Home |
Help |
Advanced search
2024-04-26 17:55:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_003728 9879 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens unc-5 homolog C (C. elegans) (UNC5C), mRNA.
ACCESSION NM_003728
VERSION NM_003728.3 GI:302058264
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9879)
AUTHORS Hibi,K., Sakuraba,K., Shirahata,A., Goto,T., Saito,M.,
Ishibashi,K., Kigawa,G., Nemoto,H. and Sanada,Y.
TITLE Methylation of the UNC5C gene is frequently detected in
hepatocellular carcinoma
JOURNAL Hepatogastroenterology 59 (120), 2573-2575 (2012)
PUBMED 23178624
REMARK GeneRIF: TNM stage 1 hepatocellular carcinoma (HCC) presented UNC5C
methylation, indicating that the UNC5C gene has been methylated
from the early stages of HCC.
REFERENCE 2 (bases 1 to 9879)
AUTHORS Purohit,A.A., Li,W., Qu,C., Dwyer,T., Shao,Q., Guan,K.L. and Liu,G.
TITLE Down syndrome cell adhesion molecule (DSCAM) associates with
uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse
JOURNAL J. Biol. Chem. 287 (32), 27126-27138 (2012)
PUBMED 22685302
REMARK GeneRIF: knockdown of DSCAM inhibits netrin-induced tyrosine
phosphorylation of UNC5C and Fyn as well as the interaction of
UNC5C with Fyn. The double knockdown of both receptors abolishes
the induction of Fyn tyrosine phosphorylation by netrin-1
REFERENCE 3 (bases 1 to 9879)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 4 (bases 1 to 9879)
AUTHORS Coissieux,M.M., Tomsic,J., Castets,M., Hampel,H., Tuupanen,S.,
Andrieu,N., Comeras,I., Drouet,Y., Lasset,C., Liyanarachchi,S.,
Mazelin,L., Puisieux,A., Saurin,J.C., Scoazec,J.Y., Wang,Q.,
Aaltonen,L., Tanner,S.M., de la Chapelle,A., Bernet,A. and
Mehlen,P.
TITLE Variants in the netrin-1 receptor UNC5C prevent apoptosis and
increase risk of familial colorectal cancer
JOURNAL Gastroenterology 141 (6), 2039-2046 (2011)
PUBMED 21893118
REMARK GeneRIF: Inherited mutations in UNC5C prevent apoptosis and
increase risk of colorectal cancer.
REFERENCE 5 (bases 1 to 9879)
AUTHORS Lv,D., Zhao,W., Dong,D., Qian,X.P., Zhang,Y., Tian,X.J. and
Zhang,J.
TITLE Genetic and epigenetic control of UNC5C expression in human renal
cell carcinoma
JOURNAL Eur. J. Cancer 47 (13), 2068-2076 (2011)
PUBMED 21600761
REMARK GeneRIF: UNC5C acts as a tumour suppressor in RCC and is
down-regulated in RCC. Loss of heterozygosity and DNA methylation
contribute to the inactivation of UNC5C in renal cell carcinoma.
REFERENCE 6 (bases 1 to 9879)
AUTHORS Geisbrecht,B.V., Dowd,K.A., Barfield,R.W., Longo,P.A. and
Leahy,D.J.
TITLE Netrin binds discrete subdomains of DCC and UNC5 and mediates
interactions between DCC and heparin
JOURNAL J. Biol. Chem. 278 (35), 32561-32568 (2003)
PUBMED 12810718
REFERENCE 7 (bases 1 to 9879)
AUTHORS Thiebault,K., Mazelin,L., Pays,L., Llambi,F., Joly,M.O.,
Scoazec,J.Y., Saurin,J.C., Romeo,G. and Mehlen,P.
TITLE The netrin-1 receptors UNC5H are putative tumor suppressors
controlling cell death commitment
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (7), 4173-4178 (2003)
PUBMED 12655055
REMARK GeneRIF: may represent tumor suppressor that inhibit tumor
extension outside the region of netrin-1 availability by inducing
apoptosis
REFERENCE 8 (bases 1 to 9879)
AUTHORS Kennedy,T.E.
TITLE Cellular mechanisms of netrin function: long-range and short-range
actions
JOURNAL Biochem. Cell Biol. 78 (5), 569-575 (2000)
PUBMED 11103947
REMARK Review article
REFERENCE 9 (bases 1 to 9879)
AUTHORS Livesey,F.J.
