor Necrosis Factor; TNF superfamily members
include the cytokines: TNF (TNF-alpha), LT
(lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL),
Fas ligand, and osteoprotegerin (OPG) ligand. These
proteins generally have an intracellular N-terminal...;
Region: TNF; cd00184"
/db_xref="CDD:29146"
misc_feature order(496..498,670..672,676..678,850..852,865..867,
943..945,955..957)
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:29146"
misc_feature order(586..591,607..609,742..744,763..765,775..777)
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/note="receptor binding sites; other site"
/db_xref="CDD:29146"
variation 172
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="g"
/db_xref="dbSNP:11545817"
exon 256..393
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/inference="alignment:Splign:1.39.8"
exon 394..436
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/inference="alignment:Splign:1.39.8"
exon 437..541
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/inference="alignment:Splign:1.39.8"
exon 542..1953
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/inference="alignment:Splign:1.39.8"
STS 850..971
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/standard_name="SHGC-77549"
/db_xref="UniSTS:16727"
variation 948
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:1131532"
variation 1070
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138020036"
STS 1131..1799
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/standard_name="TNFSF10_266"
/db_xref="UniSTS:277832"
variation 1173
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="g"
/db_xref="dbSNP:41309772"
variation 1176
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131535"
variation 1325
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="c"
/db_xref="dbSNP:1131542"
STS 1511..1677
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/standard_name="RH66570"
/db_xref="UniSTS:45442"
variation 1561
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131568"
variation 1624
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="g"
/db_xref="dbSNP:1131579"
variation 1631
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="c"
/replace="t"
/db_xref="dbSNP:1131580"
variation 1727
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="c"
/db_xref="dbSNP:17848014"
polyA_signal 1763..1768
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
variation 1764
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150169078"
polyA_site 1787
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
variation 1881
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="c"
/replace="t"
/db_xref="dbSNP:138626414"
variation 1902
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
/replace="c"
/replace="t"
/db_xref="dbSNP:149250622"
polyA_signal 1924..1929
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
polyA_site 1953
/gene="TNFSF10"
/gene_synonym="Apo-2L; APO2L; CD253; TL2; TRAIL"
ORIGIN
acagaacccagaaaaacaactcattcgctttcatttcctcactgactataaaagaatagagaaggaagggcttcagtgaccggctgcctggctgacttacagcagtcagactctgacaggatcatggctatgatggaggtccaggggggacccagcctgggacagacctgcgtgctgatcgtgatcttcacagtgctcctgcagtctctctgtgtggctgtaacttacgtgtactttaccaacgagctgaagcagatgcaggacaagtactccaaaagtggcattgcttgtttcttaaaagaagatgacagttattgggaccccaatgacgaagagagtatgaacagcccctgctggcaagtcaagtggcaactccgtcagctcgttagaaagatgattttgagaacctctgaggaaaccatttctacagttcaagaaaagcaacaaaatatttctcccctagtgagagaaagaggtcctcagagagtagcagctcacataactgggaccagaggaagaagcaacacattgtcttctccaaactccaagaatgaaaaggctctgggccgcaaaataaactcctgggaatcatcaaggagtgggcattcattcctgagcaacttgcacttgaggaatggtgaactggtcatccatgaaaaagggttttactacatctattcccaaacatactttcgatttcaggaggaaataaaagaaaacacaaagaacgacaaacaaatggtccaatatatttacaaatacacaagttatcctgaccctatattgttgatgaaaagtgctagaaatagttgttggtctaaagatgcagaatatggactctattccatctatcaagggggaatatttgagcttaaggaaaatgacagaatttttgtttctgtaacaaatgagcacttgatagacatggaccatgaagccagtttttttggggcctttttagttggctaactgacctggaaagaaaaagcaataacctcaaagtgactattcagttttcaggatgatacactatgaagatgtttcaaaaaatctgaccaaaacaaacaaacagaaaacagaaaacaaaaaaacctctatgcaatctgagtagagcagccacaaccaaaaaattctacaacacacactgttctgaaagtgactcacttatcccaagagaatgaaattgctgaaagatctttcaggactctacctcatatcagtttgctagcagaaatctagaagactgtcagcttccaaacattaatgcaatggttaacatcttctgtctttataatctactccttgtaaagactgtagaagaaagagcaacaatccatctctcaagtagtgtatcacagtagtagcctccaggtttccttaagggacaacatccttaagtcaaaagagagaagaggcaccactaaaagatcgcagtttgcctggtgcagtggctcacacctgtaatcccaacattttgggaacccaaggtgggtagatcacgagatcaagagatcaagaccatagtgaccaacatagtgaaaccccatctctactgaaagtacaaaaattagctgggtgtgttggcacatgcctgtagtcccagctacttgagaggctgaggcaagagaattgtttgaacccgggaggcagaggttgcagtgtggtgagatcatgccactacactccagcctggcgacagagcgagacttggtttcaaaaaaaaaaaaaaaaaaaacttcagtaagtacgtgttatttttttcaataaaattctattacagtatgtcatgtttgctgtagtgctcatatttattgttgtttttgttttagtactcacttgtttcataatatcaagattactaaaaatgggggaaaagacttctaatctttttttcataatatctttgacacatattacagaagaaataaatttcttacttttaatttaatatga
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8743 -> Molecular function: GO:0005102 [receptor binding] evidence: TAS
GeneID:8743 -> Molecular function: GO:0005125 [cytokine activity] evidence: IEA
GeneID:8743 -> Molecular function: GO:0005164 [tumor necrosis factor receptor binding] evidence: IEA
GeneID:8743 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8743 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:8743 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:8743 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:8743 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:8743 -> Biological process: GO:0006955 [immune response] evidence: IEA
GeneID:8743 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:8743 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
GeneID:8743 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
GeneID:8743 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:8743 -> Biological process: GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA
GeneID:8743 -> Biological process: GO:0090200 [positive regulation of release of cytochrome c from mitochondria] evidence: IDA
GeneID:8743 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:8743 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IDA
GeneID:8743 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
GeneID:8743 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:8743 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA
GeneID:8743 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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@meso_cacase at
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