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2024-03-29 09:47:41, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_003751               3009 bp    mRNA    linear   PRI 23-MAY-2013
DEFINITION  Homo sapiens eukaryotic translation initiation factor 3, subunit B
            (EIF3B), transcript variant 1, mRNA.
ACCESSION   NM_003751
VERSION     NM_003751.3  GI:83367073
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Liang,H., Ding,X., Zhou,C., Zhang,Y., Xu,M., Zhang,C. and Xu,L.
  TITLE     Knockdown of eukaryotic translation initiation factors 3B (EIF3B)
            inhibits proliferation and promotes apoptosis in glioblastoma cells
  JOURNAL   Neurol. Sci. 33 (5), 1057-1062 (2012)
   PUBMED   22234522
  REMARK    GeneRIF: EIF3B promotes the proliferation of U87 human glioblastoma
            cells and may play an important role in human glioblastoma
            development.
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Elantak,L., Wagner,S., Herrmannova,A., Karaskova,M., Rutkai,E.,
            Lukavsky,P.J. and Valasek,L.
  TITLE     The indispensable N-terminal half of eIF3j/HCR1 cooperates with its
            structurally conserved binding partner eIF3b/PRT1-RRM and with
            eIF1A in stringent AUG selection
  JOURNAL   J. Mol. Biol. 396 (4), 1097-1116 (2010)
   PUBMED   20060839
  REMARK    GeneRIF: a conserved tryptophan residue in the human eIF3j
            N-terminal acidic motif (NTA) is held in the helix alpha1 and loop
            5 hydrophobic pocket of the human eIF3b RNA recognition motif (RRM)
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Khoshnevis,S., Neumann,P. and Ficner,R.
  TITLE     Crystal structure of the RNA recognition motif of yeast translation
            initiation factor eIF3b reveals differences to human eIF3b
  JOURNAL   PLoS ONE 5 (9) (2010)
   PUBMED   20862284
  REMARK    GeneRIF: Yeast eIF3b exhibits RNA binding activity but huamn eIF3b
            doesn't.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Zhou,M., Sandercock,A.M., Fraser,C.S., Ridlova,G., Stephens,E.,
            Schenauer,M.R., Yokoi-Fong,T., Barsky,D., Leary,J.A., Hershey,J.W.,
            Doudna,J.A. and Robinson,C.V.
  TITLE     Mass spectrometry reveals modularity and a complete subunit
            interaction map of the eukaryotic translation factor eIF3
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 105 (47), 18139-18144 (2008)
   PUBMED   18599441
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Lee,C.S., Dias,A.P., Jedrychowski,M., Patel,A.H., Hsu,J.L. and
            Reed,R.
  TITLE     Human DDX3 functions in translation and interacts with the
            translation initiation factor eIF3
  JOURNAL   Nucleic Acids Res. 36 (14), 4708-4718 (2008)
   PUBMED   18628297
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J. Biol. Chem. 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Chaudhuri,J., Chakrabarti,A. and Maitra,U.
  TITLE     Biochemical characterization of mammalian translation initiation
            factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the
            mammalian homologue of Saccharomyces cerevisiae protein Prt1
  JOURNAL   J. Biol. Chem. 272 (49), 30975-30983 (1997)
   PUBMED   9388245
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Methot,N., Rom,E., Olsen,H. and Sonenberg,N.
  TITLE     The human homologue of the yeast Prt1 protein is an integral part
            of the eukaryotic initiation factor 3 complex and interacts with
            p170
  JOURNAL   J. Biol. Chem. 272 (2), 1110-1116 (1997)
   PUBMED   8995410
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Asano,K., Kinzy,T.G., Merrick,W.C. and Hershey,J.W.
  TITLE     Conservation and diversity of eukaryotic translation initiation
            factor eIF3
  JOURNAL   J. Biol. Chem. 272 (2), 1101-1109 (1997)
   PUBMED   8995409
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Kirken,R.A., Rui,H., Evans,G.A. and Farrar,W.L.
  TITLE     Characterization of an interleukin-2 (IL-2)-induced tyrosine
            phosphorylated 116-kDa protein associated with the IL-2 receptor
            beta-subunit
  JOURNAL   J. Biol. Chem. 268 (30), 22765-22770 (1993)
   PUBMED   7693677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC004971.3, U78525.1 and BQ015102.1.
            On Dec 8, 2005 this sequence version replaced gi:33239444.