TITLE Netrins and netrin receptors
JOURNAL Cell. Mol. Life Sci. 56 (1-2), 62-68 (1999)
PUBMED 11213262
REMARK Review article
REFERENCE 10 (bases 1 to 9879)
AUTHORS Ackerman,S.L. and Knowles,B.B.
TITLE Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23
JOURNAL Genomics 52 (2), 205-208 (1998)
PUBMED 9782087
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC106881.9, AK290500.1,
AF055634.1 and AC105395.1.
On Jul 31, 2010 this sequence version replaced gi:16933524.
Summary: This gene product belongs to the UNC-5 family of netrin
receptors. Netrins are secreted proteins that direct axon extension
and cell migration during neural development. They are bifunctional
proteins that act as attractants for some cell types and as
repellents for others, and these opposite actions are thought to be
mediated by two classes of receptors. The UNC-5 family of receptors
mediate the repellent response to netrin; they are transmembrane
proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I
thrombospondin motifs in the extracellular region. [provided by
RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF055634.1, AK290500.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-377 AC106881.9 93664-94040 c
378-643 AK290500.1 189-454
644-1624 AF055634.1 445-1425
1625-2214 AK290500.1 1436-2025
2215-2303 AF055634.1 2016-2104
2304-2514 AK290500.1 2115-2325
2515-2639 AC105395.1 126798-126922 c
2640-2844 AK290500.1 2451-2655
2845-3265 AF055634.1 2646-3066
3266-9879 AC105395.1 104255-110868 c
FEATURES Location/Qualifiers
source 1..9879
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q21-q23"
gene 1..9879
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="unc-5 homolog C (C. elegans)"
/db_xref="GeneID:8633"
/db_xref="HGNC:12569"
/db_xref="MIM:603610"
exon 1..477
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
CDS 354..3149
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="unc5 (C.elegans homolog) c; unc-5 homolog 3;
protein unc-5 homolog C; protein unc-5 homolog 3"
/codon_start=1
/product="netrin receptor UNC5C precursor"
/protein_id="NP_003719.3"
/db_xref="GI:302058265"
/db_xref="CCDS:CCDS3643.1"
/db_xref="GeneID:8633"
/db_xref="HGNC:12569"
/db_xref="MIM:603610"
/translation="
MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
"
sig_peptide 354..470
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 855..1124
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 864..1124
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:213125"
misc_feature 1140..1295
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="Thrombospondin type 1 repeats; Region: TSP1;
smart00209"
/db_xref="CDD:197574"
misc_feature 1308..1454
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="Thrombospondin type 1 repeats; Region: TSP1;
smart00209"
/db_xref="CDD:197574"
misc_feature 1494..1556
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O95185.2);
transmembrane region"
misc_feature 1596..1601
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cleavage, by caspase-3 (By similarity); propagated
from UniProtKB/Swiss-Prot (O95185.2); cleavage site"
misc_feature 1935..2243
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="ZU5 domain; Region: ZU5; pfam00791"
/db_xref="CDD:189721"
misc_feature 2433..2489
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O95185.2);
Region: Interaction with DCC (By similarity)"
misc_feature 2883..3134
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="Death domain found in Uncoordinated-5C; Region:
Death_UNC5C; cd08799"
/db_xref="CDD:176777"
