2024-04-18 19:10:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003804 3864 bp mRNA linear PRI 12-MAY-2013 DEFINITION Homo sapiens receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), mRNA. ACCESSION NM_003804 VERSION NM_003804.3 GI:57242760 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3864) AUTHORS Hou,X., Wang,L., Zhang,L., Pan,X. and Zhao,W. TITLE Ubiquitin-specific protease 4 promotes TNF-alpha-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma JOURNAL FEBS Lett. 587 (4), 311-316 (2013) PUBMED 23313255 REMARK GeneRIF: Data suggest that USP4 (ubiquitin specific peptidase 4) down-regulates RIP1-mediated TNF-alpha (tumor necrosis factor-alpha) activation and promotes TNF-alpha-induced apoptosis via deubiquitination of RIP1 in head/neck squamous cell carcinoma. REFERENCE 2 (bases 1 to 3864) AUTHORS Park,Y.H., Jeong,M.S., Park,H.H. and Jang,S.B. TITLE Formation of the death domain complex between FADD and RIP1 proteins in vitro JOURNAL Biochim. Biophys. Acta 1834 (1), 292-300 (2013) PUBMED 22922561 REMARK GeneRIF: Formation of the death domain complex between FADD and RIP1 proteins in vitro REFERENCE 3 (bases 1 to 3864) AUTHORS He,W., Wang,Q., Xu,J., Xu,X., Padilla,M.T., Ren,G., Gou,X. and Lin,Y. TITLE Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation JOURNAL Autophagy 8 (12), 1811-1821 (2012) PUBMED 23051914 REMARK GeneRIF: These results reveal a critical role for the MAPK8 activation pathway through TRAF2 and RIPK1 for TNFSF10-induced autophagy that blunts apoptosis in cancer cells. REFERENCE 4 (bases 1 to 3864) AUTHORS Kikuchi,M., Kuroki,S., Kayama,M., Sakaguchi,S., Lee,K.K. and Yonehara,S. TITLE Protease activity of procaspase-8 is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3 JOURNAL J. Biol. Chem. 287 (49), 41165-41173 (2012) PUBMED 23071110 REMARK GeneRIF: procaspase-8 activity is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3 REFERENCE 5 (bases 1 to 3864) AUTHORS Basit,F., Humphreys,R. and Fulda,S. TITLE RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis JOURNAL J. Biol. Chem. 287 (46), 38767-38777 (2012) PUBMED 22927431 REMARK GeneRIF: IAP inhibitors and lexatumumab synergistically trigger apoptosis in a RIP1-dependent but TNFalpha-independent manner in RMS cells REFERENCE 6 (bases 1 to 3864) AUTHORS Duan,H. and Dixit,V.M. TITLE RAIDD is a new 'death' adaptor molecule JOURNAL Nature 385 (6611), 86-89 (1997) PUBMED 8985253 REFERENCE 7 (bases 1 to 3864) AUTHORS Takeuchi,M., Rothe,M. and Goeddel,D.V. TITLE Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins JOURNAL J. Biol. Chem. 271 (33), 19935-19942 (1996) PUBMED 8702708 REFERENCE 8 (bases 1 to 3864) AUTHORS Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V. TITLE TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex JOURNAL Immunity 4 (4), 387-396 (1996) PUBMED 8612133 REFERENCE 9 (bases 1 to 3864) AUTHORS Hsu,H., Xiong,J. and Goeddel,D.V. TITLE The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation JOURNAL Cell 81 (4), 495-504 (1995) PUBMED 7758105 REFERENCE 10 (bases 1 to 3864) AUTHORS Stanger,B.Z., Leder,P., Lee,T.H., Kim,E. and Seed,B. TITLE RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death JOURNAL Cell 81 (4), 513-523 (1995) PUBMED 7538908 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U50062.1, BX348786.2 and AL031963.40. On Jan 7, 2005 this sequence version replaced gi:24475887. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U50062.1, BC126254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1312 U50062.1 1-1312 1313-1576 BX348786.2 396-659 1577-2058 U50062.1 1577-2058 2059-3864 AL031963.40 75776-77581 FEATURES Location/Qualifiers source 1..3864 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6p25.2" gene 1..3864 /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="receptor (TNFRSF)-interacting serine-threonine kinase 1" /db_xref="GeneID:8737" /db_xref="HGNC:10019" /db_xref="MIM:603453" CDS 1..2016 /gene="RIPK1" /gene_synonym="RIP; RIP1" /EC_number="2.7.11.1" /note="receptor interacting protein; serine/threonine-protein kinase RIP; cell death protein RIP; RIP-1; receptor-interacting protein 1" /codon_start=1 /product="receptor-interacting serine/threonine-protein kinase 1" /protein_id="NP_003795.2" /db_xref="GI:57242761" /db_xref="CCDS:CCDS4482.1" /db_xref="GeneID:8737" /db_xref="HGNC:10019" /db_xref="MIM:603453" /translation="
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
" misc_feature 16..18 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13546.3); phosphorylation site" misc_feature 64..858 /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="Protein Kinases, catalytic domain; Region: PKc_like; cl09925" /db_xref="CDD:213116" misc_feature 64..855 /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="Protein kinase; unclassified specificity; Region: STYKc; smart00221" /db_xref="CDD:197583" misc_feature order(67..81,91..93,127..129,133..135,226..228,274..285, 295..297,301..303,412..414,418..420,424..429,433..435, 466..468,475..477,568..573) /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="active site" /db_xref="CDD:173623" misc_feature order(67..81,91..93,127..129,133..135,226..228,274..285, 295..297,412..414,418..420,424..429,433..435,466..468) /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature 73..75 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13546.3); phosphorylation site" misc_feature order(79..81,295..297,301..303,412..414,418..420,424..426, 475..477,568..573) /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173623" misc_feature order(463..480,529..531,568..573) /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="activation loop (A-loop); other site" /db_xref="CDD:173623" misc_feature 868..1746 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13546.3); Region: Interaction with SQSTM1" misc_feature 907..909 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13546.3); phosphorylation site" misc_feature 958..960 