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2024-04-19 22:21:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003789 1496 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens TNFRSF1A-associated via death domain (TRADD), mRNA.
ACCESSION NM_003789
VERSION NM_003789.3 GI:115387096
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1496)
AUTHORS Jang,C.Y., Kim,H.D. and Kim,J.
TITLE Ribosomal protein S3 interacts with TRADD to induce apoptosis
through caspase dependent JNK activation
JOURNAL Biochem. Biophys. Res. Commun. 421 (3), 474-478 (2012)
PUBMED 22510408
REMARK GeneRIF: rpS3 appears to be recruited to the death-inducing
signaling complex (DISC) to induce apoptosis by interacting TRADD
in response to extracellular stresses.
REFERENCE 2 (bases 1 to 1496)
AUTHORS D'Agostino,L. and Giordano,A.
TITLE A novel dual signaling axis for NSP 5a3a induced apoptosis in head
and neck carcinoma
JOURNAL Oncotarget 2 (12), 1055-1074 (2011)
PUBMED 22170762
REMARK GeneRIF: NSP 5a3a induces apoptosis in Head and Neck cell line HN30
through p73-DAXX and TRAF2-TRADD.
REFERENCE 3 (bases 1 to 1496)
AUTHORS Guan,Y.J., Zhang,Z., Yu,C., Ma,L., Hu,W., Xu,L., Gao,J.S.,
Chung,C.S., Wang,L., Yang,Z.F., Fast,L.D., Chung,A.S., Kim,M.,
Ayala,A., Zhuang,S., Zheng,S. and Chin,Y.E.
TITLE Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain
complex formation for T cell activation and migration
JOURNAL J. Immunol. 187 (3), 1289-1297 (2011)
PUBMED 21724995
REMARK GeneRIF: Death domain SXXE/D motifs are phosphorylated, as is
required for stable TNFR1-TRADD complex formation and subsequent
activation of NF-kappaB in inflamed mucosa.
REFERENCE 4 (bases 1 to 1496)
AUTHORS Davidson SI, Liu Y, Danoy PA, Wu X, Thomas GP, Jiang L, Sun L, Wang
N, Han J, Han H, Visscher PM, Brown MA and Xu H.
CONSRTM Australo-Anglo-American Spondyloarthritis Consortium
TITLE Association of STAT3 and TNFRSF1A with ankylosing spondylitis in
Han Chinese
JOURNAL Ann. Rheum. Dis. 70 (2), 289-292 (2011)
PUBMED 21068102
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 1496)
AUTHORS Lee,K.M., Baris,D., Zhang,Y., Hosgood,H.D. III, Menashe,I.,
Yeager,M., Zahm,S.H., Wang,S.S., Purdue,M.P., Chanock,S., Zheng,T.,
Rothman,N. and Lan,Q.
TITLE Common single nucleotide polymorphisms in immunoregulatory genes
and multiple myeloma risk among women in Connecticut
JOURNAL Am. J. Hematol. 85 (8), 560-563 (2010)
PUBMED 20568250
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 1496)
AUTHORS Boldin,M.P., Goncharov,T.M., Goltsev,Y.V. and Wallach,D.
TITLE Involvement of MACH, a novel MORT1/FADD-interacting protease, in
Fas/APO-1- and TNF receptor-induced cell death
JOURNAL Cell 85 (6), 803-815 (1996)
PUBMED 8681376
REFERENCE 7 (bases 1 to 1496)
AUTHORS Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
TITLE TNF-dependent recruitment of the protein kinase RIP to the TNF
receptor-1 signaling complex
JOURNAL Immunity 4 (4), 387-396 (1996)
PUBMED 8612133
REFERENCE 8 (bases 1 to 1496)
AUTHORS Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
TITLE TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
receptor 1 signal transduction pathways
JOURNAL Cell 84 (2), 299-308 (1996)
PUBMED 8565075
REFERENCE 9 (bases 1 to 1496)
AUTHORS Hsu,H., Xiong,J. and Goeddel,D.V.
TITLE The TNF receptor 1-associated protein TRADD signals cell death and
NF-kappa B activation
JOURNAL Cell 81 (4), 495-504 (1995)
PUBMED 7758105
REFERENCE 10 (bases 1 to 1496)
AUTHORS Hasegawa,H.
TITLE [Nurses replies to expectations of the nursing profession]
JOURNAL Kango 27 (3), 66-80 (1975)
PUBMED 1040062
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA353575.1, BC004491.2 and
CA426418.1.
On Sep 28, 2006 this sequence version replaced gi:24234723.
Summary: The protein encoded by this gene is a death domain
containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and
mediates programmed cell death signaling and NF-kappaB activation.