misc_feature order(2982..2987,2991..2996,3024..3026,3033..3038,
3045..3050)
/gene="UNC5C"
/gene_synonym="UNC5H3"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:176777"
variation 463
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="g"
/replace="t"
/db_xref="dbSNP:2306715"
exon 478..699
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
variation 587
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="c"
/replace="t"
/db_xref="dbSNP:1843018"
exon 700..843
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 844..947
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 948..1128
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 1129..1296
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 1297..1461
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
STS 1461..1654
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="BZ897709"
/db_xref="UniSTS:475395"
exon 1462..1653
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 1654..1998
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 1999..2086
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 2087..2255
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
variation 2165
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="a"
/replace="c"
/db_xref="dbSNP:2276322"
exon 2256..2489
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
variation 2390
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3733212"
exon 2490..2639
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
variation 2515
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="c"
/replace="t"
/db_xref="dbSNP:2289043"
exon 2640..2804
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 2805..2983
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
exon 2984..9879
/gene="UNC5C"
/gene_synonym="UNC5H3"
/inference="alignment:Splign:1.39.8"
STS 2985..3839
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="UNC5C__5006"
/db_xref="UniSTS:462939"
STS 3633..3809
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="STS-N34287"
/db_xref="UniSTS:54627"
variation 3683
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="a"
/replace="t"
/db_xref="dbSNP:1369083"
variation 5391
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201446644"
variation 5395..5396
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace=""
/replace="cata"
/db_xref="dbSNP:3217294"
STS 5454..5610
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="RH93750"
/db_xref="UniSTS:90525"
variation 5561
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="a"
/replace="c"
/db_xref="dbSNP:1813074"
STS 6829..6970
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="SHGC-19072"
/db_xref="UniSTS:74737"
STS 6829..6951
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="SHGC-50331"
/db_xref="UniSTS:74736"
variation 7127
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3846450"
variation 7583
/gene="UNC5C"
/gene_synonym="UNC5H3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3857230"
STS 8045..8281
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="SHGC-8648"
/db_xref="UniSTS:41349"
STS 9560..9816
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="STS-T51283"
/db_xref="UniSTS:73506"
STS 9591..9828
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="SHGC-67342"
/db_xref="UniSTS:93041"
STS 9631..9790
/gene="UNC5C"
/gene_synonym="UNC5H3"
/standard_name="RH103210"
/db_xref="UniSTS:97543"
polyA_signal 9854..9859
/gene="UNC5C"
/gene_synonym="UNC5H3"
polyA_site 9875
/gene="UNC5C"
/gene_synonym="UNC5H3"
polyA_site 9879
/gene="UNC5C"