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13546.3); phosphorylation site" misc_feature 970..975 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Cleavage, by caspase-8; propagated from UniProtKB/Swiss-Prot (Q13546.3); cleavage site" misc_feature 970..972 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="proteolytic cleavage site; modified site" /db_xref="HPRD:03459" misc_feature 997..999 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q13546.3); phosphorylation site" misc_feature 1150..1152 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="Phosphotyrosine; propagated from UniProtKB/Swiss-Prot (Q13546.3); phosphorylation site" misc_feature 1150..1152 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1159..1161 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1165..1167 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1510..1650 /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="RIP homotypic interaction motif; Region: RHIM; pfam12721" /db_xref="CDD:205042" misc_feature 1591..1641 /gene="RIPK1" /gene_synonym="RIP; RIP1" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q13546.3); Region: RIP homotypic interaction motif (RHIM)" misc_feature 1747..2004 /gene="RIPK1" /gene_synonym="RIP; RIP1" /note="Death Domain of Receptor-Interacting Protein 1; Region: Death_RIP1; cd08777" /db_xref="CDD:176755" exon 1..164 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 27 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:371348115" variation 42 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:139862401" variation 62 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:143270556" variation 71 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:375750553" variation 82 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:146652253" variation 84 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:2272990" variation 127 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:184897325" variation 135 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:111393904" variation 155 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:149949748" variation 161 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:371940675" exon 165..321 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 168 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:145068560" variation 189 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:377207334" variation 212 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:201373013" variation 225 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:372658949" variation 226 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:376914574" variation 240 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:370515307" variation 261 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:199833061" variation 267 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:149116173" variation 270 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:148872518" variation 306 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:143110637" exon 322..459 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 332 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:181459394" variation 333 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:55916999" variation 352 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:138832019" variation 368 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:116603010" variation 390..391 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="g" /db_xref="dbSNP:35808929" variation 396 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:199932915" exon 460..688 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 463 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:368353075" variation 472 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:141642283" variation 478 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:147072629" variation 498 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:138277932" variation 540 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:150620171" variation 541 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:115041708" variation 555 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:372342373" variation 561 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:377004988" variation 562 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:369855897" variation 564 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:55662281" variation 582 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:372626426" variation 606 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:138924769" variation 607 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:149432620" variation 632 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:373377506" variation 636 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:144786197" variation 646 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:184905276" variation 654 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:200270764" variation 658 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:374972263" variation 660 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:114794680" exon 689..838 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 700 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:17548383" variation 709 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:17548390" variation 717 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:139225203" variation 720 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:142492551" variation 726 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:150933841" variation 798 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:139597659" variation 816 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:114145894" variation 833 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:369039534" exon 839..915 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 839 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:371950280" variation 