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2024-03-30 00:25:00, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003756               1286 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3, subunit H
            (EIF3H), mRNA.
ACCESSION   NM_003756
VERSION     NM_003756.2  GI:83656776
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Mishra,A., Yazar,S., Hewitt,A.W., Mountain,J.A., Ang,W.,
            Pennell,C.E., Martin,N.G., Montgomery,G.W., Hammond,C.J.,
            Young,T.L., Macgregor,S. and Mackey,D.A.
  TITLE     Genetic variants near PDGFRA are associated with corneal curvature
            in Australians
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 53 (11), 7131-7136 (2012)
   PUBMED   22969067
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Peters,U., Hutter,C.M., Hsu,L., Schumacher,F.R., Conti,D.V.,
            Carlson,C.S., Edlund,C.K., Haile,R.W., Gallinger,S., Zanke,B.W.,
            Lemire,M., Rangrej,J., Vijayaraghavan,R., Chan,A.T., Hazra,A.,
            Hunter,D.J., Ma,J., Fuchs,C.S., Giovannucci,E.L., Kraft,P., Liu,Y.,
            Chen,L., Jiao,S., Makar,K.W., Taverna,D., Gruber,S.B., Rennert,G.,
            Moreno,V., Ulrich,C.M., Woods,M.O., Green,R.C., Parfrey,P.S.,
            Prentice,R.L., Kooperberg,C., Jackson,R.D., Lacroix,A.Z.,
            Caan,B.J., Hayes,R.B., Berndt,S.I., Chanock,S.J., Schoen,R.E.,
            Chang-Claude,J., Hoffmeister,M., Brenner,H., Frank,B., Bezieau,S.,
            Kury,S., Slattery,M.L., Hopper,J.L., Jenkins,M.A., Le Marchand,L.,
            Lindor,N.M., Newcomb,P.A., Seminara,D., Hudson,T.J., Duggan,D.J.,
            Potter,J.D. and Casey,G.
  TITLE     Meta-analysis of new genome-wide association studies of colorectal
            cancer risk
  JOURNAL   Hum. Genet. 131 (2), 217-234 (2012)
   PUBMED   21761138
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Kupfer,S.S., Anderson,J.R., Hooker,S., Skol,A., Kittles,R.A.,
            Keku,T.O., Sandler,R.S. and Ellis,N.A.
  TITLE     Genetic heterogeneity in colorectal cancer associations between
            African and European americans
  JOURNAL   Gastroenterology 139 (5), 1677-1685 (2010)
   PUBMED   20659471
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Pittman,A.M., Naranjo,S., Jalava,S.E., Twiss,P., Ma,Y., Olver,B.,
            Lloyd,A., Vijayakrishnan,J., Qureshi,M., Broderick,P., van
            Wezel,T., Morreau,H., Tuupanen,S., Aaltonen,L.A., Alonso,M.E.,
            Manzanares,M., Gavilan,A., Visakorpi,T., Gomez-Skarmeta,J.L. and
            Houlston,R.S.
  TITLE     Allelic variation at the 8q23.3 colorectal cancer risk locus
            functions as a cis-acting regulator of EIF3H
  JOURNAL   PLoS Genet. 6 (9), E1001126 (2010)
   PUBMED   20862326
  REMARK    GeneRIF: Increased expression of EIF3H gene increases colorectal
            cancer growth and invasiveness thereby providing a biological
            mechanism for the 8q23.3 association.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Hawken,S.J., Greenwood,C.M., Hudson,T.J., Kustra,R., McLaughlin,J.,
            Yang,Q., Zanke,B.W. and Little,J.
  TITLE     The utility and predictive value of combinations of low penetrance
            genes for screening and risk prediction of colorectal cancer
  JOURNAL   Hum. Genet. 128 (1), 89-101 (2010)
   PUBMED   20437058
  REMARK    GeneRIF: Observational study of genetic testing. (HuGE Navigator)
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Saramaki,O., Willi,N., Bratt,O., Gasser,T.C., Koivisto,P.,
            Nupponen,N.N., Bubendorf,L. and Visakorpi,T.
  TITLE     Amplification of EIF3S3 gene is associated with advanced stage in
            prostate cancer
  JOURNAL   Am. J. Pathol. 159 (6), 2089-2094 (2001)
   PUBMED   11733359
  REMARK    GeneRIF: Gain of EIF3S3 was associated with poor cancer-specific
            survival in incidentally found prostate carcinomas.
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J. Biol. Chem. 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   8  (bases 1 to 1286)
  AUTHORS   Asano,K., Vornlocher,H.P., Richter-Cook,N.J., Merrick,W.C.,
            Hinnebusch,A.G. and Hershey,J.W.
  TITLE     Structure of cDNAs encoding human eukaryotic initiation factor 3
            subunits. Possible roles in RNA binding and macromolecular assembly
  JOURNAL   J. Biol. Chem. 272 (43), 27042-27052 (1997)
   PUBMED   9341143
REFERENCE   9  (bases 1 to 1286)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J. Biol. Chem. 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   10 (bases 1 to 1286)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J. Biol. Chem. 272 (2), 1101-1109 (1997)
   PUBMED   8995409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AU117206.1, U54559.1 and AA902770.1.