This protein binds adaptor protein TRAF2, reduces the recruitment
of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus
suppresses TRAF2 mediated apoptosis. This protein can also interact
with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is
involved in the Fas-induced cell death pathway. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC004491.2, L41690.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-23 DA353575.1 1-23
24-1468 BC004491.2 1-1445
1469-1496 CA426418.1 1-28 c
FEATURES Location/Qualifiers
source 1..1496
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q22"
gene 1..1496
/gene="TRADD"
/gene_synonym="Hs.89862"
/note="TNFRSF1A-associated via death domain"
/db_xref="GeneID:8717"
/db_xref="HGNC:12030"
/db_xref="HPRD:04610"
/db_xref="MIM:603500"
exon 1..72
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="alignment:Splign:1.39.8"
exon 73..231
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="alignment:Splign:1.39.8"
CDS 81..1019
/gene="TRADD"
/gene_synonym="Hs.89862"
/note="tumor necrosis factor receptor-1-associated
protein; TNFR1-associated death domain protein; tumor
necrosis factor receptor type 1 associated death domain
protein"
/codon_start=1
/product="tumor necrosis factor receptor type 1-associated
DEATH domain protein"
/protein_id="NP_003780.1"
/db_xref="GI:13378137"
/db_xref="CCDS:CCDS10829.1"
/db_xref="GeneID:8717"
/db_xref="HGNC:12030"
/db_xref="HPRD:04610"
/db_xref="MIM:603500"
/translation="
MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
"
misc_feature 231..512
/gene="TRADD"
/gene_synonym="Hs.89862"
/note="TRADD, N-terminal domain; Region: TRADD_N;
pfam09034"
/db_xref="CDD:117600"
misc_feature 519..569
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15628.2);
Region: Nuclear export signal (By similarity)"
misc_feature 723..992
/gene="TRADD"
/gene_synonym="Hs.89862"
/note="Death Domain of Tumor Necrosis Factor Receptor
1-Associated Death Domain protein; Region: Death_TRADD;
cd08780"
/db_xref="CDD:176758"
misc_feature 744..947
/gene="TRADD"
/gene_synonym="Hs.89862"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15628.2);
Region: Interaction with KRT14 and KRT18"
misc_feature 771..812
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q15628.2);
Region: Nuclear localization signal (By similarity)"
exon 232..509
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="alignment:Splign:1.39.8"
variation 303
/gene="TRADD"
/gene_synonym="Hs.89862"
/replace="c"
/replace="t"
/db_xref="dbSNP:11574518"
exon 510..708
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="alignment:Splign:1.39.8"
exon 709..1483
/gene="TRADD"
/gene_synonym="Hs.89862"
/inference="alignment:Splign:1.39.8"
variation 1128
/gene="TRADD"
/gene_synonym="Hs.89862"
/replace="a"
/replace="c"
/db_xref="dbSNP:13312727"
STS 1190..1311
/gene="TRADD"
/gene_synonym="Hs.89862"
/standard_name="RH69054"
/db_xref="UniSTS:27785"
STS 1194..1370
/gene="TRADD"
/gene_synonym="Hs.89862"
/standard_name="RH78922"
/db_xref="UniSTS:21246"
variation 1382
/gene="TRADD"
/gene_synonym="Hs.89862"
/replace="a"
/replace="t"
/db_xref="dbSNP:13312728"
polyA_signal 1451..1456
/gene="TRADD"
/gene_synonym="Hs.89862"
polyA_site 1483
/gene="TRADD"
/gene_synonym="Hs.89862"
ORIGIN
gcacacccggaagcggcggagtagagcggagcctggcgggcgtgggaacccaggccccgccgaggcggccaggaggtgagatggcagctgggcaaaatgggcacgaagagtgggtgggcagcgcatacctgtttgtggagtcctcgctggacaaggtggtcctgtcggatgcctacgcgcacccccagcagaaggtggcagtgtacagggctctgcaggctgccttggcagagagcggcgggagcccggacgtgctgcagatgctgaagatccaccgcagcgacccgcagctgatcgtgcagctgcgattctgcgggcggcagccctgtggccgcttcctccgcgcctaccgcgagggggcgctgcgcgccgcgctgcagaggagcctggcggccgcgctcgcccagcactcggtgccgctgcaactggagctgcgcgccggcgccgagcggctggacgctttgctggcggacgaggagcgctgtttgagttgcatcctagcccagcagcccgaccggctccgggatgaagaactggctgagctggaggatgcgctgcgaaatctgaagtgcggctcgggggcccggggtggcgacggggaggtcgcttcggcccccttgcagcccccggtgccctctctgtcggaggtgaagccgccgccgccgccgccacctgcccagacttttctgttccagggtcagcctgtagtgaatcggccgctgagcctgaaggaccaacagacgttcgcgcgctctgtgggtctcaaatggcgcaaggtggggcgctcactgcagcgaggctgccgggcgctgcgggacccggcgctggactcgctggcctacgagtacgagcgcgagggactgtacgagcaggccttccagctgctgcggcgcttcgtgcaggccgagggccgccgcgccacgctgcagcgcctggtggaggcactcgaggagaacgagctcaccagcctggcagaggacttgctgggcctgaccgatcccaatggcggcctggcctagaccaggggtgcagccagcttttggagaacctggatggccttagggttccttctgcggctattgctgaacccctgtccatccacgggaccctgaaactccacttggcctatctgctggacctgctggggcagagttgattgccttccccaggagccagaccactgggggtgcatcattggggattctgcctcaggtactttgatagagtgtggggtgggggggacctgctttggagatcagcctcaccttctcccatcccagaagcggggcttacagccagcccttacagtttcactcatgaagcaccttgatctttggtgtcctggacttcatcctgggtgctgcagatactgcagtgaagtaaaacaggaatcaatcttgcctgcccccagctcacactcagcgtgggaccccgaatgttaagcaatgataataaagtataacacggattttgatgtgagaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8717 -> Molecular function: GO:0004871 [signal transducer activity] evidence: IEA
GeneID:8717 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8717 -> Molecular function: GO:0019900 [kinase binding] evidence: IPI
GeneID:8717 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:8717 -> Molecular function: GO:0060090 [binding, bridging] evidence: IPI
GeneID:8717 -> Molecular function: GO:0070513 [death domain binding] evidence: IPI
GeneID:8717 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:8717 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:8717 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:8717 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:8717 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: TAS
GeneID:8717 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: TAS
GeneID:8717 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:8717 -> Biological process: GO:0051798 [positive regulation of hair follicle development] evidence: IEA
GeneID:8717 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:8717 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:8717 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: TAS
GeneID:8717 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
GeneID:8717 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:8717 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:8717 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:8717 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
GeneID:8717 -> Cellular component: GO:0043235 [receptor complex] evidence: IDA
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