            
            Transcript Variant: This variant (1) differs in the 3' UTR compared
            to variant 2. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U62583.1, BC110865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               AC004971.3         9177-9758           c
            583-2542            U78525.1           575-2534
            2543-3009           BQ015102.1         14-480              c
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..3009
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="eukaryotic translation initiation factor 3, subunit
                     B"
                     /db_xref="GeneID:8662"
                     /db_xref="HGNC:3280"
                     /db_xref="HPRD:06795"
                     /db_xref="MIM:603917"
     exon            1..582
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    1
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="5'-most of multiple alternative transcription
                     initiation sites"
     variation       7
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11975205"
     misc_feature    29
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="predominant transcription initiation site"
     variation       58
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376125182"
     CDS             84..2528
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="eukaryotic translation initiation factor 3, subunit
                     9 (eta, 116kD); eukaryotic translation initiation factor
                     3, subunit 9 eta, 116kDa; hPrt1; eIF-3-eta; eIF3 p110;
                     eIF3 p116; prt1 homolog; eukaryotic translation initiation
                     factor 3 subunit 9"
                     /codon_start=1
                     /product="eukaryotic translation initiation factor 3
                     subunit B"
                     /protein_id="NP_003742.2"
                     /db_xref="GI:33239445"
                     /db_xref="CCDS:CCDS5332.1"
                     /db_xref="GeneID:8662"
                     /db_xref="HGNC:3280"
                     /db_xref="HPRD:06795"
                     /db_xref="MIM:603917"
                     /translation="
MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEAGPESEVRTEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSRAQAVSEDAGGNEGRAAEAEPRALENGDADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEEDGKTKGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKIELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQIKKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRKYRKMAQELYMEQKNERLELRGGVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE
"
     misc_feature    84..86
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylmethionine; propagated from
                     UniProtKB/Swiss-Prot (P55884.3); acetylation site"
     misc_feature    315..317
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    324..326
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    330..332
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    330..332
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    336..338
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    336..338
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    438..440
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    438..440
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    453..1322
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P55884.3);
                     Region: Sufficient for interaction with EIF3E"
     misc_feature    456..458
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    456..458
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    537..539
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    537..539
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    543..545
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    543..545
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    573..575
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    573..575
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    591..905
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P55884.3);
                     Region: Sufficient for interaction with EIF3J"
     misc_feature    <702..860
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="RRM (RNA recognition motif), also known as RBD (RNA
                     binding domain) or RNP (ribonucleoprotein domain), is a
                     highly abundant domain in eukaryotes found in proteins
                     involved in post-transcriptional gene expression processes
                     including mRNA and rRNA...; Region: RRM; cd00590"
                     /db_xref="CDD:100104"
     misc_feature    708..710
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P55884.3); acetylation site"
     misc_feature    order(777..779,783..785)
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="RNA/DNA binding site [nucleotide binding]; other
                     site"
                     /db_xref="CDD:100104"
     misc_feature    798..800
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P55884.3); phosphorylation site"
     misc_feature    945..947
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P55884.3); acetylation site"
     misc_feature    1005..2381
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /note="Uncharacterized protein, contains Trp-Asp (WD)
                     repeat [General function prediction only]; Region:
                     COG5354"
                     /db_xref="CDD:34929"
     misc_feature    1173..1175
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P55884.3); acetylation site"
     misc_feature    1197..1334
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P55884.3);
                     Region: WD 2"
     misc_feature    1344..1460
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P55884.3);
                     Region: WD 3"
     misc_feature    1656..1658
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1761..1886
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P55884.3);
                     Region: WD 4"
     misc_feature    2028..2165
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P55884.3);
                     Region: WD 5"
     variation       114
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11551169"
     variation       273
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9690787"
     variation       380
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372788366"
     variation       388
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551168"
     variation       441
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369063429"
     variation       461
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:185762794"
     variation       501
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376446348"
     variation       504
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369761279"
     variation       518
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551167"
     variation       534
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191463396"
     variation       553
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369059870"
     variation       570
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78680793"
     exon            583..775
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       610
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201331895"
     variation       632
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58174334"
     variation       638
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374070548"
     variation       639
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201155310"
     variation       653
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372472481"
     variation       655
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143426217"
     variation       656
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377134404"
     variation       665
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:147152815"