            On Dec 15, 2005 this sequence version replaced gi:4503514.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222520.1, BC000386.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AU117206.1         1-21
            22-1244             U54559.1           1-1223
            1245-1286           AA902770.1         1-42                c
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.11"
     gene            1..1286
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /note="eukaryotic translation initiation factor 3, subunit
                     H"
                     /db_xref="GeneID:8667"
                     /db_xref="HGNC:3273"
                     /db_xref="HPRD:04885"
                     /db_xref="MIM:603912"
     exon            1..158
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /note="predominant transcription initiation site"
     CDS             27..1085
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /note="eukaryotic translation initiation factor 3, subunit
                     2 (beta, 36kD); eukaryotic translation initiation factor
                     3, subunit 3 (gamma, 40kD); eukaryotic translation
                     initiation factor 3, subunit 3 gamma, 40kDa; eIF-3-gamma;
                     eIF3 p40 subunit; eukaryotic translation initiation factor
                     3 subunit 3"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit H"
                     /protein_id="NP_003747.1"
                     /db_xref="GI:4503515"
                     /db_xref="CCDS:CCDS6319.1"
                     /db_xref="GeneID:8667"
                     /db_xref="HGNC:3273"
                     /db_xref="HPRD:04885"
                     /db_xref="MIM:603912"
                     /translation="
MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
"
     misc_feature    135..926
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /note="Mpr1p, Pad1p N-terminal (MPN) domains without
                     catalytic isopeptidase activity, found in eIF2h; Region:
                     MPN_eIF3h; cd08065"
                     /db_xref="CDD:163696"
     misc_feature    573..575
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (O15372.1); phosphorylation site"
     misc_feature    573..575
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       47..48
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11547842"
     variation       83
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11547841"
     exon            159..315
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     variation       251
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11547844"
     variation       280
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11547840"
     exon            316..483
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     exon            484..583
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     variation       504
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11547846"
     exon            584..733
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     exon            734..854
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     exon            855..987
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     variation       910
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804928"
     variation       962
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11547843"
     exon            988..1275
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /inference="alignment:Splign:1.39.8"
     STS             1070..1232
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /standard_name="A001W19"
                     /db_xref="UniSTS:35857"
     STS             1070..1232
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /standard_name="G19711"
                     /db_xref="UniSTS:35856"
     STS             1112..1236
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /standard_name="SHGC-31909"
                     /db_xref="UniSTS:19853"
     variation       1116
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1804926"
     variation       1135
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804927"
     variation       1149
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:10054"
     polyA_signal    1237..1242
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
     polyA_signal    1242..1247
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
     polyA_site      1259
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="predominant polyadenylation site"
     polyA_site      1275
                     /gene="EIF3H"
                     /gene_synonym="eIF3-gamma; eIF3-p40; EIF3S3"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
ctctttcttcctgtctgcttggaaagatggcgtcccgcaaggaaggtaccggctctactgccacctcttccagctccaccgccggcgcagcagggaaaggcaaaggcaaaggcggctcgggagattcagccgtgaagcaagtgcagatagatggccttgtggtattaaagataatcaaacattatcaagaagaaggacaaggaactgaagttgttcaaggagtgcttttgggtctggttgtagaagatcggcttgaaattaccaactgctttcctttccctcagcacacagaggatgatgctgactttgatgaagtccaatatcagatggaaatgatgcggagccttcgccatgtaaacattgatcatcttcacgtgggctggtatcagtccacatactatggctcattcgttacccgggcactcctggactctcagtttagttaccagcatgccattgaagaatctgtcgttctcatttatgatcccataaaaactgcccaaggatctctctcactaaaggcatacagactgactcctaaactgatggaagtttgtaaagaaaaggatttttcccctgaagcattgaaaaaagcaaatatcacctttgagtacatgtttgaagaagtgccgattgtaattaaaaattcacatctgatcaatgtcctaatgtgggaacttgaaaagaagtcagctgttgcagataaacatgaattgctcagccttgccagcagcaatcatttggggaagaatctacagttgctgatggacagagtggatgaaatgagccaagatatagttaaatacaacacatacatgaggaatactagtaaacaacagcagcagaaacatcagtatcagcagcgtcgccagcaggagaatatgcagcgccagagccgaggagaacccccgctccctgaggaggacctgtccaaactcttcaaaccaccacagccgcctgccaggatggactcgctgctcattgcaggccagataaacacttactgccagaacatcaaggagttcactgcccaaaacttaggcaagctcttcatggcccaggctcttcaagaatacaacaactaagaaaaggaagtttccagaaaagaagttaacatgaactcttgaagtcacaccagggcaactcttggaagaaatatatttgcatattgaaaagcacagaggatttctttagtgtcattgccgattttggctataacagtgtctttctagccataataaaataaaacaaaatcttgactgcttgctcatttgaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8667 -> Molecular function: GO:0003743 [translation initiation factor activity] evidence: IC
            GeneID:8667 -> Molecular function: GO:0003743 [translation initiation factor activity] evidence: IDA
            GeneID:8667 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8667 -> Biological process: GO:0001731 [formation of translation preinitiation complex] evidence: IEA
            GeneID:8667 -> Biological process: GO:0006412 [translation] evidence: TAS
            GeneID:8667 -> Biological process: GO:0006413 [translational initiation] evidence: IC
            GeneID:8667 -> Biological process: GO:0006413 [translational initiation] evidence: IDA
            GeneID:8667 -> Biological process: GO:0006413 [translational initiation] evidence: TAS
            GeneID:8667 -> Biological process: GO:0006446 [regulation of translational initiation] evidence: TAS
            GeneID:8667 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:8667 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:8667 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:8667 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:8667 -> Cellular component: GO:0005852 [eukaryotic translation initiation factor 3 complex] evidence: IDA
            GeneID:8667 -> Cellular component: GO:0016282 [eukaryotic 43S preinitiation complex] evidence: IEA
            GeneID:8667 -> Cellular component: GO:0033290 [eukaryotic 48S preinitiation complex] evidence: IEA

by @meso_cacase at DBCLS
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