876 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:201489236" variation 888 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:113602774" variation 900 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:369238450" exon 916..1006 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 931 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:184895368" variation 942 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:143730914" variation 994 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:370418004" exon 1007..1576 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 1021 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:200610530" variation 1029 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:141368248" variation 1032 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:367796517" variation 1048 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:371760083" variation 1083 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:114175266" variation 1106 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:201908938" variation 1111 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:201010882" variation 1145 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:374826907" variation 1184 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:368085162" variation 1194 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:34457341" variation 1210 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:34872409" variation 1238 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:377098078" variation 1255 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:369548921" variation 1270 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:201429839" variation 1278 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:374657927" variation 1288..1289 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="t" /db_xref="dbSNP:72055493" variation 1313 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:3173519" variation 1328 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:35722193" variation 1335 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:116696494" variation 1354 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="c" /db_xref="dbSNP:35955783" variation 1406 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:377213073" variation 1414 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:78148286" variation 1456 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:202192603" variation 1473 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:373127246" variation 1501 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:376022094" variation 1528 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:114570616" variation 1536 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:182050801" variation 1541 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:372833650" exon 1577..1729 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 1585 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:374613351" variation 1602 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:115907591" variation 1609 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:200093245" variation 1640 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:115193568" variation 1656 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:143215134" variation 1671 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:374356537" variation 1685 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:367576973" variation 1691 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:372244053" variation 1701 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:375261444" variation 1702 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:148311977" variation 1706 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:55861377" variation 1707 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:55782213" variation 1723 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:200611747" exon 1730..3864 /gene="RIPK1" /gene_synonym="RIP; RIP1" /inference="alignment:Splign:1.39.8" variation 1782 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:138400267" variation 1818 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:142928574" variation 1824 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:146128109" variation 1826 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:368981092" variation 1835 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:372917428" variation 1872 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:116517470" variation 1899 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:139157077" variation 1922 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:375933886" variation 1934 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:116040763" variation 1935 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:114183703" variation 1937 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:12194205" variation 1955 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:115355023" variation 2001 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:373199261" variation 2031 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:376644463" variation 2047 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:200498941" variation 2058 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:200023655" variation 2114 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:112918512" variation 2122 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:17548601" variation 2139 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:111679651" variation 2240 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:149708752" variation 2306 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:186901867" variation 2323 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:77736895" variation 2360 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:145642382" STS 2409..2566 /gene="RIPK1" /gene_synonym="RIP; RIP1" /standard_name="RH48319" /db_xref="UniSTS:8024" variation 2428 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:371307110" variation 2521 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:199526711" variation 2528 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="c" /db_xref="dbSNP:71761106" variation 2553 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:12478" variation 2600 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:115391592" variation 2613 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:17548608" variation 2614 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:17548615" variation 2631 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:148895227" variation 2638 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:143591575" variation 2639 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:116057912" variation 2647 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:137942850" variation 2711 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:116380813" variation 2778 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="t" /db_xref="dbSNP:141950968" variation 2843 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:17548622" variation 2900 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:17548629" variation 2912 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:190644882" variation 2933 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:138696101" variation 2955 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:17513574" variation 3084 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:17513581" variation 3163..3164 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="tc" /db_xref="dbSNP:138407817" variation 3284 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:112560918" variation 3347 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:116237824" variation 3390 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:17548315" variation 3392 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:138261259" variation 3403 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="g" /db_xref="dbSNP:1983606" variation 3412..3413 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="tc" /db_xref="dbSNP:143385010" variation 3413..3414 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="ct" /db_xref="dbSNP:374356710" variation 3435 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="g" /replace="t" /db_xref="dbSNP:9503401" variation 3501 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:114155161" variation 3508 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:182321202" variation 3511 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="c" /replace="t" /db_xref="dbSNP:114809298" variation 3670 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="a" /db_xref="dbSNP:377557256" variation 3689 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:185640889" STS 3721..3824 /gene="RIPK1" /gene_synonym="RIP; RIP1" /standard_name="D6S1199E" /db_xref="UniSTS:34000" variation 3724 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="g" /db_xref="dbSNP:17513595" polyA_signal 3745..3750 /gene="RIPK1" /gene_synonym="RIP; RIP1" variation 3745 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="a" /replace="c" /db_xref="dbSNP:188409221" polyA_site 3763 /gene="RIPK1" /gene_synonym="RIP; RIP1" variation 3796..3797 /gene="RIPK1" /gene_synonym="RIP; RIP1" /replace="" /replace="ct" /db_xref="dbSNP:113615537" polyA_signal 3845..3850 /gene="RIPK1" /gene_synonym="RIP; RIP1" polyA_site 3864 /gene="RIPK1" /gene_synonym="RIP; RIP1" ORIGIN
atgcaaccagacatgtccttgaatgtcattaagatgaaatccagtgacttcctggagagtgcagaactggacagcggaggctttgggaaggtgtctctgtgtttccacagaacccagggactcatgatcatgaaaacagtgtacaaggggcccaactgcattgagcacaacgaggccctcttggaggaggcgaagatgatgaacagactgagacacagccgggtggtgaagctcctgggcgtcatcatagaggaagggaagtactccctggtgatggagtacatggagaagggcaacctgatgcacgtgctgaaagccgagatgagtactccgctttctgtaaaaggaaggataattttggaaatcattgaaggaatgtgctacttacatggaaaaggcgtgatacacaaggacctgaagcctgaaaatatccttgttgataatgacttccacattaagatcgcagacctcggccttgcctcctttaagatgtggagcaaactgaataatgaagagcacaatgagctgagggaagtggacggcaccgctaagaagaatggcggcaccctctactacatggcgcccgagcacctgaatgacgtcaacgcaaagcccacagagaagtcggatgtgtacagctttgctgtagtactctgggcgatatttgcaaataaggagccatatgaaaatgctatctgtgagcagcagttgataatgtgcataaaatctgggaacaggccagatgtggatgacatcactgagtactgcccaagagaaattatcagtctcatgaagctctgctgggaagcgaatccggaagctcggccgacatttcctggcattgaagaaaaatttaggcctttttatttaagtcaattagaagaaagtgtagaagaggacgtgaagagtttaaagaaagagtattcaaacgaaaatgcagttgtgaagagaatgcagtctcttcaacttgattgtgtggcagtaccttcaagccggtcaaattcagccacagaacagcctggttcactgcacagttcccagggacttgggatgggtcctgtggaggagtcctggtttgctccttccctggagcacccacaagaagagaatgagcccagcctgcagagtaaactccaagacgaagccaactaccatctttatggcagccgcatggacaggcagacgaaacagcagcccagacagaatgtggcttacaacagagaggaggaaaggagacgcagggtctcccatgacccttttgcacagcaaagaccttacgagaattttcagaatacagagggaaaaggcactgcttattccagtgcagccagtcatggtaatgcagtgcaccagccctcagggctcaccagccaacctcaagtactgtatcagaacaatggattatatagctcacatggctttggaacaagaccactggatccaggaacagcaggtcccagagtttggtacaggccaattccaagtcatatgcctagtctgcataatatcccagtgcctgagaccaactatctaggaaatacacccaccatgccattcagctccttgccaccaacagatgaatctataaaatataccatatacaatagtactggcattcagattggagcctacaattatatggagattggtgggacgagttcatcactactagacagcacaaatacgaacttcaaagaagagccagctgctaagtaccaagctatctttgataataccactagtctgacggataaacacctggacccaatcagggaaaatctgggaaagcactggaaaaactgtgcccgtaaactgggcttcacacagtctcagattgatgaaattgaccatgactatgagcgagatggactgaaagaaaaggtttaccagatgctccaaaagtgggtgatgagggaaggcataaagggagccacggtggggaagctggcccaggcgctccaccagtgttccaggatcgaccttctgagcagcttgatttacgtcagccagaactaaccctggatgggctacggcagctgaagtggacgcctcacttagtggataaccccagaaagttggctgcctcagagcattcagaattctgtcctcactgataggggttctgtgtctgcagaaattttgtttcctgtacttcatagctggagaatggggaaagaaatctgcagcaaaggggtctcactctgttgccaggctggtctcaaacttctggactcaagtgatcctcccgcctcggccttccaaagtgctgggatatcaggcactgagccactgcgcccagccaacaatccgctctgaggaaagcgtaagcaggaagacctcttaatggcatagcaccaataaaaaaatgactcctagttgtgtttggaaagggagagaagagatgtctgaggaaggtcatgttctttcagcttatggcatttcctagagttttgttgaagcaagaagaaaaactcagagaatataaaatcaacttttaaaattgtgtgctctcttcttcacgtaggctcctgttaaaaacaaagtgcagtcagattctaagccctgttcagagacttcgtggatcacagctgcagctcaccgccacatcacaggatccgttaacgttaatacccaatactctgtcagccactgtaggctctaagaaccacgtgcagtcttcagcccattaaattatcgattattttttaatgaattgaatttatattgagtcttcaaattaactgaatggatttaaaggggtaccaaggaggggggaaacatcagaatttcccaggcagttgttgcaaggaattggtactaaccgtgactacaacaaaaattcttgattgacttttaaagttatttcctggcattctggtaccttcacccagcctgagtgccctggagagggaacaggaaatgctgatctctacccctgggtgagaccagaacctcagggctgatactgttgagtggcttcctcggtttactctgtgtactgtgaaagtattttcatattttttctgtgtgccagagtgaaaaaggacagcttctgagtgtggtaattgtgcctctagcacccagcctttcaaagcccacctgaaacctgggggtggatgaaagaactagaatagaagactgaagctgggtaggccgctcagtgtccactggcattttgctaaaccgacaaggaaggctgtgtgcttagctctccccagagggagggcgagaagggtgtggtgatggtcaatctggctgtcggaacagattctggtgtcttgggctgataacagtgttgttgattctgattgtgaatcccctcaactctagcagacacatacacacccctgaaatggggctgcagagcaggctgtctcagccttgccactgtcggcatctcggcctgggtaattctgttgtggggactgtcctgttccttgtaggatgtttagtagcatccctgcccccacctactagatgccaggggcactgttctccccagccccccgccccagttgtgacaatagtctctaaacattgtcaaatggtccaaggaaaggggaaaattgccccggttgagaagagcactgctgtaaagtaatgagcctcggctctcctgtctgcacctgtccggttactacttggccaccacgcagccttggctcctacagcccaaaagggagaatggagggaggctccaggctttgctggaggggcctgggtgagttctgtttgctccttgtaccaccatccaaatggtgttatcaaatctcttagattccaaagaggttgaataattaatgttcaaaggcaagagggcaaggcattttttaacactttttaaaataaaaatttataccacaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:8737 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA GeneID:8737 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:8737 -> Molecular function: GO:0005123 [death receptor binding] evidence: IPI GeneID:8737 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:8737 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:8737 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:8737 -> Molecular function: GO:0070513 [death domain binding] evidence: IPI GeneID:8737 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IMP GeneID:8737 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:8737 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS GeneID:8737 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:8737 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS GeneID:8737 -> Biological process: GO:0007257 [activation of JUN kinase activity] evidence: TAS GeneID:8737 -> Biological process: GO:0010940 [positive regulation of necrotic cell death] evidence: IMP GeneID:8737 -> Biological process: GO:0032481 [positive regulation of type I interferon production] evidence: TAS GeneID:8737 -> Biological process: GO:0032757 [positive regulation of interleukin-8 production] evidence: IDA GeneID:8737 -> Biological process: GO:0032760 [positive regulation of tumor necrosis factor production] evidence: IDA GeneID:8737 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IC GeneID:8737 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS GeneID:8737 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS GeneID:8737 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: IMP GeneID:8737 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:8737 -> Biological process: GO:0036289 [peptidyl-serine autophosphorylation] evidence: IDA GeneID:8737 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA GeneID:8737 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP GeneID:8737 -> Biological process: GO:0043068 [positive regulation of programmed cell death] evidence: IMP GeneID:8737 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IDA GeneID:8737 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP GeneID:8737 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:8737 -> Biological process: GO:0044257 [cellular protein catabolic process] evidence: IDA GeneID:8737 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:8737 -> Biological process: GO:0045651 [positive regulation of macrophage differentiation] evidence: IMP GeneID:8737 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA GeneID:8737 -> Biological process: GO:0046330 [positive regulation of JNK cascade] evidence: IDA GeneID:8737 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA GeneID:8737 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IMP GeneID:8737 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IDA GeneID:8737 -> Biological process: GO:0051291 [protein heterooligomerization] evidence: IEA GeneID:8737 -> Biological process: GO:0060545 [positive regulation of necroptosis] evidence: IMP GeneID:8737 -> Biological process: GO:0060555 [activation of necroptosis by extracellular signals] evidence: IMP GeneID:8737 -> Biological process: GO:0070926 [regulation of ATP:ADP antiporter activity] evidence: IMP GeneID:8737 -> Biological process: GO:0071356 [cellular response to tumor necrosis factor] evidence: IDA GeneID:8737 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:8737 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IDA GeneID:8737 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IMP GeneID:8737 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: TAS GeneID:8737 -> Biological process: GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] evidence: IMP GeneID:8737 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IMP GeneID:8737 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS GeneID:8737 -> Biological process: GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] evidence: IEA GeneID:8737 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:8737 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:8737 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:8737 -> Cellular component: GO:0031264 [death-inducing signaling complex] evidence: IDA GeneID:8737 -> Cellular component: GO:0043235 [receptor complex] evidence: IDA GeneID:8737 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_003795 -> EC 2.7.11.1
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