     exon            776..895
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       794
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140288121"
     variation       809
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146230401"
     variation       811
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150739455"
     variation       816
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200218143"
     variation       824
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200969617"
     variation       827
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369741313"
     variation       837
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200489277"
     variation       867
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373392664"
     variation       884
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116770364"
     exon            896..953
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       904
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150027587"
     variation       905
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370385949"
     variation       910
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:151282164"
     variation       914
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145413649"
     variation       915
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148785184"
     exon            954..1082
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       975
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77981709"
     variation       981
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11551165"
     variation       1003
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201467063"
     variation       1010
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143894408"
     variation       1027
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371362324"
     variation       1050
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146798724"
     variation       1058
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140490524"
     variation       1064
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201106605"
     variation       1065
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:374813967"
     exon            1083..1240
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1085
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551170"
     variation       1096
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375551545"
     variation       1101
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374521648"
     variation       1104
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368514580"
     variation       1115
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145719280"
     variation       1136
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371264143"
     variation       1145
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374173451"
     variation       1211
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61742669"
     exon            1241..1372
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1241
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147656962"
     variation       1259
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142377401"
     variation       1273
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371006035"
     variation       1274
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201449328"
     variation       1296
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199814936"
     variation       1315
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376326730"
     variation       1340
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144904326"
     variation       1351
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551171"
     exon            1373..1439
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     exon            1440..1486
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1484
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138033670"
     exon            1487..1697
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1496
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201839393"
     variation       1511
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142311273"
     variation       1520
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146119314"
     variation       1583
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182549563"
     variation       1589
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374012155"
     variation       1631
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377056966"
     variation       1637
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368996785"
     variation       1682
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1804773"
     exon            1698..1770
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1703
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77573843"
     exon            1771..1893
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1784
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200089529"
     variation       1826
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61742731"
     variation       1827
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144505700"
     variation       1838
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140168471"
     variation       1841
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:141948054"
     variation       1858
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150678614"
     exon            1894..1972
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1940
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201057035"
     variation       1967
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114731734"
     exon            1973..2111
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       1991
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201791942"
     variation       2005
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76153980"
     variation       2014
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181409131"
     variation       2027
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112914667"
     variation       2052
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139537965"
     variation       2079
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370274071"
     exon            2112..2237
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       2131..2132
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:372830910"
     variation       2136
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201207559"
     variation       2196..2197
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:149919744"
     variation       2209
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149974474"
     variation       2213
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373984035"
     variation       2216
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145251998"
     exon            2238..2315
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       2264
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149152140"
     variation       2267
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201291849"
     exon            2316..2424
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       2335
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375864470"
     variation       2355..2356
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:34214335"
     variation       2356
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373039793"
     variation       2374
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202106605"
     variation       2381
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200135327"
     variation       2403
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150993211"
     variation       2414
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142147533"
     exon            2425..2542