/gene_synonym="UNC5H3"
ORIGIN
agtccagacttcggcgtgcggcggagctgcggctgctcctgctgctggggggagcggcggaggtggccgccttgcgcctccctggacttcccaagtgggggcagagcagtcgctcgcgggagacgtcagttagaaggcattgggaaagagggaccttcaaactcctcctcggcgtctcctctcctcccccttttggcccctgcctttggagaaagtggagtgtggcgcttggttgtcgttatttcttcggactgcttcgcggtgcacggattcagcttctgcccagtggggctttcagctgtttgcgcgtctctctgtccccctcccctccccccggcacacctctgtctacgatgaggaaaggtctgcgggcgacagcggcccgctgcggactgggactgggatacttgctgcaaatgctcgtgctacctgccctggccctgctcagcgccagcggcactggctccgccgcccaagatgatgacttttttcatgaactcccagaaacttttccttctgatccacctgagcctctgccacatttccttattgagcctgaagaagcttatattgtgaagaataagcctgtgaacctgtactgtaaagcaagccctgccacccagatctatttcaagtgtaatagtgaatgggttcatcagaaggaccacatagtagatgaaagagtagatgaaacttccggtctcattgtccgggaagtgagcattgagatttcgcgccagcaagtggaagaactctttggacctgaagattactggtgccagtgtgtggcctggagctccgcgggtaccacaaagagccggaaggcgtatgtgcgcattgcatatctacggaagacatttgagcaggaacccctaggaaaggaagtgtctttggaacaggaagtcttactccagtgtcgaccacctgaagggatcccagtggctgaggtggaatggttgaaaaatgaagacataattgatcccgttgaagatcggaatttttatattactattgatcacaacctcatcataaagcaggcccgactctctgatactgcaaattacacctgtgttgccaaaaacattgttgccaagaggaaaagtacaactgccactgtcatagtctatgtcaacggtggctggtccacctggacggagtggtctgtgtgtaacagccgctgtggacgagggtatcagaaacgtacaaggacttgtaccaacccggcaccactcaatgggggtgccttctgtgaagggcagagtgtgcagaaaatagcctgtactacgttatgcccagtggatggcaggtggacgccatggagcaagtggtctacttgtggaactgagtgcacccactggcgcaggagggagtgcacggcgccagcccccaagaatggaggcaaggactgcgacggcctcgtcttgcaatccaagaactgcactgatgggctttgcatgcagactgctcctgattcagatgatgttgctctctatgttgggattgtgatagcagtgatcgtttgcctggcgatctctgtagttgtggccttgtttgtgtatcggaagaatcatcgtgactttgagtcagatattattgactcttcggcactcaatgggggctttcagcctgtgaacatcaaggcagcaagacaagatctgctggctgtacccccagacctcacgtcagctgcagccatgtacagaggacctgtctatgccctgcatgacgtctcagacaaaatcccaatgaccaactctccaattctggatccactgcccaacctgaaaatcaaagtgtacaacacctcaggtgctgtcaccccccaagatgacctctctgagtttacgtccaagctgtcccctcagatgacccagtcgttgttggagaatgaagccctcagcctgaagaaccagagtctagcaaggcagactgatccatcctgtaccgcatttggcagcttcaactcgctgggaggtcaccttattgttcccaattcaggagtcagcttgctgattcccgctggggccattccccaagggagagtctacgaaatgtatgtgactgtacacaggaaagaaactatgaggccacccatggatgactctcagacacttttgacccctgtggtgagctgtgggcccccaggagctctgctcacccgcccagtcgtcctcactatgcatcactgcgcagaccccaataccgaggactggaaaatactgctcaagaaccaggcagcacagggacagtgggaggatgtggtggtggtcggggaggaaaacttcaccaccccctgctacattcagctggatgcagaggcctgccacatcctcacagagaacctcagcacctacgccctggtaggacattccaccaccaaagcggctgcgaagcgcctcaagctggccatctttgggcccctgtgctgctcctcgctggagtacagcatccgagtctactgtctggatgacacccaggatgccctgaaggaaattttacatcttgagagacagatgggaggacagctcctagaagaacctaaggctcttcattttaaaggcagcacccacaacctgcgcctgtcaattcacgatatcgcccattccctctggaagagcaaattgctggctaaatatcaggaaattccattttaccatgtttggagtggatctcaaagaaacctgcactgcaccttcactctggaaagatttagcctgaacacagtggagctggtttgcaaactctgtgtgcggcaggtggaaggagaagggcagatcttccagctcaactgcaccgtgtcagaggaacctactggcatcgatttgccgctgctggatcctgcgaacaccatcaccacggtcacggggcccagtgctttcagcatccctctccctatccggcagaagctctgtagcagcctggatgccccccagacgagaggccatgactggaggatgctggcccataagctgaacctggacaggtacttgaattactttgccaccaaatccagcccaactggcgtaatcctggatctttgggaagcacagaacttcccagatggaaacctgagcatgctggcagctgtcttggaagaaatgggaagacatgaaacggtggtgtccttagcagcagaagggcagtattaaccaccatgctggaaggggaaatgaaggacaaaaatgcacagggagtctgtggccgtccaggtgaatcacagctgaggaggaaatccagatgagaccaatgcacttcacaggcaagactgcagcaggagccagaaggaaaacagatacaactgcccatgtacatgcccactttactcggacatcatcacgggagttaagaaaaattgtgtaaatttgtaccttgaatttagctatcaacctaattttcctcttagttgggctgtatgctgtgtggtacaggatcttacagtttcctaggaaacgctttttattgctatccagatatatggataaactttcttaacaaacccaatttctacaaatgttgtttacatcaaattggacagggatgcagacactgtccatggctcgttctatttttgttcaaatcatttgaagttgaagctgtggacggtttgttgtgtctatttcagattagtaatttacagagaaatcacagacttttgctacaaatcgtgtgcatcaagtgtctcagataatcctcccatcagtgttctgtttctagaacttgtagaaccagtgttactgtttgtatcagggaagtggagaatctaagtgtaaaaaagaaataactaagactcctattccttggagggacccttctggtgccctttgggaataaagctgtagcactgcagggaagacagtgattcatgttcaaccccacaaacaagcatttttttcacaacatgtgtgtttgtttgtaatatgcaatatgaagtgtttttttttaaaggtattattattatttacaggtattctggtaaaatgatttttttaaatttctatttttgttagcagtgctgtttgttagtatttggttattgactagacctgtcccaccttttcacctatcaaggtgggtgtggtcatcagtttaattcaacatgcatcacttccttgaccttttacctttcccttattccaccccagaaaggtgattgataaatgctgaatggctttgtcagtctgttccttcagcttgctcaggcagggtctttctttctcctctgaggagtcttaaggagacgtgttctctattaagttcacttaatattgccgttgtgtggccccacgtcgactccctatggtgctctactctagaggcagtgtggttggaggaatggactctaaactggagatcaagaaaccagttctcattgtgggtctgtcactgtcttgttgcgccaccttgagaaagtcatttaaccacacgacctcagtgtcctcactagaaagtgaaagggtgggattagatcatctccaagttctgaaatgctcaacttccaccgtgatgcctccagtctcattcatcagtctgaagaccacaatggactctgacctggatcatcatttaaaaatcatcagctggtcttttgcccaggctatgttacgcctttcaagtagttctgacaaggaagatgattattctaaccagcattatgatgttgtttgtttggcctgagtcgctctgcatcattgcattatgctgttcactgagagatgacatccctttattatcattttcttagcctctcttgggatgcccctgcccccagccttcctgactggttgcaaattctgttttttattattgtcttggcatcttgatatctagaccactcctacaagtttatctggcagtaggaacttggtgcatttttttctacgctacacccccccacccttaatctttctttgctgtcataatattcagtagcatttataaaagctgtctagttagctctttaaaaacttttgtcctgcaaaatgtttgttagtcaacacactactttgtgtaaacaactattatgtttccttgggaccatcacaagctctttaacaaacacaaggactcaattcattcagcaggtggggattaaagaatcaaagcccagtagcaaaaccaaaactgaagaacaagcagacatgtgtatgaatcggaacctttagaacatgactgtggtttacttttaggctggaggcacacaagttgctgaacagacttgaattatacatgtgcttccatctttccatgtttccgctcctattttggtagcatcttgagattccttgatgcctccgccatcctcatccctgaggaactgctgataccttgctatggaacctcttctttctttcatgctttttattccgtatcttctgttttggacatacatacatatattctataaaatctctctcagcccaccccctgcattaggatttccatatttaaaatatttgtacactgactggggaagggagagattgcactataaacaagttcagtggatgtttgtagcaatgagtaaaactgtattctaaattaaaaatcaaatatatatacacgcagttatacacacacattttttaaaaggaggaggaggaaagagagctattgtccattcctacattttgaaataaacttgtcaagattacgcatcagtaccagggttgtggaatcatctatggaaatcaagaactagaatctgaactgaatggtcaaagaaacttctatgcctagtgaaaactagaggggagcaactatgtagctatgaacatgaatcaattccataactgttactaaaaacttattttgactaaaaagtcaccaacacagaactattgaacacaaacaggaattgtttgtcttactgaagtcactgagaacccttggggttcacttcagatgcttttttggttcaacttcccaccaccagaaaagggaaaagtgattgatttcgtgtgtgaggtactcatctgtcagaacccttaatgtttcctattaagtgaatgacaacttccatacatacactatttataccaaataattttcactacaaattctgatttccttctcctttggagtaaagtaatagctgttagattgctttcaaacttagaaggtccagatataacagttcatttcataggaagccacttcatcaaccattctatgtgatacatcctgcttctttctacaccgctggagaggcagtttggctggtttcatttggatagaaaaaactatcatttgtgcatgctgccatctagtggtgtacaacacaatctaacctgagtttaatattcactagaatgtgtttgacgaagggaatgaaaacctgtagagttcaaggacctttatgacaaacagatgtagggaaattttcacttcaaatttataattttcttattctcacttttttttcatttgcatcactcatctcaatattaggtcactgtgagcccagtacatcaactcattcatacacaacatatcttcagttgcttcttgtaacagaactatgtaaaatctatataaaacagtctttgaagagttgtcatttttaacacttatggttttcattggggtttgtatactttaaatctccttttagttccttaatatttatctttggaaatgtaagaagtatctgcttagaaagaaataagtcttatatatgcgaatggaatactatgtctagggaagagaaaattggggttgttaatcaaagggaagaaagcagcttcttttctgctgaatttgggaatccaaaggcagaggtttcatcctgtttttattttcttcttatcacactctttcaagtttccttaatgtatctggaaggaatagaagttggattcagaattgataactggcatggtgatgacaaacctgtgtaacaccaaggttctcacagctaacagctgtttcacaaacggcatcttccaaatgaacagtcacctctgctatgcagaaaacccccatcctgctgtgagcaagttaggctcttcaagaactggacaacttttgggtgaggtgttcaatatcaaactgcataatcattagccattttcatatatactattttatagatttaagtctctcaactatcaaaaagtagagcgattttcaggagaaaaaagtcgtggggactgagttcaggacaccctgaaactatgcgaccagtaatttttttaaggtattttttcctacaagtaaggtatctgaaaagtcaacgttttgagggtggaatcaagacttttcacttctcctggcaaagagcaacaaggctcttgtctcgtgtccttctgtgtgtctctgtcaggatcacagcagctgtgctcttggtctgcttactcctctgtaatccacgtatgcagaagggagttaataaggtgatcaccatctccccagaattcaaaggtctttgcctctataaggtctgcccctatggggccaggaaaatataaacctatataaggacttgcaagagagcataaagaaggtagaaaaggtttacttgttgggttttcaagccttcaagttgaatgagtcttagcttttgctgggcagttgttctggacaagtcatcagtttcatgtggagaactcagtgtaagcccaaggctaatgaatgagaggggtcccatggaaacacagctgaaatgaaatgggactttatccatcttctttgagaatggaagagcttttgtgaagcagtacatcattgctcaagataatggttgataagcattagattttatagatctaataaggaaaatattttattatctcaagttaacaaaacatttttttacctctcgagtgcctcataggaccaactattactctttggcttttatttttctttttgtattatttttatatattctttaaccttgctgagctagtattgactgaaatctttagaactttgcctctgggcaatgaagtaatgtttctctaccctaagatatctatttgtataatctctggctgtaatgatcactttggaagatttcctttgcatctctaattatttctttttaatggaataaggcataagggggaataaatatattgtaaccaatgttatgtaaacccatatccatacaggccaggaaagccaaatgaagtcatttccagaattctagtgtgaaaaacctatttttgaaaagtggggagatggctttgtgtagaactgggtgggttttctctgcagactaagtctagccatgagcttccagatcctttagttttatcagccttgtgcttaccccattttcataaatgctactttaacagccagtcttcataagtcatggttcctaggttttcctgtcacctcattgtattcatctgtggtaggatattaacgggctcattcaaccaaatgtaatgtgtgcctcagacctatttagcatggttggggggcatcagcaggacaaaccaacaggtactccgcaagtgtactggcacagcaagcccaccaattattagcagctcttcatcagcctgctgtctactcagacgcttgcctactgaagggacctgtccagagatcttctggaatcccaggttgggaatctctgcagaatgtcgtgacagttgtggcccaactagcttctgagtagaaacaaggaagctaccctgagatatagtcagctgcccacctgccatagtatttgctactgaatgccagccttttaacataccatttcagatttgtccttcaacaaaaatataaattgcaagtcataccatttaagggtcttttacaaatatgtctaaattgtgtgtcatttttaagttccaaaggtctactggactaagtactatcagaccagctgtagaacctgatggcgctgatccggggtggaataaccctcagtactggtgtgtagaagatgaattgtaggcaggttttgctgatcagcagcctaaggattgatgggctctcttttggcctctgatcctgagcactatggaggcagcatcagagaatggggacctgagctacataggttctcaatgttaaaacaactctgttcggagtgacatataagagcaagaaatctacagctggtgtaaaatacctttgccttttctatcccgaaagtaacaaatggcatctgtacatgtaggggtaaaaactcagatgtctactcctccaggccatggacaagaaaaagtacagcagtcagaacagtggaacaagtgatttgcattctcttcttcacgctttcctagatctgccattggtagcgcagccctcgccctccagacataatgcatcgagcccagttgcagggaacatcactgtgtgtgtgtgatgtcatggtgttatatgtgttgagtttaatgttgagctgaagcaagttggtgaccttcctctttgctctttgtaaagaagacaccaatgtttgtcagagaaaaatccccagcagtcgtgttgaagaggcagtgtcatccacctactgtcccctttggaacagttcaactgcagaaaggtcggattgaggttttgtgctttgtcgtttttcttttttaaacaaaacatgacaaccttggcttttccgatatggaacacttttgttgttgtggagttccctcttgctgtatcttctatgcaattccttttctaaaaaaaccccccggcagaggcagagtgccctccggatatctgtccggcgccttgctgagtggtggaggtgagggataccagctccgggtgtgcctcttttctctccctggctgccaatcctgattttccctgcagtccccttggtttgtaaattgcctgcatttattctgtcagccaacatgtacaaaatgtaagaaagaatttttaaacaggtaataaattatatttataagcaacaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8633 -> Molecular function: GO:0005042 [netrin receptor activity] evidence: IEA
GeneID:8633 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:8633 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
GeneID:8633 -> Biological process: GO:0007420 [brain development] evidence: IEA
GeneID:8633 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IEA
GeneID:8633 -> Biological process: GO:0033564 [anterior/posterior axon guidance] evidence: IEA
GeneID:8633 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
GeneID:8633 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:8633 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.