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       2439
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141884022"
     variation       2440
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373945753"
     variation       2446
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:367843382"
     variation       2459
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146207412"
     variation       2462
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1063257"
     variation       2523
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372896684"
     variation       2534
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371972825"
     exon            2543..3009
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /inference="alignment:Splign:1.39.8"
     variation       2544
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375827322"
     variation       2550
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76988192"
     variation       2573
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:111842567"
     variation       2578
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370904265"
     variation       2590
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373009831"
     variation       2599
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145996421"
     variation       2656
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201303353"
     variation       2657
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377583925"
     variation       2696
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369577381"
     variation       2698
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370520430"
     variation       2705
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373127863"
     STS             2712..2864
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /standard_name="RH78609"
                     /db_xref="UniSTS:57270"
     STS             2720..2992
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /standard_name="A005U22"
                     /db_xref="UniSTS:41034"
     variation       2726
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1804774"
     variation       2756
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188112322"
     variation       2768
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139942907"
     variation       2783
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191639027"
     variation       2805
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142858802"
     variation       2815
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151071509"
     variation       2839
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76427867"
     variation       2920
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2301945"
     variation       2969
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373516007"
     polyA_signal    2985..2990
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
     variation       2998
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:369329003"
     polyA_site      3009
                     /gene="EIF3B"
                     /gene_synonym="EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9;
                     PRT1"
ORIGIN      
tagccgtcgcggcgcgcggtgcggcctgggagagtcggaagcgcggcggccgcggagccctgcgagtaggcagcgttgggcccatgcaggacgcggagaacgtggcggtgcccgaggcggccgaggagcgcgccgagcccggccagcagcagccggccgccgagccgccgccagccgaggggctgctgcggcccgcggggcccggcgctccggaggccgcggggaccgaggcctccagtgaggaggtggggatcgcggaggccgggccggagtccgaggtgaggaccgagccggcggccgaggcagaggcggcctccggcccgtccgagtcgccctcgccgccggccgccgaggagctgcccgggtcgcatgctgagccccctgtcccggcacagggcgaggccccaggagagcaggctcgggacgagcgctccgacagccgggcccaggcggtgtccgaggacgcgggaggaaacgagggcagagcggccgaggccgaaccccgggcgctggagaacggcgacgcggacgagccctccttcagcgaccccgaggacttcgtggacgacgtgagcgaggaagaattactgggagatgtactcaaagatcggccccaggaagcagatggaatcgattcggtgattgtagtggacaatgtccctcaggtgggacccgaccgacttgagaaactcaaaaatgtcatccacaagatcttttccaagtttgggaaaatcacaaatgatttttatcctgaagaggatgggaagacaaaagggtatattttcctggagtacgcgtcccctgcccacgctgtggatgctgtgaagaacgccgacggctacaagcttgacaagcagcacacattccgggtcaacctctttacggattttgacaagtatatgacgatcagtgacgagtgggatattccagagaaacagcctttcaaagacctggggaacttacgttactggcttgaagaggcagaatgcagagatcagtacagtgtgatttttgagagtggagaccgcacttccatattctggaatgacgtaaaagaccctgtctcaattgaagaaagagcgagatggacagagacgtatgtgcgttggtctcctaagggcacctacctggctacctttcatcaaagaggcattgctctatgggggggagagaaattcaagcaaattcagagattcagccaccaaggggttcagcttattgacttctcaccttgtgaaaggtacctggtgacctttagccccctgatggacacgcaggatgaccctcaggccataatcatctgggacatccttacggggcacaagaagaggggttttcactgtgagagctcagcccattggcctatttttaagtggagccatgatggcaaattctttgccagaatgaccctggatacgcttagcatctatgaaactccttctatgggtcttttggacaagaagagtttgaagatctctgggataaaagacttttcttggtctcctggtggtaacataatcgccttctgggtgcctgaagacaaagatattccagccagggtaaccctgatgcagctccctaccaggcaagagatccgagtgaggaacctgttcaatgtggtggactgcaagctccattggcagaagaacggagactacttgtgtgtgaaagtagataggactccgaaaggcacccagggtgttgtcacaaattttgaaattttccgaatgagggagaaacaggtacctgtggatgtggtcgagatgaaagaaaccatcatagcctttgcctgggaaccaaatggaagtaagtttgctgtgctgcacggagaggctccgcggatatctgtgtctttctaccacgtcaaaaacaacgggaagattgaactcatcaagatgttcgacaagcagcaggcgaacaccatcttctggagcccccaaggacagttcgtggtgttggcgggcctgaggagtatgaacggtgccttagcgtttgtggacacttcggactgcacggtcatgaacatcgcagagcactacatggcttccgacgtcgaatgggatcctactgggcgctacgtcgtcacctctgtgtcctggtggagccataaggtggacaacgcgtactggctgtggactttccagggacgcctcctgcagaagaacaacaaggaccgcttctgccagctgctgtggcggccccggcctcccacactcctgagccaggaacagatcaagcaaattaaaaaggatctgaagaaatactctaagatctttgaacagaaggatcgtttgagtcagtccaaagcctcaaaggaattggtggagagaaggcgcaccatgatggaagatttccggaagtaccggaaaatggcccaggagctctatatggagcagaaaaacgagcgcctggagttgcgaggaggggtggacactgacgagctggacagcaacgtggacgactgggaagaggagaccattgagttcttcgtcactgaagaaatcattcccctcgggaatcaggagtgacctggagcactgtgcgcagccgtgtgtgctgtggagccgaggccgtcctgcaggaagccgcgtgactcccgcctcctccctgtgctctctggctctggactgtgactgcgcctggattctgccattgcgacacatttttgtgcctttcagcccctggtgtctgcagtgggggatttaaggcacccgcttccacttctttcttgtttggagttttctgttggaaccgccggcgttggctccgaagacttagcgacgccactggcggcaccttctcctgcgcccagtgatgtttccacggtgcctgtacacagccgagcagcatttccgttgaaggacttgcatccccattgcgggcagtgctggacgtgtcccggagacccaccgggagggcgccgccatgccttgtacccccaccgtgcaggttgtggccggttttctccgcaggttgaacatggaaataaaagcaaacttgtatgaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8662 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
            GeneID:8662 -> Molecular function: GO:0003743 [translation initiation factor activity] evidence: IC
            GeneID:8662 -> Molecular function: GO:0003743 [translation initiation factor activity] evidence: IDA
            GeneID:8662 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8662 -> Molecular function: GO:0031369 [translation initiation factor binding] evidence: IEA
            GeneID:8662 -> Molecular function: GO:0032947 [protein complex scaffold] evidence: TAS
            GeneID:8662 -> Biological process: GO:0001731 [formation of translation preinitiation complex] evidence: IEA
            GeneID:8662 -> Biological process: GO:0006412 [translation] evidence: TAS
            GeneID:8662 -> Biological process: GO:0006413 [translational initiation] evidence: IC
            GeneID:8662 -> Biological process: GO:0006413 [translational initiation] evidence: IDA
            GeneID:8662 -> Biological process: GO:0006413 [translational initiation] evidence: TAS
            GeneID:8662 -> Biological process: GO:0006446 [regulation of translational initiation] evidence: IDA
            GeneID:8662 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:8662 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS
            GeneID:8662 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:8662 -> Cellular component: GO:0005852 [eukaryotic translation initiation factor 3 complex] evidence: IDA
            GeneID:8662 -> Cellular component: GO:0016282 [eukaryotic 43S preinitiation complex] evidence: IEA
            GeneID:8662 -> Cellular component: GO:0033290 [eukaryotic 48S preinitiation complex] evidence: IEA

by @meso_cacase at DBCLS
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